Viral loads in clinical specimens and SARS manifestations.
Identifieur interne : 002A96 ( PubMed/Corpus ); précédent : 002A95; suivant : 002A97Viral loads in clinical specimens and SARS manifestations.
Auteurs : I F N. Hung ; V C C. Cheng ; A K L. Wu ; B S F. Tang ; K H Chan ; C M Chu ; M M L. Wong ; W T Hui ; L L M. Poon ; D M W. Tse ; K S Chan ; P C Y. Woo ; S K P. Lau ; J S M. Peiris ; K Y YuenSource :
- Emerging infectious diseases [ 1080-6040 ] ; 2004.
English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Disease Outbreaks, Feces (virology), Female, Humans, Male, Middle Aged, Nasopharynx (virology), SARS Virus (isolation & purification), Severe Acute Respiratory Syndrome (blood), Severe Acute Respiratory Syndrome (physiopathology), Severe Acute Respiratory Syndrome (urine), Severe Acute Respiratory Syndrome (virology), Viral Load.
- MESH :
- blood : Severe Acute Respiratory Syndrome.
- isolation & purification : SARS Virus.
- physiopathology : Severe Acute Respiratory Syndrome.
- urine : Severe Acute Respiratory Syndrome.
- virology : Feces, Nasopharynx, Severe Acute Respiratory Syndrome.
- Adult, Aged, Aged, 80 and over, Disease Outbreaks, Female, Humans, Male, Middle Aged, Viral Load.
Abstract
A retrospective viral load study was performed on clinical specimens from 154 patients with laboratory-confirmed severe acute respiratory syndrome (SARS); the specimens were prospectively collected during patients' illness. Viral load in nasopharyngeal aspirates (n = 142) from day 10 to day 15 after onset of symptoms was associated with oxygen desaturation, mechanical ventilation, diarrhea, hepatic dysfunction, and death. Serum viral load (n = 53) was associated with oxygen desaturation, mechanical ventilation, and death. Stool viral load (n = 94) was associated with diarrhea, and urine viral load (n = 111) was associated with abnormal urinalysis results. Viral replications at different sites are important in the pathogenesis of clinical and laboratory abnormalities of SARS.
DOI: 10.3201/eid1009.040058
PubMed: 15498155
Links to Exploration step
pubmed:15498155Le document en format XML
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Tang</name></author><author><name sortKey="Chan, K H" sort="Chan, K H" uniqKey="Chan K" first="K H" last="Chan">K H Chan</name></author><author><name sortKey="Chu, C M" sort="Chu, C M" uniqKey="Chu C" first="C M" last="Chu">C M Chu</name></author><author><name sortKey="Wong, M M L" sort="Wong, M M L" uniqKey="Wong M" first="M M L" last="Wong">M M L. Wong</name></author><author><name sortKey="Hui, W T" sort="Hui, W T" uniqKey="Hui W" first="W T" last="Hui">W T Hui</name></author><author><name sortKey="Poon, L L M" sort="Poon, L L M" uniqKey="Poon L" first="L L M" last="Poon">L L M. Poon</name></author><author><name sortKey="Tse, D M W" sort="Tse, D M W" uniqKey="Tse D" first="D M W" last="Tse">D M W. Tse</name></author><author><name sortKey="Chan, K S" sort="Chan, K S" uniqKey="Chan K" first="K S" last="Chan">K S Chan</name></author><author><name sortKey="Woo, P C Y" sort="Woo, P C Y" uniqKey="Woo P" first="P C Y" last="Woo">P C Y. Woo</name></author><author><name sortKey="Lau, S K P" sort="Lau, S K P" uniqKey="Lau S" first="S K P" last="Lau">S K P. Lau</name></author><author><name sortKey="Peiris, J S M" sort="Peiris, J S M" uniqKey="Peiris J" first="J S M" last="Peiris">J S M. Peiris</name></author><author><name sortKey="Yuen, K Y" sort="Yuen, K Y" uniqKey="Yuen K" first="K Y" last="Yuen">K Y Yuen</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2004">2004</date><idno type="RBID">pubmed:15498155</idno><idno type="pmid">15498155</idno><idno type="doi">10.3201/eid1009.040058</idno><idno type="wicri:Area/PubMed/Corpus">002A96</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002A96</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Viral loads in clinical specimens and SARS manifestations.</title><author><name sortKey="Hung, I F N" sort="Hung, I F N" uniqKey="Hung I" first="I F N" last="Hung">I F N. Hung</name><affiliation><nlm:affiliation>Queen Mary Hospital at the University of Hong Kong, Hong Kong Special Administrative Region, China.</nlm:affiliation></affiliation></author><author><name sortKey="Cheng, V C C" sort="Cheng, V C C" uniqKey="Cheng V" first="V C C" last="Cheng">V C C. Cheng</name></author><author><name sortKey="Wu, A K L" sort="Wu, A K L" uniqKey="Wu A" first="A K L" last="Wu">A K L. Wu</name></author><author><name sortKey="Tang, B S F" sort="Tang, B S F" uniqKey="Tang B" first="B S F" last="Tang">B S F. Tang</name></author><author><name sortKey="Chan, K H" sort="Chan, K H" uniqKey="Chan K" first="K H" last="Chan">K H Chan</name></author><author><name sortKey="Chu, C M" sort="Chu, C M" uniqKey="Chu C" first="C M" last="Chu">C M Chu</name></author><author><name sortKey="Wong, M M L" sort="Wong, M M L" uniqKey="Wong M" first="M M L" last="Wong">M M L. Wong</name></author><author><name sortKey="Hui, W T" sort="Hui, W T" uniqKey="Hui W" first="W T" last="Hui">W T Hui</name></author><author><name sortKey="Poon, L L M" sort="Poon, L L M" uniqKey="Poon L" first="L L M" last="Poon">L L M. Poon</name></author><author><name sortKey="Tse, D M W" sort="Tse, D M W" uniqKey="Tse D" first="D M W" last="Tse">D M W. Tse</name></author><author><name sortKey="Chan, K S" sort="Chan, K S" uniqKey="Chan K" first="K S" last="Chan">K S Chan</name></author><author><name sortKey="Woo, P C Y" sort="Woo, P C Y" uniqKey="Woo P" first="P C Y" last="Woo">P C Y. Woo</name></author><author><name sortKey="Lau, S K P" sort="Lau, S K P" uniqKey="Lau S" first="S K P" last="Lau">S K P. Lau</name></author><author><name sortKey="Peiris, J S M" sort="Peiris, J S M" uniqKey="Peiris J" first="J S M" last="Peiris">J S M. Peiris</name></author><author><name sortKey="Yuen, K Y" sort="Yuen, K Y" uniqKey="Yuen K" first="K Y" last="Yuen">K Y Yuen</name></author></analytic><series><title level="j">Emerging infectious diseases</title><idno type="ISSN">1080-6040</idno><imprint><date when="2004" type="published">2004</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Disease Outbreaks</term><term>Feces (virology)</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Nasopharynx (virology)</term><term>SARS Virus (isolation & purification)</term><term>Severe Acute Respiratory Syndrome (blood)</term><term>Severe Acute Respiratory Syndrome (physiopathology)</term><term>Severe Acute Respiratory Syndrome (urine)</term><term>Severe Acute Respiratory Syndrome (virology)</term><term>Viral Load</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="urine" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Feces</term><term>Nasopharynx</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Disease Outbreaks</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Viral Load</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A retrospective viral load study was performed on clinical specimens from 154 patients with laboratory-confirmed severe acute respiratory syndrome (SARS); the specimens were prospectively collected during patients' illness. Viral load in nasopharyngeal aspirates (n = 142) from day 10 to day 15 after onset of symptoms was associated with oxygen desaturation, mechanical ventilation, diarrhea, hepatic dysfunction, and death. Serum viral load (n = 53) was associated with oxygen desaturation, mechanical ventilation, and death. Stool viral load (n = 94) was associated with diarrhea, and urine viral load (n = 111) was associated with abnormal urinalysis results. Viral replications at different sites are important in the pathogenesis of clinical and laboratory abnormalities of SARS.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">15498155</PMID><DateCompleted><Year>2004</Year><Month>12</Month><Day>08</Day></DateCompleted><DateRevised><Year>2018</Year><Month>11</Month><Day>13</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">1080-6040</ISSN><JournalIssue CitedMedium="Print"><Volume>10</Volume><Issue>9</Issue><PubDate><Year>2004</Year><Month>Sep</Month></PubDate></JournalIssue><Title>Emerging infectious diseases</Title><ISOAbbreviation>Emerging Infect. Dis.</ISOAbbreviation></Journal><ArticleTitle>Viral loads in clinical specimens and SARS manifestations.</ArticleTitle><Pagination><MedlinePgn>1550-7</MedlinePgn></Pagination><Abstract><AbstractText>A retrospective viral load study was performed on clinical specimens from 154 patients with laboratory-confirmed severe acute respiratory syndrome (SARS); the specimens were prospectively collected during patients' illness. Viral load in nasopharyngeal aspirates (n = 142) from day 10 to day 15 after onset of symptoms was associated with oxygen desaturation, mechanical ventilation, diarrhea, hepatic dysfunction, and death. Serum viral load (n = 53) was associated with oxygen desaturation, mechanical ventilation, and death. Stool viral load (n = 94) was associated with diarrhea, and urine viral load (n = 111) was associated with abnormal urinalysis results. Viral replications at different sites are important in the pathogenesis of clinical and laboratory abnormalities of SARS.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Hung</LastName><ForeName>I F N</ForeName><Initials>IF</Initials><AffiliationInfo><Affiliation>Queen Mary Hospital at the University of Hong Kong, Hong Kong Special Administrative Region, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cheng</LastName><ForeName>V C C</ForeName><Initials>VC</Initials></Author><Author ValidYN="Y"><LastName>Wu</LastName><ForeName>A K L</ForeName><Initials>AK</Initials></Author><Author ValidYN="Y"><LastName>Tang</LastName><ForeName>B S F</ForeName><Initials>BS</Initials></Author><Author ValidYN="Y"><LastName>Chan</LastName><ForeName>K H</ForeName><Initials>KH</Initials></Author><Author ValidYN="Y"><LastName>Chu</LastName><ForeName>C M</ForeName><Initials>CM</Initials></Author><Author ValidYN="Y"><LastName>Wong</LastName><ForeName>M M L</ForeName><Initials>MM</Initials></Author><Author ValidYN="Y"><LastName>Hui</LastName><ForeName>W T</ForeName><Initials>WT</Initials></Author><Author ValidYN="Y"><LastName>Poon</LastName><ForeName>L L M</ForeName><Initials>LL</Initials></Author><Author ValidYN="Y"><LastName>Tse</LastName><ForeName>D M W</ForeName><Initials>DM</Initials></Author><Author ValidYN="Y"><LastName>Chan</LastName><ForeName>K S</ForeName><Initials>KS</Initials></Author><Author ValidYN="Y"><LastName>Woo</LastName><ForeName>P C Y</ForeName><Initials>PC</Initials></Author><Author ValidYN="Y"><LastName>Lau</LastName><ForeName>S K P</ForeName><Initials>SK</Initials></Author><Author ValidYN="Y"><LastName>Peiris</LastName><ForeName>J S M</ForeName><Initials>JS</Initials></Author><Author ValidYN="Y"><LastName>Yuen</LastName><ForeName>K Y</ForeName><Initials>KY</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Emerg Infect Dis</MedlineTA><NlmUniqueID>9508155</NlmUniqueID><ISSNLinking>1080-6040</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004196" MajorTopicYN="N">Disease Outbreaks</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005243" MajorTopicYN="N">Feces</DescriptorName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" 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