Coronavirus nonstructural protein 1: Common and distinct functions in the regulation of host and viral gene expression.
Identifieur interne : 000F06 ( PubMed/Corpus ); précédent : 000F05; suivant : 000F07Coronavirus nonstructural protein 1: Common and distinct functions in the regulation of host and viral gene expression.
Auteurs : Krishna Narayanan ; Sydney I. Ramirez ; Kumari G. Lokugamage ; Shinji MakinoSource :
- Virus research [ 1872-7492 ] ; 2015.
English descriptors
- KwdEn :
- MESH :
- chemical , metabolism : Viral Nonstructural Proteins, Virulence Factors.
- growth & development : Coronavirus.
- pathogenicity : Coronavirus.
- physiology : Coronavirus.
- Animals, Gene Expression Regulation, Gene Expression Regulation, Viral, Host-Pathogen Interactions, Humans, Mammals, Virulence.
Abstract
The recent emergence of two highly pathogenic human coronaviruses (CoVs), severe acute respiratory syndrome CoV and Middle East respiratory syndrome CoV, has ignited a strong interest in the identification of viral factors that determine the virulence and pathogenesis of CoVs. The nonstructural protein 1 (nsp1) of CoVs has attracted considerable attention in this regard as a potential virulence factor and a target for CoV vaccine development because of accumulating evidence that point to its role in the downregulation of host innate immune responses to CoV infection. Studies have revealed both functional conservation and mechanistic divergence among the nsp1 of different mammalian CoVs in perturbing host gene expression and antiviral responses. This review summarizes the current knowledge about the biological functions of CoV nsp1 that provides an insight into the novel strategies utilized by this viral protein to modulate host and viral gene expression during CoV infection.
DOI: 10.1016/j.virusres.2014.11.019
PubMed: 25432065
Links to Exploration step
pubmed:25432065Le document en format XML
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Electronic address: syiramir@utmb.edu.</nlm:affiliation></affiliation></author><author><name sortKey="Lokugamage, Kumari G" sort="Lokugamage, Kumari G" uniqKey="Lokugamage K" first="Kumari G" last="Lokugamage">Kumari G. Lokugamage</name><affiliation><nlm:affiliation>Department of Microbiology and Immunology, The University of Texas Medical Branch at Galveston, Galveston, TX 77555-1019, United States. Electronic address: kglokuga@utmb.edu.</nlm:affiliation></affiliation></author><author><name sortKey="Makino, Shinji" sort="Makino, Shinji" uniqKey="Makino S" first="Shinji" last="Makino">Shinji Makino</name><affiliation><nlm:affiliation>Department of Microbiology and Immunology, The University of Texas Medical Branch at Galveston, Galveston, TX 77555-1019, United States. 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Electronic address: krnaraya@utmb.edu.</nlm:affiliation></affiliation></author><author><name sortKey="Ramirez, Sydney I" sort="Ramirez, Sydney I" uniqKey="Ramirez S" first="Sydney I" last="Ramirez">Sydney I. Ramirez</name><affiliation><nlm:affiliation>Department of Pathology, The University of Texas Medical Branch at Galveston, Galveston, TX 77555-1019, United States. Electronic address: syiramir@utmb.edu.</nlm:affiliation></affiliation></author><author><name sortKey="Lokugamage, Kumari G" sort="Lokugamage, Kumari G" uniqKey="Lokugamage K" first="Kumari G" last="Lokugamage">Kumari G. Lokugamage</name><affiliation><nlm:affiliation>Department of Microbiology and Immunology, The University of Texas Medical Branch at Galveston, Galveston, TX 77555-1019, United States. Electronic address: kglokuga@utmb.edu.</nlm:affiliation></affiliation></author><author><name sortKey="Makino, Shinji" sort="Makino, Shinji" uniqKey="Makino S" first="Shinji" last="Makino">Shinji Makino</name><affiliation><nlm:affiliation>Department of Microbiology and Immunology, The University of Texas Medical Branch at Galveston, Galveston, TX 77555-1019, United States. Electronic address: shmakino@utmb.edu.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Virus research</title><idno type="eISSN">1872-7492</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Coronavirus (growth & development)</term><term>Coronavirus (pathogenicity)</term><term>Coronavirus (physiology)</term><term>Gene Expression Regulation</term><term>Gene Expression Regulation, Viral</term><term>Host-Pathogen Interactions</term><term>Humans</term><term>Mammals</term><term>Viral Nonstructural Proteins (metabolism)</term><term>Virulence</term><term>Virulence Factors (metabolism)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Viral Nonstructural Proteins</term><term>Virulence Factors</term></keywords><keywords scheme="MESH" qualifier="growth & development" xml:lang="en"><term>Coronavirus</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Coronavirus</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Coronavirus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Gene Expression Regulation</term><term>Gene Expression Regulation, Viral</term><term>Host-Pathogen Interactions</term><term>Humans</term><term>Mammals</term><term>Virulence</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The recent emergence of two highly pathogenic human coronaviruses (CoVs), severe acute respiratory syndrome CoV and Middle East respiratory syndrome CoV, has ignited a strong interest in the identification of viral factors that determine the virulence and pathogenesis of CoVs. The nonstructural protein 1 (nsp1) of CoVs has attracted considerable attention in this regard as a potential virulence factor and a target for CoV vaccine development because of accumulating evidence that point to its role in the downregulation of host innate immune responses to CoV infection. Studies have revealed both functional conservation and mechanistic divergence among the nsp1 of different mammalian CoVs in perturbing host gene expression and antiviral responses. This review summarizes the current knowledge about the biological functions of CoV nsp1 that provides an insight into the novel strategies utilized by this viral protein to modulate host and viral gene expression during CoV infection. </div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25432065</PMID><DateCompleted><Year>2016</Year><Month>02</Month><Day>16</Day></DateCompleted><DateRevised><Year>2020</Year><Month>04</Month><Day>07</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1872-7492</ISSN><JournalIssue CitedMedium="Internet"><Volume>202</Volume><PubDate><Year>2015</Year><Month>Apr</Month><Day>16</Day></PubDate></JournalIssue><Title>Virus research</Title><ISOAbbreviation>Virus Res.</ISOAbbreviation></Journal><ArticleTitle>Coronavirus nonstructural protein 1: Common and distinct functions in the regulation of host and viral gene expression.</ArticleTitle><Pagination><MedlinePgn>89-100</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.virusres.2014.11.019</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S0168-1702(14)00494-8</ELocationID><Abstract><AbstractText>The recent emergence of two highly pathogenic human coronaviruses (CoVs), severe acute respiratory syndrome CoV and Middle East respiratory syndrome CoV, has ignited a strong interest in the identification of viral factors that determine the virulence and pathogenesis of CoVs. The nonstructural protein 1 (nsp1) of CoVs has attracted considerable attention in this regard as a potential virulence factor and a target for CoV vaccine development because of accumulating evidence that point to its role in the downregulation of host innate immune responses to CoV infection. Studies have revealed both functional conservation and mechanistic divergence among the nsp1 of different mammalian CoVs in perturbing host gene expression and antiviral responses. This review summarizes the current knowledge about the biological functions of CoV nsp1 that provides an insight into the novel strategies utilized by this viral protein to modulate host and viral gene expression during CoV infection. </AbstractText><CopyrightInformation>Copyright © 2014 Elsevier B.V. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Narayanan</LastName><ForeName>Krishna</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Microbiology and Immunology, The University of Texas Medical Branch at Galveston, Galveston, TX 77555-1019, United States. Electronic address: krnaraya@utmb.edu.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ramirez</LastName><ForeName>Sydney I</ForeName><Initials>SI</Initials><AffiliationInfo><Affiliation>Department of Pathology, The University of Texas Medical Branch at Galveston, Galveston, TX 77555-1019, United States. 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