Protective and pathologic roles of the immune response to mouse hepatitis virus type 1: implications for severe acute respiratory syndrome.
Identifieur interne : 001812 ( PubMed/Checkpoint ); précédent : 001811; suivant : 001813Protective and pathologic roles of the immune response to mouse hepatitis virus type 1: implications for severe acute respiratory syndrome.
Auteurs : Aaruni Khanolkar [États-Unis] ; Stacey M. Hartwig ; Brayton A. Haag ; David K. Meyerholz ; Lecia L. Epping ; Jodie S. Haring ; Steven M. Varga ; John T. HartySource :
- Journal of virology [ 1098-5514 ] ; 2009.
Descripteurs français
- KwdFr :
- Animaux, Cellules tueuses naturelles (immunologie), Cellules tueuses naturelles (virologie), Immunité, Interféron de type I, Lignées consanguines de souris, Lymphocytes T CD4+ (virologie), Lymphocytes T CD8+ (virologie), Réplication virale, Souris, Spécificité d'espèce, Syndrome respiratoire aigu sévère (immunologie), Syndrome respiratoire aigu sévère (étiologie), Système immunitaire (virologie), Virus de l'hépatite murine (immunologie), Virus de l'hépatite murine (pathogénicité).
- MESH :
- immunologie : Cellules tueuses naturelles, Syndrome respiratoire aigu sévère, Virus de l'hépatite murine.
- pathogénicité : Virus de l'hépatite murine.
- virologie : Cellules tueuses naturelles, Lymphocytes T CD4+, Lymphocytes T CD8+, Système immunitaire.
- étiologie : Syndrome respiratoire aigu sévère.
- Animaux, Immunité, Interféron de type I, Lignées consanguines de souris, Réplication virale, Souris, Spécificité d'espèce.
English descriptors
- KwdEn :
- Animals, CD4-Positive T-Lymphocytes (virology), CD8-Positive T-Lymphocytes (virology), Immune System (virology), Immunity, Interferon Type I, Killer Cells, Natural (immunology), Killer Cells, Natural (virology), Mice, Mice, Inbred Strains, Murine hepatitis virus (immunology), Murine hepatitis virus (pathogenicity), Severe Acute Respiratory Syndrome (etiology), Severe Acute Respiratory Syndrome (immunology), Species Specificity, Virus Replication.
- MESH :
- chemical : Interferon Type I.
- etiology : Severe Acute Respiratory Syndrome.
- immunology : Killer Cells, Natural, Murine hepatitis virus, Severe Acute Respiratory Syndrome.
- pathogenicity : Murine hepatitis virus.
- virology : CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes, Immune System, Killer Cells, Natural.
- Animals, Immunity, Mice, Mice, Inbred Strains, Species Specificity, Virus Replication.
Abstract
Intranasal mouse hepatitis virus type 1 (MHV-1) infection of mice induces lung pathology similar to that observed in severe acute respiratory syndrome (SARS) patients. However, the severity of MHV-1-induced pulmonary disease varies among mouse strains, and it has been suggested that differences in the host immune response might account for this variation. It has also been suggested that immunopathology may represent an important clinical feature of SARS. Little is known about the host immune response to MHV-1 and how it might contribute to some of the pathological changes detected in infected mice. In this study we show that an intact type I interferon system and the adaptive immune responses are required for controlling MHV-1 replication and preventing morbidity and mortality in resistant C57BL/6J mice after infection. The NK cell response also helps minimize the severity of illness following MHV-1 infection of C57BL/6J mice. In A/J and C3H/HeJ mice, which are highly susceptible to MHV-1-induced disease, we demonstrate that both CD4 and CD8 T cells contribute to morbidity during primary infection, and memory responses can enhance morbidity and mortality during subsequent reexposure to MHV-1. However, morbidity in A/J and C3H/HeJ mice can be minimized by treating them with immune serum prior to MHV-1 infection. Overall, our findings highlight the role of the host immune response in contributing to the pathogenesis of coronavirus-induced respiratory disease.
DOI: 10.1128/JVI.00355-09
PubMed: 19570864
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
pubmed:19570864Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Protective and pathologic roles of the immune response to mouse hepatitis virus type 1: implications for severe acute respiratory syndrome.</title><author><name sortKey="Khanolkar, Aaruni" sort="Khanolkar, Aaruni" uniqKey="Khanolkar A" first="Aaruni" last="Khanolkar">Aaruni Khanolkar</name><affiliation wicri:level="4"><nlm:affiliation>Department of Microbiology, University of Iowa, Iowa City, 52242, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology, University of Iowa, Iowa City, 52242</wicri:regionArea><orgName type="university">Université de l'Iowa</orgName><placeName><settlement type="city">Iowa City</settlement><region type="state">Iowa</region></placeName></affiliation></author><author><name sortKey="Hartwig, Stacey M" sort="Hartwig, Stacey M" uniqKey="Hartwig S" first="Stacey M" last="Hartwig">Stacey M. Hartwig</name></author><author><name sortKey="Haag, Brayton A" sort="Haag, Brayton A" uniqKey="Haag B" first="Brayton A" last="Haag">Brayton A. Haag</name></author><author><name sortKey="Meyerholz, David K" sort="Meyerholz, David K" uniqKey="Meyerholz D" first="David K" last="Meyerholz">David K. Meyerholz</name></author><author><name sortKey="Epping, Lecia L" sort="Epping, Lecia L" uniqKey="Epping L" first="Lecia L" last="Epping">Lecia L. Epping</name></author><author><name sortKey="Haring, Jodie S" sort="Haring, Jodie S" uniqKey="Haring J" first="Jodie S" last="Haring">Jodie S. Haring</name></author><author><name sortKey="Varga, Steven M" sort="Varga, Steven M" uniqKey="Varga S" first="Steven M" last="Varga">Steven M. Varga</name></author><author><name sortKey="Harty, John T" sort="Harty, John T" uniqKey="Harty J" first="John T" last="Harty">John T. Harty</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2009">2009</date><idno type="RBID">pubmed:19570864</idno><idno type="pmid">19570864</idno><idno type="doi">10.1128/JVI.00355-09</idno><idno type="wicri:Area/PubMed/Corpus">001869</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001869</idno><idno type="wicri:Area/PubMed/Curation">001869</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001869</idno><idno type="wicri:Area/PubMed/Checkpoint">001812</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001812</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Protective and pathologic roles of the immune response to mouse hepatitis virus type 1: implications for severe acute respiratory syndrome.</title><author><name sortKey="Khanolkar, Aaruni" sort="Khanolkar, Aaruni" uniqKey="Khanolkar A" first="Aaruni" last="Khanolkar">Aaruni Khanolkar</name><affiliation wicri:level="4"><nlm:affiliation>Department of Microbiology, University of Iowa, Iowa City, 52242, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology, University of Iowa, Iowa City, 52242</wicri:regionArea><orgName type="university">Université de l'Iowa</orgName><placeName><settlement type="city">Iowa City</settlement><region type="state">Iowa</region></placeName></affiliation></author><author><name sortKey="Hartwig, Stacey M" sort="Hartwig, Stacey M" uniqKey="Hartwig S" first="Stacey M" last="Hartwig">Stacey M. Hartwig</name></author><author><name sortKey="Haag, Brayton A" sort="Haag, Brayton A" uniqKey="Haag B" first="Brayton A" last="Haag">Brayton A. Haag</name></author><author><name sortKey="Meyerholz, David K" sort="Meyerholz, David K" uniqKey="Meyerholz D" first="David K" last="Meyerholz">David K. Meyerholz</name></author><author><name sortKey="Epping, Lecia L" sort="Epping, Lecia L" uniqKey="Epping L" first="Lecia L" last="Epping">Lecia L. Epping</name></author><author><name sortKey="Haring, Jodie S" sort="Haring, Jodie S" uniqKey="Haring J" first="Jodie S" last="Haring">Jodie S. Haring</name></author><author><name sortKey="Varga, Steven M" sort="Varga, Steven M" uniqKey="Varga S" first="Steven M" last="Varga">Steven M. Varga</name></author><author><name sortKey="Harty, John T" sort="Harty, John T" uniqKey="Harty J" first="John T" last="Harty">John T. Harty</name></author></analytic><series><title level="j">Journal of virology</title><idno type="eISSN">1098-5514</idno><imprint><date when="2009" type="published">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>CD4-Positive T-Lymphocytes (virology)</term><term>CD8-Positive T-Lymphocytes (virology)</term><term>Immune System (virology)</term><term>Immunity</term><term>Interferon Type I</term><term>Killer Cells, Natural (immunology)</term><term>Killer Cells, Natural (virology)</term><term>Mice</term><term>Mice, Inbred Strains</term><term>Murine hepatitis virus (immunology)</term><term>Murine hepatitis virus (pathogenicity)</term><term>Severe Acute Respiratory Syndrome (etiology)</term><term>Severe Acute Respiratory Syndrome (immunology)</term><term>Species Specificity</term><term>Virus Replication</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Cellules tueuses naturelles (immunologie)</term><term>Cellules tueuses naturelles (virologie)</term><term>Immunité</term><term>Interféron de type I</term><term>Lignées consanguines de souris</term><term>Lymphocytes T CD4+ (virologie)</term><term>Lymphocytes T CD8+ (virologie)</term><term>Réplication virale</term><term>Souris</term><term>Spécificité d'espèce</term><term>Syndrome respiratoire aigu sévère (immunologie)</term><term>Syndrome respiratoire aigu sévère (étiologie)</term><term>Système immunitaire (virologie)</term><term>Virus de l'hépatite murine (immunologie)</term><term>Virus de l'hépatite murine (pathogénicité)</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Interferon Type I</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Cellules tueuses naturelles</term><term>Syndrome respiratoire aigu sévère</term><term>Virus de l'hépatite murine</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Killer Cells, Natural</term><term>Murine hepatitis virus</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Murine hepatitis virus</term></keywords><keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Virus de l'hépatite murine</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Cellules tueuses naturelles</term><term>Lymphocytes T CD4+</term><term>Lymphocytes T CD8+</term><term>Système immunitaire</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>CD4-Positive T-Lymphocytes</term><term>CD8-Positive T-Lymphocytes</term><term>Immune System</term><term>Killer Cells, Natural</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Immunity</term><term>Mice</term><term>Mice, Inbred Strains</term><term>Species Specificity</term><term>Virus Replication</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Immunité</term><term>Interféron de type I</term><term>Lignées consanguines de souris</term><term>Réplication virale</term><term>Souris</term><term>Spécificité d'espèce</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Intranasal mouse hepatitis virus type 1 (MHV-1) infection of mice induces lung pathology similar to that observed in severe acute respiratory syndrome (SARS) patients. However, the severity of MHV-1-induced pulmonary disease varies among mouse strains, and it has been suggested that differences in the host immune response might account for this variation. It has also been suggested that immunopathology may represent an important clinical feature of SARS. Little is known about the host immune response to MHV-1 and how it might contribute to some of the pathological changes detected in infected mice. In this study we show that an intact type I interferon system and the adaptive immune responses are required for controlling MHV-1 replication and preventing morbidity and mortality in resistant C57BL/6J mice after infection. The NK cell response also helps minimize the severity of illness following MHV-1 infection of C57BL/6J mice. In A/J and C3H/HeJ mice, which are highly susceptible to MHV-1-induced disease, we demonstrate that both CD4 and CD8 T cells contribute to morbidity during primary infection, and memory responses can enhance morbidity and mortality during subsequent reexposure to MHV-1. However, morbidity in A/J and C3H/HeJ mice can be minimized by treating them with immune serum prior to MHV-1 infection. Overall, our findings highlight the role of the host immune response in contributing to the pathogenesis of coronavirus-induced respiratory disease.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">19570864</PMID><DateCompleted><Year>2009</Year><Month>10</Month><Day>02</Day></DateCompleted><DateRevised><Year>2018</Year><Month>11</Month><Day>13</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1098-5514</ISSN><JournalIssue CitedMedium="Internet"><Volume>83</Volume><Issue>18</Issue><PubDate><Year>2009</Year><Month>Sep</Month></PubDate></JournalIssue><Title>Journal of virology</Title><ISOAbbreviation>J. Virol.</ISOAbbreviation></Journal><ArticleTitle>Protective and pathologic roles of the immune response to mouse hepatitis virus type 1: implications for severe acute respiratory syndrome.</ArticleTitle><Pagination><MedlinePgn>9258-72</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1128/JVI.00355-09</ELocationID><Abstract><AbstractText>Intranasal mouse hepatitis virus type 1 (MHV-1) infection of mice induces lung pathology similar to that observed in severe acute respiratory syndrome (SARS) patients. However, the severity of MHV-1-induced pulmonary disease varies among mouse strains, and it has been suggested that differences in the host immune response might account for this variation. It has also been suggested that immunopathology may represent an important clinical feature of SARS. Little is known about the host immune response to MHV-1 and how it might contribute to some of the pathological changes detected in infected mice. In this study we show that an intact type I interferon system and the adaptive immune responses are required for controlling MHV-1 replication and preventing morbidity and mortality in resistant C57BL/6J mice after infection. The NK cell response also helps minimize the severity of illness following MHV-1 infection of C57BL/6J mice. In A/J and C3H/HeJ mice, which are highly susceptible to MHV-1-induced disease, we demonstrate that both CD4 and CD8 T cells contribute to morbidity during primary infection, and memory responses can enhance morbidity and mortality during subsequent reexposure to MHV-1. However, morbidity in A/J and C3H/HeJ mice can be minimized by treating them with immune serum prior to MHV-1 infection. Overall, our findings highlight the role of the host immune response in contributing to the pathogenesis of coronavirus-induced respiratory disease.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Khanolkar</LastName><ForeName>Aaruni</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Microbiology, University of Iowa, Iowa City, 52242, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hartwig</LastName><ForeName>Stacey M</ForeName><Initials>SM</Initials></Author><Author ValidYN="Y"><LastName>Haag</LastName><ForeName>Brayton A</ForeName><Initials>BA</Initials></Author><Author ValidYN="Y"><LastName>Meyerholz</LastName><ForeName>David K</ForeName><Initials>DK</Initials></Author><Author ValidYN="Y"><LastName>Epping</LastName><ForeName>Lecia L</ForeName><Initials>LL</Initials></Author><Author ValidYN="Y"><LastName>Haring</LastName><ForeName>Jodie S</ForeName><Initials>JS</Initials></Author><Author ValidYN="Y"><LastName>Varga</LastName><ForeName>Steven M</ForeName><Initials>SM</Initials></Author><Author ValidYN="Y"><LastName>Harty</LastName><ForeName>John T</ForeName><Initials>JT</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>P01 AI060699</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P01 AI-060699</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2009</Year><Month>07</Month><Day>01</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Virol</MedlineTA><NlmUniqueID>0113724</NlmUniqueID><ISSNLinking>0022-538X</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007370">Interferon Type I</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015496" MajorTopicYN="N">CD4-Positive T-Lymphocytes</DescriptorName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018414" MajorTopicYN="N">CD8-Positive T-Lymphocytes</DescriptorName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007107" MajorTopicYN="N">Immune System</DescriptorName><QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007109" MajorTopicYN="Y">Immunity</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007370" MajorTopicYN="N">Interferon Type I</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007694" MajorTopicYN="N">Killer Cells, Natural</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008815" MajorTopicYN="N">Mice, Inbred Strains</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006517" MajorTopicYN="N">Murine hepatitis virus</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName><QualifierName UI="Q000472" MajorTopicYN="Y">pathogenicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D045169" MajorTopicYN="N">Severe Acute Respiratory Syndrome</DescriptorName><QualifierName UI="Q000209" MajorTopicYN="Y">etiology</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013045" MajorTopicYN="N">Species Specificity</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014779" MajorTopicYN="N">Virus Replication</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2009</Year><Month>7</Month><Day>3</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2009</Year><Month>7</Month><Day>3</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2009</Year><Month>10</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">19570864</ArticleId><ArticleId IdType="pii">JVI.00355-09</ArticleId><ArticleId IdType="doi">10.1128/JVI.00355-09</ArticleId><ArticleId IdType="pmc">PMC2738266</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>Int J Cancer. 1983 Mar 15;31(3):309-14</Citation><ArticleIdList><ArticleId IdType="pubmed">6186617</ArticleId></ArticleIdList></Reference><Reference><Citation>J Natl Cancer Inst. 1985 Nov;75(5):917-23</Citation><ArticleIdList><ArticleId IdType="pubmed">2997536</ArticleId></ArticleIdList></Reference><Reference><Citation>Microb Pathog. 1987 Mar;2(3):185-94</Citation><ArticleIdList><ArticleId IdType="pubmed">2853274</ArticleId></ArticleIdList></Reference><Reference><Citation>J Neuroimmunol. 1991 Jun;32(3):199-207</Citation><ArticleIdList><ArticleId IdType="pubmed">1851765</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell. 1992 Mar 6;68(5):869-77</Citation><ArticleIdList><ArticleId IdType="pubmed">1547488</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 1994 Jun 24;264(5167):1918-21</Citation><ArticleIdList><ArticleId IdType="pubmed">8009221</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 1995 Feb 17;267(5200):978-9</Citation><ArticleIdList><ArticleId IdType="pubmed">7863341</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 1996 Jul;70(7):4683-90</Citation><ArticleIdList><ArticleId IdType="pubmed">8676494</ArticleId></ArticleIdList></Reference><Reference><Citation>J Neurovirol. 1996 Apr;2(2):101-10</Citation><ArticleIdList><ArticleId IdType="pubmed">8799201</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 1997 Jan;71(1):383-91</Citation><ArticleIdList><ArticleId IdType="pubmed">8985361</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 1997 Jun 10;94(12):6319-23</Citation><ArticleIdList><ArticleId IdType="pubmed">9177215</ArticleId></ArticleIdList></Reference><Reference><Citation>Curr Opin Immunol. 1997 Apr;9(2):239-44</Citation><ArticleIdList><ArticleId IdType="pubmed">9099791</ArticleId></ArticleIdList></Reference><Reference><Citation>J Immunol. 1999 Feb 1;162(3):1641-7</Citation><ArticleIdList><ArticleId IdType="pubmed">9973424</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Med. 2004 Dec;10(12 Suppl):S88-97</Citation><ArticleIdList><ArticleId IdType="pubmed">15577937</ArticleId></ArticleIdList></Reference><Reference><Citation>BMC Immunol. 2005;6:2</Citation><ArticleIdList><ArticleId IdType="pubmed">15655079</ArticleId></ArticleIdList></Reference><Reference><Citation>Annu Rev Immunol. 2002;20:551-79</Citation><ArticleIdList><ArticleId IdType="pubmed">11861612</ArticleId></ArticleIdList></Reference><Reference><Citation>Curr Opin Immunol. 2002 Aug;14(4):523-36</Citation><ArticleIdList><ArticleId IdType="pubmed">12088689</ArticleId></ArticleIdList></Reference><Reference><Citation>Immunol Res. 2002;26(1-3):309-21</Citation><ArticleIdList><ArticleId IdType="pubmed">12403369</ArticleId></ArticleIdList></Reference><Reference><Citation>Am J Respir Crit Care Med. 2003 Jan 15;167(2):103-4</Citation><ArticleIdList><ArticleId IdType="pubmed">12524246</ArticleId></ArticleIdList></Reference><Reference><Citation>Immunity. 2003 Apr;18(4):463-74</Citation><ArticleIdList><ArticleId IdType="pubmed">12705850</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2003 May 15;348(20):1995-2005</Citation><ArticleIdList><ArticleId IdType="pubmed">12671061</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2003 May 15;348(20):1986-94</Citation><ArticleIdList><ArticleId IdType="pubmed">12682352</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2003 May 15;348(20):1953-66</Citation><ArticleIdList><ArticleId IdType="pubmed">12690092</ArticleId></ArticleIdList></Reference><Reference><Citation>Nature. 2003 May 15;423(6937):240</Citation><ArticleIdList><ArticleId IdType="pubmed">12748632</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet. 2003 May 17;361(9370):1730-3</Citation><ArticleIdList><ArticleId IdType="pubmed">12767752</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 2003 May 30;300(5624):1394-9</Citation><ArticleIdList><ArticleId IdType="pubmed">12730500</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 2003 May 30;300(5624):1399-404</Citation><ArticleIdList><ArticleId IdType="pubmed">12730501</ArticleId></ArticleIdList></Reference><Reference><Citation>J Med Microbiol. 2003 Aug;52(Pt 8):715-20</Citation><ArticleIdList><ArticleId IdType="pubmed">12867568</ArticleId></ArticleIdList></Reference><Reference><Citation>J Gen Virol. 2003 Sep;84(Pt 9):2305-15</Citation><ArticleIdList><ArticleId IdType="pubmed">12917450</ArticleId></ArticleIdList></Reference><Reference><Citation>J Mol Biol. 2003 Aug 29;331(5):991-1004</Citation><ArticleIdList><ArticleId IdType="pubmed">12927536</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet. 2003 Oct 25;362(9393):1353-8</Citation><ArticleIdList><ArticleId IdType="pubmed">14585636</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2004 Jan;78(2):585-94</Citation><ArticleIdList><ArticleId IdType="pubmed">14694090</ArticleId></ArticleIdList></Reference><Reference><Citation>JAMA. 2003 Dec 24;290(24):3222-8</Citation><ArticleIdList><ArticleId IdType="pubmed">14693875</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2004 Feb;78(4):1739-50</Citation><ArticleIdList><ArticleId IdType="pubmed">14747539</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Exp Immunol. 2004 Mar;135(3):467-73</Citation><ArticleIdList><ArticleId IdType="pubmed">15008980</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Exp Immunol. 2004 Apr;136(1):95-103</Citation><ArticleIdList><ArticleId IdType="pubmed">15030519</ArticleId></ArticleIdList></Reference><Reference><Citation>Nature. 2004 Apr 1;428(6982):561-4</Citation><ArticleIdList><ArticleId IdType="pubmed">15024391</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2004 May;78(10):5486-90</Citation><ArticleIdList><ArticleId IdType="pubmed">15113927</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2005 Mar;79(5):2678-88</Citation><ArticleIdList><ArticleId IdType="pubmed">15708987</ArticleId></ArticleIdList></Reference><Reference><Citation>Am J Pathol. 2005 Mar;166(3):801-9</Citation><ArticleIdList><ArticleId IdType="pubmed">15743792</ArticleId></ArticleIdList></Reference><Reference><Citation>Virology. 2005 Apr 25;335(1):34-45</Citation><ArticleIdList><ArticleId IdType="pubmed">15823604</ArticleId></ArticleIdList></Reference><Reference><Citation>Adv Exp Med Biol. 2005;560:57-61</Citation><ArticleIdList><ArticleId IdType="pubmed">15932020</ArticleId></ArticleIdList></Reference><Reference><Citation>Immunol Res. 2005;32(1-3):317-25</Citation><ArticleIdList><ArticleId IdType="pubmed">16106081</ArticleId></ArticleIdList></Reference><Reference><Citation>World J Gastroenterol. 2005 Aug 28;11(32):5037-43</Citation><ArticleIdList><ArticleId IdType="pubmed">16124062</ArticleId></ArticleIdList></Reference><Reference><Citation>J Exp Med. 2005 Sep 5;202(5):637-50</Citation><ArticleIdList><ArticleId IdType="pubmed">16129706</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2005 Nov;79(22):13915-23</Citation><ArticleIdList><ArticleId IdType="pubmed">16254327</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2005 Nov;79(22):13974-83</Citation><ArticleIdList><ArticleId IdType="pubmed">16254333</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 2005 Oct 28;310(5748):676-9</Citation><ArticleIdList><ArticleId IdType="pubmed">16195424</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Rev Immunol. 2005 Dec;5(12):917-27</Citation><ArticleIdList><ArticleId IdType="pubmed">16322745</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2006 Mar;80(5):2506-14</Citation><ArticleIdList><ArticleId IdType="pubmed">16474157</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2006 Jun;80(12):5757-67</Citation><ArticleIdList><ArticleId IdType="pubmed">16731915</ArticleId></ArticleIdList></Reference><Reference><Citation>Vaccine. 2006 Jun 5;24(23):4905-13</Citation><ArticleIdList><ArticleId IdType="pubmed">16621188</ArticleId></ArticleIdList></Reference><Reference><Citation>Immunol Rev. 2006 Jun;211:67-80</Citation><ArticleIdList><ArticleId IdType="pubmed">16824118</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Immunol. 2006 Aug;120(2):171-8</Citation><ArticleIdList><ArticleId IdType="pubmed">16781892</ArticleId></ArticleIdList></Reference><Reference><Citation>Virology. 2006 Aug 1;351(2):466-75</Citation><ArticleIdList><ArticleId IdType="pubmed">16690096</ArticleId></ArticleIdList></Reference><Reference><Citation>Virology. 2006 Sep 15;353(1):6-16</Citation><ArticleIdList><ArticleId IdType="pubmed">16793110</ArticleId></ArticleIdList></Reference><Reference><Citation>Microbes Infect. 2006 Aug;8(9-10):2424-31</Citation><ArticleIdList><ArticleId IdType="pubmed">16844400</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2006 Nov;80(21):10382-94</Citation><ArticleIdList><ArticleId IdType="pubmed">17041219</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2007 Jan;81(2):568-74</Citation><ArticleIdList><ArticleId IdType="pubmed">17079305</ArticleId></ArticleIdList></Reference><Reference><Citation>Blood. 2007 Feb 1;109(3):1131-7</Citation><ArticleIdList><ArticleId IdType="pubmed">16985170</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 2007 Jan 23;104(4):1371-6</Citation><ArticleIdList><ArticleId IdType="pubmed">17227866</ArticleId></ArticleIdList></Reference><Reference><Citation>Immunol Cell Biol. 2007 Feb-Mar;85(2):85-92</Citation><ArticleIdList><ArticleId IdType="pubmed">17213831</ArticleId></ArticleIdList></Reference><Reference><Citation>Immunity. 2007 Apr;26(4):503-17</Citation><ArticleIdList><ArticleId IdType="pubmed">17398124</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS Pathog. 2007 Jan;3(1):e5</Citation><ArticleIdList><ArticleId IdType="pubmed">17222058</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2007 Aug;81(16):8692-706</Citation><ArticleIdList><ArticleId IdType="pubmed">17537853</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2007 Sep;81(18):9812-24</Citation><ArticleIdList><ArticleId IdType="pubmed">17596301</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS Pathog. 2007 Aug 10;3(8):e112</Citation><ArticleIdList><ArticleId IdType="pubmed">17696609</ArticleId></ArticleIdList></Reference><Reference><Citation>Vaccine. 2007 Sep 28;25(39-40):6981-91</Citation><ArticleIdList><ArticleId IdType="pubmed">17709158</ArticleId></ArticleIdList></Reference><Reference><Citation>J Immunol Methods. 2007 Oct 31;327(1-2):63-74</Citation><ArticleIdList><ArticleId IdType="pubmed">17716680</ArticleId></ArticleIdList></Reference><Reference><Citation>Immunol Res. 2007;39(1-3):94-104</Citation><ArticleIdList><ArticleId IdType="pubmed">17917058</ArticleId></ArticleIdList></Reference><Reference><Citation>Immunology. 2007 Dec;122(4):496-502</Citation><ArticleIdList><ArticleId IdType="pubmed">17680799</ArticleId></ArticleIdList></Reference><Reference><Citation>J Immunol. 2008 Jan 15;180(2):948-56</Citation><ArticleIdList><ArticleId IdType="pubmed">18178835</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2008 Mar;82(6):3021-30</Citation><ArticleIdList><ArticleId IdType="pubmed">18094157</ArticleId></ArticleIdList></Reference><Reference><Citation>Virus Res. 2008 Apr;133(1):20-32</Citation><ArticleIdList><ArticleId IdType="pubmed">17499378</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Immunol. 2008 May;9(5):477-80</Citation><ArticleIdList><ArticleId IdType="pubmed">18425103</ArticleId></ArticleIdList></Reference><Reference><Citation>Am J Pathol. 2008 Jun;172(6):1625-37</Citation><ArticleIdList><ArticleId IdType="pubmed">18467696</ArticleId></ArticleIdList></Reference><Reference><Citation>Immunol Lett. 2008 Aug 15;119(1-2):71-7</Citation><ArticleIdList><ArticleId IdType="pubmed">18533276</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2009 Sep;83(17):8946-56</Citation><ArticleIdList><ArticleId IdType="pubmed">19553337</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2003 May 15;348(20):1948-51</Citation><ArticleIdList><ArticleId IdType="pubmed">12748314</ArticleId></ArticleIdList></Reference><Reference><Citation>Annu Rev Immunol. 2000;18:275-308</Citation><ArticleIdList><ArticleId IdType="pubmed">10837060</ArticleId></ArticleIdList></Reference><Reference><Citation>J Immunol. 2000 Aug 15;165(4):2278-86</Citation><ArticleIdList><ArticleId IdType="pubmed">10925317</ArticleId></ArticleIdList></Reference><Reference><Citation>Annu Rev Immunol. 2001;19:65-91</Citation><ArticleIdList><ArticleId IdType="pubmed">11244031</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 2004 Apr 27;101(17):6641-6</Citation><ArticleIdList><ArticleId IdType="pubmed">15096611</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet. 2004 Jun 26;363(9427):2122-7</Citation><ArticleIdList><ArticleId IdType="pubmed">15220033</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 2004 Jun 29;101(26):9804-9</Citation><ArticleIdList><ArticleId IdType="pubmed">15210961</ArticleId></ArticleIdList></Reference><Reference><Citation>Infect Immun. 2004 Aug;72(8):4410-5</Citation><ArticleIdList><ArticleId IdType="pubmed">15271897</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Infect Dis. 2004 Oct 1;39(7):1071-5</Citation><ArticleIdList><ArticleId IdType="pubmed">15472864</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>États-Unis</li></country><region><li>Iowa</li></region><settlement><li>Iowa City</li></settlement><orgName><li>Université de l'Iowa</li></orgName></list><tree><noCountry><name sortKey="Epping, Lecia L" sort="Epping, Lecia L" uniqKey="Epping L" first="Lecia L" last="Epping">Lecia L. Epping</name><name sortKey="Haag, Brayton A" sort="Haag, Brayton A" uniqKey="Haag B" first="Brayton A" last="Haag">Brayton A. Haag</name><name sortKey="Haring, Jodie S" sort="Haring, Jodie S" uniqKey="Haring J" first="Jodie S" last="Haring">Jodie S. Haring</name><name sortKey="Hartwig, Stacey M" sort="Hartwig, Stacey M" uniqKey="Hartwig S" first="Stacey M" last="Hartwig">Stacey M. Hartwig</name><name sortKey="Harty, John T" sort="Harty, John T" uniqKey="Harty J" first="John T" last="Harty">John T. Harty</name><name sortKey="Meyerholz, David K" sort="Meyerholz, David K" uniqKey="Meyerholz D" first="David K" last="Meyerholz">David K. Meyerholz</name><name sortKey="Varga, Steven M" sort="Varga, Steven M" uniqKey="Varga S" first="Steven M" last="Varga">Steven M. Varga</name></noCountry><country name="États-Unis"><region name="Iowa"><name sortKey="Khanolkar, Aaruni" sort="Khanolkar, Aaruni" uniqKey="Khanolkar A" first="Aaruni" last="Khanolkar">Aaruni Khanolkar</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/PubMed/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001812 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd -nk 001812 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= SrasV1
|flux= PubMed
|étape= Checkpoint
|type= RBID
|clé= pubmed:19570864
|texte= Protective and pathologic roles of the immune response to mouse hepatitis virus type 1: implications for severe acute respiratory syndrome.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/RBID.i -Sk "pubmed:19570864" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd \
| NlmPubMed2Wicri -a SrasV1
| This area was generated with Dilib version V0.6.33. |  |