The R protein of SARS-CoV: analyses of structure and function based on four complete genome sequences of isolates BJ01-BJ04.
Identifieur interne : 003032 ( PubMed/Checkpoint ); précédent : 003031; suivant : 003033The R protein of SARS-CoV: analyses of structure and function based on four complete genome sequences of isolates BJ01-BJ04.
Auteurs : Zuyuan Xu [République populaire de Chine] ; Haiqing Zhang ; Xiangjun Tian ; Jia Ji ; Wei Li ; Yan Li ; Wei Tian ; Yujun Han ; Lili Wang ; Zizhang Zhang ; Jing Xu ; Wei Wei ; Jingui Zhu ; Haiyan Sun ; Xiaowei Zhang ; Jun Zhou ; Songgang Li ; Jun Wang ; Jian Wang ; Shengli Bi ; Huanming YangSource :
- Genomics, proteomics & bioinformatics [ 1672-0229 ] ; 2003.
Descripteurs français
- KwdFr :
- Analyse de regroupements, Analyse de séquence d'ADN, Biologie informatique, Composants de gène, Composition en bases nucléiques, Données de séquences moléculaires, Génome viral, Mutation (génétique), Phylogénie, RNA replicase (génétique), Structure tertiaire des protéines, Séquence conservée (génétique), Séquence d'acides aminés, Séquence nucléotidique, Virus du SRAS (génétique), Évolution moléculaire.
- MESH :
- génétique : Mutation, RNA replicase, Séquence conservée, Virus du SRAS.
- Analyse de regroupements, Analyse de séquence d'ADN, Biologie informatique, Composants de gène, Composition en bases nucléiques, Données de séquences moléculaires, Génome viral, Phylogénie, Structure tertiaire des protéines, Séquence d'acides aminés, Séquence nucléotidique, Évolution moléculaire.
English descriptors
- KwdEn :
- Amino Acid Sequence, Base Composition, Base Sequence, Cluster Analysis, Computational Biology, Conserved Sequence (genetics), Evolution, Molecular, Gene Components, Genome, Viral, Molecular Sequence Data, Mutation (genetics), Phylogeny, Protein Structure, Tertiary, RNA Replicase (genetics), SARS Virus (genetics), Sequence Analysis, DNA.
- MESH :
- chemical , genetics : RNA Replicase.
- genetics : Conserved Sequence, Mutation, SARS Virus.
- Amino Acid Sequence, Base Composition, Base Sequence, Cluster Analysis, Computational Biology, Evolution, Molecular, Gene Components, Genome, Viral, Molecular Sequence Data, Phylogeny, Protein Structure, Tertiary, Sequence Analysis, DNA.
Abstract
The R (replicase) protein is the uniquely defined non-structural protein (NSP) responsible for RNA replication, mutation rate or fidelity, regulation of transcription in coronaviruses and many other ssRNA viruses. Based on our complete genome sequences of four isolates (BJ01-BJ04) of SARS-CoV from Beijing, China, we analyzed the structure and predicted functions of the R protein in comparison with 13 other isolates of SARS-CoV and 6 other coronaviruses. The entire ORF (open-reading frame) encodes for two major enzyme activities, RNA-dependent RNA polymerase (RdRp) and proteinase activities. The R polyprotein undergoes a complex proteolytic process to produce 15 function-related peptides. A hydrophobic domain (HOD) and a hydrophilic domain (HID) are newly identified within NSP1. The substitution rate of the R protein is close to the average of the SARS-CoV genome. The functional domains in all NSPs of the R protein give different phylogenetic results that suggest their different mutation rate under selective pressure. Eleven highly conserved regions in RdRp and twelve cleavage sites by 3CLP (chymotrypsin-like protein) have been identified as potential drug targets. Findings suggest that it is possible to obtain information about the phylogeny of SARS-CoV, as well as potential tools for drug design, genotyping and diagnostics of SARS.
DOI: 10.1016/s1672-0229(03)01019-2
PubMed: 15626345
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
pubmed:15626345Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The R protein of SARS-CoV: analyses of structure and function based on four complete genome sequences of isolates BJ01-BJ04.</title>
<author><name sortKey="Xu, Zuyuan" sort="Xu, Zuyuan" uniqKey="Xu Z" first="Zuyuan" last="Xu">Zuyuan Xu</name>
<affiliation wicri:level="1"><nlm:affiliation>Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zhang, Haiqing" sort="Zhang, Haiqing" uniqKey="Zhang H" first="Haiqing" last="Zhang">Haiqing Zhang</name>
</author>
<author><name sortKey="Tian, Xiangjun" sort="Tian, Xiangjun" uniqKey="Tian X" first="Xiangjun" last="Tian">Xiangjun Tian</name>
</author>
<author><name sortKey="Ji, Jia" sort="Ji, Jia" uniqKey="Ji J" first="Jia" last="Ji">Jia Ji</name>
</author>
<author><name sortKey="Li, Wei" sort="Li, Wei" uniqKey="Li W" first="Wei" last="Li">Wei Li</name>
</author>
<author><name sortKey="Li, Yan" sort="Li, Yan" uniqKey="Li Y" first="Yan" last="Li">Yan Li</name>
</author>
<author><name sortKey="Tian, Wei" sort="Tian, Wei" uniqKey="Tian W" first="Wei" last="Tian">Wei Tian</name>
</author>
<author><name sortKey="Han, Yujun" sort="Han, Yujun" uniqKey="Han Y" first="Yujun" last="Han">Yujun Han</name>
</author>
<author><name sortKey="Wang, Lili" sort="Wang, Lili" uniqKey="Wang L" first="Lili" last="Wang">Lili Wang</name>
</author>
<author><name sortKey="Zhang, Zizhang" sort="Zhang, Zizhang" uniqKey="Zhang Z" first="Zizhang" last="Zhang">Zizhang Zhang</name>
</author>
<author><name sortKey="Xu, Jing" sort="Xu, Jing" uniqKey="Xu J" first="Jing" last="Xu">Jing Xu</name>
</author>
<author><name sortKey="Wei, Wei" sort="Wei, Wei" uniqKey="Wei W" first="Wei" last="Wei">Wei Wei</name>
</author>
<author><name sortKey="Zhu, Jingui" sort="Zhu, Jingui" uniqKey="Zhu J" first="Jingui" last="Zhu">Jingui Zhu</name>
</author>
<author><name sortKey="Sun, Haiyan" sort="Sun, Haiyan" uniqKey="Sun H" first="Haiyan" last="Sun">Haiyan Sun</name>
</author>
<author><name sortKey="Zhang, Xiaowei" sort="Zhang, Xiaowei" uniqKey="Zhang X" first="Xiaowei" last="Zhang">Xiaowei Zhang</name>
</author>
<author><name sortKey="Zhou, Jun" sort="Zhou, Jun" uniqKey="Zhou J" first="Jun" last="Zhou">Jun Zhou</name>
</author>
<author><name sortKey="Li, Songgang" sort="Li, Songgang" uniqKey="Li S" first="Songgang" last="Li">Songgang Li</name>
</author>
<author><name sortKey="Wang, Jun" sort="Wang, Jun" uniqKey="Wang J" first="Jun" last="Wang">Jun Wang</name>
</author>
<author><name sortKey="Wang, Jian" sort="Wang, Jian" uniqKey="Wang J" first="Jian" last="Wang">Jian Wang</name>
</author>
<author><name sortKey="Bi, Shengli" sort="Bi, Shengli" uniqKey="Bi S" first="Shengli" last="Bi">Shengli Bi</name>
</author>
<author><name sortKey="Yang, Huanming" sort="Yang, Huanming" uniqKey="Yang H" first="Huanming" last="Yang">Huanming Yang</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2003">2003</date>
<idno type="RBID">pubmed:15626345</idno>
<idno type="pmid">15626345</idno>
<idno type="doi">10.1016/s1672-0229(03)01019-2</idno>
<idno type="wicri:Area/PubMed/Corpus">002981</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002981</idno>
<idno type="wicri:Area/PubMed/Curation">002981</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002981</idno>
<idno type="wicri:Area/PubMed/Checkpoint">003032</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">003032</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">The R protein of SARS-CoV: analyses of structure and function based on four complete genome sequences of isolates BJ01-BJ04.</title>
<author><name sortKey="Xu, Zuyuan" sort="Xu, Zuyuan" uniqKey="Xu Z" first="Zuyuan" last="Xu">Zuyuan Xu</name>
<affiliation wicri:level="1"><nlm:affiliation>Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zhang, Haiqing" sort="Zhang, Haiqing" uniqKey="Zhang H" first="Haiqing" last="Zhang">Haiqing Zhang</name>
</author>
<author><name sortKey="Tian, Xiangjun" sort="Tian, Xiangjun" uniqKey="Tian X" first="Xiangjun" last="Tian">Xiangjun Tian</name>
</author>
<author><name sortKey="Ji, Jia" sort="Ji, Jia" uniqKey="Ji J" first="Jia" last="Ji">Jia Ji</name>
</author>
<author><name sortKey="Li, Wei" sort="Li, Wei" uniqKey="Li W" first="Wei" last="Li">Wei Li</name>
</author>
<author><name sortKey="Li, Yan" sort="Li, Yan" uniqKey="Li Y" first="Yan" last="Li">Yan Li</name>
</author>
<author><name sortKey="Tian, Wei" sort="Tian, Wei" uniqKey="Tian W" first="Wei" last="Tian">Wei Tian</name>
</author>
<author><name sortKey="Han, Yujun" sort="Han, Yujun" uniqKey="Han Y" first="Yujun" last="Han">Yujun Han</name>
</author>
<author><name sortKey="Wang, Lili" sort="Wang, Lili" uniqKey="Wang L" first="Lili" last="Wang">Lili Wang</name>
</author>
<author><name sortKey="Zhang, Zizhang" sort="Zhang, Zizhang" uniqKey="Zhang Z" first="Zizhang" last="Zhang">Zizhang Zhang</name>
</author>
<author><name sortKey="Xu, Jing" sort="Xu, Jing" uniqKey="Xu J" first="Jing" last="Xu">Jing Xu</name>
</author>
<author><name sortKey="Wei, Wei" sort="Wei, Wei" uniqKey="Wei W" first="Wei" last="Wei">Wei Wei</name>
</author>
<author><name sortKey="Zhu, Jingui" sort="Zhu, Jingui" uniqKey="Zhu J" first="Jingui" last="Zhu">Jingui Zhu</name>
</author>
<author><name sortKey="Sun, Haiyan" sort="Sun, Haiyan" uniqKey="Sun H" first="Haiyan" last="Sun">Haiyan Sun</name>
</author>
<author><name sortKey="Zhang, Xiaowei" sort="Zhang, Xiaowei" uniqKey="Zhang X" first="Xiaowei" last="Zhang">Xiaowei Zhang</name>
</author>
<author><name sortKey="Zhou, Jun" sort="Zhou, Jun" uniqKey="Zhou J" first="Jun" last="Zhou">Jun Zhou</name>
</author>
<author><name sortKey="Li, Songgang" sort="Li, Songgang" uniqKey="Li S" first="Songgang" last="Li">Songgang Li</name>
</author>
<author><name sortKey="Wang, Jun" sort="Wang, Jun" uniqKey="Wang J" first="Jun" last="Wang">Jun Wang</name>
</author>
<author><name sortKey="Wang, Jian" sort="Wang, Jian" uniqKey="Wang J" first="Jian" last="Wang">Jian Wang</name>
</author>
<author><name sortKey="Bi, Shengli" sort="Bi, Shengli" uniqKey="Bi S" first="Shengli" last="Bi">Shengli Bi</name>
</author>
<author><name sortKey="Yang, Huanming" sort="Yang, Huanming" uniqKey="Yang H" first="Huanming" last="Yang">Huanming Yang</name>
</author>
</analytic>
<series><title level="j">Genomics, proteomics & bioinformatics</title>
<idno type="ISSN">1672-0229</idno>
<imprint><date when="2003" type="published">2003</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence</term>
<term>Base Composition</term>
<term>Base Sequence</term>
<term>Cluster Analysis</term>
<term>Computational Biology</term>
<term>Conserved Sequence (genetics)</term>
<term>Evolution, Molecular</term>
<term>Gene Components</term>
<term>Genome, Viral</term>
<term>Molecular Sequence Data</term>
<term>Mutation (genetics)</term>
<term>Phylogeny</term>
<term>Protein Structure, Tertiary</term>
<term>RNA Replicase (genetics)</term>
<term>SARS Virus (genetics)</term>
<term>Sequence Analysis, DNA</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Analyse de regroupements</term>
<term>Analyse de séquence d'ADN</term>
<term>Biologie informatique</term>
<term>Composants de gène</term>
<term>Composition en bases nucléiques</term>
<term>Données de séquences moléculaires</term>
<term>Génome viral</term>
<term>Mutation (génétique)</term>
<term>Phylogénie</term>
<term>RNA replicase (génétique)</term>
<term>Structure tertiaire des protéines</term>
<term>Séquence conservée (génétique)</term>
<term>Séquence d'acides aminés</term>
<term>Séquence nucléotidique</term>
<term>Virus du SRAS (génétique)</term>
<term>Évolution moléculaire</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>RNA Replicase</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Conserved Sequence</term>
<term>Mutation</term>
<term>SARS Virus</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Mutation</term>
<term>RNA replicase</term>
<term>Séquence conservée</term>
<term>Virus du SRAS</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term>
<term>Base Composition</term>
<term>Base Sequence</term>
<term>Cluster Analysis</term>
<term>Computational Biology</term>
<term>Evolution, Molecular</term>
<term>Gene Components</term>
<term>Genome, Viral</term>
<term>Molecular Sequence Data</term>
<term>Phylogeny</term>
<term>Protein Structure, Tertiary</term>
<term>Sequence Analysis, DNA</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Analyse de regroupements</term>
<term>Analyse de séquence d'ADN</term>
<term>Biologie informatique</term>
<term>Composants de gène</term>
<term>Composition en bases nucléiques</term>
<term>Données de séquences moléculaires</term>
<term>Génome viral</term>
<term>Phylogénie</term>
<term>Structure tertiaire des protéines</term>
<term>Séquence d'acides aminés</term>
<term>Séquence nucléotidique</term>
<term>Évolution moléculaire</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The R (replicase) protein is the uniquely defined non-structural protein (NSP) responsible for RNA replication, mutation rate or fidelity, regulation of transcription in coronaviruses and many other ssRNA viruses. Based on our complete genome sequences of four isolates (BJ01-BJ04) of SARS-CoV from Beijing, China, we analyzed the structure and predicted functions of the R protein in comparison with 13 other isolates of SARS-CoV and 6 other coronaviruses. The entire ORF (open-reading frame) encodes for two major enzyme activities, RNA-dependent RNA polymerase (RdRp) and proteinase activities. The R polyprotein undergoes a complex proteolytic process to produce 15 function-related peptides. A hydrophobic domain (HOD) and a hydrophilic domain (HID) are newly identified within NSP1. The substitution rate of the R protein is close to the average of the SARS-CoV genome. The functional domains in all NSPs of the R protein give different phylogenetic results that suggest their different mutation rate under selective pressure. Eleven highly conserved regions in RdRp and twelve cleavage sites by 3CLP (chymotrypsin-like protein) have been identified as potential drug targets. Findings suggest that it is possible to obtain information about the phylogeny of SARS-CoV, as well as potential tools for drug design, genotyping and diagnostics of SARS.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">15626345</PMID>
<DateCompleted><Year>2005</Year>
<Month>03</Month>
<Day>04</Day>
</DateCompleted>
<DateRevised><Year>2019</Year>
<Month>05</Month>
<Day>16</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Print">1672-0229</ISSN>
<JournalIssue CitedMedium="Print"><Volume>1</Volume>
<Issue>2</Issue>
<PubDate><Year>2003</Year>
<Month>May</Month>
</PubDate>
</JournalIssue>
<Title>Genomics, proteomics & bioinformatics</Title>
<ISOAbbreviation>Genomics Proteomics Bioinformatics</ISOAbbreviation>
</Journal>
<ArticleTitle>The R protein of SARS-CoV: analyses of structure and function based on four complete genome sequences of isolates BJ01-BJ04.</ArticleTitle>
<Pagination><MedlinePgn>155-65</MedlinePgn>
</Pagination>
<Abstract><AbstractText>The R (replicase) protein is the uniquely defined non-structural protein (NSP) responsible for RNA replication, mutation rate or fidelity, regulation of transcription in coronaviruses and many other ssRNA viruses. Based on our complete genome sequences of four isolates (BJ01-BJ04) of SARS-CoV from Beijing, China, we analyzed the structure and predicted functions of the R protein in comparison with 13 other isolates of SARS-CoV and 6 other coronaviruses. The entire ORF (open-reading frame) encodes for two major enzyme activities, RNA-dependent RNA polymerase (RdRp) and proteinase activities. The R polyprotein undergoes a complex proteolytic process to produce 15 function-related peptides. A hydrophobic domain (HOD) and a hydrophilic domain (HID) are newly identified within NSP1. The substitution rate of the R protein is close to the average of the SARS-CoV genome. The functional domains in all NSPs of the R protein give different phylogenetic results that suggest their different mutation rate under selective pressure. Eleven highly conserved regions in RdRp and twelve cleavage sites by 3CLP (chymotrypsin-like protein) have been identified as potential drug targets. Findings suggest that it is possible to obtain information about the phylogeny of SARS-CoV, as well as potential tools for drug design, genotyping and diagnostics of SARS.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Xu</LastName>
<ForeName>Zuyuan</ForeName>
<Initials>Z</Initials>
<AffiliationInfo><Affiliation>Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhang</LastName>
<ForeName>Haiqing</ForeName>
<Initials>H</Initials>
</Author>
<Author ValidYN="Y"><LastName>Tian</LastName>
<ForeName>Xiangjun</ForeName>
<Initials>X</Initials>
</Author>
<Author ValidYN="Y"><LastName>Ji</LastName>
<ForeName>Jia</ForeName>
<Initials>J</Initials>
</Author>
<Author ValidYN="Y"><LastName>Li</LastName>
<ForeName>Wei</ForeName>
<Initials>W</Initials>
</Author>
<Author ValidYN="Y"><LastName>Li</LastName>
<ForeName>Yan</ForeName>
<Initials>Y</Initials>
</Author>
<Author ValidYN="Y"><LastName>Tian</LastName>
<ForeName>Wei</ForeName>
<Initials>W</Initials>
</Author>
<Author ValidYN="Y"><LastName>Han</LastName>
<ForeName>Yujun</ForeName>
<Initials>Y</Initials>
</Author>
<Author ValidYN="Y"><LastName>Wang</LastName>
<ForeName>Lili</ForeName>
<Initials>L</Initials>
</Author>
<Author ValidYN="Y"><LastName>Zhang</LastName>
<ForeName>Zizhang</ForeName>
<Initials>Z</Initials>
</Author>
<Author ValidYN="Y"><LastName>Xu</LastName>
<ForeName>Jing</ForeName>
<Initials>J</Initials>
</Author>
<Author ValidYN="Y"><LastName>Wei</LastName>
<ForeName>Wei</ForeName>
<Initials>W</Initials>
</Author>
<Author ValidYN="Y"><LastName>Zhu</LastName>
<ForeName>Jingui</ForeName>
<Initials>J</Initials>
</Author>
<Author ValidYN="Y"><LastName>Sun</LastName>
<ForeName>Haiyan</ForeName>
<Initials>H</Initials>
</Author>
<Author ValidYN="Y"><LastName>Zhang</LastName>
<ForeName>Xiaowei</ForeName>
<Initials>X</Initials>
</Author>
<Author ValidYN="Y"><LastName>Zhou</LastName>
<ForeName>Jun</ForeName>
<Initials>J</Initials>
</Author>
<Author ValidYN="Y"><LastName>Li</LastName>
<ForeName>Songgang</ForeName>
<Initials>S</Initials>
</Author>
<Author ValidYN="Y"><LastName>Wang</LastName>
<ForeName>Jun</ForeName>
<Initials>J</Initials>
</Author>
<Author ValidYN="Y"><LastName>Wang</LastName>
<ForeName>Jian</ForeName>
<Initials>J</Initials>
</Author>
<Author ValidYN="Y"><LastName>Bi</LastName>
<ForeName>Shengli</ForeName>
<Initials>S</Initials>
</Author>
<Author ValidYN="Y"><LastName>Yang</LastName>
<ForeName>Huanming</ForeName>
<Initials>H</Initials>
</Author>
</AuthorList>
<Language>eng</Language>
<DataBankList CompleteYN="Y"><DataBank><DataBankName>GENBANK</DataBankName>
<AccessionNumberList><AccessionNumber>AF220295</AccessionNumber>
<AccessionNumber>AY274119</AccessionNumber>
<AccessionNumber>AY278489</AccessionNumber>
<AccessionNumber>AY278491</AccessionNumber>
<AccessionNumber>AY278554</AccessionNumber>
<AccessionNumber>AY278741</AccessionNumber>
<AccessionNumber>AY282752</AccessionNumber>
<AccessionNumber>AY283794</AccessionNumber>
<AccessionNumber>AY283795</AccessionNumber>
<AccessionNumber>AY283796</AccessionNumber>
<AccessionNumber>AY283797</AccessionNumber>
<AccessionNumber>AY283798</AccessionNumber>
<AccessionNumber>AY291451</AccessionNumber>
<AccessionNumber>AY297028</AccessionNumber>
</AccessionNumberList>
</DataBank>
<DataBank><DataBankName>RefSeq</DataBankName>
<AccessionNumberList><AccessionNumber>NC_001451</AccessionNumber>
<AccessionNumber>NC_002306</AccessionNumber>
<AccessionNumber>NC_002645</AccessionNumber>
<AccessionNumber>NC_003045</AccessionNumber>
<AccessionNumber>NC_003436</AccessionNumber>
<AccessionNumber>NC_004718</AccessionNumber>
<AccessionNumber>NC_008146</AccessionNumber>
</AccessionNumberList>
</DataBank>
</DataBankList>
<PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType>
<PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
</Article>
<MedlineJournalInfo><Country>China</Country>
<MedlineTA>Genomics Proteomics Bioinformatics</MedlineTA>
<NlmUniqueID>101197608</NlmUniqueID>
<ISSNLinking>1672-0229</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>EC 2.7.7.48</RegistryNumber>
<NameOfSubstance UI="D012324">RNA Replicase</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000595" MajorTopicYN="N">Amino Acid Sequence</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D001482" MajorTopicYN="N">Base Composition</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D001483" MajorTopicYN="N">Base Sequence</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016000" MajorTopicYN="N">Cluster Analysis</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D019295" MajorTopicYN="N">Computational Biology</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017124" MajorTopicYN="N">Conserved Sequence</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D019143" MajorTopicYN="N">Evolution, Molecular</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D040461" MajorTopicYN="N">Gene Components</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016679" MajorTopicYN="Y">Genome, Viral</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008969" MajorTopicYN="N">Molecular Sequence Data</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009154" MajorTopicYN="N">Mutation</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010802" MajorTopicYN="Y">Phylogeny</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017434" MajorTopicYN="N">Protein Structure, Tertiary</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012324" MajorTopicYN="N">RNA Replicase</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D045473" MajorTopicYN="N">SARS Virus</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017422" MajorTopicYN="N">Sequence Analysis, DNA</DescriptorName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2005</Year>
<Month>1</Month>
<Day>1</Day>
<Hour>9</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2005</Year>
<Month>3</Month>
<Day>5</Day>
<Hour>9</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2005</Year>
<Month>1</Month>
<Day>1</Day>
<Hour>9</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">15626345</ArticleId>
<ArticleId IdType="pmc">PMC5172245</ArticleId>
<ArticleId IdType="pii">S1672-0229(03)01019-2</ArticleId>
<ArticleId IdType="doi">10.1016/s1672-0229(03)01019-2</ArticleId>
</ArticleIdList>
<ReferenceList><Reference><Citation>J Virol. 1998 Feb;72(2):910-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9444982</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Curr Opin Pharmacol. 2002 Oct;2(5):534-40</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12324255</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2000 Feb;74(4):1674-85</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10644337</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 1995 Jun;69(6):3554-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">7745703</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Gen Virol. 1995 Aug;76 ( Pt 8):1885-92</Citation>
<ArticleIdList><ArticleId IdType="pubmed">7636469</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 1995 Jul;69(7):4500-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">7769711</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 1999 Mar;73(3):2016-26</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9971782</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Comput Appl Biosci. 1988 Mar;4(1):11-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">3382986</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 1984 Jun;50(3):957-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">6726891</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2000 Mar;74(5):2333-42</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10666264</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 1995 Jul;69(7):4331-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">7769694</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 1998 Aug;72(8):6689-98</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9658116</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Gen Virol. 2000 Apr;81(Pt 4):853-79</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10725411</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Science. 2003 Jun 13;300(5626):1763-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12746549</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Clin Virol. 2001 Aug;22(1):73-89</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11418355</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nucleic Acids Res. 2003 Apr 1;31(7):1821-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12654997</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2000 Sep;74(17):7911-21</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10933699</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 1994 Sep;68(9):5772-80</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8057459</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>République populaire de Chine</li>
</country>
<settlement><li>Pékin</li>
</settlement>
</list>
<tree><noCountry><name sortKey="Bi, Shengli" sort="Bi, Shengli" uniqKey="Bi S" first="Shengli" last="Bi">Shengli Bi</name>
<name sortKey="Han, Yujun" sort="Han, Yujun" uniqKey="Han Y" first="Yujun" last="Han">Yujun Han</name>
<name sortKey="Ji, Jia" sort="Ji, Jia" uniqKey="Ji J" first="Jia" last="Ji">Jia Ji</name>
<name sortKey="Li, Songgang" sort="Li, Songgang" uniqKey="Li S" first="Songgang" last="Li">Songgang Li</name>
<name sortKey="Li, Wei" sort="Li, Wei" uniqKey="Li W" first="Wei" last="Li">Wei Li</name>
<name sortKey="Li, Yan" sort="Li, Yan" uniqKey="Li Y" first="Yan" last="Li">Yan Li</name>
<name sortKey="Sun, Haiyan" sort="Sun, Haiyan" uniqKey="Sun H" first="Haiyan" last="Sun">Haiyan Sun</name>
<name sortKey="Tian, Wei" sort="Tian, Wei" uniqKey="Tian W" first="Wei" last="Tian">Wei Tian</name>
<name sortKey="Tian, Xiangjun" sort="Tian, Xiangjun" uniqKey="Tian X" first="Xiangjun" last="Tian">Xiangjun Tian</name>
<name sortKey="Wang, Jian" sort="Wang, Jian" uniqKey="Wang J" first="Jian" last="Wang">Jian Wang</name>
<name sortKey="Wang, Jun" sort="Wang, Jun" uniqKey="Wang J" first="Jun" last="Wang">Jun Wang</name>
<name sortKey="Wang, Lili" sort="Wang, Lili" uniqKey="Wang L" first="Lili" last="Wang">Lili Wang</name>
<name sortKey="Wei, Wei" sort="Wei, Wei" uniqKey="Wei W" first="Wei" last="Wei">Wei Wei</name>
<name sortKey="Xu, Jing" sort="Xu, Jing" uniqKey="Xu J" first="Jing" last="Xu">Jing Xu</name>
<name sortKey="Yang, Huanming" sort="Yang, Huanming" uniqKey="Yang H" first="Huanming" last="Yang">Huanming Yang</name>
<name sortKey="Zhang, Haiqing" sort="Zhang, Haiqing" uniqKey="Zhang H" first="Haiqing" last="Zhang">Haiqing Zhang</name>
<name sortKey="Zhang, Xiaowei" sort="Zhang, Xiaowei" uniqKey="Zhang X" first="Xiaowei" last="Zhang">Xiaowei Zhang</name>
<name sortKey="Zhang, Zizhang" sort="Zhang, Zizhang" uniqKey="Zhang Z" first="Zizhang" last="Zhang">Zizhang Zhang</name>
<name sortKey="Zhou, Jun" sort="Zhou, Jun" uniqKey="Zhou J" first="Jun" last="Zhou">Jun Zhou</name>
<name sortKey="Zhu, Jingui" sort="Zhu, Jingui" uniqKey="Zhu J" first="Jingui" last="Zhu">Jingui Zhu</name>
</noCountry>
<country name="République populaire de Chine"><noRegion><name sortKey="Xu, Zuyuan" sort="Xu, Zuyuan" uniqKey="Xu Z" first="Zuyuan" last="Xu">Zuyuan Xu</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/PubMed/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003032 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd -nk 003032 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= SrasV1 |flux= PubMed |étape= Checkpoint |type= RBID |clé= pubmed:15626345 |texte= The R protein of SARS-CoV: analyses of structure and function based on four complete genome sequences of isolates BJ01-BJ04. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/RBID.i -Sk "pubmed:15626345" \ | HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd \ | NlmPubMed2Wicri -a SrasV1
![]() | This area was generated with Dilib version V0.6.33. | ![]() |