Molecular characterization of RIG-I, STAT-1 and IFN-beta in the horseshoe bat.
Identifieur interne : 000E63 ( PubMed/Curation ); précédent : 000E62; suivant : 000E64Molecular characterization of RIG-I, STAT-1 and IFN-beta in the horseshoe bat.
Auteurs : Jinju Li [République populaire de Chine] ; Guangxu Zhang [République populaire de Chine] ; Dalong Cheng [République populaire de Chine] ; Hua Ren [République populaire de Chine] ; Min Qian [République populaire de Chine] ; Bing Du [République populaire de Chine]Source :
- Gene [ 1879-0038 ] ; 2015.
Descripteurs français
- KwdFr :
- Alignement de séquences, Analyse de séquence d'ADN, Animaux, Antiviraux (pharmacologie), Chiroptera (génétique), Chiroptera (immunologie), Données de séquences moléculaires, Facteur de transcription STAT-1 (génétique), Humains, Immunité innée (immunologie), Interféron bêta (biosynthèse), Interféron bêta (génétique), Lignée cellulaire, Poly I-C (pharmacologie), Similitude de séquences, Souris, Stomatite vésiculeuse (immunologie), Séquence d'acides aminés, Séquence nucléotidique, Ubiquitin-protein ligases (génétique), Virus de la stomatite vésiculeuse de type Indiana (immunologie).
- MESH :
- biosynthèse : Interféron bêta.
- génétique : Chiroptera, Facteur de transcription STAT-1, Interféron bêta, Ubiquitin-protein ligases.
- immunologie : Chiroptera, Immunité innée, Stomatite vésiculeuse, Virus de la stomatite vésiculeuse de type Indiana.
- pharmacologie : Antiviraux, Poly I-C.
- Alignement de séquences, Analyse de séquence d'ADN, Animaux, Données de séquences moléculaires, Humains, Lignée cellulaire, Similitude de séquences, Souris, Séquence d'acides aminés, Séquence nucléotidique.
English descriptors
- KwdEn :
- Amino Acid Sequence, Animals, Antiviral Agents (pharmacology), Base Sequence, Cell Line, Chiroptera (genetics), Chiroptera (immunology), Humans, Immunity, Innate (immunology), Interferon-beta (biosynthesis), Interferon-beta (genetics), Mice, Molecular Sequence Data, Poly I-C (pharmacology), STAT1 Transcription Factor (genetics), Sequence Alignment, Sequence Analysis, DNA, Sequence Homology, Ubiquitin-Protein Ligases (genetics), Vesicular Stomatitis (immunology), Vesicular stomatitis Indiana virus (immunology).
- MESH :
- chemical , biosynthesis : Interferon-beta.
- chemical , genetics : Interferon-beta, STAT1 Transcription Factor, Ubiquitin-Protein Ligases.
- chemical , pharmacology : Antiviral Agents, Poly I-C.
- genetics : Chiroptera.
- immunology : Chiroptera, Immunity, Innate, Vesicular Stomatitis, Vesicular stomatitis Indiana virus.
- Amino Acid Sequence, Animals, Base Sequence, Cell Line, Humans, Mice, Molecular Sequence Data, Sequence Alignment, Sequence Analysis, DNA, Sequence Homology.
Abstract
Wild Chinese horseshoe bats have been proven to be natural reservoirs of SARS-like coronaviruses. However, the molecular characterization of key proteins in bats still needs to be explored further. In this study, we used cloning and bioinformatics to analyze the sequence of RIG-I, STAT-1 and IFN-β in the immortalized cell lines from Rhinolophus affinis and Rhinolophus sinicus. Then, we treated different bat cells, mouse embryonic fibroblasts (MEF) and splenocytes with polyinosinic-polycytidylic acid (polyI:C) and vesicular stomatitis virus (VSV) to assess and compare antiviral immune responses between bats and mice. Our results demonstrated that bat RIG-I, STAT-1 and IFN-β showed close homology with human, mouse, pig and rhesus monkey. RIG-I and STAT-1 were both highly expressed in bat spleen. Furthermore, IFN-β was induced by polyI:C and VSV in both bat and mouse cells. These findings have provided new insight into the potential characteristics of the bat innate immune system against viral infection.
DOI: 10.1016/j.gene.2015.02.013
PubMed: 25680291
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However, the molecular characterization of key proteins in bats still needs to be explored further. In this study, we used cloning and bioinformatics to analyze the sequence of RIG-I, STAT-1 and IFN-β in the immortalized cell lines from Rhinolophus affinis and Rhinolophus sinicus. Then, we treated different bat cells, mouse embryonic fibroblasts (MEF) and splenocytes with polyinosinic-polycytidylic acid (polyI:C) and vesicular stomatitis virus (VSV) to assess and compare antiviral immune responses between bats and mice. Our results demonstrated that bat RIG-I, STAT-1 and IFN-β showed close homology with human, mouse, pig and rhesus monkey. RIG-I and STAT-1 were both highly expressed in bat spleen. Furthermore, IFN-β was induced by polyI:C and VSV in both bat and mouse cells. These findings have provided new insight into the potential characteristics of the bat innate immune system against viral infection. </div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25680291</PMID><DateCompleted><Year>2015</Year><Month>06</Month><Day>19</Day></DateCompleted><DateRevised><Year>2020</Year><Month>04</Month><Day>09</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1879-0038</ISSN><JournalIssue CitedMedium="Internet"><Volume>561</Volume><Issue>1</Issue><PubDate><Year>2015</Year><Month>Apr</Month><Day>25</Day></PubDate></JournalIssue><Title>Gene</Title><ISOAbbreviation>Gene</ISOAbbreviation></Journal><ArticleTitle>Molecular characterization of RIG-I, STAT-1 and IFN-beta in the horseshoe bat.</ArticleTitle><Pagination><MedlinePgn>115-23</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.gene.2015.02.013</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S0378-1119(15)00148-1</ELocationID><Abstract><AbstractText>Wild Chinese horseshoe bats have been proven to be natural reservoirs of SARS-like coronaviruses. However, the molecular characterization of key proteins in bats still needs to be explored further. In this study, we used cloning and bioinformatics to analyze the sequence of RIG-I, STAT-1 and IFN-β in the immortalized cell lines from Rhinolophus affinis and Rhinolophus sinicus. Then, we treated different bat cells, mouse embryonic fibroblasts (MEF) and splenocytes with polyinosinic-polycytidylic acid (polyI:C) and vesicular stomatitis virus (VSV) to assess and compare antiviral immune responses between bats and mice. Our results demonstrated that bat RIG-I, STAT-1 and IFN-β showed close homology with human, mouse, pig and rhesus monkey. RIG-I and STAT-1 were both highly expressed in bat spleen. Furthermore, IFN-β was induced by polyI:C and VSV in both bat and mouse cells. These findings have provided new insight into the potential characteristics of the bat innate immune system against viral infection. </AbstractText><CopyrightInformation>Copyright © 2015 Elsevier B.V. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Jinju</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Guangxu</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cheng</LastName><ForeName>Dalong</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ren</LastName><ForeName>Hua</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Qian</LastName><ForeName>Min</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Du</LastName><ForeName>Bing</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China. Electronic address: bdu@bio.ecnu.edu.cn.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><DataBankList CompleteYN="Y"><DataBank><DataBankName>GENBANK</DataBankName><AccessionNumberList><AccessionNumber>KM056305</AccessionNumber><AccessionNumber>KM056306</AccessionNumber><AccessionNumber>KM056307</AccessionNumber><AccessionNumber>KM056308</AccessionNumber><AccessionNumber>KM056309</AccessionNumber><AccessionNumber>KM056310</AccessionNumber></AccessionNumberList></DataBank></DataBankList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>02</Month><Day>10</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Gene</MedlineTA><NlmUniqueID>7706761</NlmUniqueID><ISSNLinking>0378-1119</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000998">Antiviral Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D050794">STAT1 Transcription Factor</NameOfSubstance></Chemical><Chemical><RegistryNumber>77238-31-4</RegistryNumber><NameOfSubstance UI="D016899">Interferon-beta</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.3.2.27</RegistryNumber><NameOfSubstance UI="D044767">Ubiquitin-Protein Ligases</NameOfSubstance></Chemical><Chemical><RegistryNumber>O84C90HH2L</RegistryNumber><NameOfSubstance UI="D011070">Poly I-C</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000595" MajorTopicYN="N">Amino Acid Sequence</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000998" MajorTopicYN="N">Antiviral Agents</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001483" MajorTopicYN="N">Base Sequence</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002460" MajorTopicYN="N">Cell Line</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002685" MajorTopicYN="N">Chiroptera</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" 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