Are we facing a crashing wave of neuropsychiatric sequelae of COVID-19? Neuropsychiatric symptoms and potential immunologic mechanisms.
Identifieur interne : 000071 ( PubMed/Corpus ); précédent : 000070; suivant : 000072Are we facing a crashing wave of neuropsychiatric sequelae of COVID-19? Neuropsychiatric symptoms and potential immunologic mechanisms.
Auteurs : Emily A. Troyer ; Jordan N. Kohn ; Suzi HongSource :
- Brain, behavior, and immunity [ 1090-2139 ] ; 2020.
Abstract
The coronavirus disease 19 (COVID-19) pandemic is a significant psychological stressor in addition to its tremendous impact on every facet of individuals' lives and organizations in virtually all social and economic sectors worldwide. Fear of illness and uncertainty about the future precipitate anxiety- and stress-related disorders, and several groups have rightfully called for the creation and dissemination of robust mental health screening and treatment programs for the general public and front-line healthcare workers. However, in addition to pandemic-associated psychological distress, the direct effects of the virus itself (several acute respiratory syndrome coronavirus; SARS-CoV-2), and the subsequent host immunologic response, on the human central nervous system (CNS) and related outcomes are unknown. We discuss currently available evidence of COVID-19 related neuropsychiatric sequelae while drawing parallels to past viral pandemic-related outcomes. Past pandemics have demonstrated that diverse types of neuropsychiatric symptoms, such as encephalopathy, mood changes, psychosis, neuromuscular dysfunction, or demyelinating processes, may accompany acute viral infection, or may follow infection by weeks, months, or longer in recovered patients. The potential mechanisms are also discussed, including viral and immunological underpinnings. Therefore, prospective neuropsychiatric monitoring of individuals exposed to SARS-CoV-2 at various points in the life course, as well as their neuroimmune status, are needed to fully understand the long-term impact of COVID-19, and to establish a framework for integrating psychoneuroimmunology into epidemiologic studies of pandemics.
DOI: 10.1016/j.bbi.2020.04.027
PubMed: 32298803
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Electronic address: jokohn@health.ucsd.edu.</nlm:affiliation></affiliation></author><author><name sortKey="Hong, Suzi" sort="Hong, Suzi" uniqKey="Hong S" first="Suzi" last="Hong">Suzi Hong</name><affiliation><nlm:affiliation>Departments of Family Medicine and Public Health, Psychiatry, University of California San Diego, 9500 Gilman Dr. MC0804, La Jolla, California 92093-0804, USA. Electronic address: suzihong@health.ucsd.edu.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32298803</idno><idno type="pmid">32298803</idno><idno type="doi">10.1016/j.bbi.2020.04.027</idno><idno type="wicri:Area/PubMed/Corpus">000071</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000071</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Are we facing a crashing wave of neuropsychiatric sequelae of COVID-19? Neuropsychiatric symptoms and potential immunologic mechanisms.</title><author><name sortKey="Troyer, Emily A" sort="Troyer, Emily A" uniqKey="Troyer E" first="Emily A" last="Troyer">Emily A. Troyer</name><affiliation><nlm:affiliation>Department of Psychiatry, University of California San Diego, 9500 Gilman Dr. MC0804, La Jolla, California 92093-0804, USA. Electronic address: etroyer@health.ucsd.edu.</nlm:affiliation></affiliation></author><author><name sortKey="Kohn, Jordan N" sort="Kohn, Jordan N" uniqKey="Kohn J" first="Jordan N" last="Kohn">Jordan N. Kohn</name><affiliation><nlm:affiliation>Department of Psychiatry, University of California San Diego, 9500 Gilman Dr. MC0804, La Jolla, California 92093-0804, USA. Electronic address: jokohn@health.ucsd.edu.</nlm:affiliation></affiliation></author><author><name sortKey="Hong, Suzi" sort="Hong, Suzi" uniqKey="Hong S" first="Suzi" last="Hong">Suzi Hong</name><affiliation><nlm:affiliation>Departments of Family Medicine and Public Health, Psychiatry, University of California San Diego, 9500 Gilman Dr. MC0804, La Jolla, California 92093-0804, USA. Electronic address: suzihong@health.ucsd.edu.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Brain, behavior, and immunity</title><idno type="eISSN">1090-2139</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The coronavirus disease 19 (COVID-19) pandemic is a significant psychological stressor in addition to its tremendous impact on every facet of individuals' lives and organizations in virtually all social and economic sectors worldwide. Fear of illness and uncertainty about the future precipitate anxiety- and stress-related disorders, and several groups have rightfully called for the creation and dissemination of robust mental health screening and treatment programs for the general public and front-line healthcare workers. However, in addition to pandemic-associated psychological distress, the direct effects of the virus itself (several acute respiratory syndrome coronavirus; SARS-CoV-2), and the subsequent host immunologic response, on the human central nervous system (CNS) and related outcomes are unknown. We discuss currently available evidence of COVID-19 related neuropsychiatric sequelae while drawing parallels to past viral pandemic-related outcomes. Past pandemics have demonstrated that diverse types of neuropsychiatric symptoms, such as encephalopathy, mood changes, psychosis, neuromuscular dysfunction, or demyelinating processes, may accompany acute viral infection, or may follow infection by weeks, months, or longer in recovered patients. The potential mechanisms are also discussed, including viral and immunological underpinnings. Therefore, prospective neuropsychiatric monitoring of individuals exposed to SARS-CoV-2 at various points in the life course, as well as their neuroimmune status, are needed to fully understand the long-term impact of COVID-19, and to establish a framework for integrating psychoneuroimmunology into epidemiologic studies of pandemics.</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">32298803</PMID><DateRevised><Year>2020</Year><Month>04</Month><Day>18</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1090-2139</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2020</Year><Month>Apr</Month><Day>13</Day></PubDate></JournalIssue><Title>Brain, behavior, and immunity</Title><ISOAbbreviation>Brain Behav. Immun.</ISOAbbreviation></Journal><ArticleTitle>Are we facing a crashing wave of neuropsychiatric sequelae of COVID-19? Neuropsychiatric symptoms and potential immunologic mechanisms.</ArticleTitle><ELocationID EIdType="pii" ValidYN="Y">S0889-1591(20)30489-X</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.bbi.2020.04.027</ELocationID><Abstract><AbstractText>The coronavirus disease 19 (COVID-19) pandemic is a significant psychological stressor in addition to its tremendous impact on every facet of individuals' lives and organizations in virtually all social and economic sectors worldwide. Fear of illness and uncertainty about the future precipitate anxiety- and stress-related disorders, and several groups have rightfully called for the creation and dissemination of robust mental health screening and treatment programs for the general public and front-line healthcare workers. However, in addition to pandemic-associated psychological distress, the direct effects of the virus itself (several acute respiratory syndrome coronavirus; SARS-CoV-2), and the subsequent host immunologic response, on the human central nervous system (CNS) and related outcomes are unknown. We discuss currently available evidence of COVID-19 related neuropsychiatric sequelae while drawing parallels to past viral pandemic-related outcomes. Past pandemics have demonstrated that diverse types of neuropsychiatric symptoms, such as encephalopathy, mood changes, psychosis, neuromuscular dysfunction, or demyelinating processes, may accompany acute viral infection, or may follow infection by weeks, months, or longer in recovered patients. The potential mechanisms are also discussed, including viral and immunological underpinnings. Therefore, prospective neuropsychiatric monitoring of individuals exposed to SARS-CoV-2 at various points in the life course, as well as their neuroimmune status, are needed to fully understand the long-term impact of COVID-19, and to establish a framework for integrating psychoneuroimmunology into epidemiologic studies of pandemics.</AbstractText><CopyrightInformation>Copyright © 2020. Published by Elsevier Inc.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Troyer</LastName><ForeName>Emily A</ForeName><Initials>EA</Initials><AffiliationInfo><Affiliation>Department of Psychiatry, University of California San Diego, 9500 Gilman Dr. MC0804, La Jolla, California 92093-0804, USA. Electronic address: etroyer@health.ucsd.edu.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kohn</LastName><ForeName>Jordan N</ForeName><Initials>JN</Initials><AffiliationInfo><Affiliation>Department of Psychiatry, University of California San Diego, 9500 Gilman Dr. MC0804, La Jolla, California 92093-0804, USA. Electronic address: jokohn@health.ucsd.edu.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hong</LastName><ForeName>Suzi</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Departments of Family Medicine and Public Health, Psychiatry, University of California San Diego, 9500 Gilman Dr. MC0804, La Jolla, California 92093-0804, USA. 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