Potent and selective inhibition of SARS coronavirus replication by aurintricarboxylic acid.
Identifieur interne : 002C65 ( PubMed/Corpus ); précédent : 002C64; suivant : 002C66Potent and selective inhibition of SARS coronavirus replication by aurintricarboxylic acid.
Auteurs : Runtao He ; Anton Adonov ; Maya Traykova-Adonova ; Jingxin Cao ; Todd Cutts ; Elsie Grudesky ; Yvon Deschambaul ; Jody Berry ; Michael Drebot ; Xuguang LiSource :
- Biochemical and biophysical research communications [ 0006-291X ] ; 2004.
English descriptors
- KwdEn :
- Animals, Antiviral Agents (pharmacology), Antiviral Agents (therapeutic use), Aurintricarboxylic Acid (pharmacology), Cell Division (drug effects), Chlorocebus aethiops, Dose-Response Relationship, Drug, Reproducibility of Results, SARS Virus (drug effects), SARS Virus (growth & development), SARS Virus (ultrastructure), Sensitivity and Specificity, Severe Acute Respiratory Syndrome (drug therapy), Severe Acute Respiratory Syndrome (virology), Vero Cells, Virus Replication (drug effects).
- MESH :
- chemical , pharmacology : Antiviral Agents, Aurintricarboxylic Acid.
- chemical , therapeutic use : Antiviral Agents.
- drug effects : Cell Division, SARS Virus, Virus Replication.
- drug therapy : Severe Acute Respiratory Syndrome.
- growth & development : SARS Virus.
- ultrastructure : SARS Virus.
- virology : Severe Acute Respiratory Syndrome.
- Animals, Chlorocebus aethiops, Dose-Response Relationship, Drug, Reproducibility of Results, Sensitivity and Specificity, Vero Cells.
Abstract
The severe acute respiratory syndrome virus (SARS) is a coronavirus that instigated regional epidemics in Canada and several Asian countries in 2003. The newly identified SARS coronavirus (SARS-CoV) can be transmitted among humans and cause severe or even fatal illnesses. As preventive vaccine development takes years to complete and adverse reactions have been reported to some veterinary coronaviral vaccines, anti-viral compounds must be relentlessly pursued. In this study, we analyzed the effect of aurintricarboxylic acid (ATA) on SARS-CoV replication in cell culture, and found that ATA could drastically inhibit SARS-CoV replication, with viral production being 1000-fold less than that in the untreated control. Importantly, when compared with IFNs alpha and beta, viral production was inhibited by more than 1000-fold as compared with the untreated control. In addition, when compared with IFNs alpha and beta, ATA was approximately 10 times more potent than IFN alpha and 100 times more than interferon beta at their highest concentrations reported in the literature previously. Our data indicated that ATA should be considered as a candidate anti-SARS compound for future clinical evaluation.
DOI: 10.1016/j.bbrc.2004.06.076
PubMed: 15249217
Links to Exploration step
pubmed:15249217Le document en format XML
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<front><div type="abstract" xml:lang="en">The severe acute respiratory syndrome virus (SARS) is a coronavirus that instigated regional epidemics in Canada and several Asian countries in 2003. The newly identified SARS coronavirus (SARS-CoV) can be transmitted among humans and cause severe or even fatal illnesses. As preventive vaccine development takes years to complete and adverse reactions have been reported to some veterinary coronaviral vaccines, anti-viral compounds must be relentlessly pursued. In this study, we analyzed the effect of aurintricarboxylic acid (ATA) on SARS-CoV replication in cell culture, and found that ATA could drastically inhibit SARS-CoV replication, with viral production being 1000-fold less than that in the untreated control. Importantly, when compared with IFNs alpha and beta, viral production was inhibited by more than 1000-fold as compared with the untreated control. In addition, when compared with IFNs alpha and beta, ATA was approximately 10 times more potent than IFN alpha and 100 times more than interferon beta at their highest concentrations reported in the literature previously. Our data indicated that ATA should be considered as a candidate anti-SARS compound for future clinical evaluation.</div>
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