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Central nervous system manifestations of COVID-19: A systematic review.

Identifieur interne : 000070 ( PubMed/Corpus ); précédent : 000069; suivant : 000071

Central nervous system manifestations of COVID-19: A systematic review.

Auteurs : Ali A. Asadi-Pooya ; Leila Simani

Source :

RBID : pubmed:32299017

Abstract

In this systematic review, we will discuss the evidence on the occurrence of central nervous system (CNS) involvement and neurological manifestations in patients with COVID-19.

DOI: 10.1016/j.jns.2020.116832
PubMed: 32299017

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pubmed:32299017

Le document en format XML

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<name sortKey="Asadi Pooya, Ali A" sort="Asadi Pooya, Ali A" uniqKey="Asadi Pooya A" first="Ali A" last="Asadi-Pooya">Ali A. Asadi-Pooya</name>
<affiliation>
<nlm:affiliation>Epilepsy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran; Jefferson Comprehensive Epilepsy Center, Department of Neurology, Thomas Jefferson University, Philadelphia, USA. Electronic address: aliasadipooya@yahoo.com.</nlm:affiliation>
</affiliation>
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<name sortKey="Simani, Leila" sort="Simani, Leila" uniqKey="Simani L" first="Leila" last="Simani">Leila Simani</name>
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<nlm:affiliation>Skull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti Univsersity of Medical Sciences, Tehran, Iran.</nlm:affiliation>
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<title xml:lang="en">Central nervous system manifestations of COVID-19: A systematic review.</title>
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<nlm:affiliation>Epilepsy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran; Jefferson Comprehensive Epilepsy Center, Department of Neurology, Thomas Jefferson University, Philadelphia, USA. Electronic address: aliasadipooya@yahoo.com.</nlm:affiliation>
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<name sortKey="Simani, Leila" sort="Simani, Leila" uniqKey="Simani L" first="Leila" last="Simani">Leila Simani</name>
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<nlm:affiliation>Skull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti Univsersity of Medical Sciences, Tehran, Iran.</nlm:affiliation>
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<series>
<title level="j">Journal of the neurological sciences</title>
<idno type="eISSN">1878-5883</idno>
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<date when="2020" type="published">2020</date>
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<div type="abstract" xml:lang="en">In this systematic review, we will discuss the evidence on the occurrence of central nervous system (CNS) involvement and neurological manifestations in patients with COVID-19.</div>
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<MedlineCitation Status="Publisher" Owner="NLM">
<PMID Version="1">32299017</PMID>
<DateRevised>
<Year>2020</Year>
<Month>04</Month>
<Day>20</Day>
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<Journal>
<ISSN IssnType="Electronic">1878-5883</ISSN>
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<Volume>413</Volume>
<PubDate>
<Year>2020</Year>
<Month>Apr</Month>
<Day>11</Day>
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</JournalIssue>
<Title>Journal of the neurological sciences</Title>
<ISOAbbreviation>J. Neurol. Sci.</ISOAbbreviation>
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<ArticleTitle>Central nervous system manifestations of COVID-19: A systematic review.</ArticleTitle>
<Pagination>
<MedlinePgn>116832</MedlinePgn>
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<Abstract>
<AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">In this systematic review, we will discuss the evidence on the occurrence of central nervous system (CNS) involvement and neurological manifestations in patients with COVID-19.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">MEDLINE (accessed from PubMed) and Scopus from December 01, 2019 to March 26, 2020 were systematically searched for related published articles. In both electronic databases, the following search strategy was implemented and these key words (in the title/abstract) were used: "COVID 19" OR "coronavirus" AND "brain" OR "CNS" OR "neurologic".</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Through the search strategy, we could identify two articles about neurological involvement by COVID-19. One of these publications was a narrative review and the other one was a viewpoint. However, the authors scanned the reference lists of the included studies and could identify multiple references. One study, specifically investigated the neurological manifestations of COVID-19 and could document CNS manifestations in 25% of the patients. Most of the studies investigated the manifestations of COVID-19 in general.</AbstractText>
<AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">While neurological manifestations of COVID-19 have not been studied appropriately, it is highly likely that some of these patients, particularly those who suffer from a severe illness, have CNS involvement and neurological manifestations. Precise and targeted documentation of neurological symptoms, detailed clinical, neurological, and electrophysiological investigations of the patients, attempts to isolate SARS-CoV-2 from cerebrospinal fluid, and autopsies of the COVID-19 victims may clarify the role played by this virus in causing neurological manifestations.</AbstractText>
<CopyrightInformation>Copyright © 2020 Elsevier B.V. All rights reserved.</CopyrightInformation>
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<LastName>Asadi-Pooya</LastName>
<ForeName>Ali A</ForeName>
<Initials>AA</Initials>
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<Affiliation>Epilepsy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran; Jefferson Comprehensive Epilepsy Center, Department of Neurology, Thomas Jefferson University, Philadelphia, USA. Electronic address: aliasadipooya@yahoo.com.</Affiliation>
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<Affiliation>Skull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti Univsersity of Medical Sciences, Tehran, Iran.</Affiliation>
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<Country>Netherlands</Country>
<MedlineTA>J Neurol Sci</MedlineTA>
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<ISSNLinking>0022-510X</ISSNLinking>
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<KeywordList Owner="NOTNLM">
<Keyword MajorTopicYN="N">CNS</Keyword>
<Keyword MajorTopicYN="N">COVID-19</Keyword>
<Keyword MajorTopicYN="N">Coronavirus</Keyword>
<Keyword MajorTopicYN="N">Neurological</Keyword>
<Keyword MajorTopicYN="N">Seizure</Keyword>
</KeywordList>
<CoiStatement>Disclosures Ali A. Asadi-Pooya, M.D.: Honoraria from Cobel Daruo, RaymandRad and Tekaje; Royalty: Oxford University Press (Book publication). Leila Simani, PhD.: none.</CoiStatement>
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