Fatal swine acute diarrhoea syndrome caused by an HKU2-related coronavirus of bat origin.
Identifieur interne : 000A13 ( PubMed/Corpus ); précédent : 000A12; suivant : 000A14Fatal swine acute diarrhoea syndrome caused by an HKU2-related coronavirus of bat origin.
Auteurs : Peng Zhou ; Hang Fan ; Tian Lan ; Xing-Lou Yang ; Wei-Feng Shi ; Wei Zhang ; Yan Zhu ; Ya-Wei Zhang ; Qing-Mei Xie ; Shailendra Mani ; Xiao-Shuang Zheng ; Bei Li ; Jin-Man Li ; Hua Guo ; Guang-Qian Pei ; Xiao-Ping An ; Jun-Wei Chen ; Ling Zhou ; Kai-Jie Mai ; Zi-Xian Wu ; Di Li ; Danielle E. Anderson ; Li-Biao Zhang ; Shi-Yue Li ; Zhi-Qiang Mi ; Tong-Tong He ; Feng Cong ; Peng-Ju Guo ; Ren Huang ; Yun Luo ; Xiang-Ling Liu ; Jing Chen ; Yong Huang ; Qiang Sun ; Xiang-Li-Lan Zhang ; Yuan-Yuan Wang ; Shao-Zhen Xing ; Yan-Shan Chen ; Yuan Sun ; Juan Li ; Peter Daszak ; Lin-Fa Wang ; Zheng-Li Shi ; Yi-Gang Tong ; Jing-Yun MaSource :
- Nature [ 1476-4687 ] ; 2018.
English descriptors
- KwdEn :
- Alphacoronavirus (classification), Alphacoronavirus (genetics), Alphacoronavirus (isolation & purification), Alphacoronavirus (pathogenicity), Animal Diseases (epidemiology), Animal Diseases (transmission), Animal Diseases (virology), Animals, Biodiversity, China (epidemiology), Chiroptera (virology), Coronavirus Infections (epidemiology), Coronavirus Infections (transmission), Coronavirus Infections (veterinary), Diarrhea (pathology), Diarrhea (veterinary), Diarrhea (virology), Disease Reservoirs (veterinary), Disease Reservoirs (virology), Genome, Viral (genetics), Humans, Jejunum (pathology), Jejunum (virology), Phylogeny, Severe Acute Respiratory Syndrome (epidemiology), Severe Acute Respiratory Syndrome (veterinary), Severe Acute Respiratory Syndrome (virology), Spatio-Temporal Analysis, Swine (virology), Zoonoses (epidemiology), Zoonoses (transmission), Zoonoses (virology).
- MESH :
- classification : Alphacoronavirus.
- epidemiology : Animal Diseases, China, Coronavirus Infections, Severe Acute Respiratory Syndrome, Zoonoses.
- genetics : Alphacoronavirus, Genome, Viral.
- isolation & purification : Alphacoronavirus.
- pathogenicity : Alphacoronavirus.
- pathology : Diarrhea, Jejunum.
- transmission : Animal Diseases, Coronavirus Infections, Zoonoses.
- veterinary : Coronavirus Infections, Diarrhea, Disease Reservoirs, Severe Acute Respiratory Syndrome.
- virology : Animal Diseases, Chiroptera, Diarrhea, Disease Reservoirs, Jejunum, Severe Acute Respiratory Syndrome, Swine, Zoonoses.
- Animals, Biodiversity, Humans, Phylogeny, Spatio-Temporal Analysis.
Abstract
Cross-species transmission of viruses from wildlife animal reservoirs poses a marked threat to human and animal health 1 . Bats have been recognized as one of the most important reservoirs for emerging viruses and the transmission of a coronavirus that originated in bats to humans via intermediate hosts was responsible for the high-impact emerging zoonosis, severe acute respiratory syndrome (SARS) 2-10 . Here we provide virological, epidemiological, evolutionary and experimental evidence that a novel HKU2-related bat coronavirus, swine acute diarrhoea syndrome coronavirus (SADS-CoV), is the aetiological agent that was responsible for a large-scale outbreak of fatal disease in pigs in China that has caused the death of 24,693 piglets across four farms. Notably, the outbreak began in Guangdong province in the vicinity of the origin of the SARS pandemic. Furthermore, we identified SADS-related CoVs with 96-98% sequence identity in 9.8% (58 out of 591) of anal swabs collected from bats in Guangdong province during 2013-2016, predominantly in horseshoe bats (Rhinolophus spp.) that are known reservoirs of SARS-related CoVs. We found that there were striking similarities between the SADS and SARS outbreaks in geographical, temporal, ecological and aetiological settings. This study highlights the importance of identifying coronavirus diversity and distribution in bats to mitigate future outbreaks that could threaten livestock, public health and economic growth.
DOI: 10.1038/s41586-018-0010-9
PubMed: 29618817
Links to Exploration step
pubmed:29618817Le document en format XML
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sortKey="Yang, Xing Lou" sort="Yang, Xing Lou" uniqKey="Yang X" first="Xing-Lou" last="Yang">Xing-Lou Yang</name><affiliation><nlm:affiliation>CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Shi, Wei Feng" sort="Shi, Wei Feng" uniqKey="Shi W" first="Wei-Feng" last="Shi">Wei-Feng Shi</name><affiliation><nlm:affiliation>Key Laboratory of Etiology and Epidemiology of Emerging Infectious Diseases in Universities of Shandong, Taishan Medical College, Taian, China.</nlm:affiliation></affiliation></author><author><name sortKey="Zhang, Wei" sort="Zhang, Wei" uniqKey="Zhang W" first="Wei" last="Zhang">Wei Zhang</name><affiliation><nlm:affiliation>CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Zhu, Yan" sort="Zhu, Yan" uniqKey="Zhu Y" first="Yan" last="Zhu">Yan Zhu</name><affiliation><nlm:affiliation>CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Zhang, Ya Wei" sort="Zhang, Ya Wei" uniqKey="Zhang Y" first="Ya-Wei" last="Zhang">Ya-Wei Zhang</name><affiliation><nlm:affiliation>Beijing Institute of Microbiology and Epidemiology, Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Xie, Qing Mei" sort="Xie, Qing Mei" uniqKey="Xie Q" first="Qing-Mei" last="Xie">Qing-Mei Xie</name><affiliation><nlm:affiliation>College of Animal Science, South China Agricultural University, Guangzhou, China.</nlm:affiliation></affiliation></author><author><name sortKey="Mani, Shailendra" sort="Mani, Shailendra" uniqKey="Mani S" first="Shailendra" last="Mani">Shailendra Mani</name><affiliation><nlm:affiliation>Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore.</nlm:affiliation></affiliation></author><author><name sortKey="Zheng, Xiao Shuang" sort="Zheng, Xiao Shuang" uniqKey="Zheng X" first="Xiao-Shuang" last="Zheng">Xiao-Shuang Zheng</name><affiliation><nlm:affiliation>CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Li, Bei" sort="Li, Bei" uniqKey="Li B" first="Bei" last="Li">Bei Li</name><affiliation><nlm:affiliation>CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Li, Jin Man" sort="Li, Jin Man" uniqKey="Li J" first="Jin-Man" last="Li">Jin-Man Li</name><affiliation><nlm:affiliation>Beijing Institute of Microbiology and Epidemiology, Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Guo, Hua" sort="Guo, Hua" uniqKey="Guo H" first="Hua" last="Guo">Hua Guo</name><affiliation><nlm:affiliation>CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Pei, Guang Qian" sort="Pei, Guang Qian" uniqKey="Pei G" first="Guang-Qian" last="Pei">Guang-Qian Pei</name><affiliation><nlm:affiliation>Beijing Institute of Microbiology and Epidemiology, Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="An, Xiao Ping" sort="An, Xiao Ping" uniqKey="An X" first="Xiao-Ping" last="An">Xiao-Ping An</name><affiliation><nlm:affiliation>Beijing Institute of Microbiology and Epidemiology, Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Chen, Jun Wei" sort="Chen, Jun Wei" uniqKey="Chen J" first="Jun-Wei" last="Chen">Jun-Wei Chen</name><affiliation><nlm:affiliation>College of Animal Science, South China Agricultural University, Guangzhou, China.</nlm:affiliation></affiliation></author><author><name sortKey="Zhou, Ling" sort="Zhou, Ling" uniqKey="Zhou L" first="Ling" last="Zhou">Ling Zhou</name><affiliation><nlm:affiliation>College of Animal Science, South China Agricultural University, Guangzhou, China.</nlm:affiliation></affiliation></author><author><name sortKey="Mai, Kai Jie" sort="Mai, Kai Jie" uniqKey="Mai K" first="Kai-Jie" last="Mai">Kai-Jie Mai</name><affiliation><nlm:affiliation>College of Animal Science, South China Agricultural University, Guangzhou, China.</nlm:affiliation></affiliation></author><author><name sortKey="Wu, Zi Xian" sort="Wu, Zi Xian" uniqKey="Wu Z" first="Zi-Xian" last="Wu">Zi-Xian Wu</name><affiliation><nlm:affiliation>College of Animal Science, South China Agricultural University, Guangzhou, China.</nlm:affiliation></affiliation></author><author><name sortKey="Li, Di" sort="Li, Di" uniqKey="Li D" first="Di" last="Li">Di Li</name><affiliation><nlm:affiliation>College of Animal Science, South China Agricultural University, Guangzhou, China.</nlm:affiliation></affiliation></author><author><name sortKey="Anderson, Danielle E" sort="Anderson, Danielle E" uniqKey="Anderson D" first="Danielle E" last="Anderson">Danielle E. Anderson</name><affiliation><nlm:affiliation>Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore.</nlm:affiliation></affiliation></author><author><name sortKey="Zhang, Li Biao" sort="Zhang, Li Biao" uniqKey="Zhang L" first="Li-Biao" last="Zhang">Li-Biao Zhang</name><affiliation><nlm:affiliation>Guangdong Key Laboratory of Animal Conservation and Resource Utilization, Guangdong Public Laboratory of Wild Animal Conservation and Utilization, Guangdong Institute of Applied Biological Resources, Guangzhou, China.</nlm:affiliation></affiliation></author><author><name sortKey="Li, Shi Yue" sort="Li, Shi Yue" uniqKey="Li S" first="Shi-Yue" last="Li">Shi-Yue Li</name><affiliation><nlm:affiliation>School of Public Health, Wuhan University, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Mi, Zhi Qiang" sort="Mi, Zhi Qiang" uniqKey="Mi Z" first="Zhi-Qiang" last="Mi">Zhi-Qiang Mi</name><affiliation><nlm:affiliation>Beijing Institute of Microbiology and Epidemiology, Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="He, Tong Tong" sort="He, Tong Tong" uniqKey="He T" first="Tong-Tong" last="He">Tong-Tong He</name><affiliation><nlm:affiliation>Beijing Institute of Microbiology and Epidemiology, Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Cong, Feng" sort="Cong, Feng" uniqKey="Cong F" first="Feng" last="Cong">Feng Cong</name><affiliation><nlm:affiliation>Guangdong Key Laboratory of Laboratory Animals, Guangdong Laboratory Animals Monitoring Institute, Guangzhou, China.</nlm:affiliation></affiliation></author><author><name sortKey="Guo, Peng Ju" sort="Guo, Peng Ju" uniqKey="Guo P" first="Peng-Ju" last="Guo">Peng-Ju Guo</name><affiliation><nlm:affiliation>Guangdong Key Laboratory of Laboratory Animals, Guangdong Laboratory Animals Monitoring Institute, Guangzhou, China.</nlm:affiliation></affiliation></author><author><name sortKey="Huang, Ren" sort="Huang, Ren" uniqKey="Huang R" first="Ren" last="Huang">Ren Huang</name><affiliation><nlm:affiliation>Guangdong Key Laboratory of Laboratory Animals, Guangdong Laboratory Animals Monitoring Institute, Guangzhou, China.</nlm:affiliation></affiliation></author><author><name sortKey="Luo, Yun" sort="Luo, Yun" uniqKey="Luo Y" first="Yun" last="Luo">Yun Luo</name><affiliation><nlm:affiliation>CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Liu, Xiang Ling" sort="Liu, Xiang Ling" uniqKey="Liu X" first="Xiang-Ling" last="Liu">Xiang-Ling Liu</name><affiliation><nlm:affiliation>CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Chen, Jing" sort="Chen, Jing" uniqKey="Chen J" first="Jing" last="Chen">Jing Chen</name><affiliation><nlm:affiliation>CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Huang, Yong" sort="Huang, Yong" uniqKey="Huang Y" first="Yong" last="Huang">Yong Huang</name><affiliation><nlm:affiliation>Beijing Institute of Microbiology and Epidemiology, Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Sun, Qiang" sort="Sun, Qiang" uniqKey="Sun Q" first="Qiang" last="Sun">Qiang Sun</name><affiliation><nlm:affiliation>Beijing Institute of Microbiology and Epidemiology, Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Zhang, Xiang Li Lan" sort="Zhang, Xiang Li Lan" uniqKey="Zhang X" first="Xiang-Li-Lan" last="Zhang">Xiang-Li-Lan Zhang</name><affiliation><nlm:affiliation>Beijing Institute of Microbiology and Epidemiology, Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Yuan Yuan" sort="Wang, Yuan Yuan" uniqKey="Wang Y" first="Yuan-Yuan" last="Wang">Yuan-Yuan Wang</name><affiliation><nlm:affiliation>Beijing Institute of Microbiology and Epidemiology, Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Xing, Shao Zhen" sort="Xing, Shao Zhen" uniqKey="Xing S" first="Shao-Zhen" last="Xing">Shao-Zhen Xing</name><affiliation><nlm:affiliation>Beijing Institute of Microbiology and Epidemiology, Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Chen, Yan Shan" sort="Chen, Yan Shan" uniqKey="Chen Y" first="Yan-Shan" last="Chen">Yan-Shan Chen</name><affiliation><nlm:affiliation>College of Animal Science, South China Agricultural University, Guangzhou, China.</nlm:affiliation></affiliation></author><author><name sortKey="Sun, Yuan" sort="Sun, Yuan" uniqKey="Sun Y" first="Yuan" last="Sun">Yuan Sun</name><affiliation><nlm:affiliation>College of Animal Science, South China Agricultural University, Guangzhou, China.</nlm:affiliation></affiliation></author><author><name sortKey="Li, Juan" sort="Li, Juan" uniqKey="Li J" first="Juan" last="Li">Juan Li</name><affiliation><nlm:affiliation>Key Laboratory of Etiology and Epidemiology of Emerging Infectious Diseases in Universities of Shandong, Taishan Medical College, Taian, China.</nlm:affiliation></affiliation></author><author><name sortKey="Daszak, Peter" sort="Daszak, Peter" uniqKey="Daszak P" first="Peter" last="Daszak">Peter Daszak</name><affiliation><nlm:affiliation>EcoHealth Alliance, New York, NY, USA. daszak@ecohealthalliance.org.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Lin Fa" sort="Wang, Lin Fa" uniqKey="Wang L" first="Lin-Fa" last="Wang">Lin-Fa Wang</name><affiliation><nlm:affiliation>Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore. linfa.wang@duke-nus.edu.sg.</nlm:affiliation></affiliation></author><author><name sortKey="Shi, Zheng Li" sort="Shi, Zheng Li" uniqKey="Shi Z" first="Zheng-Li" last="Shi">Zheng-Li Shi</name><affiliation><nlm:affiliation>CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China. zlshi@wh.iov.cn.</nlm:affiliation></affiliation></author><author><name sortKey="Tong, Yi Gang" sort="Tong, Yi Gang" uniqKey="Tong Y" first="Yi-Gang" last="Tong">Yi-Gang Tong</name><affiliation><nlm:affiliation>Beijing Institute of Microbiology and Epidemiology, Beijing, China. tong.yigang@gmail.com.</nlm:affiliation></affiliation></author><author><name sortKey="Ma, Jing Yun" sort="Ma, Jing Yun" uniqKey="Ma J" first="Jing-Yun" last="Ma">Jing-Yun Ma</name><affiliation><nlm:affiliation>College of Animal Science, South China Agricultural University, Guangzhou, China. majy2400@scau.edu.cn.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2018">2018</date><idno type="RBID">pubmed:29618817</idno><idno type="pmid">29618817</idno><idno type="doi">10.1038/s41586-018-0010-9</idno><idno type="wicri:Area/PubMed/Corpus">000A13</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000A13</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Fatal swine acute diarrhoea syndrome caused by an HKU2-related coronavirus of bat origin.</title><author><name sortKey="Zhou, Peng" sort="Zhou, Peng" uniqKey="Zhou P" first="Peng" last="Zhou">Peng Zhou</name><affiliation><nlm:affiliation>CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Fan, Hang" sort="Fan, Hang" uniqKey="Fan H" first="Hang" last="Fan">Hang Fan</name><affiliation><nlm:affiliation>Beijing Institute of Microbiology and Epidemiology, Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Lan, Tian" sort="Lan, Tian" uniqKey="Lan T" first="Tian" last="Lan">Tian Lan</name><affiliation><nlm:affiliation>College of Animal Science, South China Agricultural University, Guangzhou, China.</nlm:affiliation></affiliation></author><author><name sortKey="Yang, Xing Lou" sort="Yang, Xing Lou" uniqKey="Yang X" first="Xing-Lou" last="Yang">Xing-Lou Yang</name><affiliation><nlm:affiliation>CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Shi, Wei Feng" sort="Shi, Wei Feng" uniqKey="Shi W" first="Wei-Feng" last="Shi">Wei-Feng Shi</name><affiliation><nlm:affiliation>Key Laboratory of Etiology and Epidemiology of Emerging Infectious Diseases in Universities of Shandong, Taishan Medical College, Taian, China.</nlm:affiliation></affiliation></author><author><name sortKey="Zhang, Wei" sort="Zhang, Wei" uniqKey="Zhang W" first="Wei" last="Zhang">Wei Zhang</name><affiliation><nlm:affiliation>CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Zhu, Yan" sort="Zhu, Yan" uniqKey="Zhu Y" first="Yan" last="Zhu">Yan Zhu</name><affiliation><nlm:affiliation>CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Zhang, Ya Wei" sort="Zhang, Ya Wei" uniqKey="Zhang Y" first="Ya-Wei" last="Zhang">Ya-Wei Zhang</name><affiliation><nlm:affiliation>Beijing Institute of Microbiology and Epidemiology, Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Xie, Qing Mei" sort="Xie, Qing Mei" uniqKey="Xie Q" first="Qing-Mei" last="Xie">Qing-Mei Xie</name><affiliation><nlm:affiliation>College of Animal Science, South China Agricultural University, Guangzhou, China.</nlm:affiliation></affiliation></author><author><name sortKey="Mani, Shailendra" sort="Mani, Shailendra" uniqKey="Mani S" first="Shailendra" last="Mani">Shailendra Mani</name><affiliation><nlm:affiliation>Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore.</nlm:affiliation></affiliation></author><author><name sortKey="Zheng, Xiao Shuang" sort="Zheng, Xiao Shuang" uniqKey="Zheng X" first="Xiao-Shuang" last="Zheng">Xiao-Shuang Zheng</name><affiliation><nlm:affiliation>CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Li, Bei" sort="Li, Bei" uniqKey="Li B" first="Bei" last="Li">Bei Li</name><affiliation><nlm:affiliation>CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Li, Jin Man" sort="Li, Jin Man" uniqKey="Li J" first="Jin-Man" last="Li">Jin-Man Li</name><affiliation><nlm:affiliation>Beijing Institute of Microbiology and Epidemiology, Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Guo, Hua" sort="Guo, Hua" uniqKey="Guo H" first="Hua" last="Guo">Hua Guo</name><affiliation><nlm:affiliation>CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Pei, Guang Qian" sort="Pei, Guang Qian" uniqKey="Pei G" first="Guang-Qian" last="Pei">Guang-Qian Pei</name><affiliation><nlm:affiliation>Beijing Institute of Microbiology and Epidemiology, Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="An, Xiao Ping" sort="An, Xiao Ping" uniqKey="An X" first="Xiao-Ping" last="An">Xiao-Ping An</name><affiliation><nlm:affiliation>Beijing Institute of Microbiology and Epidemiology, Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Chen, Jun Wei" sort="Chen, Jun Wei" uniqKey="Chen J" first="Jun-Wei" last="Chen">Jun-Wei Chen</name><affiliation><nlm:affiliation>College of Animal Science, South China Agricultural University, Guangzhou, China.</nlm:affiliation></affiliation></author><author><name sortKey="Zhou, Ling" sort="Zhou, Ling" uniqKey="Zhou L" first="Ling" last="Zhou">Ling Zhou</name><affiliation><nlm:affiliation>College of Animal Science, South China Agricultural University, Guangzhou, China.</nlm:affiliation></affiliation></author><author><name sortKey="Mai, Kai Jie" sort="Mai, Kai Jie" uniqKey="Mai K" first="Kai-Jie" last="Mai">Kai-Jie Mai</name><affiliation><nlm:affiliation>College of Animal Science, South China Agricultural University, Guangzhou, China.</nlm:affiliation></affiliation></author><author><name sortKey="Wu, Zi Xian" sort="Wu, Zi Xian" uniqKey="Wu Z" first="Zi-Xian" last="Wu">Zi-Xian Wu</name><affiliation><nlm:affiliation>College of Animal Science, South China Agricultural University, Guangzhou, China.</nlm:affiliation></affiliation></author><author><name sortKey="Li, Di" sort="Li, Di" uniqKey="Li D" first="Di" last="Li">Di Li</name><affiliation><nlm:affiliation>College of Animal Science, South China Agricultural University, Guangzhou, China.</nlm:affiliation></affiliation></author><author><name sortKey="Anderson, Danielle E" sort="Anderson, Danielle E" uniqKey="Anderson D" first="Danielle E" last="Anderson">Danielle E. Anderson</name><affiliation><nlm:affiliation>Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore.</nlm:affiliation></affiliation></author><author><name sortKey="Zhang, Li Biao" sort="Zhang, Li Biao" uniqKey="Zhang L" first="Li-Biao" last="Zhang">Li-Biao Zhang</name><affiliation><nlm:affiliation>Guangdong Key Laboratory of Animal Conservation and Resource Utilization, Guangdong Public Laboratory of Wild Animal Conservation and Utilization, Guangdong Institute of Applied Biological Resources, Guangzhou, China.</nlm:affiliation></affiliation></author><author><name sortKey="Li, Shi Yue" sort="Li, Shi Yue" uniqKey="Li S" first="Shi-Yue" last="Li">Shi-Yue Li</name><affiliation><nlm:affiliation>School of Public Health, Wuhan University, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Mi, Zhi Qiang" sort="Mi, Zhi Qiang" uniqKey="Mi Z" first="Zhi-Qiang" last="Mi">Zhi-Qiang Mi</name><affiliation><nlm:affiliation>Beijing Institute of Microbiology and Epidemiology, Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="He, Tong Tong" sort="He, Tong Tong" uniqKey="He T" first="Tong-Tong" last="He">Tong-Tong He</name><affiliation><nlm:affiliation>Beijing Institute of Microbiology and Epidemiology, Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Cong, Feng" sort="Cong, Feng" uniqKey="Cong F" first="Feng" last="Cong">Feng Cong</name><affiliation><nlm:affiliation>Guangdong Key Laboratory of Laboratory Animals, Guangdong Laboratory Animals Monitoring Institute, Guangzhou, China.</nlm:affiliation></affiliation></author><author><name sortKey="Guo, Peng Ju" sort="Guo, Peng Ju" uniqKey="Guo P" first="Peng-Ju" last="Guo">Peng-Ju Guo</name><affiliation><nlm:affiliation>Guangdong Key Laboratory of Laboratory Animals, Guangdong Laboratory Animals Monitoring Institute, Guangzhou, China.</nlm:affiliation></affiliation></author><author><name sortKey="Huang, Ren" sort="Huang, Ren" uniqKey="Huang R" first="Ren" last="Huang">Ren Huang</name><affiliation><nlm:affiliation>Guangdong Key Laboratory of Laboratory Animals, Guangdong Laboratory Animals Monitoring Institute, Guangzhou, China.</nlm:affiliation></affiliation></author><author><name sortKey="Luo, Yun" sort="Luo, Yun" uniqKey="Luo Y" first="Yun" last="Luo">Yun Luo</name><affiliation><nlm:affiliation>CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Liu, Xiang Ling" sort="Liu, Xiang Ling" uniqKey="Liu X" first="Xiang-Ling" last="Liu">Xiang-Ling Liu</name><affiliation><nlm:affiliation>CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Chen, Jing" sort="Chen, Jing" uniqKey="Chen J" first="Jing" last="Chen">Jing Chen</name><affiliation><nlm:affiliation>CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Huang, Yong" sort="Huang, Yong" uniqKey="Huang Y" first="Yong" last="Huang">Yong Huang</name><affiliation><nlm:affiliation>Beijing Institute of Microbiology and Epidemiology, Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Sun, Qiang" sort="Sun, Qiang" uniqKey="Sun Q" first="Qiang" last="Sun">Qiang Sun</name><affiliation><nlm:affiliation>Beijing Institute of Microbiology and Epidemiology, Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Zhang, Xiang Li Lan" sort="Zhang, Xiang Li Lan" uniqKey="Zhang X" first="Xiang-Li-Lan" last="Zhang">Xiang-Li-Lan Zhang</name><affiliation><nlm:affiliation>Beijing Institute of Microbiology and Epidemiology, Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Yuan Yuan" sort="Wang, Yuan Yuan" uniqKey="Wang Y" first="Yuan-Yuan" last="Wang">Yuan-Yuan Wang</name><affiliation><nlm:affiliation>Beijing Institute of Microbiology and Epidemiology, Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Xing, Shao Zhen" sort="Xing, Shao Zhen" uniqKey="Xing S" first="Shao-Zhen" last="Xing">Shao-Zhen Xing</name><affiliation><nlm:affiliation>Beijing Institute of Microbiology and Epidemiology, Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Chen, Yan Shan" sort="Chen, Yan Shan" uniqKey="Chen Y" first="Yan-Shan" last="Chen">Yan-Shan Chen</name><affiliation><nlm:affiliation>College of Animal Science, South China Agricultural University, Guangzhou, China.</nlm:affiliation></affiliation></author><author><name sortKey="Sun, Yuan" sort="Sun, Yuan" uniqKey="Sun Y" first="Yuan" last="Sun">Yuan Sun</name><affiliation><nlm:affiliation>College of Animal Science, South China Agricultural University, Guangzhou, China.</nlm:affiliation></affiliation></author><author><name sortKey="Li, Juan" sort="Li, Juan" uniqKey="Li J" first="Juan" last="Li">Juan Li</name><affiliation><nlm:affiliation>Key Laboratory of Etiology and Epidemiology of Emerging Infectious Diseases in Universities of Shandong, Taishan Medical College, Taian, China.</nlm:affiliation></affiliation></author><author><name sortKey="Daszak, Peter" sort="Daszak, Peter" uniqKey="Daszak P" first="Peter" last="Daszak">Peter Daszak</name><affiliation><nlm:affiliation>EcoHealth Alliance, New York, NY, USA. daszak@ecohealthalliance.org.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Lin Fa" sort="Wang, Lin Fa" uniqKey="Wang L" first="Lin-Fa" last="Wang">Lin-Fa Wang</name><affiliation><nlm:affiliation>Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore. linfa.wang@duke-nus.edu.sg.</nlm:affiliation></affiliation></author><author><name sortKey="Shi, Zheng Li" sort="Shi, Zheng Li" uniqKey="Shi Z" first="Zheng-Li" last="Shi">Zheng-Li Shi</name><affiliation><nlm:affiliation>CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China. zlshi@wh.iov.cn.</nlm:affiliation></affiliation></author><author><name sortKey="Tong, Yi Gang" sort="Tong, Yi Gang" uniqKey="Tong Y" first="Yi-Gang" last="Tong">Yi-Gang Tong</name><affiliation><nlm:affiliation>Beijing Institute of Microbiology and Epidemiology, Beijing, China. tong.yigang@gmail.com.</nlm:affiliation></affiliation></author><author><name sortKey="Ma, Jing Yun" sort="Ma, Jing Yun" uniqKey="Ma J" first="Jing-Yun" last="Ma">Jing-Yun Ma</name><affiliation><nlm:affiliation>College of Animal Science, South China Agricultural University, Guangzhou, China. majy2400@scau.edu.cn.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Nature</title><idno type="eISSN">1476-4687</idno><imprint><date when="2018" type="published">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alphacoronavirus (classification)</term><term>Alphacoronavirus (genetics)</term><term>Alphacoronavirus (isolation & purification)</term><term>Alphacoronavirus (pathogenicity)</term><term>Animal Diseases (epidemiology)</term><term>Animal Diseases (transmission)</term><term>Animal Diseases (virology)</term><term>Animals</term><term>Biodiversity</term><term>China (epidemiology)</term><term>Chiroptera (virology)</term><term>Coronavirus Infections (epidemiology)</term><term>Coronavirus Infections (transmission)</term><term>Coronavirus Infections (veterinary)</term><term>Diarrhea (pathology)</term><term>Diarrhea (veterinary)</term><term>Diarrhea (virology)</term><term>Disease Reservoirs (veterinary)</term><term>Disease Reservoirs (virology)</term><term>Genome, Viral (genetics)</term><term>Humans</term><term>Jejunum (pathology)</term><term>Jejunum (virology)</term><term>Phylogeny</term><term>Severe Acute Respiratory Syndrome (epidemiology)</term><term>Severe Acute Respiratory Syndrome (veterinary)</term><term>Severe Acute Respiratory Syndrome (virology)</term><term>Spatio-Temporal Analysis</term><term>Swine (virology)</term><term>Zoonoses (epidemiology)</term><term>Zoonoses (transmission)</term><term>Zoonoses (virology)</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Alphacoronavirus</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Animal Diseases</term><term>China</term><term>Coronavirus Infections</term><term>Severe Acute Respiratory Syndrome</term><term>Zoonoses</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Alphacoronavirus</term><term>Genome, Viral</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Alphacoronavirus</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Alphacoronavirus</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Diarrhea</term><term>Jejunum</term></keywords><keywords scheme="MESH" qualifier="transmission" xml:lang="en"><term>Animal Diseases</term><term>Coronavirus Infections</term><term>Zoonoses</term></keywords><keywords scheme="MESH" qualifier="veterinary" xml:lang="en"><term>Coronavirus Infections</term><term>Diarrhea</term><term>Disease Reservoirs</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Animal Diseases</term><term>Chiroptera</term><term>Diarrhea</term><term>Disease Reservoirs</term><term>Jejunum</term><term>Severe Acute Respiratory Syndrome</term><term>Swine</term><term>Zoonoses</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Biodiversity</term><term>Humans</term><term>Phylogeny</term><term>Spatio-Temporal Analysis</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Cross-species transmission of viruses from wildlife animal reservoirs poses a marked threat to human and animal health <sup>1</sup> . Bats have been recognized as one of the most important reservoirs for emerging viruses and the transmission of a coronavirus that originated in bats to humans via intermediate hosts was responsible for the high-impact emerging zoonosis, severe acute respiratory syndrome (SARS) <sup>2-10</sup> . Here we provide virological, epidemiological, evolutionary and experimental evidence that a novel HKU2-related bat coronavirus, swine acute diarrhoea syndrome coronavirus (SADS-CoV), is the aetiological agent that was responsible for a large-scale outbreak of fatal disease in pigs in China that has caused the death of 24,693 piglets across four farms. Notably, the outbreak began in Guangdong province in the vicinity of the origin of the SARS pandemic. Furthermore, we identified SADS-related CoVs with 96-98% sequence identity in 9.8% (58 out of 591) of anal swabs collected from bats in Guangdong province during 2013-2016, predominantly in horseshoe bats (Rhinolophus spp.) that are known reservoirs of SARS-related CoVs. We found that there were striking similarities between the SADS and SARS outbreaks in geographical, temporal, ecological and aetiological settings. This study highlights the importance of identifying coronavirus diversity and distribution in bats to mitigate future outbreaks that could threaten livestock, public health and economic growth.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">29618817</PMID><DateCompleted><Year>2018</Year><Month>08</Month><Day>17</Day></DateCompleted><DateRevised><Year>2020</Year><Month>03</Month><Day>27</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1476-4687</ISSN><JournalIssue CitedMedium="Internet"><Volume>556</Volume><Issue>7700</Issue><PubDate><Year>2018</Year><Month>04</Month></PubDate></JournalIssue><Title>Nature</Title><ISOAbbreviation>Nature</ISOAbbreviation></Journal><ArticleTitle>Fatal swine acute diarrhoea syndrome caused by an HKU2-related coronavirus of bat origin.</ArticleTitle><Pagination><MedlinePgn>255-258</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1038/s41586-018-0010-9</ELocationID><Abstract><AbstractText>Cross-species transmission of viruses from wildlife animal reservoirs poses a marked threat to human and animal health <sup>1</sup> . Bats have been recognized as one of the most important reservoirs for emerging viruses and the transmission of a coronavirus that originated in bats to humans via intermediate hosts was responsible for the high-impact emerging zoonosis, severe acute respiratory syndrome (SARS) <sup>2-10</sup> . Here we provide virological, epidemiological, evolutionary and experimental evidence that a novel HKU2-related bat coronavirus, swine acute diarrhoea syndrome coronavirus (SADS-CoV), is the aetiological agent that was responsible for a large-scale outbreak of fatal disease in pigs in China that has caused the death of 24,693 piglets across four farms. Notably, the outbreak began in Guangdong province in the vicinity of the origin of the SARS pandemic. Furthermore, we identified SADS-related CoVs with 96-98% sequence identity in 9.8% (58 out of 591) of anal swabs collected from bats in Guangdong province during 2013-2016, predominantly in horseshoe bats (Rhinolophus spp.) that are known reservoirs of SARS-related CoVs. We found that there were striking similarities between the SADS and SARS outbreaks in geographical, temporal, ecological and aetiological settings. This study highlights the importance of identifying coronavirus diversity and distribution in bats to mitigate future outbreaks that could threaten livestock, public health and economic growth.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Zhou</LastName><ForeName>Peng</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fan</LastName><ForeName>Hang</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Beijing Institute of Microbiology and Epidemiology, Beijing, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lan</LastName><ForeName>Tian</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>College of Animal Science, South China Agricultural University, Guangzhou, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Key Laboratory of Animal Health Aquaculture and Environmental Control, Guangzhou, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yang</LastName><ForeName>Xing-Lou</ForeName><Initials>XL</Initials><AffiliationInfo><Affiliation>CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shi</LastName><ForeName>Wei-Feng</ForeName><Initials>WF</Initials><AffiliationInfo><Affiliation>Key Laboratory of Etiology and Epidemiology of Emerging Infectious Diseases in Universities of Shandong, Taishan Medical College, Taian, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Wei</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhu</LastName><ForeName>Yan</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Ya-Wei</ForeName><Initials>YW</Initials><AffiliationInfo><Affiliation>Beijing Institute of Microbiology and Epidemiology, Beijing, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Xie</LastName><ForeName>Qing-Mei</ForeName><Initials>QM</Initials><AffiliationInfo><Affiliation>College of Animal Science, South China Agricultural University, Guangzhou, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Key Laboratory of Animal Health Aquaculture and Environmental Control, Guangzhou, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mani</LastName><ForeName>Shailendra</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zheng</LastName><ForeName>Xiao-Shuang</ForeName><Initials>XS</Initials><AffiliationInfo><Affiliation>CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Bei</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Jin-Man</ForeName><Initials>JM</Initials><AffiliationInfo><Affiliation>Beijing Institute of Microbiology and Epidemiology, Beijing, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Guo</LastName><ForeName>Hua</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pei</LastName><ForeName>Guang-Qian</ForeName><Initials>GQ</Initials><AffiliationInfo><Affiliation>Beijing Institute of Microbiology and Epidemiology, Beijing, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>An</LastName><ForeName>Xiao-Ping</ForeName><Initials>XP</Initials><AffiliationInfo><Affiliation>Beijing Institute of Microbiology and Epidemiology, Beijing, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Jun-Wei</ForeName><Initials>JW</Initials><AffiliationInfo><Affiliation>College of Animal Science, South China Agricultural University, Guangzhou, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Key Laboratory of Animal Health Aquaculture and Environmental Control, Guangzhou, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhou</LastName><ForeName>Ling</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>College of Animal Science, South China Agricultural University, Guangzhou, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Key Laboratory of Animal Health Aquaculture and Environmental Control, Guangzhou, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mai</LastName><ForeName>Kai-Jie</ForeName><Initials>KJ</Initials><AffiliationInfo><Affiliation>College of Animal Science, South China Agricultural University, Guangzhou, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Key Laboratory of Animal Health Aquaculture and Environmental Control, Guangzhou, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wu</LastName><ForeName>Zi-Xian</ForeName><Initials>ZX</Initials><AffiliationInfo><Affiliation>College of Animal Science, South China Agricultural University, Guangzhou, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Key Laboratory of Animal Health Aquaculture and Environmental Control, Guangzhou, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Di</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>College of Animal Science, South China Agricultural University, Guangzhou, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Key Laboratory of Animal Health Aquaculture and Environmental Control, Guangzhou, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Anderson</LastName><ForeName>Danielle E</ForeName><Initials>DE</Initials><AffiliationInfo><Affiliation>Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Li-Biao</ForeName><Initials>LB</Initials><AffiliationInfo><Affiliation>Guangdong Key Laboratory of Animal Conservation and Resource Utilization, Guangdong Public Laboratory of Wild Animal Conservation and Utilization, Guangdong Institute of Applied Biological Resources, Guangzhou, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Shi-Yue</ForeName><Initials>SY</Initials><AffiliationInfo><Affiliation>School of Public Health, Wuhan University, Wuhan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mi</LastName><ForeName>Zhi-Qiang</ForeName><Initials>ZQ</Initials><AffiliationInfo><Affiliation>Beijing Institute of Microbiology and Epidemiology, Beijing, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>He</LastName><ForeName>Tong-Tong</ForeName><Initials>TT</Initials><AffiliationInfo><Affiliation>Beijing Institute of Microbiology and Epidemiology, Beijing, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cong</LastName><ForeName>Feng</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Guangdong Key Laboratory of Laboratory Animals, Guangdong Laboratory Animals Monitoring Institute, Guangzhou, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Guo</LastName><ForeName>Peng-Ju</ForeName><Initials>PJ</Initials><AffiliationInfo><Affiliation>Guangdong Key Laboratory of Laboratory Animals, Guangdong Laboratory Animals Monitoring Institute, Guangzhou, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Huang</LastName><ForeName>Ren</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Guangdong Key Laboratory of Laboratory Animals, Guangdong Laboratory Animals Monitoring Institute, Guangzhou, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Luo</LastName><ForeName>Yun</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Xiang-Ling</ForeName><Initials>XL</Initials><AffiliationInfo><Affiliation>CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Jing</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Huang</LastName><ForeName>Yong</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Beijing Institute of Microbiology and Epidemiology, Beijing, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sun</LastName><ForeName>Qiang</ForeName><Initials>Q</Initials><AffiliationInfo><Affiliation>Beijing Institute of Microbiology and Epidemiology, Beijing, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Xiang-Li-Lan</ForeName><Initials>XL</Initials><AffiliationInfo><Affiliation>Beijing Institute of Microbiology and Epidemiology, Beijing, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Yuan-Yuan</ForeName><Initials>YY</Initials><AffiliationInfo><Affiliation>Beijing Institute of Microbiology and Epidemiology, Beijing, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Xing</LastName><ForeName>Shao-Zhen</ForeName><Initials>SZ</Initials><AffiliationInfo><Affiliation>Beijing Institute of Microbiology and Epidemiology, Beijing, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Yan-Shan</ForeName><Initials>YS</Initials><AffiliationInfo><Affiliation>College of Animal Science, South China Agricultural University, Guangzhou, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Key Laboratory of Animal Health Aquaculture and Environmental Control, Guangzhou, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sun</LastName><ForeName>Yuan</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>College of Animal Science, South China Agricultural University, Guangzhou, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Key Laboratory of Animal Health Aquaculture and Environmental Control, Guangzhou, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Juan</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Key Laboratory of Etiology and Epidemiology of Emerging Infectious Diseases in Universities of Shandong, Taishan Medical College, Taian, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Daszak</LastName><ForeName>Peter</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>EcoHealth Alliance, New York, NY, USA. daszak@ecohealthalliance.org.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Lin-Fa</ForeName><Initials>LF</Initials><AffiliationInfo><Affiliation>Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore. linfa.wang@duke-nus.edu.sg.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shi</LastName><ForeName>Zheng-Li</ForeName><Initials>ZL</Initials><AffiliationInfo><Affiliation>CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China. zlshi@wh.iov.cn.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tong</LastName><ForeName>Yi-Gang</ForeName><Initials>YG</Initials><AffiliationInfo><Affiliation>Beijing Institute of Microbiology and Epidemiology, Beijing, China. tong.yigang@gmail.com.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>School of Life Sciences, North China University of Science and Technology, Tangshan, China. tong.yigang@gmail.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ma</LastName><ForeName>Jing-Yun</ForeName><Initials>JY</Initials><AffiliationInfo><Affiliation>College of Animal Science, South China Agricultural University, Guangzhou, China. majy2400@scau.edu.cn.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Key Laboratory of Animal Health Aquaculture and Environmental Control, Guangzhou, China. majy2400@scau.edu.cn.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>R01 AI110964</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType><PublicationType UI="D013486">Research Support, U.S. Gov't, Non-P.H.S.</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2018</Year><Month>04</Month><Day>04</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Nature</MedlineTA><NlmUniqueID>0410462</NlmUniqueID><ISSNLinking>0028-0836</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000073638" MajorTopicYN="N">Alphacoronavirus</DescriptorName><QualifierName UI="Q000145" MajorTopicYN="N">classification</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000302" MajorTopicYN="Y">isolation & purification</QualifierName><QualifierName UI="Q000472" MajorTopicYN="Y">pathogenicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000820" MajorTopicYN="N">Animal Diseases</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName><QualifierName UI="Q000635" MajorTopicYN="N">transmission</QualifierName><QualifierName UI="Q000821" 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