[Lung pathology and pathogenesis of severe acute respiratory syndrome: a report of six full autopsies].
Identifieur interne : 002361 ( PubMed/Checkpoint ); précédent : 002360; suivant : 002362[Lung pathology and pathogenesis of severe acute respiratory syndrome: a report of six full autopsies].
Auteurs : Fei Pei [République populaire de Chine] ; Jie Zheng ; Zi-Fen Gao ; Yan-Feng Zhong ; Wei-Gang Fang ; En-Cong Gong ; Wan-Zhong Zou ; Sheng-Lan Wang ; Dong-Xia Gao ; Zhi-Gang Xie ; Min Lu ; Xue-Ying Shi ; Cong-Rong Liu ; Jing-Ping Yang ; Yu-Ping Wang ; Zhi-Hui Han ; Xiao-Hong Shi ; Wen-Bin Dao ; Jiang GuSource :
- Zhonghua bing li xue za zhi = Chinese journal of pathology [ 0529-5807 ] ; 2005.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Alvéoles pulmonaires (anatomopathologie), Anticorps monoclonaux (métabolisme), Antigènes CD (métabolisme), Antigènes de différenciation des myélomonocytes (métabolisme), Femelle, Fibrose pulmonaire (anatomopathologie), Fibrose pulmonaire (étiologie), Humains, Kératines (immunologie), Mâle, Poumon (anatomopathologie), Poumon (ultrastructure), Poumon (virologie), Syndrome respiratoire aigu sévère (), Syndrome respiratoire aigu sévère (anatomopathologie), Syndrome respiratoire aigu sévère (métabolisme), Syndrome respiratoire aigu sévère (virologie), Virus du SRAS (isolement et purification), Épithélium (anatomopathologie).
- MESH :
- anatomopathologie : Alvéoles pulmonaires, Fibrose pulmonaire, Poumon, Syndrome respiratoire aigu sévère, Épithélium.
- immunologie : Kératines.
- isolement et purification : Virus du SRAS.
- métabolisme : Anticorps monoclonaux, Antigènes CD, Antigènes de différenciation des myélomonocytes, Syndrome respiratoire aigu sévère.
- virologie : Poumon, Syndrome respiratoire aigu sévère.
- étiologie : Fibrose pulmonaire, Poumon.
- Adulte, Adulte d'âge moyen, Femelle, Humains, Mâle, Syndrome respiratoire aigu sévère.
English descriptors
- KwdEn :
- Adult, Antibodies, Monoclonal (metabolism), Antigens, CD (metabolism), Antigens, Differentiation, Myelomonocytic (metabolism), Epithelium (pathology), Female, Humans, Keratins (immunology), Lung (pathology), Lung (ultrastructure), Lung (virology), Male, Middle Aged, Pulmonary Alveoli (pathology), Pulmonary Fibrosis (etiology), Pulmonary Fibrosis (pathology), SARS Virus (isolation & purification), Severe Acute Respiratory Syndrome (complications), Severe Acute Respiratory Syndrome (metabolism), Severe Acute Respiratory Syndrome (pathology), Severe Acute Respiratory Syndrome (virology).
- MESH :
- chemical , immunology : Keratins.
- chemical , metabolism : Antibodies, Monoclonal, Antigens, CD, Antigens, Differentiation, Myelomonocytic.
- complications : Severe Acute Respiratory Syndrome.
- etiology : Pulmonary Fibrosis.
- isolation & purification : SARS Virus.
- metabolism : Severe Acute Respiratory Syndrome.
- pathology : Epithelium, Lung, Pulmonary Alveoli, Pulmonary Fibrosis, Severe Acute Respiratory Syndrome.
- ultrastructure : Lung.
- virology : Lung, Severe Acute Respiratory Syndrome.
- Adult, Female, Humans, Male, Middle Aged.
Abstract
Severe acute respiratory syndrome (SARS) is an emerging infectious disease that first manifested in humans in November 2002. The SARS-associated coronavirus (SARS-CoV) has been identified as the causal agent, but the pathology and pathogenesis are still not quite clear.
PubMed: 16536279
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wicri:level="3"><nlm:affiliation>Department of Pathology, Peking University Health Science Center, Beijing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Pathology, Peking University Health Science Center, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Zheng, Jie" sort="Zheng, Jie" uniqKey="Zheng J" first="Jie" last="Zheng">Jie Zheng</name></author><author><name sortKey="Gao, Zi Fen" sort="Gao, Zi Fen" uniqKey="Gao Z" first="Zi-Fen" last="Gao">Zi-Fen Gao</name></author><author><name sortKey="Zhong, Yan Feng" sort="Zhong, Yan Feng" uniqKey="Zhong Y" first="Yan-Feng" last="Zhong">Yan-Feng Zhong</name></author><author><name sortKey="Fang, Wei Gang" sort="Fang, Wei Gang" uniqKey="Fang W" first="Wei-Gang" last="Fang">Wei-Gang Fang</name></author><author><name sortKey="Gong, En Cong" sort="Gong, En Cong" uniqKey="Gong E" 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type="published">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Antibodies, Monoclonal (metabolism)</term><term>Antigens, CD (metabolism)</term><term>Antigens, Differentiation, Myelomonocytic (metabolism)</term><term>Epithelium (pathology)</term><term>Female</term><term>Humans</term><term>Keratins (immunology)</term><term>Lung (pathology)</term><term>Lung (ultrastructure)</term><term>Lung (virology)</term><term>Male</term><term>Middle Aged</term><term>Pulmonary Alveoli (pathology)</term><term>Pulmonary Fibrosis (etiology)</term><term>Pulmonary Fibrosis (pathology)</term><term>SARS Virus (isolation & purification)</term><term>Severe Acute Respiratory Syndrome (complications)</term><term>Severe Acute Respiratory Syndrome (metabolism)</term><term>Severe Acute Respiratory Syndrome (pathology)</term><term>Severe Acute Respiratory Syndrome (virology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Alvéoles pulmonaires (anatomopathologie)</term><term>Anticorps monoclonaux (métabolisme)</term><term>Antigènes CD (métabolisme)</term><term>Antigènes de différenciation des myélomonocytes (métabolisme)</term><term>Femelle</term><term>Fibrose pulmonaire (anatomopathologie)</term><term>Fibrose pulmonaire (étiologie)</term><term>Humains</term><term>Kératines (immunologie)</term><term>Mâle</term><term>Poumon (anatomopathologie)</term><term>Poumon (ultrastructure)</term><term>Poumon (virologie)</term><term>Syndrome respiratoire aigu sévère ()</term><term>Syndrome respiratoire aigu sévère (anatomopathologie)</term><term>Syndrome respiratoire aigu sévère (métabolisme)</term><term>Syndrome respiratoire aigu sévère (virologie)</term><term>Virus du SRAS (isolement et purification)</term><term>Épithélium (anatomopathologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Keratins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Antibodies, Monoclonal</term><term>Antigens, CD</term><term>Antigens, Differentiation, Myelomonocytic</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Alvéoles pulmonaires</term><term>Fibrose pulmonaire</term><term>Poumon</term><term>Syndrome respiratoire aigu sévère</term><term>Épithélium</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Pulmonary Fibrosis</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Kératines</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Anticorps monoclonaux</term><term>Antigènes CD</term><term>Antigènes de différenciation des myélomonocytes</term><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Epithelium</term><term>Lung</term><term>Pulmonary Alveoli</term><term>Pulmonary Fibrosis</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="ultrastructure" xml:lang="en"><term>Lung</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Poumon</term><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Lung</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Fibrose pulmonaire</term><term>Poumon</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Syndrome respiratoire aigu sévère</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Severe acute respiratory syndrome (SARS) is an emerging infectious disease that first manifested in humans in November 2002. The SARS-associated coronavirus (SARS-CoV) has been identified as the causal agent, but the pathology and pathogenesis are still not quite clear.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">16536279</PMID><DateCompleted><Year>2007</Year><Month>06</Month><Day>22</Day></DateCompleted><DateRevised><Year>2016</Year><Month>08</Month><Day>18</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0529-5807</ISSN><JournalIssue CitedMedium="Print"><Volume>34</Volume><Issue>10</Issue><PubDate><Year>2005</Year><Month>Oct</Month></PubDate></JournalIssue><Title>Zhonghua bing li xue za zhi = Chinese journal of pathology</Title><ISOAbbreviation>Zhonghua Bing Li Xue Za Zhi</ISOAbbreviation></Journal><ArticleTitle>[Lung pathology and pathogenesis of severe acute respiratory syndrome: a report of six full autopsies].</ArticleTitle><Pagination><MedlinePgn>656-60</MedlinePgn></Pagination><Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">Severe acute respiratory syndrome (SARS) is an emerging infectious disease that first manifested in humans in November 2002. The SARS-associated coronavirus (SARS-CoV) has been identified as the causal agent, but the pathology and pathogenesis are still not quite clear.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Post-mortem lung samples from six patients who died from SARS from April to July 2003 were studied by light and electron microscopy, Masson trichromal staining and immunohistochemistry. Evidence of infection with the SARS-CoV was determined by reverse-transcription PCR (RT-PCR) , serological examination and electron microscopy.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Four of six patients had serological and RT-PCR evidence of recent infection of SARS-CoV. Morphologic changes are summarized as follows: (1) Diffuse and bilateral lung consolidation was seen in all patients (6/6) with increasing lung weight. (2) Diffuse alveolar damage was universal (6/6) with hyaline membrane formation (6/6), intra-alveolar edema/hemorrhage (6/6), fibrin deposition (6/6), pneumocyte desquamation (6/6). A marked disruption in the integrity of the alveolar epithelium was confirmed by immunostaining for the epithelial marker AE1/AE3 (6/6). (3) Type II pneumocytes, with mild hyperplasia, atypia, cytomegaly with granular amphophilic cytoplasm and intracytoplasmic lipid accumulation (5/6). (4) Giant cells in the alveoli were seen in five of 6 patients (5/6) , most of which were positive for the epithelial marker AE1/AE3 (5/6), but some cells were positive for the macrophage marker CD68(2/6). (5) A pronounced increase of macrophages were seen in the alveoli and the interstitium of the lung (6/6), which was confirmed by histological study and immunohistochemistry. (6) Haemophagocytosis was present in five of the 6 patients(5/6). (7) Lung fibrosis was seen in five patients(5/6), with alveolar septa and interstitium thickening(5/6), intraalveolar organizing exudates (6/6) and pleura thickening (4/6). Proliferation of collagen was confirmed by Masson trichromal staining, most of which was type III collagen by immunostaining. The formation of distinctive fibroblast/myofibroblast foci was seen in five patients (5/6) by light microscopy and immunochemistry. (8) Squamous metaplasia of bronchial mucosa was seen in five patients(5/6). (9) Thrombi was seen in all patients(6/6). (10) Accompanying infection was present in two patients, one was bacteria, the other was fungus. In addition, electron microscopy revealed viral particles in the cytoplasm of alveolar epithelial cells and endothelial cells corresponding to coronavirus.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Direct injury of SARS-CoV on alveolar epithelium, prominent macrophage infiltration and distinctive fibroblast/myofibroblast proliferation may play major roles in the pathogenesis of SARS.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Pei</LastName><ForeName>Fei</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Department of Pathology, Peking University Health Science Center, Beijing, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zheng</LastName><ForeName>Jie</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Gao</LastName><ForeName>Zi-fen</ForeName><Initials>ZF</Initials></Author><Author ValidYN="Y"><LastName>Zhong</LastName><ForeName>Yan-feng</ForeName><Initials>YF</Initials></Author><Author ValidYN="Y"><LastName>Fang</LastName><ForeName>Wei-gang</ForeName><Initials>WG</Initials></Author><Author ValidYN="Y"><LastName>Gong</LastName><ForeName>En-cong</ForeName><Initials>EC</Initials></Author><Author ValidYN="Y"><LastName>Zou</LastName><ForeName>Wan-zhong</ForeName><Initials>WZ</Initials></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Sheng-lan</ForeName><Initials>SL</Initials></Author><Author ValidYN="Y"><LastName>Gao</LastName><ForeName>Dong-xia</ForeName><Initials>DX</Initials></Author><Author ValidYN="Y"><LastName>Xie</LastName><ForeName>Zhi-gang</ForeName><Initials>ZG</Initials></Author><Author ValidYN="Y"><LastName>Lu</LastName><ForeName>Min</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Shi</LastName><ForeName>Xue-ying</ForeName><Initials>XY</Initials></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Cong-rong</ForeName><Initials>CR</Initials></Author><Author ValidYN="Y"><LastName>Yang</LastName><ForeName>Jing-ping</ForeName><Initials>JP</Initials></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Yu-ping</ForeName><Initials>YP</Initials></Author><Author ValidYN="Y"><LastName>Han</LastName><ForeName>Zhi-hui</ForeName><Initials>ZH</Initials></Author><Author ValidYN="Y"><LastName>Shi</LastName><ForeName>Xiao-hong</ForeName><Initials>XH</Initials></Author><Author ValidYN="Y"><LastName>Dao</LastName><ForeName>Wen-bin</ForeName><Initials>WB</Initials></Author><Author ValidYN="Y"><LastName>Gu</LastName><ForeName>Jiang</ForeName><Initials>J</Initials></Author></AuthorList><Language>chi</Language><PublicationTypeList><PublicationType UI="D004740">English Abstract</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>China</Country><MedlineTA>Zhonghua Bing Li Xue Za Zhi</MedlineTA><NlmUniqueID>0005331</NlmUniqueID><ISSNLinking>0529-5807</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000911">Antibodies, Monoclonal</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015703">Antigens, CD</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015214">Antigens, Differentiation, Myelomonocytic</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C067980">CD68 antigen, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>68238-35-7</RegistryNumber><NameOfSubstance UI="D007633">Keratins</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000911" MajorTopicYN="N">Antibodies, Monoclonal</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015703" MajorTopicYN="N">Antigens, CD</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015214" MajorTopicYN="N">Antigens, Differentiation, Myelomonocytic</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004848" MajorTopicYN="N">Epithelium</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" 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Fibrosis</DescriptorName><QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D045473" MajorTopicYN="N">SARS Virus</DescriptorName><QualifierName UI="Q000302" MajorTopicYN="Y">isolation & purification</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D045169" MajorTopicYN="N">Severe Acute Respiratory Syndrome</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2006</Year><Month>3</Month><Day>16</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2007</Year><Month>6</Month><Day>23</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2006</Year><Month>3</Month><Day>16</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">16536279</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>République populaire de Chine</li></country><settlement><li>Pékin</li></settlement></list><tree><noCountry><name sortKey="Dao, Wen Bin" sort="Dao, Wen Bin" uniqKey="Dao W" first="Wen-Bin" last="Dao">Wen-Bin Dao</name><name sortKey="Fang, Wei Gang" sort="Fang, Wei Gang" uniqKey="Fang W" first="Wei-Gang" last="Fang">Wei-Gang Fang</name><name sortKey="Gao, Dong Xia" sort="Gao, Dong Xia" uniqKey="Gao D" first="Dong-Xia" last="Gao">Dong-Xia Gao</name><name sortKey="Gao, Zi Fen" sort="Gao, Zi Fen" uniqKey="Gao Z" first="Zi-Fen" last="Gao">Zi-Fen Gao</name><name sortKey="Gong, En Cong" sort="Gong, En Cong" uniqKey="Gong E" first="En-Cong" last="Gong">En-Cong Gong</name><name sortKey="Gu, Jiang" sort="Gu, Jiang" uniqKey="Gu J" first="Jiang" last="Gu">Jiang Gu</name><name sortKey="Han, Zhi Hui" sort="Han, Zhi Hui" uniqKey="Han Z" first="Zhi-Hui" last="Han">Zhi-Hui Han</name><name sortKey="Liu, Cong Rong" sort="Liu, Cong Rong" uniqKey="Liu C" first="Cong-Rong" last="Liu">Cong-Rong Liu</name><name sortKey="Lu, Min" sort="Lu, Min" uniqKey="Lu M" first="Min" last="Lu">Min Lu</name><name sortKey="Shi, Xiao Hong" sort="Shi, Xiao Hong" uniqKey="Shi X" first="Xiao-Hong" last="Shi">Xiao-Hong Shi</name><name sortKey="Shi, Xue Ying" sort="Shi, Xue Ying" uniqKey="Shi X" first="Xue-Ying" last="Shi">Xue-Ying Shi</name><name sortKey="Wang, Sheng Lan" sort="Wang, Sheng Lan" uniqKey="Wang S" first="Sheng-Lan" last="Wang">Sheng-Lan Wang</name><name sortKey="Wang, Yu Ping" sort="Wang, Yu Ping" uniqKey="Wang Y" first="Yu-Ping" last="Wang">Yu-Ping Wang</name><name sortKey="Xie, Zhi Gang" sort="Xie, Zhi Gang" uniqKey="Xie Z" first="Zhi-Gang" last="Xie">Zhi-Gang Xie</name><name sortKey="Yang, Jing Ping" sort="Yang, Jing Ping" uniqKey="Yang J" first="Jing-Ping" last="Yang">Jing-Ping Yang</name><name sortKey="Zheng, Jie" sort="Zheng, Jie" uniqKey="Zheng J" first="Jie" last="Zheng">Jie Zheng</name><name sortKey="Zhong, Yan Feng" sort="Zhong, Yan Feng" uniqKey="Zhong Y" first="Yan-Feng" last="Zhong">Yan-Feng Zhong</name><name sortKey="Zou, Wan Zhong" sort="Zou, Wan Zhong" uniqKey="Zou W" first="Wan-Zhong" last="Zou">Wan-Zhong Zou</name></noCountry><country name="République populaire de Chine"><noRegion><name sortKey="Pei, Fei" sort="Pei, Fei" uniqKey="Pei F" first="Fei" last="Pei">Fei Pei</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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