The replication of a mouse adapted SARS-CoV in a mouse cell line stably expressing the murine SARS-CoV receptor mACE2 efficiently induces the expression of proinflammatory cytokines.
Identifieur interne : 001155 ( PubMed/Curation ); précédent : 001154; suivant : 001156The replication of a mouse adapted SARS-CoV in a mouse cell line stably expressing the murine SARS-CoV receptor mACE2 efficiently induces the expression of proinflammatory cytokines.
Auteurs : Jose A. Regla-Nava [Espagne] ; Jose M. Jimenez-Guarde O ; Jose L. Nieto-Torres ; Thomas M. Gallagher ; Luis Enjuanes ; Marta L. DediegoSource :
- Journal of virological methods [ 1879-0984 ] ; 2013.
Descripteurs français
- KwdFr :
- Adaptation biologique, Animaux, Charge virale, Cytokines (biosynthèse), Expression des gènes, Lignée cellulaire, Méthode des plages virales, Peptidyl-Dipeptidase A (génétique), Peptidyl-Dipeptidase A (métabolisme), Souris, Souris de lignée BALB C, Virus du SRAS (croissance et développement), Virus du SRAS (immunologie).
- MESH :
- biosynthèse : Cytokines.
- croissance et développement : Virus du SRAS.
- génétique : Peptidyl-Dipeptidase A.
- immunologie : Virus du SRAS.
- métabolisme : Peptidyl-Dipeptidase A.
- Adaptation biologique, Animaux, Charge virale, Expression des gènes, Lignée cellulaire, Méthode des plages virales, Souris, Souris de lignée BALB C.
English descriptors
- KwdEn :
- MESH :
- chemical , biosynthesis : Cytokines.
- chemical , genetics : Peptidyl-Dipeptidase A.
- chemical , metabolism : Peptidyl-Dipeptidase A.
- growth & development : SARS Virus.
- immunology : SARS Virus.
- Adaptation, Biological, Animals, Cell Line, Gene Expression, Mice, Mice, Inbred BALB C, Viral Load, Viral Plaque Assay.
Abstract
Infection of conventional mice with a mouse adapted (MA15) severe acute respiratory syndrome (SARS) coronavirus (CoV) reproduces many aspects of human SARS such as pathological changes in lung, viremia, neutrophilia, and lethality. However, established mouse cell lines highly susceptible to mouse-adapted SARS-CoV infection are not available. In this work, efficiently transfectable mouse cell lines stably expressing the murine SARS-CoV receptor angiotensin converting enzyme 2 (ACE2) have been generated. These cells yielded high SARS-CoV-MA15 titers and also served as excellent tools for plaque assays. In addition, in these cell lines, SARS-CoV-MA15 induced the expression of proinflammatory cytokines and IFN-β, mimicking what has been observed in experimental animal models infected with SARS-CoV and SARS patients. These cell lines are valuable tools to perform in vitro studies in a mouse cell system that reflects the species used for in vivo studies of SARS-CoV-MA15 pathogenesis.
DOI: 10.1016/j.jviromet.2013.07.039
PubMed: 23911968
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pubmed:23911968Le document en format XML
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<term>Expression des gènes</term>
<term>Lignée cellulaire</term>
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<front><div type="abstract" xml:lang="en">Infection of conventional mice with a mouse adapted (MA15) severe acute respiratory syndrome (SARS) coronavirus (CoV) reproduces many aspects of human SARS such as pathological changes in lung, viremia, neutrophilia, and lethality. However, established mouse cell lines highly susceptible to mouse-adapted SARS-CoV infection are not available. In this work, efficiently transfectable mouse cell lines stably expressing the murine SARS-CoV receptor angiotensin converting enzyme 2 (ACE2) have been generated. These cells yielded high SARS-CoV-MA15 titers and also served as excellent tools for plaque assays. In addition, in these cell lines, SARS-CoV-MA15 induced the expression of proinflammatory cytokines and IFN-β, mimicking what has been observed in experimental animal models infected with SARS-CoV and SARS patients. These cell lines are valuable tools to perform in vitro studies in a mouse cell system that reflects the species used for in vivo studies of SARS-CoV-MA15 pathogenesis. </div>
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<Abstract><AbstractText>Infection of conventional mice with a mouse adapted (MA15) severe acute respiratory syndrome (SARS) coronavirus (CoV) reproduces many aspects of human SARS such as pathological changes in lung, viremia, neutrophilia, and lethality. However, established mouse cell lines highly susceptible to mouse-adapted SARS-CoV infection are not available. In this work, efficiently transfectable mouse cell lines stably expressing the murine SARS-CoV receptor angiotensin converting enzyme 2 (ACE2) have been generated. These cells yielded high SARS-CoV-MA15 titers and also served as excellent tools for plaque assays. In addition, in these cell lines, SARS-CoV-MA15 induced the expression of proinflammatory cytokines and IFN-β, mimicking what has been observed in experimental animal models infected with SARS-CoV and SARS patients. These cell lines are valuable tools to perform in vitro studies in a mouse cell system that reflects the species used for in vivo studies of SARS-CoV-MA15 pathogenesis. </AbstractText>
<CopyrightInformation>Copyright © 2013 Elsevier B.V. All rights reserved.</CopyrightInformation>
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