Specific plant terpenoids and lignoids possess potent antiviral activities against severe acute respiratory syndrome coronavirus.
Identifieur interne : 001D57 ( PubMed/Curation ); précédent : 001D56; suivant : 001D58Specific plant terpenoids and lignoids possess potent antiviral activities against severe acute respiratory syndrome coronavirus.
Auteurs : Chih-Chun Wen [République populaire de Chine] ; Yueh-Hsiung Kuo ; Jia-Tsrong Jan ; Po-Huang Liang ; Sheng-Yang Wang ; Hong-Gi Liu ; Ching-Kuo Lee ; Shang-Tzen Chang ; Chih-Jung Kuo ; Shoei-Sheng Lee ; Chia-Chung Hou ; Pei-Wen Hsiao ; Shih-Chang Chien ; Lie-Fen Shyur ; Ning-Sun YangSource :
- Journal of medicinal chemistry [ 0022-2623 ] ; 2007.
Descripteurs français
- KwdFr :
- Animaux, Cellules Vero, Cysteine endopeptidases (), Lignanes (), Modèles moléculaires, Plantes médicinales, Prolifération cellulaire (), Protéines virales (), Protéines virales (antagonistes et inhibiteurs), Relation structure-activité, Réplication virale, Terpènes (), Terpènes (pharmacologie), Triterpènes (), Virus du SRAS (), Virus du SRAS (enzymologie).
- MESH :
- antagonistes et inhibiteurs : Protéines virales.
- enzymologie : Virus du SRAS.
- pharmacologie : Terpènes.
- Animaux, Cellules Vero, Cysteine endopeptidases, Lignanes, Modèles moléculaires, Plantes médicinales, Prolifération cellulaire, Protéines virales, Relation structure-activité, Réplication virale, Terpènes, Triterpènes, Virus du SRAS.
English descriptors
- KwdEn :
- Animals, Cell Proliferation (drug effects), Chlorocebus aethiops, Cysteine Endopeptidases (chemistry), Lignans (chemistry), Models, Molecular, Plants, Medicinal, SARS Virus (drug effects), SARS Virus (enzymology), Structure-Activity Relationship, Terpenes (chemistry), Terpenes (pharmacology), Triterpenes (chemistry), Vero Cells, Viral Proteins (antagonists & inhibitors), Viral Proteins (chemistry), Virus Replication.
- MESH :
- chemical , antagonists & inhibitors : Viral Proteins.
- chemical , chemistry : Cysteine Endopeptidases, Lignans, Terpenes, Triterpenes, Viral Proteins.
- drug effects : Cell Proliferation, SARS Virus.
- enzymology : SARS Virus.
- chemical , pharmacology : Terpenes.
- Animals, Chlorocebus aethiops, Models, Molecular, Plants, Medicinal, Structure-Activity Relationship, Vero Cells, Virus Replication.
Abstract
In this study, 221 phytocompounds were evaluated for activity against anti-severe acute respiratory syndrome associated coronavirus (SARS-CoV) activities using a cell-based assay measuring SARS-CoV-induced cytopathogenic effect on Vero E6 cells. Ten diterpenoids (1-10), two sesquiterpenoids (11 and 12), two triterpenoids (13 and 14), five lignoids (15-19), curcumin (20), and reference controls niclosamide (21) and valinomycin (22) were potent inhibitors at concentrations between 3.3 and 10 microM. The concentrations of the 22 compounds to inhibit 50% of Vero E6 cell proliferation (CC50) and viral replication (EC50) were measured. The selective index values (SI = CC50/EC50) of the most potent compounds 1, 5, 6, 8, 14, and 16 were 58, >510, 111, 193, 180, and >667, respectively. Betulinic acid (13) and savinin (16) were competitive inhibitors of SARS-CoV 3CL protease with Ki values = 8.2 +/- 0.7 and 9.1 +/- 2.4 microM, respectively. Our findings suggest that specific abietane-type diterpenoids and lignoids exhibit strong anti-SARS-CoV effects.
DOI: 10.1021/jm070295s
PubMed: 17663539
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last="Kuo">Yueh-Hsiung Kuo</name></author><author><name sortKey="Jan, Jia Tsrong" sort="Jan, Jia Tsrong" uniqKey="Jan J" first="Jia-Tsrong" last="Jan">Jia-Tsrong Jan</name></author><author><name sortKey="Liang, Po Huang" sort="Liang, Po Huang" uniqKey="Liang P" first="Po-Huang" last="Liang">Po-Huang Liang</name></author><author><name sortKey="Wang, Sheng Yang" sort="Wang, Sheng Yang" uniqKey="Wang S" first="Sheng-Yang" last="Wang">Sheng-Yang Wang</name></author><author><name sortKey="Liu, Hong Gi" sort="Liu, Hong Gi" uniqKey="Liu H" first="Hong-Gi" last="Liu">Hong-Gi Liu</name></author><author><name sortKey="Lee, Ching Kuo" sort="Lee, Ching Kuo" uniqKey="Lee C" first="Ching-Kuo" last="Lee">Ching-Kuo Lee</name></author><author><name sortKey="Chang, Shang Tzen" sort="Chang, Shang Tzen" uniqKey="Chang S" first="Shang-Tzen" last="Chang">Shang-Tzen Chang</name></author><author><name sortKey="Kuo, Chih Jung" sort="Kuo, Chih Jung" uniqKey="Kuo C" first="Chih-Jung" last="Kuo">Chih-Jung Kuo</name></author><author><name sortKey="Lee, Shoei Sheng" sort="Lee, Shoei Sheng" uniqKey="Lee S" first="Shoei-Sheng" last="Lee">Shoei-Sheng Lee</name></author><author><name sortKey="Hou, Chia Chung" sort="Hou, Chia Chung" uniqKey="Hou C" first="Chia-Chung" last="Hou">Chia-Chung Hou</name></author><author><name sortKey="Hsiao, Pei Wen" sort="Hsiao, Pei Wen" uniqKey="Hsiao P" first="Pei-Wen" last="Hsiao">Pei-Wen Hsiao</name></author><author><name sortKey="Chien, Shih Chang" sort="Chien, Shih Chang" uniqKey="Chien S" first="Shih-Chang" last="Chien">Shih-Chang Chien</name></author><author><name sortKey="Shyur, Lie Fen" sort="Shyur, Lie Fen" uniqKey="Shyur L" first="Lie-Fen" last="Shyur">Lie-Fen Shyur</name></author><author><name sortKey="Yang, Ning Sun" sort="Yang, Ning Sun" uniqKey="Yang N" first="Ning-Sun" last="Yang">Ning-Sun Yang</name></author></analytic><series><title level="j">Journal of medicinal chemistry</title><idno type="ISSN">0022-2623</idno><imprint><date when="2007" type="published">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Cell Proliferation (drug effects)</term><term>Chlorocebus aethiops</term><term>Cysteine Endopeptidases (chemistry)</term><term>Lignans (chemistry)</term><term>Models, Molecular</term><term>Plants, Medicinal</term><term>SARS Virus (drug effects)</term><term>SARS Virus (enzymology)</term><term>Structure-Activity Relationship</term><term>Terpenes (chemistry)</term><term>Terpenes (pharmacology)</term><term>Triterpenes (chemistry)</term><term>Vero Cells</term><term>Viral Proteins (antagonists & inhibitors)</term><term>Viral Proteins (chemistry)</term><term>Virus Replication</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Cellules Vero</term><term>Cysteine endopeptidases ()</term><term>Lignanes ()</term><term>Modèles moléculaires</term><term>Plantes médicinales</term><term>Prolifération cellulaire ()</term><term>Protéines virales ()</term><term>Protéines virales (antagonistes et inhibiteurs)</term><term>Relation structure-activité</term><term>Réplication virale</term><term>Terpènes ()</term><term>Terpènes (pharmacologie)</term><term>Triterpènes ()</term><term>Virus du SRAS ()</term><term>Virus du SRAS (enzymologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Viral Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Cysteine Endopeptidases</term><term>Lignans</term><term>Terpenes</term><term>Triterpenes</term><term>Viral Proteins</term></keywords><keywords scheme="MESH" qualifier="antagonistes et inhibiteurs" xml:lang="fr"><term>Protéines virales</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Cell Proliferation</term><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="enzymologie" xml:lang="fr"><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Terpènes</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Terpenes</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Chlorocebus aethiops</term><term>Models, Molecular</term><term>Plants, Medicinal</term><term>Structure-Activity Relationship</term><term>Vero Cells</term><term>Virus Replication</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Cellules Vero</term><term>Cysteine endopeptidases</term><term>Lignanes</term><term>Modèles moléculaires</term><term>Plantes médicinales</term><term>Prolifération cellulaire</term><term>Protéines virales</term><term>Relation structure-activité</term><term>Réplication virale</term><term>Terpènes</term><term>Triterpènes</term><term>Virus du SRAS</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In this study, 221 phytocompounds were evaluated for activity against anti-severe acute respiratory syndrome associated coronavirus (SARS-CoV) activities using a cell-based assay measuring SARS-CoV-induced cytopathogenic effect on Vero E6 cells. Ten diterpenoids (1-10), two sesquiterpenoids (11 and 12), two triterpenoids (13 and 14), five lignoids (15-19), curcumin (20), and reference controls niclosamide (21) and valinomycin (22) were potent inhibitors at concentrations between 3.3 and 10 microM. The concentrations of the 22 compounds to inhibit 50% of Vero E6 cell proliferation (CC50) and viral replication (EC50) were measured. The selective index values (SI = CC50/EC50) of the most potent compounds 1, 5, 6, 8, 14, and 16 were 58, >510, 111, 193, 180, and >667, respectively. Betulinic acid (13) and savinin (16) were competitive inhibitors of SARS-CoV 3CL protease with Ki values = 8.2 +/- 0.7 and 9.1 +/- 2.4 microM, respectively. Our findings suggest that specific abietane-type diterpenoids and lignoids exhibit strong anti-SARS-CoV effects.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">17663539</PMID><DateCompleted><Year>2007</Year><Month>10</Month><Day>29</Day></DateCompleted><DateRevised><Year>2020</Year><Month>03</Month><Day>25</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">0022-2623</ISSN><JournalIssue CitedMedium="Print"><Volume>50</Volume><Issue>17</Issue><PubDate><Year>2007</Year><Month>Aug</Month><Day>23</Day></PubDate></JournalIssue><Title>Journal of medicinal chemistry</Title><ISOAbbreviation>J. Med. Chem.</ISOAbbreviation></Journal><ArticleTitle>Specific plant terpenoids and lignoids possess potent antiviral activities against severe acute respiratory syndrome coronavirus.</ArticleTitle><Pagination><MedlinePgn>4087-95</MedlinePgn></Pagination><Abstract><AbstractText>In this study, 221 phytocompounds were evaluated for activity against anti-severe acute respiratory syndrome associated coronavirus (SARS-CoV) activities using a cell-based assay measuring SARS-CoV-induced cytopathogenic effect on Vero E6 cells. Ten diterpenoids (1-10), two sesquiterpenoids (11 and 12), two triterpenoids (13 and 14), five lignoids (15-19), curcumin (20), and reference controls niclosamide (21) and valinomycin (22) were potent inhibitors at concentrations between 3.3 and 10 microM. The concentrations of the 22 compounds to inhibit 50% of Vero E6 cell proliferation (CC50) and viral replication (EC50) were measured. The selective index values (SI = CC50/EC50) of the most potent compounds 1, 5, 6, 8, 14, and 16 were 58, >510, 111, 193, 180, and >667, respectively. Betulinic acid (13) and savinin (16) were competitive inhibitors of SARS-CoV 3CL protease with Ki values = 8.2 +/- 0.7 and 9.1 +/- 2.4 microM, respectively. Our findings suggest that specific abietane-type diterpenoids and lignoids exhibit strong anti-SARS-CoV effects.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Wen</LastName><ForeName>Chih-Chun</ForeName><Initials>CC</Initials><AffiliationInfo><Affiliation>Agricultural Biotechnology Research Center, Academia Sinica, Taipei 115, Taiwan, ROC.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kuo</LastName><ForeName>Yueh-Hsiung</ForeName><Initials>YH</Initials></Author><Author ValidYN="Y"><LastName>Jan</LastName><ForeName>Jia-Tsrong</ForeName><Initials>JT</Initials></Author><Author ValidYN="Y"><LastName>Liang</LastName><ForeName>Po-Huang</ForeName><Initials>PH</Initials></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Sheng-Yang</ForeName><Initials>SY</Initials></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Hong-Gi</ForeName><Initials>HG</Initials></Author><Author ValidYN="Y"><LastName>Lee</LastName><ForeName>Ching-Kuo</ForeName><Initials>CK</Initials></Author><Author ValidYN="Y"><LastName>Chang</LastName><ForeName>Shang-Tzen</ForeName><Initials>ST</Initials></Author><Author ValidYN="Y"><LastName>Kuo</LastName><ForeName>Chih-Jung</ForeName><Initials>CJ</Initials></Author><Author ValidYN="Y"><LastName>Lee</LastName><ForeName>Shoei-Sheng</ForeName><Initials>SS</Initials></Author><Author ValidYN="Y"><LastName>Hou</LastName><ForeName>Chia-Chung</ForeName><Initials>CC</Initials></Author><Author ValidYN="Y"><LastName>Hsiao</LastName><ForeName>Pei-Wen</ForeName><Initials>PW</Initials></Author><Author ValidYN="Y"><LastName>Chien</LastName><ForeName>Shih-Chang</ForeName><Initials>SC</Initials></Author><Author ValidYN="Y"><LastName>Shyur</LastName><ForeName>Lie-Fen</ForeName><Initials>LF</Initials></Author><Author ValidYN="Y"><LastName>Yang</LastName><ForeName>Ning-Sun</ForeName><Initials>NS</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2007</Year><Month>07</Month><Day>31</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Med Chem</MedlineTA><NlmUniqueID>9716531</NlmUniqueID><ISSNLinking>0022-2623</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D017705">Lignans</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D013729">Terpenes</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014315">Triterpenes</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014764">Viral Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C425325">savinin</NameOfSubstance></Chemical><Chemical><RegistryNumber>4G6A18707N</RegistryNumber><NameOfSubstance UI="C002070">betulinic acid</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.4.22.-</RegistryNumber><NameOfSubstance UI="C099456">3C-like proteinase, Coronavirus</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.4.22.-</RegistryNumber><NameOfSubstance UI="D003546">Cysteine Endopeptidases</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D049109" MajorTopicYN="N">Cell Proliferation</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002522" MajorTopicYN="N">Chlorocebus aethiops</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003546" MajorTopicYN="N">Cysteine Endopeptidases</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017705" MajorTopicYN="N">Lignans</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008958" MajorTopicYN="N">Models, Molecular</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010946" MajorTopicYN="Y">Plants, Medicinal</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D045473" MajorTopicYN="N">SARS Virus</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName><QualifierName UI="Q000201" MajorTopicYN="N">enzymology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013329" MajorTopicYN="N">Structure-Activity Relationship</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013729" MajorTopicYN="N">Terpenes</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014315" MajorTopicYN="N">Triterpenes</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014709" MajorTopicYN="N">Vero Cells</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014764" MajorTopicYN="N">Viral Proteins</DescriptorName><QualifierName UI="Q000037" MajorTopicYN="N">antagonists & inhibitors</QualifierName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014779" MajorTopicYN="N">Virus Replication</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2007</Year><Month>8</Month><Day>1</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2007</Year><Month>10</Month><Day>30</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2007</Year><Month>8</Month><Day>1</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">17663539</ArticleId><ArticleId IdType="doi">10.1021/jm070295s</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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