SrasV1, PubMed, Curation, bibRecord, 002111

Modulation of the unfolded protein response by the severe acute respiratory syndrome coronavirus spike protein.

Identifieur interne : 002111 ( PubMed/Curation ); précédent : 002110; suivant : 002112

Modulation of the unfolded protein response by the severe acute respiratory syndrome coronavirus spike protein.

Auteurs : Ching-Ping Chan [Hong Kong] ; Kam-Leung Siu ; King-Tung Chin ; Kwok-Yung Yuen ; Bojian Zheng ; Dong-Yan Jin

Source :

Journal of virology [ 0022-538X ] ; 2006.

RBID : pubmed:16940539

Descripteurs français

English descriptors

KwdEn :
- Animals, CCAAT-Enhancer-Binding Proteins (metabolism), Cell Line, Chlorocebus aethiops, Endoplasmic Reticulum (metabolism), HSP70 Heat-Shock Proteins (metabolism), Heat-Shock Proteins (metabolism), Humans, Membrane Glycoproteins (chemistry), Membrane Proteins (metabolism), Molecular Chaperones (metabolism), Plasmids (metabolism), Protein Denaturation, SARS Virus (metabolism), Spike Glycoprotein, Coronavirus, Vero Cells, Viral Envelope Proteins (chemistry).
MESH :
- chemical , chemistry : Membrane Glycoproteins, Viral Envelope Proteins.
- chemical , metabolism : CCAAT-Enhancer-Binding Proteins, HSP70 Heat-Shock Proteins, Heat-Shock Proteins, Membrane Proteins, Molecular Chaperones.
- metabolism : Endoplasmic Reticulum, Plasmids, SARS Virus.
- Animals, Cell Line, Chlorocebus aethiops, Humans, Protein Denaturation, Spike Glycoprotein, Coronavirus, Vero Cells.

Abstract

Perturbation of the function of endoplasmic reticulum (ER) causes stress leading to the activation of cell signaling pathways known as the unfolded protein response (UPR). Severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV) uses ER as a site for synthesis and processing of viral proteins. In this report, we demonstrate that infection with SARS-CoV induces the UPR in cultured cells. A comparison with M, E, and NSP6 proteins indicates that SARS-CoV spike (S) protein sufficiently induces transcriptional activation of several UPR effectors, including glucose-regulated protein 78 (GRP78), GRP94, and C/EBP homologous protein. A substantial amount of S protein accumulates in the ER. The expression of S protein exerts different effects on the three major signaling pathways of the UPR. Particularly, it induces GRP78/94 through PKR-like ER kinase but has no influence on activating transcription factor 6 or X box-binding protein 1. Taken together, our findings suggest that SARS-CoV S protein specifically modulates the UPR to facilitate viral replication.

DOI: 10.1128/JVI.00659-06
PubMed: 16940539

Links toward previous steps (curation, corpus...)

to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :002111

Links to Exploration step

pubmed:16940539

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Modulation of the unfolded protein response by the severe acute respiratory syndrome coronavirus spike protein.</title>
<author><name sortKey="Chan, Ching Ping" sort="Chan, Ching Ping" uniqKey="Chan C" first="Ching-Ping" last="Chan">Ching-Ping Chan</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry, The University of Hong Kong, 3/F Laboratory Block, Faculty of Medicine Building, 21 Sassoon Road, Hong Kong.</nlm:affiliation>
<country xml:lang="fr">Hong Kong</country>
<wicri:regionArea>Department of Biochemistry, The University of Hong Kong, 3/F Laboratory Block, Faculty of Medicine Building, 21 Sassoon Road</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Siu, Kam Leung" sort="Siu, Kam Leung" uniqKey="Siu K" first="Kam-Leung" last="Siu">Kam-Leung Siu</name>
</author>
<author><name sortKey="Chin, King Tung" sort="Chin, King Tung" uniqKey="Chin K" first="King-Tung" last="Chin">King-Tung Chin</name>
</author>
<author><name sortKey="Yuen, Kwok Yung" sort="Yuen, Kwok Yung" uniqKey="Yuen K" first="Kwok-Yung" last="Yuen">Kwok-Yung Yuen</name>
</author>
<author><name sortKey="Zheng, Bojian" sort="Zheng, Bojian" uniqKey="Zheng B" first="Bojian" last="Zheng">Bojian Zheng</name>
</author>
<author><name sortKey="Jin, Dong Yan" sort="Jin, Dong Yan" uniqKey="Jin D" first="Dong-Yan" last="Jin">Dong-Yan Jin</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2006">2006</date>
<idno type="RBID">pubmed:16940539</idno>
<idno type="pmid">16940539</idno>
<idno type="doi">10.1128/JVI.00659-06</idno>
<idno type="wicri:Area/PubMed/Corpus">002111</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002111</idno>
<idno type="wicri:Area/PubMed/Curation">002111</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002111</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Modulation of the unfolded protein response by the severe acute respiratory syndrome coronavirus spike protein.</title>
<author><name sortKey="Chan, Ching Ping" sort="Chan, Ching Ping" uniqKey="Chan C" first="Ching-Ping" last="Chan">Ching-Ping Chan</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry, The University of Hong Kong, 3/F Laboratory Block, Faculty of Medicine Building, 21 Sassoon Road, Hong Kong.</nlm:affiliation>
<country xml:lang="fr">Hong Kong</country>
<wicri:regionArea>Department of Biochemistry, The University of Hong Kong, 3/F Laboratory Block, Faculty of Medicine Building, 21 Sassoon Road</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Siu, Kam Leung" sort="Siu, Kam Leung" uniqKey="Siu K" first="Kam-Leung" last="Siu">Kam-Leung Siu</name>
</author>
<author><name sortKey="Chin, King Tung" sort="Chin, King Tung" uniqKey="Chin K" first="King-Tung" last="Chin">King-Tung Chin</name>
</author>
<author><name sortKey="Yuen, Kwok Yung" sort="Yuen, Kwok Yung" uniqKey="Yuen K" first="Kwok-Yung" last="Yuen">Kwok-Yung Yuen</name>
</author>
<author><name sortKey="Zheng, Bojian" sort="Zheng, Bojian" uniqKey="Zheng B" first="Bojian" last="Zheng">Bojian Zheng</name>
</author>
<author><name sortKey="Jin, Dong Yan" sort="Jin, Dong Yan" uniqKey="Jin D" first="Dong-Yan" last="Jin">Dong-Yan Jin</name>
</author>
</analytic>
<series><title level="j">Journal of virology</title>
<idno type="ISSN">0022-538X</idno>
<imprint><date when="2006" type="published">2006</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>CCAAT-Enhancer-Binding Proteins (metabolism)</term>
<term>Cell Line</term>
<term>Chlorocebus aethiops</term>
<term>Endoplasmic Reticulum (metabolism)</term>
<term>HSP70 Heat-Shock Proteins (metabolism)</term>
<term>Heat-Shock Proteins (metabolism)</term>
<term>Humans</term>
<term>Membrane Glycoproteins (chemistry)</term>
<term>Membrane Proteins (metabolism)</term>
<term>Molecular Chaperones (metabolism)</term>
<term>Plasmids (metabolism)</term>
<term>Protein Denaturation</term>
<term>SARS Virus (metabolism)</term>
<term>Spike Glycoprotein, Coronavirus</term>
<term>Vero Cells</term>
<term>Viral Envelope Proteins (chemistry)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Cellules Vero</term>
<term>Chaperons moléculaires (métabolisme)</term>
<term>Dénaturation des protéines</term>
<term>Glycoprotéine de spicule des coronavirus</term>
<term>Glycoprotéines membranaires ()</term>
<term>Humains</term>
<term>Lignée cellulaire</term>
<term>Plasmides (métabolisme)</term>
<term>Protéines de l'enveloppe virale ()</term>
<term>Protéines du choc thermique (métabolisme)</term>
<term>Protéines du choc thermique HSP70 (métabolisme)</term>
<term>Protéines liant les séquences stimulatrices de type CCAAT (métabolisme)</term>
<term>Protéines membranaires (métabolisme)</term>
<term>Réticulum endoplasmique (métabolisme)</term>
<term>Virus du SRAS (métabolisme)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Membrane Glycoproteins</term>
<term>Viral Envelope Proteins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>CCAAT-Enhancer-Binding Proteins</term>
<term>HSP70 Heat-Shock Proteins</term>
<term>Heat-Shock Proteins</term>
<term>Membrane Proteins</term>
<term>Molecular Chaperones</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Endoplasmic Reticulum</term>
<term>Plasmids</term>
<term>SARS Virus</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Chaperons moléculaires</term>
<term>Plasmides</term>
<term>Protéines du choc thermique</term>
<term>Protéines du choc thermique HSP70</term>
<term>Protéines liant les séquences stimulatrices de type CCAAT</term>
<term>Protéines membranaires</term>
<term>Réticulum endoplasmique</term>
<term>Virus du SRAS</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Cell Line</term>
<term>Chlorocebus aethiops</term>
<term>Humans</term>
<term>Protein Denaturation</term>
<term>Spike Glycoprotein, Coronavirus</term>
<term>Vero Cells</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Cellules Vero</term>
<term>Dénaturation des protéines</term>
<term>Glycoprotéine de spicule des coronavirus</term>
<term>Glycoprotéines membranaires</term>
<term>Humains</term>
<term>Lignée cellulaire</term>
<term>Protéines de l'enveloppe virale</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Perturbation of the function of endoplasmic reticulum (ER) causes stress leading to the activation of cell signaling pathways known as the unfolded protein response (UPR). Severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV) uses ER as a site for synthesis and processing of viral proteins. In this report, we demonstrate that infection with SARS-CoV induces the UPR in cultured cells. A comparison with M, E, and NSP6 proteins indicates that SARS-CoV spike (S) protein sufficiently induces transcriptional activation of several UPR effectors, including glucose-regulated protein 78 (GRP78), GRP94, and C/EBP homologous protein. A substantial amount of S protein accumulates in the ER. The expression of S protein exerts different effects on the three major signaling pathways of the UPR. Particularly, it induces GRP78/94 through PKR-like ER kinase but has no influence on activating transcription factor 6 or X box-binding protein 1. Taken together, our findings suggest that SARS-CoV S protein specifically modulates the UPR to facilitate viral replication.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">16940539</PMID>
<DateCompleted><Year>2006</Year>
<Month>10</Month>
<Day>20</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>04</Month>
<Day>15</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Print">0022-538X</ISSN>
<JournalIssue CitedMedium="Print"><Volume>80</Volume>
<Issue>18</Issue>
<PubDate><Year>2006</Year>
<Month>Sep</Month>
</PubDate>
</JournalIssue>
<Title>Journal of virology</Title>
<ISOAbbreviation>J. Virol.</ISOAbbreviation>
</Journal>
<ArticleTitle>Modulation of the unfolded protein response by the severe acute respiratory syndrome coronavirus spike protein.</ArticleTitle>
<Pagination><MedlinePgn>9279-87</MedlinePgn>
</Pagination>
<Abstract><AbstractText>Perturbation of the function of endoplasmic reticulum (ER) causes stress leading to the activation of cell signaling pathways known as the unfolded protein response (UPR). Severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV) uses ER as a site for synthesis and processing of viral proteins. In this report, we demonstrate that infection with SARS-CoV induces the UPR in cultured cells. A comparison with M, E, and NSP6 proteins indicates that SARS-CoV spike (S) protein sufficiently induces transcriptional activation of several UPR effectors, including glucose-regulated protein 78 (GRP78), GRP94, and C/EBP homologous protein. A substantial amount of S protein accumulates in the ER. The expression of S protein exerts different effects on the three major signaling pathways of the UPR. Particularly, it induces GRP78/94 through PKR-like ER kinase but has no influence on activating transcription factor 6 or X box-binding protein 1. Taken together, our findings suggest that SARS-CoV S protein specifically modulates the UPR to facilitate viral replication.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Chan</LastName>
<ForeName>Ching-Ping</ForeName>
<Initials>CP</Initials>
<AffiliationInfo><Affiliation>Department of Biochemistry, The University of Hong Kong, 3/F Laboratory Block, Faculty of Medicine Building, 21 Sassoon Road, Hong Kong.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Siu</LastName>
<ForeName>Kam-Leung</ForeName>
<Initials>KL</Initials>
</Author>
<Author ValidYN="Y"><LastName>Chin</LastName>
<ForeName>King-Tung</ForeName>
<Initials>KT</Initials>
</Author>
<Author ValidYN="Y"><LastName>Yuen</LastName>
<ForeName>Kwok-Yung</ForeName>
<Initials>KY</Initials>
</Author>
<Author ValidYN="Y"><LastName>Zheng</LastName>
<ForeName>Bojian</ForeName>
<Initials>B</Initials>
</Author>
<Author ValidYN="Y"><LastName>Jin</LastName>
<ForeName>Dong-Yan</ForeName>
<Initials>DY</Initials>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>J Virol</MedlineTA>
<NlmUniqueID>0113724</NlmUniqueID>
<ISSNLinking>0022-538X</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D022762">CCAAT-Enhancer-Binding Proteins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D018840">HSP70 Heat-Shock Proteins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D006360">Heat-Shock Proteins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C578553">MHV surface projection glycoprotein</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D008562">Membrane Glycoproteins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D008565">Membrane Proteins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D018832">Molecular Chaperones</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D064370">Spike Glycoprotein, Coronavirus</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D014759">Viral Envelope Proteins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C018551">glucose-regulated proteins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C578557">spike glycoprotein, SARS-CoV</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>YCYIS6GADR</RegistryNumber>
<NameOfSubstance UI="C048690">molecular chaperone GRP78</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D022762" MajorTopicYN="N">CCAAT-Enhancer-Binding Proteins</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002460" MajorTopicYN="N">Cell Line</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002522" MajorTopicYN="N">Chlorocebus aethiops</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004721" MajorTopicYN="N">Endoplasmic Reticulum</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018840" MajorTopicYN="N">HSP70 Heat-Shock Proteins</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006360" MajorTopicYN="N">Heat-Shock Proteins</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008562" MajorTopicYN="N">Membrane Glycoproteins</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008565" MajorTopicYN="N">Membrane Proteins</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018832" MajorTopicYN="N">Molecular Chaperones</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010957" MajorTopicYN="N">Plasmids</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011489" MajorTopicYN="N">Protein Denaturation</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D045473" MajorTopicYN="N">SARS Virus</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D064370" MajorTopicYN="N">Spike Glycoprotein, Coronavirus</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014709" MajorTopicYN="N">Vero Cells</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014759" MajorTopicYN="N">Viral Envelope Proteins</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2006</Year>
<Month>8</Month>
<Day>31</Day>
<Hour>9</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2006</Year>
<Month>10</Month>
<Day>21</Day>
<Hour>9</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2006</Year>
<Month>8</Month>
<Day>31</Day>
<Hour>9</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">16940539</ArticleId>
<ArticleId IdType="pii">80/18/9279</ArticleId>
<ArticleId IdType="doi">10.1128/JVI.00659-06</ArticleId>
<ArticleId IdType="pmc">PMC1563899</ArticleId>
</ArticleIdList>
<ReferenceList><Reference><Citation>J Virol. 1991 Jul;65(7):3590-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">2041085</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2005 Mar;79(5):2768-79</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15708995</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 1997 Oct;71(10):7387-92</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9311817</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 1998 Dec;72(12):9865-72</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9811722</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Gen Virol. 2005 May;86(Pt 5):1423-34</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15831954</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2005 Jun;79(11):6890-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15890928</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Cell Biol. 2005 Jun;25(11):4529-40</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15899857</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Free Radic Biol Med. 2005 Jun 15;38(12):1585-93</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15917187</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2005 May 31;102(22):7988-93</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15897467</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Annu Rev Biochem. 2005;74:739-89</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15952902</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Cell Proteomics. 2005 Jul;4(7):902-13</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15784933</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Oncogene. 2005 Jul 21;24(31):4921-33</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15897896</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Biol Cell. 2005 Aug;16(8):3753-63</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15930128</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>FASEB J. 2005 Sep;19(11):1510-2</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16006626</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Blood. 2005 Oct 1;106(7):2366-74</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15860669</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol Methods. 2005 Nov;129(2):152-61</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16023741</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2005 Sep 27;102(39):14040-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16169905</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Clin Invest. 2005 Oct;115(10):2656-64</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16200199</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Science. 2005 Oct 28;310(5748):676-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16195424</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2005 Dec;79(24):15388-97</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16306610</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Microbiol Mol Biol Rev. 2005 Dec;69(4):635-64</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16339739</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>FEBS Lett. 2006 Jan 9;580(1):191-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16364308</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Genes Dev. 2006 Jan 1;20(1):87-100</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16391235</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2006 Feb;80(4):2019-33</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16439558</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell. 2006 Feb 10;124(3):587-99</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16469704</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell Death Differ. 2006 Mar;13(3):393-403</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16397582</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell Death Differ. 2006 Mar;13(3):363-73</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16397583</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nucleic Acids Res. 2005;33(6):1859-73</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15800215</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Trends Microbiol. 2005 Apr;13(4):159-63</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15817385</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Virology. 2006 Jun 5;349(2):264-75</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16507314</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2006 Jul;80(14):7052-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16809310</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Cell Biol. 2006 Jul;8(7):717-24</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16767081</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>EMBO J. 2000 Feb 15;19(4):729-40</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10675342</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Virology. 2001 Jan 20;279(2):371-4</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11162792</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Cell Biol. 2001 May 28;153(5):1011-22</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11381086</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Genes Dev. 2002 Feb 15;16(4):452-66</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11850408</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2002 May;76(9):4162-71</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11932381</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2002 May 24;277(21):18728-35</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11907036</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2002 Aug;76(15):7453-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12097557</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2002 Oct;76(19):9588-99</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12208938</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2003 Mar;77(6):3578-85</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12610133</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2003 Apr 4;278(14):12530-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12560341</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Lancet. 2003 Apr 19;361(9366):1319-25</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12711465</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9946-51</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12902539</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2003 Sep 26;278(39):37375-85</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12871976</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2003 Sep 26;278(39):37439-50</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12876282</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2003 Dec;77(23):12617-29</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14610184</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell Death Differ. 2004 Apr;11(4):381-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14685163</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Med. 2004 Apr;10(4):368-73</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15034574</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2004 Apr 23;279(17):17158-64</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14960590</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2004 Apr 20;101(16):6212-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15073334</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2004 Aug 3;101(31):11269-74</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15277680</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol Methods. 2004 Oct;121(1):85-91</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15350737</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Cell Biol. 2004 Oct 11;167(1):27-33</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15479734</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 1998 Dec 11;273(50):33741-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9837962</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 1999 May;73(5):3718-22</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10196264</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Genes Dev. 2004 Dec 15;18(24):3066-77</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15601821</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2005 Jan;79(2):884-95</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15613317</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2005 Feb;79(3):1379-88</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15650164</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Science. 2005 Feb 11;307(5711):935-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15705855</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Science. 1996 Apr 5;272(5258):101-4</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8600515</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/PubMed/Curation

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002111 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd -nk 002111 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    SrasV1
   |flux=    PubMed
   |étape=   Curation
   |type=    RBID
   |clé=     pubmed:16940539
   |texte=   Modulation of the unfolded protein response by the severe acute respiratory syndrome coronavirus spike protein.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Curation/RBID.i   -Sk "pubmed:16940539" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd   \
       | NlmPubMed2Wicri -a SrasV1

This area was generated with Dilib version V0.6.33.
Data generation: Tue Apr 28 14:49:16 2020. Site generation: Sat Mar 27 22:06:49 2021

	Serveur d'exploration SRAS
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration SRAS

Modulation of the unfolded protein response by the severe acute respiratory syndrome coronavirus spike protein.

Modulation of the unfolded protein response by the severe acute respiratory syndrome coronavirus spike protein.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki