SrasV1, PubMed, Checkpoint, bibRecord, 002E63

A human in vitro model system for investigating genome-wide host responses to SARS coronavirus infection.

Identifieur interne : 002E63 ( PubMed/Checkpoint ); précédent : 002E62; suivant : 002E64

A human in vitro model system for investigating genome-wide host responses to SARS coronavirus infection.

Auteurs : Lisa F P. Ng [Singapour] ; Martin L. Hibberd ; Eng-Eong Ooi ; Kin-Fai Tang ; Soek-Ying Neo ; Jenny Tan ; Karuturi R Krishna Murthy ; Vinsensius B. Vega ; Jer-Ming Chia ; Edison T. Liu ; Ee-Chee Ren

Source :

BMC infectious diseases [ 1471-2334 ] ; 2004.

RBID : pubmed:15357874

Descripteurs français

KwdFr :
- ARN viral (génétique), ARN viral (isolement et purification), Agranulocytes (virologie), Animaux, Cellules Vero, Cinétique, Humains, Réaction de polymérisation en chaîne, Régulation de l'expression des gènes viraux, Réplication virale (physiologie), Syndrome respiratoire aigu sévère (immunologie), Syndrome respiratoire aigu sévère (virologie), Séquençage par oligonucléotides en batterie, Virus du SRAS (génétique), Virus du SRAS (immunologie), Virus du SRAS (physiologie).
MESH :
- génétique : ARN viral, Virus du SRAS.
- immunologie : Syndrome respiratoire aigu sévère, Virus du SRAS.
- isolement et purification : ARN viral.
- physiologie : Réplication virale, Virus du SRAS.
- virologie : Agranulocytes, Syndrome respiratoire aigu sévère.
- Animaux, Cellules Vero, Cinétique, Humains, Réaction de polymérisation en chaîne, Régulation de l'expression des gènes viraux, Séquençage par oligonucléotides en batterie.

English descriptors

KwdEn :
- Animals, Chlorocebus aethiops, Gene Expression Regulation, Viral, Humans, Kinetics, Leukocytes, Mononuclear (virology), Oligonucleotide Array Sequence Analysis, Polymerase Chain Reaction, RNA, Viral (genetics), RNA, Viral (isolation & purification), SARS Virus (genetics), SARS Virus (immunology), SARS Virus (physiology), Severe Acute Respiratory Syndrome (immunology), Severe Acute Respiratory Syndrome (virology), Vero Cells, Virus Replication (physiology).
MESH :
- chemical , genetics : RNA, Viral.
- chemical , isolation & purification : RNA, Viral.
- genetics : SARS Virus.
- immunology : SARS Virus, Severe Acute Respiratory Syndrome.
- physiology : SARS Virus, Virus Replication.
- virology : Leukocytes, Mononuclear, Severe Acute Respiratory Syndrome.
- Animals, Chlorocebus aethiops, Gene Expression Regulation, Viral, Humans, Kinetics, Oligonucleotide Array Sequence Analysis, Polymerase Chain Reaction, Vero Cells.

Abstract

The molecular basis of severe acute respiratory syndrome (SARS) coronavirus (CoV) induced pathology is still largely unclear. Many SARS patients suffer respiratory distress brought on by interstitial infiltration and frequently show peripheral blood lymphopenia and occasional leucopenia. One possible cause of this could be interstitial inflammation, following a localized host response. In this study, we therefore examine the immune response of SARS-CoV in human peripheral blood mononuclear cells (PBMCs) over the first 24 hours.

DOI: 10.1186/1471-2334-4-34
PubMed: 15357874

Affiliations:

Singapour

Links toward previous steps (curation, corpus...)

to stream PubMed, to step Corpus: 002B65
to stream PubMed, to step Curation: 002B65

Links to Exploration step

pubmed:15357874

Le document en format XML

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<term>Leukocytes, Mononuclear (virology)</term>
<term>Oligonucleotide Array Sequence Analysis</term>
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<term>Severe Acute Respiratory Syndrome (virology)</term>
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<term>ARN viral (isolement et purification)</term>
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<term>Animaux</term>
<term>Cellules Vero</term>
<term>Cinétique</term>
<term>Humains</term>
<term>Réaction de polymérisation en chaîne</term>
<term>Régulation de l'expression des gènes viraux</term>
<term>Réplication virale (physiologie)</term>
<term>Syndrome respiratoire aigu sévère (immunologie)</term>
<term>Syndrome respiratoire aigu sévère (virologie)</term>
<term>Séquençage par oligonucléotides en batterie</term>
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<term>Virus du SRAS (immunologie)</term>
<term>Virus du SRAS (physiologie)</term>
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<term>Virus du SRAS</term>
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<term>Virus du SRAS</term>
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<term>Severe Acute Respiratory Syndrome</term>
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<term>Chlorocebus aethiops</term>
<term>Gene Expression Regulation, Viral</term>
<term>Humans</term>
<term>Kinetics</term>
<term>Oligonucleotide Array Sequence Analysis</term>
<term>Polymerase Chain Reaction</term>
<term>Vero Cells</term>
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<term>Cellules Vero</term>
<term>Cinétique</term>
<term>Humains</term>
<term>Réaction de polymérisation en chaîne</term>
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<front><div type="abstract" xml:lang="en">The molecular basis of severe acute respiratory syndrome (SARS) coronavirus (CoV) induced pathology is still largely unclear. Many SARS patients suffer respiratory distress brought on by interstitial infiltration and frequently show peripheral blood lymphopenia and occasional leucopenia. One possible cause of this could be interstitial inflammation, following a localized host response. In this study, we therefore examine the immune response of SARS-CoV in human peripheral blood mononuclear cells (PBMCs) over the first 24 hours.</div>
</front>
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<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">15357874</PMID>
<DateCompleted><Year>2005</Year>
<Month>05</Month>
<Day>02</Day>
</DateCompleted>
<DateRevised><Year>2019</Year>
<Month>12</Month>
<Day>10</Day>
</DateRevised>
<Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1471-2334</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>4</Volume>
<PubDate><Year>2004</Year>
<Month>Sep</Month>
<Day>09</Day>
</PubDate>
</JournalIssue>
<Title>BMC infectious diseases</Title>
<ISOAbbreviation>BMC Infect. Dis.</ISOAbbreviation>
</Journal>
<ArticleTitle>A human in vitro model system for investigating genome-wide host responses to SARS coronavirus infection.</ArticleTitle>
<Pagination><MedlinePgn>34</MedlinePgn>
</Pagination>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">The molecular basis of severe acute respiratory syndrome (SARS) coronavirus (CoV) induced pathology is still largely unclear. Many SARS patients suffer respiratory distress brought on by interstitial infiltration and frequently show peripheral blood lymphopenia and occasional leucopenia. One possible cause of this could be interstitial inflammation, following a localized host response. In this study, we therefore examine the immune response of SARS-CoV in human peripheral blood mononuclear cells (PBMCs) over the first 24 hours.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">PBMCs from normal healthy donors were inoculated in vitro with SARS-CoV and the viral replication kinetics was studied by real-time quantitative assays. SARS-CoV specific gene expression changes were examined by high-density oligonucleotide array analysis.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">We observed that SARS-CoV was capable of infecting and replicating in PBMCs and the kinetics of viral replication was variable among the donors. SARS-CoV antibody binding assays indicated that SARS specific antibodies inhibited SARS-CoV viral replication. Array data showed monocyte-macrophage cell activation, coagulation pathway upregulation and cytokine production together with lung trafficking chemokines such as IL8 and IL17, possibly activated through the TLR9 signaling pathway; that mimicked clinical features of the disease.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">The identification of human blood mononuclear cells as a direct target of SARS-CoV in the model system described here provides a new insight into disease pathology and a tool for investigating the host response and mechanisms of pathogenesis.</AbstractText>
</Abstract>
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<ForeName>Lisa F P</ForeName>
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<AffiliationInfo><Affiliation>Genome Institute of Singapore, 60 Biopolis Street, Genome, #02-01, Singapore 138672. ngfp@gis.a-star.edu.sg</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Hibberd</LastName>
<ForeName>Martin L</ForeName>
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</Author>
<Author ValidYN="Y"><LastName>Ooi</LastName>
<ForeName>Eng-Eong</ForeName>
<Initials>EE</Initials>
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<Author ValidYN="Y"><LastName>Tang</LastName>
<ForeName>Kin-Fai</ForeName>
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<Author ValidYN="Y"><LastName>Neo</LastName>
<ForeName>Soek-Ying</ForeName>
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<Author ValidYN="Y"><LastName>Tan</LastName>
<ForeName>Jenny</ForeName>
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<Author ValidYN="Y"><LastName>Murthy</LastName>
<ForeName>Karuturi R Krishna</ForeName>
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<Author ValidYN="Y"><LastName>Vega</LastName>
<ForeName>Vinsensius B</ForeName>
<Initials>VB</Initials>
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<Author ValidYN="Y"><LastName>Chia</LastName>
<ForeName>Jer-Ming</ForeName>
<Initials>JM</Initials>
</Author>
<Author ValidYN="Y"><LastName>Liu</LastName>
<ForeName>Edison T</ForeName>
<Initials>ET</Initials>
</Author>
<Author ValidYN="Y"><LastName>Ren</LastName>
<ForeName>Ee-Chee</ForeName>
<Initials>EC</Initials>
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<Month>09</Month>
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</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007700" MajorTopicYN="N">Kinetics</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007963" MajorTopicYN="N">Leukocytes, Mononuclear</DescriptorName>
<QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D020411" MajorTopicYN="N">Oligonucleotide Array Sequence Analysis</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016133" MajorTopicYN="N">Polymerase Chain Reaction</DescriptorName>
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<MeshHeading><DescriptorName UI="D012367" MajorTopicYN="N">RNA, Viral</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D045473" MajorTopicYN="N">SARS Virus</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
<QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D045169" MajorTopicYN="N">Severe Acute Respiratory Syndrome</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014709" MajorTopicYN="N">Vero Cells</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014779" MajorTopicYN="N">Virus Replication</DescriptorName>
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<name sortKey="Murthy, Karuturi R Krishna" sort="Murthy, Karuturi R Krishna" uniqKey="Murthy K" first="Karuturi R Krishna" last="Murthy">Karuturi R Krishna Murthy</name>
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A human in vitro model system for investigating genome-wide host responses to SARS coronavirus infection.

A human in vitro model system for investigating genome-wide host responses to SARS coronavirus infection.

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