The M protein of SARS-CoV: basic structural and immunological properties.
Identifieur interne : 003033 ( PubMed/Checkpoint ); précédent : 003032; suivant : 003034The M protein of SARS-CoV: basic structural and immunological properties.
Auteurs : Yongwu Hu [République populaire de Chine] ; Jie Wen ; Lin Tang ; Haijun Zhang ; Xiaowei Zhang ; Yan Li ; Jing Wang ; Yujun Han ; Guoqing Li ; Jianping Shi ; Xiangjun Tian ; Feng Jiang ; Xiaoqian Zhao ; Jun Wang ; Siqi Liu ; Changqing Zeng ; Jian Wang ; Huanming YangSource :
- Genomics, proteomics & bioinformatics [ 1672-0229 ] ; 2003.
Descripteurs français
- KwdFr :
- Alignement de séquences, Analyse de regroupements, Analyse de séquence d'ADN, Données de séquences moléculaires, Dosage immunologique, Mutation (génétique), Oligopeptides, Phylogénie, Protéines de la matrice virale (), Protéines de la matrice virale (génétique), Protéines de la matrice virale (immunologie), Structure tertiaire des protéines, Séquence d'acides aminés, Séquence nucléotidique, Test ELISA, Virus du SRAS (génétique).
- MESH :
- génétique : Mutation, Protéines de la matrice virale, Virus du SRAS.
- immunologie : Protéines de la matrice virale.
- Alignement de séquences, Analyse de regroupements, Analyse de séquence d'ADN, Données de séquences moléculaires, Dosage immunologique, Oligopeptides, Phylogénie, Protéines de la matrice virale, Structure tertiaire des protéines, Séquence d'acides aminés, Séquence nucléotidique, Test ELISA.
English descriptors
- KwdEn :
- Amino Acid Sequence, Base Sequence, Cluster Analysis, Enzyme-Linked Immunosorbent Assay, Immunoassay, Molecular Sequence Data, Mutation (genetics), Oligopeptides, Phylogeny, Protein Structure, Tertiary, SARS Virus (genetics), Sequence Alignment, Sequence Analysis, DNA, Viral Matrix Proteins (chemistry), Viral Matrix Proteins (genetics), Viral Matrix Proteins (immunology).
- MESH :
- chemical , chemistry : Viral Matrix Proteins.
- chemical , genetics : Viral Matrix Proteins.
- chemical , immunology : Viral Matrix Proteins.
- chemical : Oligopeptides.
- genetics : Mutation, SARS Virus.
- Amino Acid Sequence, Base Sequence, Cluster Analysis, Enzyme-Linked Immunosorbent Assay, Immunoassay, Molecular Sequence Data, Phylogeny, Protein Structure, Tertiary, Sequence Alignment, Sequence Analysis, DNA.
Abstract
We studied structural and immunological properties of the SARS-CoV M (membrane) protein, based on comparative analyses of sequence features, phylogenetic investigation, and experimental results. The M protein is predicted to contain a triple-spanning transmembrane (TM) region, a single N-glycosylation site near its N-terminus that is in the exterior of the virion, and a long C-terminal region in the interior. The M protein harbors a higher substitution rate (0.6% correlated to its size) among viral open reading frames (ORFs) from published data. The four substitutions detected in the M protein, which cause non-synonymous changes, can be classified into three types. One of them results in changes of pI (isoelectric point) and charge, affecting antigenicity. The second changes hydrophobicity of the TM region, and the third one relates to hydrophilicity of the interior structure. Phylogenetic tree building based on the variations of the M protein appears to support the non-human origin of SARS-CoV. To investigate its immunogenicity, we synthesized eight oligopeptides covering 69.2% of the entire ORF and screened them by using ELISA (enzyme-linked immunosorbent assay) with sera from SARS patients. The results confirmed our predictions on antigenic sites.
DOI: 10.1016/s1672-0229(03)01016-7
PubMed: 15626342
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
pubmed:15626342Le document en format XML
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<front><div type="abstract" xml:lang="en">We studied structural and immunological properties of the SARS-CoV M (membrane) protein, based on comparative analyses of sequence features, phylogenetic investigation, and experimental results. The M protein is predicted to contain a triple-spanning transmembrane (TM) region, a single N-glycosylation site near its N-terminus that is in the exterior of the virion, and a long C-terminal region in the interior. The M protein harbors a higher substitution rate (0.6% correlated to its size) among viral open reading frames (ORFs) from published data. The four substitutions detected in the M protein, which cause non-synonymous changes, can be classified into three types. One of them results in changes of pI (isoelectric point) and charge, affecting antigenicity. The second changes hydrophobicity of the TM region, and the third one relates to hydrophilicity of the interior structure. Phylogenetic tree building based on the variations of the M protein appears to support the non-human origin of SARS-CoV. To investigate its immunogenicity, we synthesized eight oligopeptides covering 69.2% of the entire ORF and screened them by using ELISA (enzyme-linked immunosorbent assay) with sera from SARS patients. The results confirmed our predictions on antigenic sites.</div>
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<Abstract><AbstractText>We studied structural and immunological properties of the SARS-CoV M (membrane) protein, based on comparative analyses of sequence features, phylogenetic investigation, and experimental results. The M protein is predicted to contain a triple-spanning transmembrane (TM) region, a single N-glycosylation site near its N-terminus that is in the exterior of the virion, and a long C-terminal region in the interior. The M protein harbors a higher substitution rate (0.6% correlated to its size) among viral open reading frames (ORFs) from published data. The four substitutions detected in the M protein, which cause non-synonymous changes, can be classified into three types. One of them results in changes of pI (isoelectric point) and charge, affecting antigenicity. The second changes hydrophobicity of the TM region, and the third one relates to hydrophilicity of the interior structure. Phylogenetic tree building based on the variations of the M protein appears to support the non-human origin of SARS-CoV. To investigate its immunogenicity, we synthesized eight oligopeptides covering 69.2% of the entire ORF and screened them by using ELISA (enzyme-linked immunosorbent assay) with sera from SARS patients. The results confirmed our predictions on antigenic sites.</AbstractText>
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<affiliations><list><country><li>République populaire de Chine</li>
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<settlement><li>Pékin</li>
</settlement>
</list>
<tree><noCountry><name sortKey="Han, Yujun" sort="Han, Yujun" uniqKey="Han Y" first="Yujun" last="Han">Yujun Han</name>
<name sortKey="Jiang, Feng" sort="Jiang, Feng" uniqKey="Jiang F" first="Feng" last="Jiang">Feng Jiang</name>
<name sortKey="Li, Guoqing" sort="Li, Guoqing" uniqKey="Li G" first="Guoqing" last="Li">Guoqing Li</name>
<name sortKey="Li, Yan" sort="Li, Yan" uniqKey="Li Y" first="Yan" last="Li">Yan Li</name>
<name sortKey="Liu, Siqi" sort="Liu, Siqi" uniqKey="Liu S" first="Siqi" last="Liu">Siqi Liu</name>
<name sortKey="Shi, Jianping" sort="Shi, Jianping" uniqKey="Shi J" first="Jianping" last="Shi">Jianping Shi</name>
<name sortKey="Tang, Lin" sort="Tang, Lin" uniqKey="Tang L" first="Lin" last="Tang">Lin Tang</name>
<name sortKey="Tian, Xiangjun" sort="Tian, Xiangjun" uniqKey="Tian X" first="Xiangjun" last="Tian">Xiangjun Tian</name>
<name sortKey="Wang, Jian" sort="Wang, Jian" uniqKey="Wang J" first="Jian" last="Wang">Jian Wang</name>
<name sortKey="Wang, Jing" sort="Wang, Jing" uniqKey="Wang J" first="Jing" last="Wang">Jing Wang</name>
<name sortKey="Wang, Jun" sort="Wang, Jun" uniqKey="Wang J" first="Jun" last="Wang">Jun Wang</name>
<name sortKey="Wen, Jie" sort="Wen, Jie" uniqKey="Wen J" first="Jie" last="Wen">Jie Wen</name>
<name sortKey="Yang, Huanming" sort="Yang, Huanming" uniqKey="Yang H" first="Huanming" last="Yang">Huanming Yang</name>
<name sortKey="Zeng, Changqing" sort="Zeng, Changqing" uniqKey="Zeng C" first="Changqing" last="Zeng">Changqing Zeng</name>
<name sortKey="Zhang, Haijun" sort="Zhang, Haijun" uniqKey="Zhang H" first="Haijun" last="Zhang">Haijun Zhang</name>
<name sortKey="Zhang, Xiaowei" sort="Zhang, Xiaowei" uniqKey="Zhang X" first="Xiaowei" last="Zhang">Xiaowei Zhang</name>
<name sortKey="Zhao, Xiaoqian" sort="Zhao, Xiaoqian" uniqKey="Zhao X" first="Xiaoqian" last="Zhao">Xiaoqian Zhao</name>
</noCountry>
<country name="République populaire de Chine"><noRegion><name sortKey="Hu, Yongwu" sort="Hu, Yongwu" uniqKey="Hu Y" first="Yongwu" last="Hu">Yongwu Hu</name>
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