SrasV1, PubMed, Curation, bibRecord, 000A13

Fatal swine acute diarrhoea syndrome caused by an HKU2-related coronavirus of bat origin.

Identifieur interne : 000A13 ( PubMed/Curation ); précédent : 000A12; suivant : 000A14

Fatal swine acute diarrhoea syndrome caused by an HKU2-related coronavirus of bat origin.

Source :

Nature [ 1476-4687 ] ; 2018.

RBID : pubmed:29618817

Descripteurs français

KwdFr :
- Analyse spatio-temporelle, Animaux, Biodiversité, Chine (épidémiologie), Chiroptera (virologie), Diarrhée (anatomopathologie), Diarrhée (médecine vétérinaire), Diarrhée (virologie), Génome viral (génétique), Humains, Infections à coronavirus (médecine vétérinaire), Infections à coronavirus (transmission), Infections à coronavirus (épidémiologie), Jéjunum (anatomopathologie), Jéjunum (virologie), Maladies de l'animal (transmission), Maladies de l'animal (virologie), Maladies de l'animal (épidémiologie), Phylogénie, Réservoirs d'agents pathogènes (médecine vétérinaire), Réservoirs d'agents pathogènes (virologie), Suidae (virologie), Syndrome respiratoire aigu sévère (médecine vétérinaire), Syndrome respiratoire aigu sévère (virologie), Syndrome respiratoire aigu sévère (épidémiologie), Zoonoses (transmission), Zoonoses (virologie), Zoonoses (épidémiologie).
MESH :
- anatomopathologie : Diarrhée, Jéjunum.
- génétique : Génome viral.
- médecine vétérinaire : Diarrhée, Infections à coronavirus, Réservoirs d'agents pathogènes, Syndrome respiratoire aigu sévère.
- virologie : Chiroptera, Diarrhée, Jéjunum, Maladies de l'animal, Réservoirs d'agents pathogènes, Suidae, Syndrome respiratoire aigu sévère, Zoonoses.
- épidémiologie : Chine, Infections à coronavirus, Maladies de l'animal, Syndrome respiratoire aigu sévère, Zoonoses.
- Analyse spatio-temporelle, Animaux, Biodiversité, Humains, Phylogénie.

English descriptors

KwdEn :
- Alphacoronavirus (classification), Alphacoronavirus (genetics), Alphacoronavirus (isolation & purification), Alphacoronavirus (pathogenicity), Animal Diseases (epidemiology), Animal Diseases (transmission), Animal Diseases (virology), Animals, Biodiversity, China (epidemiology), Chiroptera (virology), Coronavirus Infections (epidemiology), Coronavirus Infections (transmission), Coronavirus Infections (veterinary), Diarrhea (pathology), Diarrhea (veterinary), Diarrhea (virology), Disease Reservoirs (veterinary), Disease Reservoirs (virology), Genome, Viral (genetics), Humans, Jejunum (pathology), Jejunum (virology), Phylogeny, Severe Acute Respiratory Syndrome (epidemiology), Severe Acute Respiratory Syndrome (veterinary), Severe Acute Respiratory Syndrome (virology), Spatio-Temporal Analysis, Swine (virology), Zoonoses (epidemiology), Zoonoses (transmission), Zoonoses (virology).
MESH :
- classification : Alphacoronavirus.
- epidemiology : Animal Diseases, China, Coronavirus Infections, Severe Acute Respiratory Syndrome, Zoonoses.
- genetics : Alphacoronavirus, Genome, Viral.
- isolation & purification : Alphacoronavirus.
- pathogenicity : Alphacoronavirus.
- pathology : Diarrhea, Jejunum.
- transmission : Animal Diseases, Coronavirus Infections, Zoonoses.
- veterinary : Coronavirus Infections, Diarrhea, Disease Reservoirs, Severe Acute Respiratory Syndrome.
- virology : Animal Diseases, Chiroptera, Diarrhea, Disease Reservoirs, Jejunum, Severe Acute Respiratory Syndrome, Swine, Zoonoses.
- Animals, Biodiversity, Humans, Phylogeny, Spatio-Temporal Analysis.

Abstract

Cross-species transmission of viruses from wildlife animal reservoirs poses a marked threat to human and animal health ¹ . Bats have been recognized as one of the most important reservoirs for emerging viruses and the transmission of a coronavirus that originated in bats to humans via intermediate hosts was responsible for the high-impact emerging zoonosis, severe acute respiratory syndrome (SARS) ^2-10 . Here we provide virological, epidemiological, evolutionary and experimental evidence that a novel HKU2-related bat coronavirus, swine acute diarrhoea syndrome coronavirus (SADS-CoV), is the aetiological agent that was responsible for a large-scale outbreak of fatal disease in pigs in China that has caused the death of 24,693 piglets across four farms. Notably, the outbreak began in Guangdong province in the vicinity of the origin of the SARS pandemic. Furthermore, we identified SADS-related CoVs with 96-98% sequence identity in 9.8% (58 out of 591) of anal swabs collected from bats in Guangdong province during 2013-2016, predominantly in horseshoe bats (Rhinolophus spp.) that are known reservoirs of SARS-related CoVs. We found that there were striking similarities between the SADS and SARS outbreaks in geographical, temporal, ecological and aetiological settings. This study highlights the importance of identifying coronavirus diversity and distribution in bats to mitigate future outbreaks that could threaten livestock, public health and economic growth.

DOI: 10.1038/s41586-018-0010-9
PubMed: 29618817

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Le document en format XML

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<author><name sortKey="Zheng, Xiao Shuang" sort="Zheng, Xiao Shuang" uniqKey="Zheng X" first="Xiao-Shuang" last="Zheng">Xiao-Shuang Zheng</name>
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<author><name sortKey="An, Xiao Ping" sort="An, Xiao Ping" uniqKey="An X" first="Xiao-Ping" last="An">Xiao-Ping An</name>
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<author><name sortKey="Chen, Jun Wei" sort="Chen, Jun Wei" uniqKey="Chen J" first="Jun-Wei" last="Chen">Jun-Wei Chen</name>
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<author><name sortKey="Mai, Kai Jie" sort="Mai, Kai Jie" uniqKey="Mai K" first="Kai-Jie" last="Mai">Kai-Jie Mai</name>
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<author><name sortKey="Li, Di" sort="Li, Di" uniqKey="Li D" first="Di" last="Li">Di Li</name>
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<author><name sortKey="Anderson, Danielle E" sort="Anderson, Danielle E" uniqKey="Anderson D" first="Danielle E" last="Anderson">Danielle E. Anderson</name>
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<author><name sortKey="Zhang, Li Biao" sort="Zhang, Li Biao" uniqKey="Zhang L" first="Li-Biao" last="Zhang">Li-Biao Zhang</name>
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<country xml:lang="fr">République populaire de Chine</country>
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<author><name sortKey="Li, Shi Yue" sort="Li, Shi Yue" uniqKey="Li S" first="Shi-Yue" last="Li">Shi-Yue Li</name>
<affiliation wicri:level="1"><nlm:affiliation>School of Public Health, Wuhan University, Wuhan, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>School of Public Health, Wuhan University, Wuhan</wicri:regionArea>
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<author><name sortKey="Mi, Zhi Qiang" sort="Mi, Zhi Qiang" uniqKey="Mi Z" first="Zhi-Qiang" last="Mi">Zhi-Qiang Mi</name>
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</affiliation>
</author>
<author><name sortKey="He, Tong Tong" sort="He, Tong Tong" uniqKey="He T" first="Tong-Tong" last="He">Tong-Tong He</name>
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<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Beijing Institute of Microbiology and Epidemiology, Beijing</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Cong, Feng" sort="Cong, Feng" uniqKey="Cong F" first="Feng" last="Cong">Feng Cong</name>
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<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Guangdong Key Laboratory of Laboratory Animals, Guangdong Laboratory Animals Monitoring Institute, Guangzhou</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Guo, Peng Ju" sort="Guo, Peng Ju" uniqKey="Guo P" first="Peng-Ju" last="Guo">Peng-Ju Guo</name>
<affiliation wicri:level="1"><nlm:affiliation>Guangdong Key Laboratory of Laboratory Animals, Guangdong Laboratory Animals Monitoring Institute, Guangzhou, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Guangdong Key Laboratory of Laboratory Animals, Guangdong Laboratory Animals Monitoring Institute, Guangzhou</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Huang, Ren" sort="Huang, Ren" uniqKey="Huang R" first="Ren" last="Huang">Ren Huang</name>
<affiliation wicri:level="1"><nlm:affiliation>Guangdong Key Laboratory of Laboratory Animals, Guangdong Laboratory Animals Monitoring Institute, Guangzhou, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Guangdong Key Laboratory of Laboratory Animals, Guangdong Laboratory Animals Monitoring Institute, Guangzhou</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Luo, Yun" sort="Luo, Yun" uniqKey="Luo Y" first="Yun" last="Luo">Yun Luo</name>
<affiliation wicri:level="1"><nlm:affiliation>CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Liu, Xiang Ling" sort="Liu, Xiang Ling" uniqKey="Liu X" first="Xiang-Ling" last="Liu">Xiang-Ling Liu</name>
<affiliation wicri:level="1"><nlm:affiliation>CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Chen, Jing" sort="Chen, Jing" uniqKey="Chen J" first="Jing" last="Chen">Jing Chen</name>
<affiliation wicri:level="1"><nlm:affiliation>CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Huang, Yong" sort="Huang, Yong" uniqKey="Huang Y" first="Yong" last="Huang">Yong Huang</name>
<affiliation wicri:level="1"><nlm:affiliation>Beijing Institute of Microbiology and Epidemiology, Beijing, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Beijing Institute of Microbiology and Epidemiology, Beijing</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sun, Qiang" sort="Sun, Qiang" uniqKey="Sun Q" first="Qiang" last="Sun">Qiang Sun</name>
<affiliation wicri:level="1"><nlm:affiliation>Beijing Institute of Microbiology and Epidemiology, Beijing, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Beijing Institute of Microbiology and Epidemiology, Beijing</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Zhang, Xiang Li Lan" sort="Zhang, Xiang Li Lan" uniqKey="Zhang X" first="Xiang-Li-Lan" last="Zhang">Xiang-Li-Lan Zhang</name>
<affiliation wicri:level="1"><nlm:affiliation>Beijing Institute of Microbiology and Epidemiology, Beijing, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Beijing Institute of Microbiology and Epidemiology, Beijing</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wang, Yuan Yuan" sort="Wang, Yuan Yuan" uniqKey="Wang Y" first="Yuan-Yuan" last="Wang">Yuan-Yuan Wang</name>
<affiliation wicri:level="1"><nlm:affiliation>Beijing Institute of Microbiology and Epidemiology, Beijing, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Beijing Institute of Microbiology and Epidemiology, Beijing</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Xing, Shao Zhen" sort="Xing, Shao Zhen" uniqKey="Xing S" first="Shao-Zhen" last="Xing">Shao-Zhen Xing</name>
<affiliation wicri:level="1"><nlm:affiliation>Beijing Institute of Microbiology and Epidemiology, Beijing, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Beijing Institute of Microbiology and Epidemiology, Beijing</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Chen, Yan Shan" sort="Chen, Yan Shan" uniqKey="Chen Y" first="Yan-Shan" last="Chen">Yan-Shan Chen</name>
<affiliation wicri:level="1"><nlm:affiliation>College of Animal Science, South China Agricultural University, Guangzhou, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>College of Animal Science, South China Agricultural University, Guangzhou</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sun, Yuan" sort="Sun, Yuan" uniqKey="Sun Y" first="Yuan" last="Sun">Yuan Sun</name>
<affiliation wicri:level="1"><nlm:affiliation>College of Animal Science, South China Agricultural University, Guangzhou, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>College of Animal Science, South China Agricultural University, Guangzhou</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Li, Juan" sort="Li, Juan" uniqKey="Li J" first="Juan" last="Li">Juan Li</name>
<affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Etiology and Epidemiology of Emerging Infectious Diseases in Universities of Shandong, Taishan Medical College, Taian, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Key Laboratory of Etiology and Epidemiology of Emerging Infectious Diseases in Universities of Shandong, Taishan Medical College, Taian</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Daszak, Peter" sort="Daszak, Peter" uniqKey="Daszak P" first="Peter" last="Daszak">Peter Daszak</name>
<affiliation wicri:level="1"><nlm:affiliation>EcoHealth Alliance, New York, NY, USA. daszak@ecohealthalliance.org.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>EcoHealth Alliance, New York, NY</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wang, Lin Fa" sort="Wang, Lin Fa" uniqKey="Wang L" first="Lin-Fa" last="Wang">Lin-Fa Wang</name>
<affiliation wicri:level="1"><nlm:affiliation>Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore. linfa.wang@duke-nus.edu.sg.</nlm:affiliation>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Shi, Zheng Li" sort="Shi, Zheng Li" uniqKey="Shi Z" first="Zheng-Li" last="Shi">Zheng-Li Shi</name>
<affiliation wicri:level="1"><nlm:affiliation>CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China. zlshi@wh.iov.cn.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan</wicri:regionArea>
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</author>
<author><name sortKey="Tong, Yi Gang" sort="Tong, Yi Gang" uniqKey="Tong Y" first="Yi-Gang" last="Tong">Yi-Gang Tong</name>
<affiliation wicri:level="1"><nlm:affiliation>Beijing Institute of Microbiology and Epidemiology, Beijing, China. tong.yigang@gmail.com.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Beijing Institute of Microbiology and Epidemiology, Beijing</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ma, Jing Yun" sort="Ma, Jing Yun" uniqKey="Ma J" first="Jing-Yun" last="Ma">Jing-Yun Ma</name>
<affiliation wicri:level="1"><nlm:affiliation>College of Animal Science, South China Agricultural University, Guangzhou, China. majy2400@scau.edu.cn.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>College of Animal Science, South China Agricultural University, Guangzhou</wicri:regionArea>
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</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2018">2018</date>
<idno type="RBID">pubmed:29618817</idno>
<idno type="pmid">29618817</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Fatal swine acute diarrhoea syndrome caused by an HKU2-related coronavirus of bat origin.</title>
<author><name sortKey="Zhou, Peng" sort="Zhou, Peng" uniqKey="Zhou P" first="Peng" last="Zhou">Peng Zhou</name>
<affiliation wicri:level="1"><nlm:affiliation>CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan</wicri:regionArea>
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<affiliation wicri:level="1"><nlm:affiliation>Beijing Institute of Microbiology and Epidemiology, Beijing, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Beijing Institute of Microbiology and Epidemiology, Beijing</wicri:regionArea>
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<affiliation wicri:level="1"><nlm:affiliation>College of Animal Science, South China Agricultural University, Guangzhou, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>College of Animal Science, South China Agricultural University, Guangzhou</wicri:regionArea>
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<affiliation wicri:level="1"><nlm:affiliation>CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan</wicri:regionArea>
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<affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Etiology and Epidemiology of Emerging Infectious Diseases in Universities of Shandong, Taishan Medical College, Taian, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Key Laboratory of Etiology and Epidemiology of Emerging Infectious Diseases in Universities of Shandong, Taishan Medical College, Taian</wicri:regionArea>
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<affiliation wicri:level="1"><nlm:affiliation>CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan</wicri:regionArea>
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<affiliation wicri:level="1"><nlm:affiliation>CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan</wicri:regionArea>
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<affiliation wicri:level="1"><nlm:affiliation>Beijing Institute of Microbiology and Epidemiology, Beijing, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Beijing Institute of Microbiology and Epidemiology, Beijing</wicri:regionArea>
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<affiliation wicri:level="1"><nlm:affiliation>College of Animal Science, South China Agricultural University, Guangzhou, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>College of Animal Science, South China Agricultural University, Guangzhou</wicri:regionArea>
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<affiliation wicri:level="1"><nlm:affiliation>Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore.</nlm:affiliation>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore</wicri:regionArea>
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<author><name sortKey="Zheng, Xiao Shuang" sort="Zheng, Xiao Shuang" uniqKey="Zheng X" first="Xiao-Shuang" last="Zheng">Xiao-Shuang Zheng</name>
<affiliation wicri:level="1"><nlm:affiliation>CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan</wicri:regionArea>
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<affiliation wicri:level="1"><nlm:affiliation>CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan</wicri:regionArea>
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<affiliation wicri:level="1"><nlm:affiliation>Beijing Institute of Microbiology and Epidemiology, Beijing, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Beijing Institute of Microbiology and Epidemiology, Beijing</wicri:regionArea>
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<affiliation wicri:level="1"><nlm:affiliation>CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan</wicri:regionArea>
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</author>
<author><name sortKey="Pei, Guang Qian" sort="Pei, Guang Qian" uniqKey="Pei G" first="Guang-Qian" last="Pei">Guang-Qian Pei</name>
<affiliation wicri:level="1"><nlm:affiliation>Beijing Institute of Microbiology and Epidemiology, Beijing, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Beijing Institute of Microbiology and Epidemiology, Beijing</wicri:regionArea>
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<affiliation wicri:level="1"><nlm:affiliation>Beijing Institute of Microbiology and Epidemiology, Beijing, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Beijing Institute of Microbiology and Epidemiology, Beijing</wicri:regionArea>
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<affiliation wicri:level="1"><nlm:affiliation>College of Animal Science, South China Agricultural University, Guangzhou, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>College of Animal Science, South China Agricultural University, Guangzhou</wicri:regionArea>
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<author><name sortKey="Zhou, Ling" sort="Zhou, Ling" uniqKey="Zhou L" first="Ling" last="Zhou">Ling Zhou</name>
<affiliation wicri:level="1"><nlm:affiliation>College of Animal Science, South China Agricultural University, Guangzhou, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>College of Animal Science, South China Agricultural University, Guangzhou</wicri:regionArea>
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<author><name sortKey="Mai, Kai Jie" sort="Mai, Kai Jie" uniqKey="Mai K" first="Kai-Jie" last="Mai">Kai-Jie Mai</name>
<affiliation wicri:level="1"><nlm:affiliation>College of Animal Science, South China Agricultural University, Guangzhou, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>College of Animal Science, South China Agricultural University, Guangzhou</wicri:regionArea>
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<affiliation wicri:level="1"><nlm:affiliation>College of Animal Science, South China Agricultural University, Guangzhou, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>College of Animal Science, South China Agricultural University, Guangzhou</wicri:regionArea>
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<author><name sortKey="Li, Di" sort="Li, Di" uniqKey="Li D" first="Di" last="Li">Di Li</name>
<affiliation wicri:level="1"><nlm:affiliation>College of Animal Science, South China Agricultural University, Guangzhou, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>College of Animal Science, South China Agricultural University, Guangzhou</wicri:regionArea>
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<affiliation wicri:level="1"><nlm:affiliation>Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore.</nlm:affiliation>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore</wicri:regionArea>
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<author><name sortKey="Zhang, Li Biao" sort="Zhang, Li Biao" uniqKey="Zhang L" first="Li-Biao" last="Zhang">Li-Biao Zhang</name>
<affiliation wicri:level="1"><nlm:affiliation>Guangdong Key Laboratory of Animal Conservation and Resource Utilization, Guangdong Public Laboratory of Wild Animal Conservation and Utilization, Guangdong Institute of Applied Biological Resources, Guangzhou, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Guangdong Key Laboratory of Animal Conservation and Resource Utilization, Guangdong Public Laboratory of Wild Animal Conservation and Utilization, Guangdong Institute of Applied Biological Resources, Guangzhou</wicri:regionArea>
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<affiliation wicri:level="1"><nlm:affiliation>School of Public Health, Wuhan University, Wuhan, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>School of Public Health, Wuhan University, Wuhan</wicri:regionArea>
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<author><name sortKey="Mi, Zhi Qiang" sort="Mi, Zhi Qiang" uniqKey="Mi Z" first="Zhi-Qiang" last="Mi">Zhi-Qiang Mi</name>
<affiliation wicri:level="1"><nlm:affiliation>Beijing Institute of Microbiology and Epidemiology, Beijing, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Beijing Institute of Microbiology and Epidemiology, Beijing</wicri:regionArea>
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<affiliation wicri:level="1"><nlm:affiliation>Beijing Institute of Microbiology and Epidemiology, Beijing, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Beijing Institute of Microbiology and Epidemiology, Beijing</wicri:regionArea>
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</author>
<author><name sortKey="Cong, Feng" sort="Cong, Feng" uniqKey="Cong F" first="Feng" last="Cong">Feng Cong</name>
<affiliation wicri:level="1"><nlm:affiliation>Guangdong Key Laboratory of Laboratory Animals, Guangdong Laboratory Animals Monitoring Institute, Guangzhou, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Guangdong Key Laboratory of Laboratory Animals, Guangdong Laboratory Animals Monitoring Institute, Guangzhou</wicri:regionArea>
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<affiliation wicri:level="1"><nlm:affiliation>Guangdong Key Laboratory of Laboratory Animals, Guangdong Laboratory Animals Monitoring Institute, Guangzhou, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Guangdong Key Laboratory of Laboratory Animals, Guangdong Laboratory Animals Monitoring Institute, Guangzhou</wicri:regionArea>
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<affiliation wicri:level="1"><nlm:affiliation>Guangdong Key Laboratory of Laboratory Animals, Guangdong Laboratory Animals Monitoring Institute, Guangzhou, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Guangdong Key Laboratory of Laboratory Animals, Guangdong Laboratory Animals Monitoring Institute, Guangzhou</wicri:regionArea>
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<affiliation wicri:level="1"><nlm:affiliation>CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan</wicri:regionArea>
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<affiliation wicri:level="1"><nlm:affiliation>CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan</wicri:regionArea>
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<author><name sortKey="Chen, Jing" sort="Chen, Jing" uniqKey="Chen J" first="Jing" last="Chen">Jing Chen</name>
<affiliation wicri:level="1"><nlm:affiliation>CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan</wicri:regionArea>
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<author><name sortKey="Huang, Yong" sort="Huang, Yong" uniqKey="Huang Y" first="Yong" last="Huang">Yong Huang</name>
<affiliation wicri:level="1"><nlm:affiliation>Beijing Institute of Microbiology and Epidemiology, Beijing, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Beijing Institute of Microbiology and Epidemiology, Beijing</wicri:regionArea>
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<affiliation wicri:level="1"><nlm:affiliation>Beijing Institute of Microbiology and Epidemiology, Beijing, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Beijing Institute of Microbiology and Epidemiology, Beijing</wicri:regionArea>
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<affiliation wicri:level="1"><nlm:affiliation>Beijing Institute of Microbiology and Epidemiology, Beijing, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Beijing Institute of Microbiology and Epidemiology, Beijing</wicri:regionArea>
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<affiliation wicri:level="1"><nlm:affiliation>Beijing Institute of Microbiology and Epidemiology, Beijing, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Beijing Institute of Microbiology and Epidemiology, Beijing</wicri:regionArea>
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<author><name sortKey="Xing, Shao Zhen" sort="Xing, Shao Zhen" uniqKey="Xing S" first="Shao-Zhen" last="Xing">Shao-Zhen Xing</name>
<affiliation wicri:level="1"><nlm:affiliation>Beijing Institute of Microbiology and Epidemiology, Beijing, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Beijing Institute of Microbiology and Epidemiology, Beijing</wicri:regionArea>
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<affiliation wicri:level="1"><nlm:affiliation>College of Animal Science, South China Agricultural University, Guangzhou, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>College of Animal Science, South China Agricultural University, Guangzhou</wicri:regionArea>
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<affiliation wicri:level="1"><nlm:affiliation>College of Animal Science, South China Agricultural University, Guangzhou, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>College of Animal Science, South China Agricultural University, Guangzhou</wicri:regionArea>
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<affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Etiology and Epidemiology of Emerging Infectious Diseases in Universities of Shandong, Taishan Medical College, Taian, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Key Laboratory of Etiology and Epidemiology of Emerging Infectious Diseases in Universities of Shandong, Taishan Medical College, Taian</wicri:regionArea>
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<affiliation wicri:level="1"><nlm:affiliation>Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore. linfa.wang@duke-nus.edu.sg.</nlm:affiliation>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore</wicri:regionArea>
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<affiliation wicri:level="1"><nlm:affiliation>CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China. zlshi@wh.iov.cn.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan</wicri:regionArea>
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<affiliation wicri:level="1"><nlm:affiliation>Beijing Institute of Microbiology and Epidemiology, Beijing, China. tong.yigang@gmail.com.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
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<affiliation wicri:level="1"><nlm:affiliation>College of Animal Science, South China Agricultural University, Guangzhou, China. majy2400@scau.edu.cn.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>College of Animal Science, South China Agricultural University, Guangzhou</wicri:regionArea>
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<series><title level="j">Nature</title>
<idno type="eISSN">1476-4687</idno>
<imprint><date when="2018" type="published">2018</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alphacoronavirus (classification)</term>
<term>Alphacoronavirus (genetics)</term>
<term>Alphacoronavirus (isolation & purification)</term>
<term>Alphacoronavirus (pathogenicity)</term>
<term>Animal Diseases (epidemiology)</term>
<term>Animal Diseases (transmission)</term>
<term>Animal Diseases (virology)</term>
<term>Animals</term>
<term>Biodiversity</term>
<term>China (epidemiology)</term>
<term>Chiroptera (virology)</term>
<term>Coronavirus Infections (epidemiology)</term>
<term>Coronavirus Infections (transmission)</term>
<term>Coronavirus Infections (veterinary)</term>
<term>Diarrhea (pathology)</term>
<term>Diarrhea (veterinary)</term>
<term>Diarrhea (virology)</term>
<term>Disease Reservoirs (veterinary)</term>
<term>Disease Reservoirs (virology)</term>
<term>Genome, Viral (genetics)</term>
<term>Humans</term>
<term>Jejunum (pathology)</term>
<term>Jejunum (virology)</term>
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<term>Severe Acute Respiratory Syndrome (epidemiology)</term>
<term>Severe Acute Respiratory Syndrome (veterinary)</term>
<term>Severe Acute Respiratory Syndrome (virology)</term>
<term>Spatio-Temporal Analysis</term>
<term>Swine (virology)</term>
<term>Zoonoses (epidemiology)</term>
<term>Zoonoses (transmission)</term>
<term>Zoonoses (virology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Analyse spatio-temporelle</term>
<term>Animaux</term>
<term>Biodiversité</term>
<term>Chine (épidémiologie)</term>
<term>Chiroptera (virologie)</term>
<term>Diarrhée (anatomopathologie)</term>
<term>Diarrhée (médecine vétérinaire)</term>
<term>Diarrhée (virologie)</term>
<term>Génome viral (génétique)</term>
<term>Humains</term>
<term>Infections à coronavirus (médecine vétérinaire)</term>
<term>Infections à coronavirus (transmission)</term>
<term>Infections à coronavirus (épidémiologie)</term>
<term>Jéjunum (anatomopathologie)</term>
<term>Jéjunum (virologie)</term>
<term>Maladies de l'animal (transmission)</term>
<term>Maladies de l'animal (virologie)</term>
<term>Maladies de l'animal (épidémiologie)</term>
<term>Phylogénie</term>
<term>Réservoirs d'agents pathogènes (médecine vétérinaire)</term>
<term>Réservoirs d'agents pathogènes (virologie)</term>
<term>Suidae (virologie)</term>
<term>Syndrome respiratoire aigu sévère (médecine vétérinaire)</term>
<term>Syndrome respiratoire aigu sévère (virologie)</term>
<term>Syndrome respiratoire aigu sévère (épidémiologie)</term>
<term>Zoonoses (transmission)</term>
<term>Zoonoses (virologie)</term>
<term>Zoonoses (épidémiologie)</term>
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<term>Jéjunum</term>
</keywords>
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<term>Coronavirus Infections</term>
<term>Severe Acute Respiratory Syndrome</term>
<term>Zoonoses</term>
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<term>Genome, Viral</term>
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</keywords>
<keywords scheme="MESH" qualifier="médecine vétérinaire" xml:lang="fr"><term>Diarrhée</term>
<term>Infections à coronavirus</term>
<term>Réservoirs d'agents pathogènes</term>
<term>Syndrome respiratoire aigu sévère</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Alphacoronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Diarrhea</term>
<term>Jejunum</term>
</keywords>
<keywords scheme="MESH" qualifier="transmission" xml:lang="en"><term>Animal Diseases</term>
<term>Coronavirus Infections</term>
<term>Zoonoses</term>
</keywords>
<keywords scheme="MESH" qualifier="veterinary" xml:lang="en"><term>Coronavirus Infections</term>
<term>Diarrhea</term>
<term>Disease Reservoirs</term>
<term>Severe Acute Respiratory Syndrome</term>
</keywords>
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<term>Diarrhée</term>
<term>Jéjunum</term>
<term>Maladies de l'animal</term>
<term>Réservoirs d'agents pathogènes</term>
<term>Suidae</term>
<term>Syndrome respiratoire aigu sévère</term>
<term>Zoonoses</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Animal Diseases</term>
<term>Chiroptera</term>
<term>Diarrhea</term>
<term>Disease Reservoirs</term>
<term>Jejunum</term>
<term>Severe Acute Respiratory Syndrome</term>
<term>Swine</term>
<term>Zoonoses</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Chine</term>
<term>Infections à coronavirus</term>
<term>Maladies de l'animal</term>
<term>Syndrome respiratoire aigu sévère</term>
<term>Zoonoses</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Biodiversity</term>
<term>Humans</term>
<term>Phylogeny</term>
<term>Spatio-Temporal Analysis</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Analyse spatio-temporelle</term>
<term>Animaux</term>
<term>Biodiversité</term>
<term>Humains</term>
<term>Phylogénie</term>
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<front><div type="abstract" xml:lang="en">Cross-species transmission of viruses from wildlife animal reservoirs poses a marked threat to human and animal health <sup>1</sup>
 . Bats have been recognized as one of the most important reservoirs for emerging viruses and the transmission of a coronavirus that originated in bats to humans via intermediate hosts was responsible for the high-impact emerging zoonosis, severe acute respiratory syndrome (SARS) <sup>2-10</sup>
 . Here we provide virological, epidemiological, evolutionary and experimental evidence that a novel HKU2-related bat coronavirus, swine acute diarrhoea syndrome coronavirus (SADS-CoV), is the aetiological agent that was responsible for a large-scale outbreak of fatal disease in pigs in China that has caused the death of 24,693 piglets across four farms. Notably, the outbreak began in Guangdong province in the vicinity of the origin of the SARS pandemic. Furthermore, we identified SADS-related CoVs with 96-98% sequence identity in 9.8% (58 out of 591) of anal swabs collected from bats in Guangdong province during 2013-2016, predominantly in horseshoe bats (Rhinolophus spp.) that are known reservoirs of SARS-related CoVs. We found that there were striking similarities between the SADS and SARS outbreaks in geographical, temporal, ecological and aetiological settings. This study highlights the importance of identifying coronavirus diversity and distribution in bats to mitigate future outbreaks that could threaten livestock, public health and economic growth.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">29618817</PMID>
<DateCompleted><Year>2018</Year>
<Month>08</Month>
<Day>17</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>03</Month>
<Day>27</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1476-4687</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>556</Volume>
<Issue>7700</Issue>
<PubDate><Year>2018</Year>
<Month>04</Month>
</PubDate>
</JournalIssue>
<Title>Nature</Title>
<ISOAbbreviation>Nature</ISOAbbreviation>
</Journal>
<ArticleTitle>Fatal swine acute diarrhoea syndrome caused by an HKU2-related coronavirus of bat origin.</ArticleTitle>
<Pagination><MedlinePgn>255-258</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1038/s41586-018-0010-9</ELocationID>
<Abstract><AbstractText>Cross-species transmission of viruses from wildlife animal reservoirs poses a marked threat to human and animal health <sup>1</sup>
 . Bats have been recognized as one of the most important reservoirs for emerging viruses and the transmission of a coronavirus that originated in bats to humans via intermediate hosts was responsible for the high-impact emerging zoonosis, severe acute respiratory syndrome (SARS) <sup>2-10</sup>
 . Here we provide virological, epidemiological, evolutionary and experimental evidence that a novel HKU2-related bat coronavirus, swine acute diarrhoea syndrome coronavirus (SADS-CoV), is the aetiological agent that was responsible for a large-scale outbreak of fatal disease in pigs in China that has caused the death of 24,693 piglets across four farms. Notably, the outbreak began in Guangdong province in the vicinity of the origin of the SARS pandemic. Furthermore, we identified SADS-related CoVs with 96-98% sequence identity in 9.8% (58 out of 591) of anal swabs collected from bats in Guangdong province during 2013-2016, predominantly in horseshoe bats (Rhinolophus spp.) that are known reservoirs of SARS-related CoVs. We found that there were striking similarities between the SADS and SARS outbreaks in geographical, temporal, ecological and aetiological settings. This study highlights the importance of identifying coronavirus diversity and distribution in bats to mitigate future outbreaks that could threaten livestock, public health and economic growth.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Zhou</LastName>
<ForeName>Peng</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Fan</LastName>
<ForeName>Hang</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>Beijing Institute of Microbiology and Epidemiology, Beijing, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lan</LastName>
<ForeName>Tian</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>College of Animal Science, South China Agricultural University, Guangzhou, China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Key Laboratory of Animal Health Aquaculture and Environmental Control, Guangzhou, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Yang</LastName>
<ForeName>Xing-Lou</ForeName>
<Initials>XL</Initials>
<AffiliationInfo><Affiliation>CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Shi</LastName>
<ForeName>Wei-Feng</ForeName>
<Initials>WF</Initials>
<AffiliationInfo><Affiliation>Key Laboratory of Etiology and Epidemiology of Emerging Infectious Diseases in Universities of Shandong, Taishan Medical College, Taian, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhang</LastName>
<ForeName>Wei</ForeName>
<Initials>W</Initials>
<AffiliationInfo><Affiliation>CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhu</LastName>
<ForeName>Yan</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhang</LastName>
<ForeName>Ya-Wei</ForeName>
<Initials>YW</Initials>
<AffiliationInfo><Affiliation>Beijing Institute of Microbiology and Epidemiology, Beijing, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Xie</LastName>
<ForeName>Qing-Mei</ForeName>
<Initials>QM</Initials>
<AffiliationInfo><Affiliation>College of Animal Science, South China Agricultural University, Guangzhou, China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Key Laboratory of Animal Health Aquaculture and Environmental Control, Guangzhou, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mani</LastName>
<ForeName>Shailendra</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zheng</LastName>
<ForeName>Xiao-Shuang</ForeName>
<Initials>XS</Initials>
<AffiliationInfo><Affiliation>CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Li</LastName>
<ForeName>Bei</ForeName>
<Initials>B</Initials>
<AffiliationInfo><Affiliation>CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Li</LastName>
<ForeName>Jin-Man</ForeName>
<Initials>JM</Initials>
<AffiliationInfo><Affiliation>Beijing Institute of Microbiology and Epidemiology, Beijing, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Guo</LastName>
<ForeName>Hua</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Pei</LastName>
<ForeName>Guang-Qian</ForeName>
<Initials>GQ</Initials>
<AffiliationInfo><Affiliation>Beijing Institute of Microbiology and Epidemiology, Beijing, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>An</LastName>
<ForeName>Xiao-Ping</ForeName>
<Initials>XP</Initials>
<AffiliationInfo><Affiliation>Beijing Institute of Microbiology and Epidemiology, Beijing, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chen</LastName>
<ForeName>Jun-Wei</ForeName>
<Initials>JW</Initials>
<AffiliationInfo><Affiliation>College of Animal Science, South China Agricultural University, Guangzhou, China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Key Laboratory of Animal Health Aquaculture and Environmental Control, Guangzhou, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhou</LastName>
<ForeName>Ling</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>College of Animal Science, South China Agricultural University, Guangzhou, China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Key Laboratory of Animal Health Aquaculture and Environmental Control, Guangzhou, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mai</LastName>
<ForeName>Kai-Jie</ForeName>
<Initials>KJ</Initials>
<AffiliationInfo><Affiliation>College of Animal Science, South China Agricultural University, Guangzhou, China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Key Laboratory of Animal Health Aquaculture and Environmental Control, Guangzhou, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wu</LastName>
<ForeName>Zi-Xian</ForeName>
<Initials>ZX</Initials>
<AffiliationInfo><Affiliation>College of Animal Science, South China Agricultural University, Guangzhou, China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Key Laboratory of Animal Health Aquaculture and Environmental Control, Guangzhou, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Li</LastName>
<ForeName>Di</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>College of Animal Science, South China Agricultural University, Guangzhou, China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Key Laboratory of Animal Health Aquaculture and Environmental Control, Guangzhou, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Anderson</LastName>
<ForeName>Danielle E</ForeName>
<Initials>DE</Initials>
<AffiliationInfo><Affiliation>Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhang</LastName>
<ForeName>Li-Biao</ForeName>
<Initials>LB</Initials>
<AffiliationInfo><Affiliation>Guangdong Key Laboratory of Animal Conservation and Resource Utilization, Guangdong Public Laboratory of Wild Animal Conservation and Utilization, Guangdong Institute of Applied Biological Resources, Guangzhou, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Li</LastName>
<ForeName>Shi-Yue</ForeName>
<Initials>SY</Initials>
<AffiliationInfo><Affiliation>School of Public Health, Wuhan University, Wuhan, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mi</LastName>
<ForeName>Zhi-Qiang</ForeName>
<Initials>ZQ</Initials>
<AffiliationInfo><Affiliation>Beijing Institute of Microbiology and Epidemiology, Beijing, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>He</LastName>
<ForeName>Tong-Tong</ForeName>
<Initials>TT</Initials>
<AffiliationInfo><Affiliation>Beijing Institute of Microbiology and Epidemiology, Beijing, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Cong</LastName>
<ForeName>Feng</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>Guangdong Key Laboratory of Laboratory Animals, Guangdong Laboratory Animals Monitoring Institute, Guangzhou, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Guo</LastName>
<ForeName>Peng-Ju</ForeName>
<Initials>PJ</Initials>
<AffiliationInfo><Affiliation>Guangdong Key Laboratory of Laboratory Animals, Guangdong Laboratory Animals Monitoring Institute, Guangzhou, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Huang</LastName>
<ForeName>Ren</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Guangdong Key Laboratory of Laboratory Animals, Guangdong Laboratory Animals Monitoring Institute, Guangzhou, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Luo</LastName>
<ForeName>Yun</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Liu</LastName>
<ForeName>Xiang-Ling</ForeName>
<Initials>XL</Initials>
<AffiliationInfo><Affiliation>CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chen</LastName>
<ForeName>Jing</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Huang</LastName>
<ForeName>Yong</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Beijing Institute of Microbiology and Epidemiology, Beijing, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Sun</LastName>
<ForeName>Qiang</ForeName>
<Initials>Q</Initials>
<AffiliationInfo><Affiliation>Beijing Institute of Microbiology and Epidemiology, Beijing, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhang</LastName>
<ForeName>Xiang-Li-Lan</ForeName>
<Initials>XL</Initials>
<AffiliationInfo><Affiliation>Beijing Institute of Microbiology and Epidemiology, Beijing, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wang</LastName>
<ForeName>Yuan-Yuan</ForeName>
<Initials>YY</Initials>
<AffiliationInfo><Affiliation>Beijing Institute of Microbiology and Epidemiology, Beijing, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Xing</LastName>
<ForeName>Shao-Zhen</ForeName>
<Initials>SZ</Initials>
<AffiliationInfo><Affiliation>Beijing Institute of Microbiology and Epidemiology, Beijing, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chen</LastName>
<ForeName>Yan-Shan</ForeName>
<Initials>YS</Initials>
<AffiliationInfo><Affiliation>College of Animal Science, South China Agricultural University, Guangzhou, China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Key Laboratory of Animal Health Aquaculture and Environmental Control, Guangzhou, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Sun</LastName>
<ForeName>Yuan</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>College of Animal Science, South China Agricultural University, Guangzhou, China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Key Laboratory of Animal Health Aquaculture and Environmental Control, Guangzhou, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Li</LastName>
<ForeName>Juan</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Key Laboratory of Etiology and Epidemiology of Emerging Infectious Diseases in Universities of Shandong, Taishan Medical College, Taian, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Daszak</LastName>
<ForeName>Peter</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>EcoHealth Alliance, New York, NY, USA. daszak@ecohealthalliance.org.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wang</LastName>
<ForeName>Lin-Fa</ForeName>
<Initials>LF</Initials>
<AffiliationInfo><Affiliation>Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore. linfa.wang@duke-nus.edu.sg.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Shi</LastName>
<ForeName>Zheng-Li</ForeName>
<Initials>ZL</Initials>
<AffiliationInfo><Affiliation>CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China. zlshi@wh.iov.cn.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Tong</LastName>
<ForeName>Yi-Gang</ForeName>
<Initials>YG</Initials>
<AffiliationInfo><Affiliation>Beijing Institute of Microbiology and Epidemiology, Beijing, China. tong.yigang@gmail.com.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>School of Life Sciences, North China University of Science and Technology, Tangshan, China. tong.yigang@gmail.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ma</LastName>
<ForeName>Jing-Yun</ForeName>
<Initials>JY</Initials>
<AffiliationInfo><Affiliation>College of Animal Science, South China Agricultural University, Guangzhou, China. majy2400@scau.edu.cn.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Key Laboratory of Animal Health Aquaculture and Environmental Control, Guangzhou, China. majy2400@scau.edu.cn.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>R01 AI110964</GrantID>
<Acronym>AI</Acronym>
<Agency>NIAID NIH HHS</Agency>
<Country>United States</Country>
</Grant>
</GrantList>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
<PublicationType UI="D013486">Research Support, U.S. Gov't, Non-P.H.S.</PublicationType>
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<ArticleDate DateType="Electronic"><Year>2018</Year>
<Month>04</Month>
<Day>04</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>Nature</MedlineTA>
<NlmUniqueID>0410462</NlmUniqueID>
<ISSNLinking>0028-0836</ISSNLinking>
</MedlineJournalInfo>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000073638" MajorTopicYN="N">Alphacoronavirus</DescriptorName>
<QualifierName UI="Q000145" MajorTopicYN="N">classification</QualifierName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000302" MajorTopicYN="Y">isolation & purification</QualifierName>
<QualifierName UI="Q000472" MajorTopicYN="Y">pathogenicity</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000820" MajorTopicYN="N">Animal Diseases</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName>
<QualifierName UI="Q000635" MajorTopicYN="N">transmission</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D044822" MajorTopicYN="N">Biodiversity</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002681" MajorTopicYN="N">China</DescriptorName>
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Fatal swine acute diarrhoea syndrome caused by an HKU2-related coronavirus of bat origin.

Fatal swine acute diarrhoea syndrome caused by an HKU2-related coronavirus of bat origin.

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