T-cell epitopes in severe acute respiratory syndrome (SARS) coronavirus spike protein elicit a specific T-cell immune response in patients who recover from SARS.
Identifieur interne : 002999 ( PubMed/Checkpoint ); précédent : 002998; suivant : 002A00T-cell epitopes in severe acute respiratory syndrome (SARS) coronavirus spike protein elicit a specific T-cell immune response in patients who recover from SARS.
Auteurs : Yue-Dan Wang [République populaire de Chine] ; Wan-Yee Fion Sin ; Guo-Bing Xu ; Huang-Hao Yang ; Tin-Yau Wong ; Xue-Wen Pang ; Xiao-Yan He ; Hua-Gang Zhang ; Joice Na Lee Ng ; Chak-Sum Samuel Cheng ; Jing Yu ; Li Meng ; Rui-Feng Yang ; Sik-To Lai ; Zhi-Hong Guo ; Yong Xie ; Wei-Feng Chen ; Huang-Hua YangSource :
- Journal of virology [ 0022-538X ] ; 2004.
Descripteurs français
- KwdFr :
- Antigène HLA-A2 (analyse), Données de séquences moléculaires, Déterminants antigéniques des lymphocytes T, Glycoprotéine de spicule des coronavirus, Glycoprotéines membranaires (immunologie), Humains, Interféron gamma (biosynthèse), Lymphocytes T (immunologie), Protéines de l'enveloppe virale (immunologie), Syndrome respiratoire aigu sévère (immunologie), Séquence d'acides aminés, Virus du SRAS (immunologie).
- MESH :
- analyse : Antigène HLA-A2.
- biosynthèse : Interféron gamma.
- immunologie : Glycoprotéines membranaires, Lymphocytes T, Protéines de l'enveloppe virale, Syndrome respiratoire aigu sévère, Virus du SRAS.
- Données de séquences moléculaires, Déterminants antigéniques des lymphocytes T, Glycoprotéine de spicule des coronavirus, Humains, Séquence d'acides aminés.
English descriptors
- KwdEn :
- Amino Acid Sequence, Epitopes, T-Lymphocyte, HLA-A2 Antigen (analysis), Humans, Interferon-gamma (biosynthesis), Membrane Glycoproteins (immunology), Molecular Sequence Data, SARS Virus (immunology), Severe Acute Respiratory Syndrome (immunology), Spike Glycoprotein, Coronavirus, T-Lymphocytes (immunology), Viral Envelope Proteins (immunology).
- MESH :
- chemical , analysis : HLA-A2 Antigen.
- chemical , biosynthesis : Interferon-gamma.
- chemical , immunology : Membrane Glycoproteins, Viral Envelope Proteins.
- chemical : Epitopes, T-Lymphocyte, Spike Glycoprotein, Coronavirus.
- immunology : SARS Virus, Severe Acute Respiratory Syndrome, T-Lymphocytes.
- Amino Acid Sequence, Humans, Molecular Sequence Data.
Abstract
The immunogenicity of HLA-A2-restricted T-cell epitopes in the S protein of the Severe acute respiratory syndrome coronavirus (SARS-CoV) and of human coronavirus strain 229e (HCoV-229e) was analyzed for the elicitation of a T-cell immune response in donors who had fully recovered from SARS-CoV infection. We employed online database analysis to compare the differences in the amino acid sequences of the homologous T epitopes of HCoV-229e and SARS-CoV. The identified T-cell epitope peptides were synthesized, and their binding affinities for HLA-A2 were validated and compared in the T2 cell system. The immunogenicity of all these peptides was assessed by using T cells obtained from donors who had fully recovered from SARS-CoV infection and from healthy donors with no history of SARS-CoV infection. HLA-A2 typing by indirect immunofluorescent antibody staining showed that 51.6% of SARS-CoV-infected patients were HLA-A2 positive. Online database analysis and the T2 cell binding test disclosed that the number of HLA-A2-restricted immunogenic epitopes of the S protein of SARS-CoV was decreased or even lost in comparison with the homologous sequences of the S protein of HCoV-229e. Among the peptides used in the study, the affinity of peptides from HCoV-229e (H77 and H881) and peptides from SARS-CoV (S978 and S1203) for binding to HLA-A2 was higher than that of other sequences. The gamma interferon (IFN-gamma) release Elispot assay revealed that only SARS-CoV-specific peptides S1203 and S978 induced a high frequency of IFN-gamma-secreting T-cell response in HLA-A2(+) donors who had fully recovered from SARS-CoV infection; such a T-cell epitope-specific response was not observed in HLA-A2(+) healthy donors or in HLA-A2(-) donors who had been infected with SARS-CoV after full recovery. Thus, T-cell epitopes S1203 and S978 are immunogenic and elicit an overt specific T-cell response in HLA-A2(+) SARS-CoV-infected patients.
DOI: 10.1128/JVI.78.11.5612-5618.2004
PubMed: 15140958
Affiliations:
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sortKey="Wang, Yue Dan" sort="Wang, Yue Dan" uniqKey="Wang Y" first="Yue-Dan" last="Wang">Yue-Dan Wang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Immunology, Peking University Health Science Centre, 38, Xueyuanlu, Beijing, 100083, People's Republic of China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Immunology, Peking University Health Science Centre, 38, Xueyuanlu, Beijing, 100083</wicri:regionArea><wicri:noRegion>100083</wicri:noRegion></affiliation></author><author><name sortKey="Sin, Wan Yee Fion" sort="Sin, Wan Yee Fion" uniqKey="Sin W" first="Wan-Yee Fion" last="Sin">Wan-Yee Fion Sin</name></author><author><name sortKey="Xu, Guo Bing" sort="Xu, Guo Bing" uniqKey="Xu G" first="Guo-Bing" last="Xu">Guo-Bing Xu</name></author><author><name sortKey="Yang, Huang Hao" sort="Yang, Huang Hao" uniqKey="Yang H" first="Huang-Hao" last="Yang">Huang-Hao Yang</name></author><author><name sortKey="Wong, Tin Yau" sort="Wong, Tin Yau" uniqKey="Wong T" first="Tin-Yau" last="Wong">Tin-Yau Wong</name></author><author><name sortKey="Pang, Xue Wen" sort="Pang, Xue Wen" uniqKey="Pang X" first="Xue-Wen" last="Pang">Xue-Wen Pang</name></author><author><name sortKey="He, Xiao Yan" sort="He, Xiao Yan" uniqKey="He X" first="Xiao-Yan" last="He">Xiao-Yan He</name></author><author><name sortKey="Zhang, Hua Gang" sort="Zhang, Hua Gang" uniqKey="Zhang H" first="Hua-Gang" last="Zhang">Hua-Gang Zhang</name></author><author><name sortKey="Ng, Joice Na Lee" sort="Ng, Joice Na Lee" uniqKey="Ng J" first="Joice Na Lee" last="Ng">Joice Na Lee Ng</name></author><author><name sortKey="Cheng, Chak Sum Samuel" sort="Cheng, Chak Sum Samuel" uniqKey="Cheng C" first="Chak-Sum Samuel" last="Cheng">Chak-Sum Samuel Cheng</name></author><author><name sortKey="Yu, Jing" sort="Yu, Jing" uniqKey="Yu J" first="Jing" last="Yu">Jing Yu</name></author><author><name sortKey="Meng, Li" sort="Meng, Li" uniqKey="Meng L" first="Li" last="Meng">Li Meng</name></author><author><name sortKey="Yang, Rui Feng" sort="Yang, Rui Feng" uniqKey="Yang R" first="Rui-Feng" last="Yang">Rui-Feng Yang</name></author><author><name sortKey="Lai, Sik To" sort="Lai, Sik To" uniqKey="Lai S" first="Sik-To" last="Lai">Sik-To Lai</name></author><author><name sortKey="Guo, Zhi Hong" sort="Guo, Zhi Hong" uniqKey="Guo Z" first="Zhi-Hong" last="Guo">Zhi-Hong Guo</name></author><author><name sortKey="Xie, Yong" sort="Xie, Yong" uniqKey="Xie Y" first="Yong" last="Xie">Yong Xie</name></author><author><name sortKey="Chen, Wei Feng" sort="Chen, Wei Feng" uniqKey="Chen W" first="Wei-Feng" last="Chen">Wei-Feng Chen</name></author><author><name sortKey="Yang, Huang Hua" sort="Yang, Huang Hua" uniqKey="Yang H" first="Huang-Hua" last="Yang">Huang-Hua Yang</name></author></analytic><series><title level="j">Journal of virology</title><idno type="ISSN">0022-538X</idno><imprint><date when="2004" type="published">2004</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence</term><term>Epitopes, T-Lymphocyte</term><term>HLA-A2 Antigen (analysis)</term><term>Humans</term><term>Interferon-gamma (biosynthesis)</term><term>Membrane Glycoproteins (immunology)</term><term>Molecular Sequence Data</term><term>SARS Virus (immunology)</term><term>Severe Acute Respiratory Syndrome (immunology)</term><term>Spike Glycoprotein, Coronavirus</term><term>T-Lymphocytes (immunology)</term><term>Viral Envelope Proteins (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Antigène HLA-A2 (analyse)</term><term>Données de séquences moléculaires</term><term>Déterminants antigéniques des lymphocytes T</term><term>Glycoprotéine de spicule des coronavirus</term><term>Glycoprotéines membranaires (immunologie)</term><term>Humains</term><term>Interféron gamma (biosynthèse)</term><term>Lymphocytes T (immunologie)</term><term>Protéines de l'enveloppe virale (immunologie)</term><term>Syndrome respiratoire aigu sévère (immunologie)</term><term>Séquence d'acides aminés</term><term>Virus du SRAS (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>HLA-A2 Antigen</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Interferon-gamma</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Membrane Glycoproteins</term><term>Viral Envelope Proteins</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Epitopes, T-Lymphocyte</term><term>Spike Glycoprotein, Coronavirus</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Antigène HLA-A2</term></keywords><keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>Interféron gamma</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Glycoprotéines membranaires</term><term>Lymphocytes T</term><term>Protéines de l'enveloppe virale</term><term>Syndrome respiratoire aigu sévère</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>SARS Virus</term><term>Severe Acute Respiratory Syndrome</term><term>T-Lymphocytes</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term><term>Humans</term><term>Molecular Sequence Data</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Données de séquences moléculaires</term><term>Déterminants antigéniques des lymphocytes T</term><term>Glycoprotéine de spicule des coronavirus</term><term>Humains</term><term>Séquence d'acides aminés</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The immunogenicity of HLA-A2-restricted T-cell epitopes in the S protein of the Severe acute respiratory syndrome coronavirus (SARS-CoV) and of human coronavirus strain 229e (HCoV-229e) was analyzed for the elicitation of a T-cell immune response in donors who had fully recovered from SARS-CoV infection. We employed online database analysis to compare the differences in the amino acid sequences of the homologous T epitopes of HCoV-229e and SARS-CoV. The identified T-cell epitope peptides were synthesized, and their binding affinities for HLA-A2 were validated and compared in the T2 cell system. The immunogenicity of all these peptides was assessed by using T cells obtained from donors who had fully recovered from SARS-CoV infection and from healthy donors with no history of SARS-CoV infection. HLA-A2 typing by indirect immunofluorescent antibody staining showed that 51.6% of SARS-CoV-infected patients were HLA-A2 positive. Online database analysis and the T2 cell binding test disclosed that the number of HLA-A2-restricted immunogenic epitopes of the S protein of SARS-CoV was decreased or even lost in comparison with the homologous sequences of the S protein of HCoV-229e. Among the peptides used in the study, the affinity of peptides from HCoV-229e (H77 and H881) and peptides from SARS-CoV (S978 and S1203) for binding to HLA-A2 was higher than that of other sequences. The gamma interferon (IFN-gamma) release Elispot assay revealed that only SARS-CoV-specific peptides S1203 and S978 induced a high frequency of IFN-gamma-secreting T-cell response in HLA-A2(+) donors who had fully recovered from SARS-CoV infection; such a T-cell epitope-specific response was not observed in HLA-A2(+) healthy donors or in HLA-A2(-) donors who had been infected with SARS-CoV after full recovery. Thus, T-cell epitopes S1203 and S978 are immunogenic and elicit an overt specific T-cell response in HLA-A2(+) SARS-CoV-infected patients.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">15140958</PMID><DateCompleted><Year>2004</Year><Month>06</Month><Day>10</Day></DateCompleted><DateRevised><Year>2020</Year><Month>04</Month><Day>15</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0022-538X</ISSN><JournalIssue CitedMedium="Print"><Volume>78</Volume><Issue>11</Issue><PubDate><Year>2004</Year><Month>Jun</Month></PubDate></JournalIssue><Title>Journal of virology</Title><ISOAbbreviation>J. Virol.</ISOAbbreviation></Journal><ArticleTitle>T-cell epitopes in severe acute respiratory syndrome (SARS) coronavirus spike protein elicit a specific T-cell immune response in patients who recover from SARS.</ArticleTitle><Pagination><MedlinePgn>5612-8</MedlinePgn></Pagination><Abstract><AbstractText>The immunogenicity of HLA-A2-restricted T-cell epitopes in the S protein of the Severe acute respiratory syndrome coronavirus (SARS-CoV) and of human coronavirus strain 229e (HCoV-229e) was analyzed for the elicitation of a T-cell immune response in donors who had fully recovered from SARS-CoV infection. We employed online database analysis to compare the differences in the amino acid sequences of the homologous T epitopes of HCoV-229e and SARS-CoV. The identified T-cell epitope peptides were synthesized, and their binding affinities for HLA-A2 were validated and compared in the T2 cell system. The immunogenicity of all these peptides was assessed by using T cells obtained from donors who had fully recovered from SARS-CoV infection and from healthy donors with no history of SARS-CoV infection. HLA-A2 typing by indirect immunofluorescent antibody staining showed that 51.6% of SARS-CoV-infected patients were HLA-A2 positive. Online database analysis and the T2 cell binding test disclosed that the number of HLA-A2-restricted immunogenic epitopes of the S protein of SARS-CoV was decreased or even lost in comparison with the homologous sequences of the S protein of HCoV-229e. Among the peptides used in the study, the affinity of peptides from HCoV-229e (H77 and H881) and peptides from SARS-CoV (S978 and S1203) for binding to HLA-A2 was higher than that of other sequences. The gamma interferon (IFN-gamma) release Elispot assay revealed that only SARS-CoV-specific peptides S1203 and S978 induced a high frequency of IFN-gamma-secreting T-cell response in HLA-A2(+) donors who had fully recovered from SARS-CoV infection; such a T-cell epitope-specific response was not observed in HLA-A2(+) healthy donors or in HLA-A2(-) donors who had been infected with SARS-CoV after full recovery. Thus, T-cell epitopes S1203 and S978 are immunogenic and elicit an overt specific T-cell response in HLA-A2(+) SARS-CoV-infected patients.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Yue-Dan</ForeName><Initials>YD</Initials><AffiliationInfo><Affiliation>Department of Immunology, Peking University Health Science Centre, 38, Xueyuanlu, Beijing, 100083, People's Republic of China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sin</LastName><ForeName>Wan-Yee Fion</ForeName><Initials>WY</Initials></Author><Author ValidYN="Y"><LastName>Xu</LastName><ForeName>Guo-Bing</ForeName><Initials>GB</Initials></Author><Author ValidYN="Y"><LastName>Yang</LastName><ForeName>Huang-Hao</ForeName><Initials>HH</Initials></Author><Author ValidYN="Y"><LastName>Wong</LastName><ForeName>Tin-yau</ForeName><Initials>TY</Initials></Author><Author ValidYN="Y"><LastName>Pang</LastName><ForeName>Xue-Wen</ForeName><Initials>XW</Initials></Author><Author ValidYN="Y"><LastName>He</LastName><ForeName>Xiao-Yan</ForeName><Initials>XY</Initials></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Hua-Gang</ForeName><Initials>HG</Initials></Author><Author ValidYN="Y"><LastName>Ng</LastName><ForeName>Joice Na Lee</ForeName><Initials>JN</Initials></Author><Author ValidYN="Y"><LastName>Cheng</LastName><ForeName>Chak-Sum Samuel</ForeName><Initials>CS</Initials></Author><Author ValidYN="Y"><LastName>Yu</LastName><ForeName>Jing</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Meng</LastName><ForeName>Li</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Yang</LastName><ForeName>Rui-Feng</ForeName><Initials>RF</Initials></Author><Author ValidYN="Y"><LastName>Lai</LastName><ForeName>Sik-To</ForeName><Initials>ST</Initials></Author><Author ValidYN="Y"><LastName>Guo</LastName><ForeName>Zhi-Hong</ForeName><Initials>ZH</Initials></Author><Author ValidYN="Y"><LastName>Xie</LastName><ForeName>Yong</ForeName><Initials>Y</Initials></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Wei-Feng</ForeName><Initials>WF</Initials></Author><Author ValidYN="N"><LastName>Yang</LastName><ForeName>Huang-Hua</ForeName><Initials>HH</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Virol</MedlineTA><NlmUniqueID>0113724</NlmUniqueID><ISSNLinking>0022-538X</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018984">Epitopes, T-Lymphocyte</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015789">HLA-A2 Antigen</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C578553">MHV surface projection glycoprotein</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D008562">Membrane Glycoproteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D064370">Spike Glycoprotein, Coronavirus</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014759">Viral Envelope Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C578557">spike glycoprotein, SARS-CoV</NameOfSubstance></Chemical><Chemical><RegistryNumber>82115-62-6</RegistryNumber><NameOfSubstance UI="D007371">Interferon-gamma</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="ErratumIn"><RefSource>J Virol. 2004 Jul;78(14):7861</RefSource><Note>Yang Huang-Hua [corrected to Yang Huang-Hao]</Note></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000595" MajorTopicYN="N">Amino Acid Sequence</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018984" MajorTopicYN="Y">Epitopes, T-Lymphocyte</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015789" MajorTopicYN="N">HLA-A2 Antigen</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007371" MajorTopicYN="N">Interferon-gamma</DescriptorName><QualifierName UI="Q000096" MajorTopicYN="N">biosynthesis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008562" MajorTopicYN="N">Membrane Glycoproteins</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008969" MajorTopicYN="N">Molecular Sequence Data</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D045473" MajorTopicYN="N">SARS Virus</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D045169" MajorTopicYN="N">Severe Acute Respiratory Syndrome</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D064370" MajorTopicYN="N">Spike Glycoprotein, Coronavirus</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013601" MajorTopicYN="N">T-Lymphocytes</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014759" MajorTopicYN="N">Viral Envelope Proteins</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2004</Year><Month>5</Month><Day>14</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2004</Year><Month>6</Month><Day>21</Day><Hour>10</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2004</Year><Month>5</Month><Day>14</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">15140958</ArticleId><ArticleId IdType="doi">10.1128/JVI.78.11.5612-5618.2004</ArticleId><ArticleId IdType="pii">78/11/5612</ArticleId><ArticleId IdType="pmc">PMC415819</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>J Virol. 2001 Oct;75(20):9741-52</Citation><ArticleIdList><ArticleId IdType="pubmed">11559807</ArticleId></ArticleIdList></Reference><Reference><Citation>Cancer Res. 2001 Jul 1;61(13):5145-52</Citation><ArticleIdList><ArticleId IdType="pubmed">11431353</ArticleId></ArticleIdList></Reference><Reference><Citation>Blood. 2002 May 1;99(9):3360-6</Citation><ArticleIdList><ArticleId IdType="pubmed">11964304</ArticleId></ArticleIdList></Reference><Reference><Citation>J Immunol. 2003 Feb 1;170(3):1191-6</Citation><ArticleIdList><ArticleId IdType="pubmed">12538675</ArticleId></ArticleIdList></Reference><Reference><Citation>J Immunol. 2003 Feb 1;170(3):1291-8</Citation><ArticleIdList><ArticleId IdType="pubmed">12538688</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biomol Struct Dyn. 2003 Apr;20(5):635-44</Citation><ArticleIdList><ArticleId IdType="pubmed">12643766</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Infect Dis. 2003 Apr 15;36(8):985-9</Citation><ArticleIdList><ArticleId IdType="pubmed">12684910</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2003 May;77(9):5464-74</Citation><ArticleIdList><ArticleId IdType="pubmed">12692247</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2003 May 15;348(20):1953-66</Citation><ArticleIdList><ArticleId IdType="pubmed">12690092</ArticleId></ArticleIdList></Reference><Reference><Citation>Virus Res. 2002 Mar 20;84(1-2):135-49</Citation><ArticleIdList><ArticleId IdType="pubmed">11900846</ArticleId></ArticleIdList></Reference><Reference><Citation>Virology. 1992 Nov;191(1):502-5</Citation><ArticleIdList><ArticleId IdType="pubmed">1413524</ArticleId></ArticleIdList></Reference><Reference><Citation>J Immunother Emphasis Tumor Immunol. 1993 Aug;14(2):94-103</Citation><ArticleIdList><ArticleId IdType="pubmed">7506576</ArticleId></ArticleIdList></Reference><Reference><Citation>Adv Exp Med Biol. 1993;342:339-46</Citation><ArticleIdList><ArticleId IdType="pubmed">8209751</ArticleId></ArticleIdList></Reference><Reference><Citation>J Immunol. 1996 May 15;156(10):3882-91</Citation><ArticleIdList><ArticleId IdType="pubmed">8621927</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 1998 Aug;72(8):6511-9</Citation><ArticleIdList><ArticleId IdType="pubmed">9658094</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2003 May 15;348(20):1948-51</Citation><ArticleIdList><ArticleId IdType="pubmed">12748314</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 2003 May 30;300(5624):1394-9</Citation><ArticleIdList><ArticleId IdType="pubmed">12730500</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 2003 May 30;300(5624):1399-404</Citation><ArticleIdList><ArticleId IdType="pubmed">12730501</ArticleId></ArticleIdList></Reference><Reference><Citation>Blood. 2003 Jun 15;101(12):4930-6</Citation><ArticleIdList><ArticleId IdType="pubmed">12576325</ArticleId></ArticleIdList></Reference><Reference><Citation>JAMA. 2003 Jul 16;290(3):374-80</Citation><ArticleIdList><ArticleId IdType="pubmed">12865379</ArticleId></ArticleIdList></Reference><Reference><Citation>Beijing Da Xue Xue Bao. 2003 May 31;35 Suppl:70-1</Citation><ArticleIdList><ArticleId IdType="pubmed">12914223</ArticleId></ArticleIdList></Reference><Reference><Citation>Tissue Antigens. 2003 Oct;62(4):285-95</Citation><ArticleIdList><ArticleId IdType="pubmed">12974795</ArticleId></ArticleIdList></Reference><Reference><Citation>Virology. 1982 Jun;119(2):358-71</Citation><ArticleIdList><ArticleId IdType="pubmed">6281979</ArticleId></ArticleIdList></Reference><Reference><Citation>Curr Top Microbiol Immunol. 1982;99:165-200</Citation><ArticleIdList><ArticleId IdType="pubmed">6178564</ArticleId></ArticleIdList></Reference><Reference><Citation>J Gen Virol. 1983 Apr;64 (Pt 4):761-76</Citation><ArticleIdList><ArticleId IdType="pubmed">6300299</ArticleId></ArticleIdList></Reference><Reference><Citation>Nature. 1990 May 31;345(6274):449-52</Citation><ArticleIdList><ArticleId IdType="pubmed">2342577</ArticleId></ArticleIdList></Reference><Reference><Citation>Immunogenetics. 1999 Nov;50(3-4):213-9</Citation><ArticleIdList><ArticleId IdType="pubmed">10602881</ArticleId></ArticleIdList></Reference><Reference><Citation>Acta Biochim Pol. 2000;47(1):23-35</Citation><ArticleIdList><ArticleId IdType="pubmed">10961675</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><noCountry><name sortKey="Chen, Wei Feng" sort="Chen, Wei Feng" uniqKey="Chen W" first="Wei-Feng" last="Chen">Wei-Feng Chen</name><name sortKey="Cheng, Chak Sum Samuel" sort="Cheng, Chak Sum Samuel" uniqKey="Cheng C" first="Chak-Sum Samuel" last="Cheng">Chak-Sum Samuel Cheng</name><name sortKey="Guo, Zhi Hong" sort="Guo, Zhi Hong" uniqKey="Guo Z" first="Zhi-Hong" last="Guo">Zhi-Hong Guo</name><name sortKey="He, Xiao Yan" sort="He, Xiao Yan" uniqKey="He X" first="Xiao-Yan" last="He">Xiao-Yan He</name><name sortKey="Lai, Sik To" sort="Lai, Sik To" uniqKey="Lai S" first="Sik-To" last="Lai">Sik-To Lai</name><name sortKey="Meng, Li" sort="Meng, Li" uniqKey="Meng L" first="Li" last="Meng">Li Meng</name><name sortKey="Ng, Joice Na Lee" sort="Ng, Joice Na Lee" uniqKey="Ng J" first="Joice Na Lee" last="Ng">Joice Na Lee Ng</name><name sortKey="Pang, Xue Wen" sort="Pang, Xue Wen" uniqKey="Pang X" first="Xue-Wen" last="Pang">Xue-Wen Pang</name><name sortKey="Sin, Wan Yee Fion" sort="Sin, Wan Yee Fion" uniqKey="Sin W" first="Wan-Yee Fion" last="Sin">Wan-Yee Fion Sin</name><name sortKey="Wong, Tin Yau" sort="Wong, Tin Yau" uniqKey="Wong T" first="Tin-Yau" last="Wong">Tin-Yau Wong</name><name sortKey="Xie, Yong" sort="Xie, Yong" uniqKey="Xie Y" first="Yong" last="Xie">Yong Xie</name><name sortKey="Xu, Guo Bing" sort="Xu, Guo Bing" uniqKey="Xu G" first="Guo-Bing" last="Xu">Guo-Bing Xu</name><name sortKey="Yang, Huang Hao" sort="Yang, Huang Hao" uniqKey="Yang H" first="Huang-Hao" last="Yang">Huang-Hao Yang</name><name sortKey="Yang, Huang Hua" sort="Yang, Huang Hua" uniqKey="Yang H" first="Huang-Hua" last="Yang">Huang-Hua Yang</name><name sortKey="Yang, Rui Feng" sort="Yang, Rui Feng" uniqKey="Yang R" first="Rui-Feng" last="Yang">Rui-Feng Yang</name><name sortKey="Yu, Jing" sort="Yu, Jing" uniqKey="Yu J" first="Jing" last="Yu">Jing Yu</name><name sortKey="Zhang, Hua Gang" sort="Zhang, Hua Gang" uniqKey="Zhang H" first="Hua-Gang" last="Zhang">Hua-Gang Zhang</name></noCountry><country name="République populaire de Chine"><noRegion><name sortKey="Wang, Yue Dan" sort="Wang, Yue Dan" uniqKey="Wang Y" first="Yue-Dan" last="Wang">Yue-Dan 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