Characteristics of pediatric SARS-CoV-2 infection and potential evidence for persistent fecal viral shedding.
Identifieur interne : 000183 ( PubMed/Corpus ); précédent : 000182; suivant : 000184Characteristics of pediatric SARS-CoV-2 infection and potential evidence for persistent fecal viral shedding.
Auteurs : Yi Xu ; Xufang Li ; Bing Zhu ; Huiying Liang ; Chunxiao Fang ; Yu Gong ; Qiaozhi Guo ; Xin Sun ; Danyang Zhao ; Jun Shen ; Huayan Zhang ; Hongsheng Liu ; Huimin Xia ; Jinling Tang ; Kang Zhang ; Sitang GongSource :
- Nature medicine [ 1546-170X ] ; 2020.
English descriptors
- KwdEn :
- Betacoronavirus (genetics), Betacoronavirus (isolation & purification), Child, Child, Preschool, Clinical Laboratory Techniques, Coronavirus Infections (complications), Coronavirus Infections (diagnosis), Coronavirus Infections (virology), Feces (virology), Female, Humans, Infant, Male, Nasopharynx (virology), Pandemics, Pneumonia, Viral (complications), Pneumonia, Viral (diagnosis), Pneumonia, Viral (virology), Radiography, Thoracic, Real-Time Polymerase Chain Reaction, Rectum (virology), Virus Shedding.
- MESH :
- complications : Coronavirus Infections, Pneumonia, Viral.
- diagnosis : Coronavirus Infections, Pneumonia, Viral.
- genetics : Betacoronavirus.
- isolation & purification : Betacoronavirus.
- virology : Coronavirus Infections, Feces, Nasopharynx, Pneumonia, Viral, Rectum.
- Child, Child, Preschool, Clinical Laboratory Techniques, Female, Humans, Infant, Male, Pandemics, Radiography, Thoracic, Real-Time Polymerase Chain Reaction, Virus Shedding.
Abstract
We report epidemiological and clinical investigations on ten pediatric SARS-CoV-2 infection cases confirmed by real-time reverse transcription PCR assay of SARS-CoV-2 RNA. Symptoms in these cases were nonspecific and no children required respiratory support or intensive care. Chest X-rays lacked definite signs of pneumonia, a defining feature of the infection in adult cases. Notably, eight children persistently tested positive on rectal swabs even after nasopharyngeal testing was negative, raising the possibility of fecal-oral transmission.
DOI: 10.1038/s41591-020-0817-4
PubMed: 32284613
Links to Exploration step
pubmed:32284613Le document en format XML
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<front><div type="abstract" xml:lang="en">We report epidemiological and clinical investigations on ten pediatric SARS-CoV-2 infection cases confirmed by real-time reverse transcription PCR assay of SARS-CoV-2 RNA. Symptoms in these cases were nonspecific and no children required respiratory support or intensive care. Chest X-rays lacked definite signs of pneumonia, a defining feature of the infection in adult cases. Notably, eight children persistently tested positive on rectal swabs even after nasopharyngeal testing was negative, raising the possibility of fecal-oral transmission.</div>
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<ArticleTitle>Characteristics of pediatric SARS-CoV-2 infection and potential evidence for persistent fecal viral shedding.</ArticleTitle>
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<Abstract><AbstractText>We report epidemiological and clinical investigations on ten pediatric SARS-CoV-2 infection cases confirmed by real-time reverse transcription PCR assay of SARS-CoV-2 RNA. Symptoms in these cases were nonspecific and no children required respiratory support or intensive care. Chest X-rays lacked definite signs of pneumonia, a defining feature of the infection in adult cases. Notably, eight children persistently tested positive on rectal swabs even after nasopharyngeal testing was negative, raising the possibility of fecal-oral transmission.</AbstractText>
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<AffiliationInfo><Affiliation>Division of Neonatology and Department of Pediatrics, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA, USA.</Affiliation>
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<AffiliationInfo><Affiliation>Center for Biomedicine and Innovations, Faculty of Medicine, Macau University of Science and Technology, Macau, China. kang.zhang@gmail.com.</Affiliation>
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<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year>
<Month>02</Month>
<Day>10</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2020</Year>
<Month>03</Month>
<Day>02</Day>
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<PubMedPubDate PubStatus="entrez"><Year>2020</Year>
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<PubMedPubDate PubStatus="medline"><Year>2020</Year>
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<ArticleIdList><ArticleId IdType="pubmed">32284613</ArticleId>
<ArticleId IdType="doi">10.1038/s41591-020-0817-4</ArticleId>
<ArticleId IdType="pii">10.1038/s41591-020-0817-4</ArticleId>
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