Network pharmacology-based analysis of the role of traditional Chinese herbal medicines in the treatment of COVID-19.
Identifieur interne : 000425 ( PubMed/Corpus ); précédent : 000424; suivant : 000426Network pharmacology-based analysis of the role of traditional Chinese herbal medicines in the treatment of COVID-19.
Auteurs : Shengwei Yu ; Junwu Wang ; Haitao ShenSource :
- Annals of palliative medicine [ 2224-5839 ] ; 2020.
English descriptors
- KwdEn :
- MESH :
- geographic : China.
- drug therapy : Coronavirus Infections.
- methods : Infection Control, Medicine, Chinese Traditional.
- therapy : Severe Acute Respiratory Syndrome.
- Betacoronavirus, Humans.
Abstract
The novel coronavirus named COVID-19, which originated in Wuhan, China, has spread to many countries around the world. Currently, no effective medical treatment exists to combat this disease. Traditional Chinese herbal medicines (CHM) have unique roles in the treatment of viral infections. In this article we analyzed the effectiveness and possible molecular mechanisms of CHM formulas for the prevention of COVID-19.
DOI: 10.21037/apm.2020.03.27
PubMed: 32233641
Links to Exploration step
pubmed:32233641Le document en format XML
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<author><name sortKey="Yu, Shengwei" sort="Yu, Shengwei" uniqKey="Yu S" first="Shengwei" last="Yu">Shengwei Yu</name>
<affiliation><nlm:affiliation>Department of Emergency Medicine, Shengjing Hospital of China Medical University, Shenyang 110004, China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Wang, Junwu" sort="Wang, Junwu" uniqKey="Wang J" first="Junwu" last="Wang">Junwu Wang</name>
<affiliation><nlm:affiliation>Department of Emergency Medicine, Shengjing Hospital of China Medical University, Shenyang 110004, China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Shen, Haitao" sort="Shen, Haitao" uniqKey="Shen H" first="Haitao" last="Shen">Haitao Shen</name>
<affiliation><nlm:affiliation>Department of Emergency Medicine, Shengjing Hospital of China Medical University, Shenyang 110004, China. shenht@sj-hospital.org.</nlm:affiliation>
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<author><name sortKey="Yu, Shengwei" sort="Yu, Shengwei" uniqKey="Yu S" first="Shengwei" last="Yu">Shengwei Yu</name>
<affiliation><nlm:affiliation>Department of Emergency Medicine, Shengjing Hospital of China Medical University, Shenyang 110004, China.</nlm:affiliation>
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<author><name sortKey="Wang, Junwu" sort="Wang, Junwu" uniqKey="Wang J" first="Junwu" last="Wang">Junwu Wang</name>
<affiliation><nlm:affiliation>Department of Emergency Medicine, Shengjing Hospital of China Medical University, Shenyang 110004, China.</nlm:affiliation>
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<author><name sortKey="Shen, Haitao" sort="Shen, Haitao" uniqKey="Shen H" first="Haitao" last="Shen">Haitao Shen</name>
<affiliation><nlm:affiliation>Department of Emergency Medicine, Shengjing Hospital of China Medical University, Shenyang 110004, China. shenht@sj-hospital.org.</nlm:affiliation>
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<series><title level="j">Annals of palliative medicine</title>
<idno type="eISSN">2224-5839</idno>
<imprint><date when="2020" type="published">2020</date>
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<term>Coronavirus Infections (drug therapy)</term>
<term>Humans</term>
<term>Infection Control (methods)</term>
<term>Medicine, Chinese Traditional (methods)</term>
<term>Severe Acute Respiratory Syndrome (therapy)</term>
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<front><div type="abstract" xml:lang="en">The novel coronavirus named COVID-19, which originated in Wuhan, China, has spread to many countries around the world. Currently, no effective medical treatment exists to combat this disease. Traditional Chinese herbal medicines (CHM) have unique roles in the treatment of viral infections. In this article we analyzed the effectiveness and possible molecular mechanisms of CHM formulas for the prevention of COVID-19.</div>
</front>
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<DateCompleted><Year>2020</Year>
<Month>04</Month>
<Day>13</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>04</Month>
<Day>13</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">2224-5839</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>9</Volume>
<Issue>2</Issue>
<PubDate><Year>2020</Year>
<Month>Mar</Month>
</PubDate>
</JournalIssue>
<Title>Annals of palliative medicine</Title>
<ISOAbbreviation>Ann Palliat Med</ISOAbbreviation>
</Journal>
<ArticleTitle>Network pharmacology-based analysis of the role of traditional Chinese herbal medicines in the treatment of COVID-19.</ArticleTitle>
<Pagination><MedlinePgn>437-446</MedlinePgn>
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<ELocationID EIdType="doi" ValidYN="Y">10.21037/apm.2020.03.27</ELocationID>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">The novel coronavirus named COVID-19, which originated in Wuhan, China, has spread to many countries around the world. Currently, no effective medical treatment exists to combat this disease. Traditional Chinese herbal medicines (CHM) have unique roles in the treatment of viral infections. In this article we analyzed the effectiveness and possible molecular mechanisms of CHM formulas for the prevention of COVID-19.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">The active ingredients and action targets of CHM formulas were obtained from the TCMSP database. Genes related to severe acute respiratory syndromes (SARS) and Middle East respiratory syndrome (MERS) were queried on the GeneCards database. The action mechanisms of these genes were predicted using a Gene Ontology (GO)-based functional enrichment and annotation tool and the Kyoto Encyclopedia of Genes and Genomes (KEGG).</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">CHM formulas played a positive role in preventing COVID-19 and warrant further application.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Our research provides new evidence to support the possible value of CHM formulas for the prevention of COVID-19. However, further clinical studies with large sample sizes are required to verify their effectiveness.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Yu</LastName>
<ForeName>Shengwei</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Department of Emergency Medicine, Shengjing Hospital of China Medical University, Shenyang 110004, China.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Wang</LastName>
<ForeName>Junwu</ForeName>
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<AffiliationInfo><Affiliation>Department of Emergency Medicine, Shengjing Hospital of China Medical University, Shenyang 110004, China.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Shen</LastName>
<ForeName>Haitao</ForeName>
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<AffiliationInfo><Affiliation>Department of Emergency Medicine, Shengjing Hospital of China Medical University, Shenyang 110004, China. shenht@sj-hospital.org.</Affiliation>
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<ArticleDate DateType="Electronic"><Year>2020</Year>
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<MedlineJournalInfo><Country>China</Country>
<MedlineTA>Ann Palliat Med</MedlineTA>
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<ISSNLinking>2224-5820</ISSNLinking>
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<SupplMeshList><SupplMeshName Type="Protocol" UI="C000705127">COVID-19 drug treatment</SupplMeshName>
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<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">COVID-19</Keyword>
<Keyword MajorTopicYN="N">Novel coronavirus</Keyword>
<Keyword MajorTopicYN="N">network pharmacology</Keyword>
<Keyword MajorTopicYN="N">traditional Chinese herbal medicines (traditional CHM)</Keyword>
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