SrasV1, PubMed, Curation, bibRecord, 002660

Reduced bone mineral density in male Severe Acute Respiratory Syndrome (SARS) patients in Hong Kong.

Identifieur interne : 002660 ( PubMed/Curation ); précédent : 002659; suivant : 002661

Reduced bone mineral density in male Severe Acute Respiratory Syndrome (SARS) patients in Hong Kong.

Auteurs : E M C. Lau [Hong Kong] ; F W K. Chan ; D S C. Hui ; A K L. Wu ; P C Leung

Source :

Bone [ 8756-3282 ] ; 2005.

RBID : pubmed:15993669

Descripteurs français

KwdFr :
- Adulte, Adulte d'âge moyen, Densité osseuse (physiologie), Hong Kong, Humains, Mâle, Os et tissu osseux (anatomopathologie), Os et tissu osseux (physiopathologie), Sujet âgé, Sujet âgé de 80 ans ou plus, Syndrome respiratoire aigu sévère (anatomopathologie), Syndrome respiratoire aigu sévère (physiopathologie), Virus du SRAS (physiologie).
MESH :
- anatomopathologie : Os et tissu osseux, Syndrome respiratoire aigu sévère.
- physiologie : Densité osseuse, Virus du SRAS.
- physiopathologie : Os et tissu osseux, Syndrome respiratoire aigu sévère.
- Adulte, Adulte d'âge moyen, Hong Kong, Humains, Mâle, Sujet âgé, Sujet âgé de 80 ans ou plus.
Wicri :
- geographic : Hong Kong.

English descriptors

KwdEn :
- Adult, Aged, Aged, 80 and over, Bone Density (physiology), Bone and Bones (pathology), Bone and Bones (physiopathology), Hong Kong, Humans, Male, Middle Aged, SARS Virus (physiology), Severe Acute Respiratory Syndrome (pathology), Severe Acute Respiratory Syndrome (physiopathology).
MESH :
- geographic : Hong Kong.
- pathology : Bone and Bones, Severe Acute Respiratory Syndrome.
- physiology : Bone Density, SARS Virus.
- physiopathology : Bone and Bones, Severe Acute Respiratory Syndrome.
- Adult, Aged, Aged, 80 and over, Humans, Male, Middle Aged.

Abstract

During the Severe Acute Respiratory Syndrome (SARS) outbreak in Hong Kong in 2003, patients were treated with very high doses of corticosteroid and ribavirin. The detrimental effects of such treatment on the bone mineral density (BMD) of SARS patients are unknown. To compare the BMD of SARS patients with normal range data, a cross-sectional survey was conducted. The bone mineral density of 224 patients with SARS, who were treated with an average of 2753 mg (SD = 2152 mg) prednisolone and 29,344 mg (SD = 15,849 mg) of ribavirin was compared to normal data. Six percent of men had a hip BMD Z score of < or =-2 (P = 0.057 for testing the hypothesis that >2.5% of subjects should have a Z score of < or =-2). Moreover, there was a negative association (r = -0.25, P = 0.023) between the duration of steroid therapy and BMD in men. We conclude that male SARS patients had lower BMD at the hip than normal controls, and this could be attributed to prolonged steroid therapy.

DOI: 10.1016/j.bone.2005.04.018
PubMed: 15993669

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<author><name sortKey="Lau, E M C" sort="Lau, E M C" uniqKey="Lau E" first="E M C" last="Lau">E M C. Lau</name>
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<term>Sujet âgé de 80 ans ou plus</term>
<term>Syndrome respiratoire aigu sévère (anatomopathologie)</term>
<term>Syndrome respiratoire aigu sévère (physiopathologie)</term>
<term>Virus du SRAS (physiologie)</term>
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<term>Syndrome respiratoire aigu sévère</term>
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<term>Severe Acute Respiratory Syndrome</term>
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<front><div type="abstract" xml:lang="en">During the Severe Acute Respiratory Syndrome (SARS) outbreak in Hong Kong in 2003, patients were treated with very high doses of corticosteroid and ribavirin. The detrimental effects of such treatment on the bone mineral density (BMD) of SARS patients are unknown. To compare the BMD of SARS patients with normal range data, a cross-sectional survey was conducted. The bone mineral density of 224 patients with SARS, who were treated with an average of 2753 mg (SD = 2152 mg) prednisolone and 29,344 mg (SD = 15,849 mg) of ribavirin was compared to normal data. Six percent of men had a hip BMD Z score of < or =-2 (P = 0.057 for testing the hypothesis that >2.5% of subjects should have a Z score of < or =-2). Moreover, there was a negative association (r = -0.25, P = 0.023) between the duration of steroid therapy and BMD in men. We conclude that male SARS patients had lower BMD at the hip than normal controls, and this could be attributed to prolonged steroid therapy.</div>
</front>
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<Abstract><AbstractText>During the Severe Acute Respiratory Syndrome (SARS) outbreak in Hong Kong in 2003, patients were treated with very high doses of corticosteroid and ribavirin. The detrimental effects of such treatment on the bone mineral density (BMD) of SARS patients are unknown. To compare the BMD of SARS patients with normal range data, a cross-sectional survey was conducted. The bone mineral density of 224 patients with SARS, who were treated with an average of 2753 mg (SD = 2152 mg) prednisolone and 29,344 mg (SD = 15,849 mg) of ribavirin was compared to normal data. Six percent of men had a hip BMD Z score of < or =-2 (P = 0.057 for testing the hypothesis that >2.5% of subjects should have a Z score of < or =-2). Moreover, there was a negative association (r = -0.25, P = 0.023) between the duration of steroid therapy and BMD in men. We conclude that male SARS patients had lower BMD at the hip than normal controls, and this could be attributed to prolonged steroid therapy.</AbstractText>
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Reduced bone mineral density in male Severe Acute Respiratory Syndrome (SARS) patients in Hong Kong.

Reduced bone mineral density in male Severe Acute Respiratory Syndrome (SARS) patients in Hong Kong.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki