SrasV1, PubMed, Corpus, bibRecord, 002260

Design and synthesis of hydroxyferroquine derivatives with antimalarial and antiviral activities.

Identifieur interne : 002260 ( PubMed/Corpus ); précédent : 002259; suivant : 002261

Design and synthesis of hydroxyferroquine derivatives with antimalarial and antiviral activities.

Auteurs : Christophe Biot ; Wassim Daher ; Natascha Chavain ; Thierry Fandeur ; Jamal Khalife ; Daniel Dive ; Erik De Clercq

Source :

Journal of medicinal chemistry [ 0022-2623 ] ; 2006.

RBID : pubmed:16640347

English descriptors

KwdEn :
- Animals, Antimalarials (chemical synthesis), Antimalarials (chemistry), Antimalarials (pharmacology), Antimalarials (toxicity), Antiviral Agents (chemical synthesis), Antiviral Agents (chemistry), Antiviral Agents (pharmacology), Antiviral Agents (toxicity), Drug Design, Ferrous Compounds (chemical synthesis), Ferrous Compounds (chemistry), Ferrous Compounds (pharmacology), Ferrous Compounds (toxicity), HIV-1 (drug effects), Molecular Structure, Plasmodium falciparum (drug effects), Quinolines (chemical synthesis), Quinolines (chemistry), Quinolines (pharmacology), Quinolines (toxicity), SARS Virus (drug effects).
MESH :
- chemical , chemical synthesis : Antimalarials, Antiviral Agents, Ferrous Compounds, Quinolines.
- chemical , chemistry : Antimalarials, Antiviral Agents, Ferrous Compounds, Quinolines.
- chemical , pharmacology : Antimalarials, Antiviral Agents, Ferrous Compounds, Quinolines.
- chemical , toxicity : Antimalarials, Antiviral Agents, Ferrous Compounds, Quinolines.
- drug effects : HIV-1, Plasmodium falciparum, SARS Virus.
- Animals, Drug Design, Molecular Structure.

Abstract

Three ferroquine (FQ) derivatives, closely mimicking the antimalarial drug hydroxychloroquine (HCQ), have been prepared. Whereas these organometallic compounds provide the expected reduced cytotoxic effects compared to FQ, they inhibit in vitro growth of Plasmodium falciparum far better than chloroquine (CQ). Moreover, this new class of bioorganometallic compounds exert antiviral effects with some selectivity toward SARS-CoV infection. These new drugs may offer an interesting alternative for Asia where SARS originated and malaria has remained endemic.

DOI: 10.1021/jm0601856
PubMed: 16640347

Links to Exploration step

pubmed:16640347

Le document en format XML

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<author><name sortKey="Biot, Christophe" sort="Biot, Christophe" uniqKey="Biot C" first="Christophe" last="Biot">Christophe Biot</name>
<affiliation><nlm:affiliation>Unité de Catalyse et Chimie du Solide - UMR CNRS 8181, ENSCL, Bâtiment C7, USTL, B.P. 90108, 59652 Villeneuve d' Ascq Cedex, France. christophe.biot@ensc-lille.fr</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Daher, Wassim" sort="Daher, Wassim" uniqKey="Daher W" first="Wassim" last="Daher">Wassim Daher</name>
</author>
<author><name sortKey="Chavain, Natascha" sort="Chavain, Natascha" uniqKey="Chavain N" first="Natascha" last="Chavain">Natascha Chavain</name>
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<author><name sortKey="Fandeur, Thierry" sort="Fandeur, Thierry" uniqKey="Fandeur T" first="Thierry" last="Fandeur">Thierry Fandeur</name>
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<author><name sortKey="Khalife, Jamal" sort="Khalife, Jamal" uniqKey="Khalife J" first="Jamal" last="Khalife">Jamal Khalife</name>
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<author><name sortKey="Dive, Daniel" sort="Dive, Daniel" uniqKey="Dive D" first="Daniel" last="Dive">Daniel Dive</name>
</author>
<author><name sortKey="De Clercq, Erik" sort="De Clercq, Erik" uniqKey="De Clercq E" first="Erik" last="De Clercq">Erik De Clercq</name>
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<affiliation><nlm:affiliation>Unité de Catalyse et Chimie du Solide - UMR CNRS 8181, ENSCL, Bâtiment C7, USTL, B.P. 90108, 59652 Villeneuve d' Ascq Cedex, France. christophe.biot@ensc-lille.fr</nlm:affiliation>
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<author><name sortKey="Chavain, Natascha" sort="Chavain, Natascha" uniqKey="Chavain N" first="Natascha" last="Chavain">Natascha Chavain</name>
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<author><name sortKey="Khalife, Jamal" sort="Khalife, Jamal" uniqKey="Khalife J" first="Jamal" last="Khalife">Jamal Khalife</name>
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<term>Antimalarials (chemistry)</term>
<term>Antimalarials (pharmacology)</term>
<term>Antimalarials (toxicity)</term>
<term>Antiviral Agents (chemical synthesis)</term>
<term>Antiviral Agents (chemistry)</term>
<term>Antiviral Agents (pharmacology)</term>
<term>Antiviral Agents (toxicity)</term>
<term>Drug Design</term>
<term>Ferrous Compounds (chemical synthesis)</term>
<term>Ferrous Compounds (chemistry)</term>
<term>Ferrous Compounds (pharmacology)</term>
<term>Ferrous Compounds (toxicity)</term>
<term>HIV-1 (drug effects)</term>
<term>Molecular Structure</term>
<term>Plasmodium falciparum (drug effects)</term>
<term>Quinolines (chemical synthesis)</term>
<term>Quinolines (chemistry)</term>
<term>Quinolines (pharmacology)</term>
<term>Quinolines (toxicity)</term>
<term>SARS Virus (drug effects)</term>
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<keywords scheme="MESH" type="chemical" qualifier="chemical synthesis" xml:lang="en"><term>Antimalarials</term>
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<front><div type="abstract" xml:lang="en">Three ferroquine (FQ) derivatives, closely mimicking the antimalarial drug hydroxychloroquine (HCQ), have been prepared. Whereas these organometallic compounds provide the expected reduced cytotoxic effects compared to FQ, they inhibit in vitro growth of Plasmodium falciparum far better than chloroquine (CQ). Moreover, this new class of bioorganometallic compounds exert antiviral effects with some selectivity toward SARS-CoV infection. These new drugs may offer an interesting alternative for Asia where SARS originated and malaria has remained endemic.</div>
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<Title>Journal of medicinal chemistry</Title>
<ISOAbbreviation>J. Med. Chem.</ISOAbbreviation>
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<ArticleTitle>Design and synthesis of hydroxyferroquine derivatives with antimalarial and antiviral activities.</ArticleTitle>
<Pagination><MedlinePgn>2845-9</MedlinePgn>
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<Abstract><AbstractText>Three ferroquine (FQ) derivatives, closely mimicking the antimalarial drug hydroxychloroquine (HCQ), have been prepared. Whereas these organometallic compounds provide the expected reduced cytotoxic effects compared to FQ, they inhibit in vitro growth of Plasmodium falciparum far better than chloroquine (CQ). Moreover, this new class of bioorganometallic compounds exert antiviral effects with some selectivity toward SARS-CoV infection. These new drugs may offer an interesting alternative for Asia where SARS originated and malaria has remained endemic.</AbstractText>
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Design and synthesis of hydroxyferroquine derivatives with antimalarial and antiviral activities.

Design and synthesis of hydroxyferroquine derivatives with antimalarial and antiviral activities.

Source :

English descriptors

Abstract

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki