Characteristics of pediatric SARS-CoV-2 infection and potential evidence for persistent fecal viral shedding.
Identifieur interne : 000183 ( PubMed/Curation ); précédent : 000182; suivant : 000184Characteristics of pediatric SARS-CoV-2 infection and potential evidence for persistent fecal viral shedding.
Auteurs : Yi Xu [République populaire de Chine] ; Xufang Li [République populaire de Chine] ; Bing Zhu [République populaire de Chine] ; Huiying Liang [République populaire de Chine] ; Chunxiao Fang [République populaire de Chine] ; Yu Gong [République populaire de Chine] ; Qiaozhi Guo [République populaire de Chine] ; Xin Sun [République populaire de Chine] ; Danyang Zhao [République populaire de Chine] ; Jun Shen [République populaire de Chine] ; Huayan Zhang [République populaire de Chine] ; Hongsheng Liu [République populaire de Chine] ; Huimin Xia [République populaire de Chine] ; Jinling Tang [République populaire de Chine] ; Kang Zhang [République populaire de Chine] ; Sitang Gong [République populaire de Chine]Source :
- Nature medicine [ 1546-170X ] ; 2020.
Descripteurs français
- KwdFr :
- Enfant, Enfant d'âge préscolaire, Excrétion virale, Femelle, Fèces (virologie), Humains, Infections à coronavirus (), Infections à coronavirus (diagnostic), Infections à coronavirus (virologie), Mâle, Nourrisson, Pandémies, Partie nasale du pharynx (virologie), Pneumopathie virale (), Pneumopathie virale (diagnostic), Pneumopathie virale (virologie), Radiographie thoracique, Rectum (virologie), Réaction de polymérisation en chaine en temps réel, Techniques de laboratoire clinique.
- MESH :
- diagnostic : Infections à coronavirus, Pneumopathie virale.
- virologie : Fèces, Infections à coronavirus, Partie nasale du pharynx, Pneumopathie virale, Rectum.
- Enfant, Enfant d'âge préscolaire, Excrétion virale, Femelle, Humains, Infections à coronavirus, Mâle, Nourrisson, Pandémies, Pneumopathie virale, Radiographie thoracique, Réaction de polymérisation en chaine en temps réel, Techniques de laboratoire clinique.
English descriptors
- KwdEn :
- Betacoronavirus (genetics), Betacoronavirus (isolation & purification), Child, Child, Preschool, Clinical Laboratory Techniques, Coronavirus Infections (complications), Coronavirus Infections (diagnosis), Coronavirus Infections (virology), Feces (virology), Female, Humans, Infant, Male, Nasopharynx (virology), Pandemics, Pneumonia, Viral (complications), Pneumonia, Viral (diagnosis), Pneumonia, Viral (virology), Radiography, Thoracic, Real-Time Polymerase Chain Reaction, Rectum (virology), Virus Shedding.
- MESH :
- complications : Coronavirus Infections, Pneumonia, Viral.
- diagnosis : Coronavirus Infections, Pneumonia, Viral.
- genetics : Betacoronavirus.
- isolation & purification : Betacoronavirus.
- virology : Coronavirus Infections, Feces, Nasopharynx, Pneumonia, Viral, Rectum.
- Child, Child, Preschool, Clinical Laboratory Techniques, Female, Humans, Infant, Male, Pandemics, Radiography, Thoracic, Real-Time Polymerase Chain Reaction, Virus Shedding.
Abstract
We report epidemiological and clinical investigations on ten pediatric SARS-CoV-2 infection cases confirmed by real-time reverse transcription PCR assay of SARS-CoV-2 RNA. Symptoms in these cases were nonspecific and no children required respiratory support or intensive care. Chest X-rays lacked definite signs of pneumonia, a defining feature of the infection in adult cases. Notably, eight children persistently tested positive on rectal swabs even after nasopharyngeal testing was negative, raising the possibility of fecal-oral transmission.
DOI: 10.1038/s41591-020-0817-4
PubMed: 32284613
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sort="Sun, Xin" uniqKey="Sun X" first="Xin" last="Sun">Xin Sun</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Administration, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Medical Administration, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou</wicri:regionArea></affiliation></author><author><name sortKey="Zhao, Danyang" sort="Zhao, Danyang" uniqKey="Zhao D" first="Danyang" last="Zhao">Danyang Zhao</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Administration, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Medical Administration, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou</wicri:regionArea></affiliation></author><author><name sortKey="Shen, Jun" sort="Shen, Jun" uniqKey="Shen J" first="Jun" last="Shen">Jun Shen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatric, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Pediatric, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou</wicri:regionArea></affiliation></author><author><name sortKey="Zhang, Huayan" sort="Zhang, Huayan" uniqKey="Zhang H" first="Huayan" last="Zhang">Huayan Zhang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatric, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Pediatric, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou</wicri:regionArea></affiliation></author><author><name sortKey="Liu, Hongsheng" sort="Liu, Hongsheng" uniqKey="Liu H" first="Hongsheng" last="Liu">Hongsheng Liu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Radiology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Radiology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou</wicri:regionArea></affiliation></author><author><name sortKey="Xia, Huimin" sort="Xia, Huimin" uniqKey="Xia H" first="Huimin" last="Xia">Huimin Xia</name><affiliation wicri:level="1"><nlm:affiliation>Clinical Data Center, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China. huiminxia@hotmail.com.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Clinical Data Center, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou</wicri:regionArea></affiliation></author><author><name sortKey="Tang, Jinling" sort="Tang, Jinling" uniqKey="Tang J" first="Jinling" last="Tang">Jinling Tang</name><affiliation wicri:level="1"><nlm:affiliation>Clinical Data Center, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China. jltang@cuhk.edu.hk.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Clinical Data Center, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou</wicri:regionArea></affiliation></author><author><name sortKey="Zhang, Kang" sort="Zhang, Kang" uniqKey="Zhang K" first="Kang" last="Zhang">Kang Zhang</name><affiliation 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Medical Center, Guangzhou Medical University, Guangzhou, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Pediatric, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou</wicri:regionArea></affiliation></author><author><name sortKey="Li, Xufang" sort="Li, Xufang" uniqKey="Li X" first="Xufang" last="Li">Xufang Li</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatric, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Pediatric, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou</wicri:regionArea></affiliation></author><author><name sortKey="Zhu, Bing" sort="Zhu, Bing" uniqKey="Zhu B" first="Bing" last="Zhu">Bing Zhu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Center Laboratory, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Center Laboratory, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou</wicri:regionArea></affiliation></author><author><name sortKey="Liang, Huiying" sort="Liang, Huiying" uniqKey="Liang H" first="Huiying" last="Liang">Huiying Liang</name><affiliation wicri:level="1"><nlm:affiliation>Clinical Data Center, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Clinical Data Center, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou</wicri:regionArea></affiliation></author><author><name sortKey="Fang, Chunxiao" sort="Fang, Chunxiao" uniqKey="Fang C" first="Chunxiao" last="Fang">Chunxiao Fang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatric, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Pediatric, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou</wicri:regionArea></affiliation></author><author><name sortKey="Gong, Yu" sort="Gong, Yu" uniqKey="Gong Y" first="Yu" last="Gong">Yu Gong</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatric, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Pediatric, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou</wicri:regionArea></affiliation></author><author><name sortKey="Guo, Qiaozhi" sort="Guo, Qiaozhi" uniqKey="Guo Q" first="Qiaozhi" last="Guo">Qiaozhi Guo</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Administration, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Medical Administration, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou</wicri:regionArea></affiliation></author><author><name sortKey="Sun, Xin" sort="Sun, Xin" uniqKey="Sun X" first="Xin" last="Sun">Xin Sun</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Administration, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Medical Administration, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou</wicri:regionArea></affiliation></author><author><name sortKey="Zhao, Danyang" sort="Zhao, Danyang" uniqKey="Zhao D" first="Danyang" last="Zhao">Danyang Zhao</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Administration, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Medical Administration, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou</wicri:regionArea></affiliation></author><author><name sortKey="Shen, Jun" sort="Shen, Jun" uniqKey="Shen J" first="Jun" last="Shen">Jun Shen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatric, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Pediatric, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou</wicri:regionArea></affiliation></author><author><name sortKey="Zhang, Huayan" sort="Zhang, Huayan" uniqKey="Zhang H" first="Huayan" last="Zhang">Huayan Zhang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatric, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Pediatric, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou</wicri:regionArea></affiliation></author><author><name sortKey="Liu, Hongsheng" sort="Liu, Hongsheng" uniqKey="Liu H" first="Hongsheng" last="Liu">Hongsheng Liu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Radiology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Radiology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou</wicri:regionArea></affiliation></author><author><name sortKey="Xia, Huimin" sort="Xia, Huimin" uniqKey="Xia H" first="Huimin" last="Xia">Huimin Xia</name><affiliation wicri:level="1"><nlm:affiliation>Clinical Data Center, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China. huiminxia@hotmail.com.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Clinical Data Center, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou</wicri:regionArea></affiliation></author><author><name sortKey="Tang, Jinling" sort="Tang, Jinling" uniqKey="Tang J" first="Jinling" last="Tang">Jinling Tang</name><affiliation wicri:level="1"><nlm:affiliation>Clinical Data Center, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China. jltang@cuhk.edu.hk.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Clinical Data Center, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou</wicri:regionArea></affiliation></author><author><name sortKey="Zhang, Kang" sort="Zhang, Kang" uniqKey="Zhang K" first="Kang" last="Zhang">Kang Zhang</name><affiliation wicri:level="1"><nlm:affiliation>Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China. kang.zhang@gmail.com.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou</wicri:regionArea></affiliation></author><author><name sortKey="Gong, Sitang" sort="Gong, Sitang" uniqKey="Gong S" first="Sitang" last="Gong">Sitang Gong</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatric, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China. sitangg@126.com.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Pediatric, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou</wicri:regionArea></affiliation></author></analytic><series><title level="j">Nature medicine</title><idno type="eISSN">1546-170X</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Betacoronavirus 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coronavirus (diagnostic)</term><term>Infections à coronavirus (virologie)</term><term>Mâle</term><term>Nourrisson</term><term>Pandémies</term><term>Partie nasale du pharynx (virologie)</term><term>Pneumopathie virale ()</term><term>Pneumopathie virale (diagnostic)</term><term>Pneumopathie virale (virologie)</term><term>Radiographie thoracique</term><term>Rectum (virologie)</term><term>Réaction de polymérisation en chaine en temps réel</term><term>Techniques de laboratoire clinique</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Infections à coronavirus</term><term>Pneumopathie virale</term></keywords><keywords scheme="MESH" qualifier="genetics" 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préscolaire</term><term>Excrétion virale</term><term>Femelle</term><term>Humains</term><term>Infections à coronavirus</term><term>Mâle</term><term>Nourrisson</term><term>Pandémies</term><term>Pneumopathie virale</term><term>Radiographie thoracique</term><term>Réaction de polymérisation en chaine en temps réel</term><term>Techniques de laboratoire clinique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We report epidemiological and clinical investigations on ten pediatric SARS-CoV-2 infection cases confirmed by real-time reverse transcription PCR assay of SARS-CoV-2 RNA. Symptoms in these cases were nonspecific and no children required respiratory support or intensive care. Chest X-rays lacked definite signs of pneumonia, a defining feature of the infection in adult cases. Notably, eight children persistently tested positive on rectal swabs even after nasopharyngeal testing was negative, raising the possibility of fecal-oral transmission.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32284613</PMID><DateCompleted><Year>2020</Year><Month>04</Month><Day>16</Day></DateCompleted><DateRevised><Year>2020</Year><Month>04</Month><Day>16</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1546-170X</ISSN><JournalIssue CitedMedium="Internet"><Volume>26</Volume><Issue>4</Issue><PubDate><Year>2020</Year><Month>04</Month></PubDate></JournalIssue><Title>Nature medicine</Title><ISOAbbreviation>Nat. Med.</ISOAbbreviation></Journal><ArticleTitle>Characteristics of pediatric SARS-CoV-2 infection and potential evidence for persistent fecal viral shedding.</ArticleTitle><Pagination><MedlinePgn>502-505</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1038/s41591-020-0817-4</ELocationID><Abstract><AbstractText>We report epidemiological and clinical investigations on ten pediatric SARS-CoV-2 infection cases confirmed by real-time reverse transcription PCR assay of SARS-CoV-2 RNA. Symptoms in these cases were nonspecific and no children required respiratory support or intensive care. Chest X-rays lacked definite signs of pneumonia, a defining feature of the infection in adult cases. Notably, eight children persistently tested positive on rectal swabs even after nasopharyngeal testing was negative, raising the possibility of fecal-oral transmission.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Xu</LastName><ForeName>Yi</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Pediatric, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Xufang</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Department of Pediatric, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhu</LastName><ForeName>Bing</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Department of Center Laboratory, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liang</LastName><ForeName>Huiying</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Clinical Data Center, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Guangdong Provincial Children's Medical Research Center, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fang</LastName><ForeName>Chunxiao</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Pediatric, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gong</LastName><ForeName>Yu</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Pediatric, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Guo</LastName><ForeName>Qiaozhi</ForeName><Initials>Q</Initials><AffiliationInfo><Affiliation>Department of Medical Administration, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sun</LastName><ForeName>Xin</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Department of Medical Administration, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhao</LastName><ForeName>Danyang</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Medical Administration, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shen</LastName><ForeName>Jun</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Pediatric, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Huayan</ForeName><Initials>H</Initials><Identifier Source="ORCID">0000-0003-0843-8448</Identifier><AffiliationInfo><Affiliation>Department of Pediatric, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Guangdong Provincial Children's Medical Research Center, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Division of Neonatology and Department of Pediatrics, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Hongsheng</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Radiology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Xia</LastName><ForeName>Huimin</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Clinical Data Center, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China. huiminxia@hotmail.com.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Guangdong Provincial Children's Medical Research Center, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China. huiminxia@hotmail.com.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China. huiminxia@hotmail.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tang</LastName><ForeName>Jinling</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Clinical Data Center, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China. jltang@cuhk.edu.hk.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Guangdong Provincial Children's Medical Research Center, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China. jltang@cuhk.edu.hk.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Kang</ForeName><Initials>K</Initials><Identifier Source="ORCID">0000-0002-4549-1697</Identifier><AffiliationInfo><Affiliation>Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China. kang.zhang@gmail.com.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou, China. kang.zhang@gmail.com.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Center for Biomedicine and Innovations, Faculty of Medicine, Macau University of Science and Technology, Macau, China. kang.zhang@gmail.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gong</LastName><ForeName>Sitang</ForeName><Initials>S</Initials><Identifier Source="ORCID">0000-0002-6899-0616</Identifier><AffiliationInfo><Affiliation>Department of Pediatric, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China. sitangg@126.com.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Guangdong Provincial Children's Medical Research Center, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China. sitangg@126.com.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D002363">Case Reports</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D064888">Observational Study</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>03</Month><Day>13</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Nat Med</MedlineTA><NlmUniqueID>9502015</NlmUniqueID><ISSNLinking>1078-8956</ISSNLinking></MedlineJournalInfo><SupplMeshList><SupplMeshName Type="Disease" UI="C000657245">COVID-19</SupplMeshName><SupplMeshName Type="Protocol" UI="C000657964">COVID-19 diagnostic testing</SupplMeshName><SupplMeshName Type="Organism" UI="C000656484">severe acute respiratory syndrome coronavirus 2</SupplMeshName></SupplMeshList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000073640" MajorTopicYN="N">Betacoronavirus</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000302" MajorTopicYN="Y">isolation & purification</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002648" MajorTopicYN="N">Child</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002675" MajorTopicYN="N">Child, Preschool</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019411" MajorTopicYN="N">Clinical Laboratory Techniques</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName><QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName><QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005243" MajorTopicYN="N">Feces</DescriptorName><QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007223" MajorTopicYN="N">Infant</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009305" MajorTopicYN="N">Nasopharynx</DescriptorName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D058873" MajorTopicYN="N">Pandemics</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011024" MajorTopicYN="N">Pneumonia, Viral</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName><QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName><QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013902" MajorTopicYN="N">Radiography, Thoracic</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D060888" MajorTopicYN="N">Real-Time Polymerase Chain Reaction</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012007" MajorTopicYN="N">Rectum</DescriptorName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017201" MajorTopicYN="Y">Virus Shedding</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>02</Month><Day>10</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>03</Month><Day>02</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>4</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>4</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>4</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32284613</ArticleId><ArticleId IdType="doi">10.1038/s41591-020-0817-4</ArticleId><ArticleId IdType="pii">10.1038/s41591-020-0817-4</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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