SrasV1, PubMed, Corpus, bibRecord, 002794

Aged BALB/c mice as a model for increased severity of severe acute respiratory syndrome in elderly humans.

Identifieur interne : 002794 ( PubMed/Corpus ); précédent : 002793; suivant : 002795

Aged BALB/c mice as a model for increased severity of severe acute respiratory syndrome in elderly humans.

Auteurs : Anjeanette Roberts ; Christopher Paddock ; Leatrice Vogel ; Emily Butler ; Sherif Zaki ; Kanta Subbarao

Source :

Journal of virology [ 0022-538X ] ; 2005.

RBID : pubmed:15827197

English descriptors

KwdEn :
- Age Factors, Animals, Disease Models, Animal, Disease Progression, Disease Susceptibility, Mice, Mice, Inbred BALB C, Pneumonia (pathology), SARS Virus, Severe Acute Respiratory Syndrome (diagnosis), Severe Acute Respiratory Syndrome (virology).
MESH :
- diagnosis : Severe Acute Respiratory Syndrome.
- pathology : Pneumonia.
- virology : Severe Acute Respiratory Syndrome.
- Age Factors, Animals, Disease Models, Animal, Disease Progression, Disease Susceptibility, Mice, Mice, Inbred BALB C, SARS Virus.

Abstract

Advanced age has repeatedly been identified as an independent correlate of adverse outcome and a predictor of mortality in cases of severe acute respiratory syndrome (SARS). SARS-associated mortality may exceed 50% for persons aged 60 years or older. Heightened susceptibility of the elderly to severe SARS and the ability of SARS coronavirus to replicate in mice led us to examine whether aged mice might be susceptible to disease. We report here that viral replication in aged mice was associated with clinical illness and pneumonia, demonstrating an age-related susceptibility to SARS disease in animals that parallels the human experience.

DOI: 10.1128/JVI.79.9.5833-5838.2005
PubMed: 15827197

Links to Exploration step

pubmed:15827197

Le document en format XML

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<author><name sortKey="Roberts, Anjeanette" sort="Roberts, Anjeanette" uniqKey="Roberts A" first="Anjeanette" last="Roberts">Anjeanette Roberts</name>
<affiliation><nlm:affiliation>LID, NIAID, NIH, 50 South Dr., Room 6351, MSC 8007, Bethesda, MD 20892, USA. ajroberts@niaid.nih.gov</nlm:affiliation>
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<author><name sortKey="Paddock, Christopher" sort="Paddock, Christopher" uniqKey="Paddock C" first="Christopher" last="Paddock">Christopher Paddock</name>
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<author><name sortKey="Vogel, Leatrice" sort="Vogel, Leatrice" uniqKey="Vogel L" first="Leatrice" last="Vogel">Leatrice Vogel</name>
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<author><name sortKey="Butler, Emily" sort="Butler, Emily" uniqKey="Butler E" first="Emily" last="Butler">Emily Butler</name>
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<author><name sortKey="Zaki, Sherif" sort="Zaki, Sherif" uniqKey="Zaki S" first="Sherif" last="Zaki">Sherif Zaki</name>
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<author><name sortKey="Subbarao, Kanta" sort="Subbarao, Kanta" uniqKey="Subbarao K" first="Kanta" last="Subbarao">Kanta Subbarao</name>
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<author><name sortKey="Paddock, Christopher" sort="Paddock, Christopher" uniqKey="Paddock C" first="Christopher" last="Paddock">Christopher Paddock</name>
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<author><name sortKey="Zaki, Sherif" sort="Zaki, Sherif" uniqKey="Zaki S" first="Sherif" last="Zaki">Sherif Zaki</name>
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<term>Mice</term>
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<term>Severe Acute Respiratory Syndrome (diagnosis)</term>
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<term>Disease Models, Animal</term>
<term>Disease Progression</term>
<term>Disease Susceptibility</term>
<term>Mice</term>
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<front><div type="abstract" xml:lang="en">Advanced age has repeatedly been identified as an independent correlate of adverse outcome and a predictor of mortality in cases of severe acute respiratory syndrome (SARS). SARS-associated mortality may exceed 50% for persons aged 60 years or older. Heightened susceptibility of the elderly to severe SARS and the ability of SARS coronavirus to replicate in mice led us to examine whether aged mice might be susceptible to disease. We report here that viral replication in aged mice was associated with clinical illness and pneumonia, demonstrating an age-related susceptibility to SARS disease in animals that parallels the human experience.</div>
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<Abstract><AbstractText>Advanced age has repeatedly been identified as an independent correlate of adverse outcome and a predictor of mortality in cases of severe acute respiratory syndrome (SARS). SARS-associated mortality may exceed 50% for persons aged 60 years or older. Heightened susceptibility of the elderly to severe SARS and the ability of SARS coronavirus to replicate in mice led us to examine whether aged mice might be susceptible to disease. We report here that viral replication in aged mice was associated with clinical illness and pneumonia, demonstrating an age-related susceptibility to SARS disease in animals that parallels the human experience.</AbstractText>
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Aged BALB/c mice as a model for increased severity of severe acute respiratory syndrome in elderly humans.

Aged BALB/c mice as a model for increased severity of severe acute respiratory syndrome in elderly humans.

Source :

English descriptors

Abstract

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

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