Molecular epidemiology of SARS-associated coronavirus, Beijing.
Identifieur interne : 002492 ( PubMed/Corpus ); précédent : 002491; suivant : 002493Molecular epidemiology of SARS-associated coronavirus, Beijing.
Auteurs : Wei Liu ; Fang Tang ; Arnaud Fontanet ; Lin Zhan ; Tian-Bao Wang ; Pan-He Zhang ; Yi-He Luan ; Chao-Yang Cao ; Qiu-Min Zhao ; Xiao-Ming Wu ; Zhong-Tao Xin ; Shu-Qing Zuo ; Laurence Baril ; Astrid Vabret ; Yi-Ming Shao ; Hong Yang ; Wu-Chun CaoSource :
- Emerging infectious diseases [ 1080-6040 ] ; 2005.
English descriptors
- KwdEn :
- Adult, Aged, China (epidemiology), Communicable Diseases, Emerging (epidemiology), Communicable Diseases, Emerging (genetics), Female, Genotype, Humans, Male, Middle Aged, Molecular Epidemiology, Polymorphism, Single Nucleotide (genetics), SARS Virus (genetics), SARS Virus (isolation & purification), Severe Acute Respiratory Syndrome (epidemiology), Severe Acute Respiratory Syndrome (genetics).
- MESH :
- geographic , epidemiology : China.
- epidemiology : Communicable Diseases, Emerging, Severe Acute Respiratory Syndrome.
- genetics : Communicable Diseases, Emerging, Polymorphism, Single Nucleotide, SARS Virus, Severe Acute Respiratory Syndrome.
- isolation & purification : SARS Virus.
- Adult, Aged, Female, Genotype, Humans, Male, Middle Aged, Molecular Epidemiology.
Abstract
Single nucleotide variations (SNVs) at 5 loci (17564, 21721, 22222, 23823, and 27827) were used to define the molecular epidemiologic characteristics of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) from Beijing patients. Five fragments targeted at the SNV loci were amplified directly from clinical samples by using reverse transcription-polymerase chain reaction (RT-PCR), before sequencing the amplified products. Analyses of 45 sequences obtained from 29 patients showed that the GGCTC motif dominated among samples collected from March to early April 2003; the TGTTT motif predominanted afterwards. The switch from GGCTC to TGTTT was observed among patients belonging to the same cluster, which ruled out the possibility of the coincidental superposition of 2 epidemics running in parallel in Beijing. The Beijing isolates underwent the same change pattern reported from Guangdong Province. The same series of mutations occurring in separate geographic locations and at different times suggests a dominant process of viral adaptation to the host.
DOI: 10.3201/eid1109.040773
PubMed: 16229772
Links to Exploration step
pubmed:16229772Le document en format XML
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first="Pan-He" last="Zhang">Pan-He Zhang</name></author><author><name sortKey="Luan, Yi He" sort="Luan, Yi He" uniqKey="Luan Y" first="Yi-He" last="Luan">Yi-He Luan</name></author><author><name sortKey="Cao, Chao Yang" sort="Cao, Chao Yang" uniqKey="Cao C" first="Chao-Yang" last="Cao">Chao-Yang Cao</name></author><author><name sortKey="Zhao, Qiu Min" sort="Zhao, Qiu Min" uniqKey="Zhao Q" first="Qiu-Min" last="Zhao">Qiu-Min Zhao</name></author><author><name sortKey="Wu, Xiao Ming" sort="Wu, Xiao Ming" uniqKey="Wu X" first="Xiao-Ming" last="Wu">Xiao-Ming Wu</name></author><author><name sortKey="Xin, Zhong Tao" sort="Xin, Zhong Tao" uniqKey="Xin Z" first="Zhong-Tao" last="Xin">Zhong-Tao Xin</name></author><author><name sortKey="Zuo, Shu Qing" sort="Zuo, Shu Qing" uniqKey="Zuo S" first="Shu-Qing" last="Zuo">Shu-Qing Zuo</name></author><author><name sortKey="Baril, Laurence" sort="Baril, Laurence" uniqKey="Baril L" first="Laurence" last="Baril">Laurence Baril</name></author><author><name 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coronavirus, Beijing.</title><author><name sortKey="Liu, Wei" sort="Liu, Wei" uniqKey="Liu W" first="Wei" last="Liu">Wei Liu</name><affiliation><nlm:affiliation>Beijing Institute of Microbiology and Epidemiology, Beijing, People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Tang, Fang" sort="Tang, Fang" uniqKey="Tang F" first="Fang" last="Tang">Fang Tang</name></author><author><name sortKey="Fontanet, Arnaud" sort="Fontanet, Arnaud" uniqKey="Fontanet A" first="Arnaud" last="Fontanet">Arnaud Fontanet</name></author><author><name sortKey="Zhan, Lin" sort="Zhan, Lin" uniqKey="Zhan L" first="Lin" last="Zhan">Lin Zhan</name></author><author><name sortKey="Wang, Tian Bao" sort="Wang, Tian Bao" uniqKey="Wang T" first="Tian-Bao" last="Wang">Tian-Bao Wang</name></author><author><name sortKey="Zhang, Pan He" sort="Zhang, Pan He" uniqKey="Zhang P" first="Pan-He" last="Zhang">Pan-He Zhang</name></author><author><name sortKey="Luan, Yi He" sort="Luan, Yi He" uniqKey="Luan Y" first="Yi-He" last="Luan">Yi-He Luan</name></author><author><name sortKey="Cao, Chao Yang" sort="Cao, Chao Yang" uniqKey="Cao C" first="Chao-Yang" last="Cao">Chao-Yang Cao</name></author><author><name sortKey="Zhao, Qiu Min" sort="Zhao, Qiu Min" uniqKey="Zhao Q" first="Qiu-Min" last="Zhao">Qiu-Min Zhao</name></author><author><name sortKey="Wu, Xiao Ming" sort="Wu, Xiao Ming" uniqKey="Wu X" first="Xiao-Ming" last="Wu">Xiao-Ming Wu</name></author><author><name sortKey="Xin, Zhong Tao" sort="Xin, Zhong Tao" uniqKey="Xin Z" first="Zhong-Tao" last="Xin">Zhong-Tao Xin</name></author><author><name sortKey="Zuo, Shu Qing" sort="Zuo, Shu Qing" uniqKey="Zuo S" first="Shu-Qing" last="Zuo">Shu-Qing Zuo</name></author><author><name sortKey="Baril, Laurence" sort="Baril, Laurence" uniqKey="Baril L" first="Laurence" last="Baril">Laurence Baril</name></author><author><name sortKey="Vabret, Astrid" sort="Vabret, Astrid" uniqKey="Vabret A" first="Astrid" last="Vabret">Astrid Vabret</name></author><author><name sortKey="Shao, Yi Ming" sort="Shao, Yi Ming" uniqKey="Shao Y" first="Yi-Ming" last="Shao">Yi-Ming Shao</name></author><author><name sortKey="Yang, Hong" sort="Yang, Hong" uniqKey="Yang H" first="Hong" last="Yang">Hong Yang</name></author><author><name sortKey="Cao, Wu Chun" sort="Cao, Wu Chun" uniqKey="Cao W" first="Wu-Chun" last="Cao">Wu-Chun Cao</name></author></analytic><series><title level="j">Emerging infectious diseases</title><idno type="ISSN">1080-6040</idno><imprint><date when="2005" type="published">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>China (epidemiology)</term><term>Communicable Diseases, Emerging (epidemiology)</term><term>Communicable Diseases, Emerging (genetics)</term><term>Female</term><term>Genotype</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Molecular Epidemiology</term><term>Polymorphism, Single Nucleotide (genetics)</term><term>SARS Virus (genetics)</term><term>SARS Virus (isolation & purification)</term><term>Severe Acute Respiratory Syndrome (epidemiology)</term><term>Severe Acute Respiratory Syndrome (genetics)</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>China</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Communicable Diseases, Emerging</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Communicable Diseases, Emerging</term><term>Polymorphism, Single Nucleotide</term><term>SARS Virus</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Female</term><term>Genotype</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Molecular Epidemiology</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Single nucleotide variations (SNVs) at 5 loci (17564, 21721, 22222, 23823, and 27827) were used to define the molecular epidemiologic characteristics of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) from Beijing patients. Five fragments targeted at the SNV loci were amplified directly from clinical samples by using reverse transcription-polymerase chain reaction (RT-PCR), before sequencing the amplified products. Analyses of 45 sequences obtained from 29 patients showed that the GGCTC motif dominated among samples collected from March to early April 2003; the TGTTT motif predominanted afterwards. The switch from GGCTC to TGTTT was observed among patients belonging to the same cluster, which ruled out the possibility of the coincidental superposition of 2 epidemics running in parallel in Beijing. The Beijing isolates underwent the same change pattern reported from Guangdong Province. The same series of mutations occurring in separate geographic locations and at different times suggests a dominant process of viral adaptation to the host.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">16229772</PMID><DateCompleted><Year>2006</Year><Month>05</Month><Day>18</Day></DateCompleted><DateRevised><Year>2018</Year><Month>11</Month><Day>13</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">1080-6040</ISSN><JournalIssue CitedMedium="Print"><Volume>11</Volume><Issue>9</Issue><PubDate><Year>2005</Year><Month>Sep</Month></PubDate></JournalIssue><Title>Emerging infectious diseases</Title><ISOAbbreviation>Emerging Infect. Dis.</ISOAbbreviation></Journal><ArticleTitle>Molecular epidemiology of SARS-associated coronavirus, Beijing.</ArticleTitle><Pagination><MedlinePgn>1420-4</MedlinePgn></Pagination><Abstract><AbstractText>Single nucleotide variations (SNVs) at 5 loci (17564, 21721, 22222, 23823, and 27827) were used to define the molecular epidemiologic characteristics of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) from Beijing patients. Five fragments targeted at the SNV loci were amplified directly from clinical samples by using reverse transcription-polymerase chain reaction (RT-PCR), before sequencing the amplified products. Analyses of 45 sequences obtained from 29 patients showed that the GGCTC motif dominated among samples collected from March to early April 2003; the TGTTT motif predominanted afterwards. The switch from GGCTC to TGTTT was observed among patients belonging to the same cluster, which ruled out the possibility of the coincidental superposition of 2 epidemics running in parallel in Beijing. The Beijing isolates underwent the same change pattern reported from Guangdong Province. The same series of mutations occurring in separate geographic locations and at different times suggests a dominant process of viral adaptation to the host.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Wei</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Beijing Institute of Microbiology and Epidemiology, Beijing, People's Republic of China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tang</LastName><ForeName>Fang</ForeName><Initials>F</Initials></Author><Author ValidYN="Y"><LastName>Fontanet</LastName><ForeName>Arnaud</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Zhan</LastName><ForeName>Lin</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Tian-Bao</ForeName><Initials>TB</Initials></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Pan-He</ForeName><Initials>PH</Initials></Author><Author ValidYN="Y"><LastName>Luan</LastName><ForeName>Yi-He</ForeName><Initials>YH</Initials></Author><Author ValidYN="Y"><LastName>Cao</LastName><ForeName>Chao-Yang</ForeName><Initials>CY</Initials></Author><Author ValidYN="Y"><LastName>Zhao</LastName><ForeName>Qiu-Min</ForeName><Initials>QM</Initials></Author><Author ValidYN="Y"><LastName>Wu</LastName><ForeName>Xiao-Ming</ForeName><Initials>XM</Initials></Author><Author ValidYN="Y"><LastName>Xin</LastName><ForeName>Zhong-Tao</ForeName><Initials>ZT</Initials></Author><Author ValidYN="Y"><LastName>Zuo</LastName><ForeName>Shu-Qing</ForeName><Initials>SQ</Initials></Author><Author ValidYN="Y"><LastName>Baril</LastName><ForeName>Laurence</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Vabret</LastName><ForeName>Astrid</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Shao</LastName><ForeName>Yi-Ming</ForeName><Initials>YM</Initials></Author><Author 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Dis</MedlineTA><NlmUniqueID>9508155</NlmUniqueID><ISSNLinking>1080-6040</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002681" MajorTopicYN="N" Type="Geographic">China</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D021821" MajorTopicYN="N">Communicable Diseases, Emerging</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005838" 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Syndrome</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2005</Year><Month>10</Month><Day>19</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2006</Year><Month>5</Month><Day>19</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2005</Year><Month>10</Month><Day>19</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">16229772</ArticleId><ArticleId IdType="pmc">PMC3310602</ArticleId><ArticleId IdType="doi">10.3201/eid1109.040773</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>N Engl J Med. 2003 May 15;348(20):1977-85</Citation><ArticleIdList><ArticleId 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