Host and viral ecology determine bat rabies seasonality and maintenance.
Identifieur interne : 001493 ( PubMed/Checkpoint ); précédent : 001492; suivant : 001494Host and viral ecology determine bat rabies seasonality and maintenance.
Auteurs : Dylan B. George [États-Unis] ; Colleen T. Webb ; Matthew L. Farnsworth ; Thomas J. O'Shea ; Richard A. Bowen ; David L. Smith ; Thomas R. Stanley ; Laura E. Ellison ; Charles E. RupprechtSource :
- Proceedings of the National Academy of Sciences of the United States of America [ 1091-6490 ] ; 2011.
Descripteurs français
- KwdFr :
- MESH :
- virologie : Chiroptera, Rage (maladie), Ratons laveurs, Renards, Zoonoses.
- épidémiologie : Colorado, Rage (maladie), Zoonoses.
- Animaux, Modèles théoriques, Vecteurs de maladie, Écologie.
English descriptors
- KwdEn :
- MESH :
- geographic , epidemiology : Colorado.
- epidemiology : Rabies, Zoonoses.
- transmission : Zoonoses.
- virology : Chiroptera, Foxes, Rabies, Raccoons, Zoonoses.
- Animals, Disease Vectors, Ecology, Models, Theoretical.
Abstract
Rabies is an acute viral infection that is typically fatal. Most rabies modeling has focused on disease dynamics and control within terrestrial mammals (e.g., raccoons and foxes). As such, rabies in bats has been largely neglected until recently. Because bats have been implicated as natural reservoirs for several emerging zoonotic viruses, including SARS-like corona viruses, henipaviruses, and lyssaviruses, understanding how pathogens are maintained within a population becomes vital. Unfortunately, little is known about maintenance mechanisms for any pathogen in bat populations. We present a mathematical model parameterized with unique data from an extensive study of rabies in a Colorado population of big brown bats (Eptesicus fuscus) to elucidate general maintenance mechanisms. We propose that life history patterns of many species of temperate-zone bats, coupled with sufficiently long incubation periods, allows for rabies virus maintenance. Seasonal variability in bat mortality rates, specifically low mortality during hibernation, allows long-term bat population viability. Within viable bat populations, sufficiently long incubation periods allow enough infected individuals to enter hibernation and survive until the following year, and hence avoid an epizootic fadeout of rabies virus. We hypothesize that the slowing effects of hibernation on metabolic and viral activity maintains infected individuals and their pathogens until susceptibles from the annual birth pulse become infected and continue the cycle. This research provides a context to explore similar host ecology and viral dynamics that may explain seasonal patterns and maintenance of other bat-borne diseases.
DOI: 10.1073/pnas.1010875108
PubMed: 21646516
Affiliations:
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Farnsworth</name></author><author><name sortKey="O Shea, Thomas J" sort="O Shea, Thomas J" uniqKey="O Shea T" first="Thomas J" last="O'Shea">Thomas J. O'Shea</name></author><author><name sortKey="Bowen, Richard A" sort="Bowen, Richard A" uniqKey="Bowen R" first="Richard A" last="Bowen">Richard A. Bowen</name></author><author><name sortKey="Smith, David L" sort="Smith, David L" uniqKey="Smith D" first="David L" last="Smith">David L. Smith</name></author><author><name sortKey="Stanley, Thomas R" sort="Stanley, Thomas R" uniqKey="Stanley T" first="Thomas R" last="Stanley">Thomas R. Stanley</name></author><author><name sortKey="Ellison, Laura E" sort="Ellison, Laura E" uniqKey="Ellison L" first="Laura E" last="Ellison">Laura E. Ellison</name></author><author><name sortKey="Rupprecht, Charles E" sort="Rupprecht, Charles E" uniqKey="Rupprecht C" first="Charles E" last="Rupprecht">Charles E. 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George</name><affiliation wicri:level="2"><nlm:affiliation>Department of Biology, Colorado State University, Fort Collins, CO 80523, USA. dylangeorge@gmail.com</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biology, Colorado State University, Fort Collins, CO 80523</wicri:regionArea><placeName><region type="state">Colorado</region></placeName></affiliation></author><author><name sortKey="Webb, Colleen T" sort="Webb, Colleen T" uniqKey="Webb C" first="Colleen T" last="Webb">Colleen T. Webb</name></author><author><name sortKey="Farnsworth, Matthew L" sort="Farnsworth, Matthew L" uniqKey="Farnsworth M" first="Matthew L" last="Farnsworth">Matthew L. Farnsworth</name></author><author><name sortKey="O Shea, Thomas J" sort="O Shea, Thomas J" uniqKey="O Shea T" first="Thomas J" last="O'Shea">Thomas J. O'Shea</name></author><author><name sortKey="Bowen, Richard A" sort="Bowen, Richard A" uniqKey="Bowen R" first="Richard A" last="Bowen">Richard A. Bowen</name></author><author><name sortKey="Smith, David L" sort="Smith, David L" uniqKey="Smith D" first="David L" last="Smith">David L. Smith</name></author><author><name sortKey="Stanley, Thomas R" sort="Stanley, Thomas R" uniqKey="Stanley T" first="Thomas R" last="Stanley">Thomas R. Stanley</name></author><author><name sortKey="Ellison, Laura E" sort="Ellison, Laura E" uniqKey="Ellison L" first="Laura E" last="Ellison">Laura E. Ellison</name></author><author><name sortKey="Rupprecht, Charles E" sort="Rupprecht, Charles E" uniqKey="Rupprecht C" first="Charles E" last="Rupprecht">Charles E. Rupprecht</name></author></analytic><series><title level="j">Proceedings of the National Academy of Sciences of the United States of America</title><idno type="eISSN">1091-6490</idno><imprint><date when="2011" type="published">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Chiroptera (virology)</term><term>Colorado (epidemiology)</term><term>Disease Vectors</term><term>Ecology</term><term>Foxes (virology)</term><term>Models, Theoretical</term><term>Rabies (epidemiology)</term><term>Rabies (virology)</term><term>Raccoons (virology)</term><term>Zoonoses (epidemiology)</term><term>Zoonoses (transmission)</term><term>Zoonoses (virology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Chiroptera (virologie)</term><term>Colorado (épidémiologie)</term><term>Modèles théoriques</term><term>Rage (maladie) (virologie)</term><term>Rage (maladie) (épidémiologie)</term><term>Ratons laveurs (virologie)</term><term>Renards (virologie)</term><term>Vecteurs de maladie</term><term>Zoonoses (transmission)</term><term>Zoonoses (virologie)</term><term>Zoonoses (épidémiologie)</term><term>Écologie</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Colorado</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Rabies</term><term>Zoonoses</term></keywords><keywords scheme="MESH" qualifier="transmission" xml:lang="en"><term>Zoonoses</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Chiroptera</term><term>Rage (maladie)</term><term>Ratons laveurs</term><term>Renards</term><term>Zoonoses</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Chiroptera</term><term>Foxes</term><term>Rabies</term><term>Raccoons</term><term>Zoonoses</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Colorado</term><term>Rage (maladie)</term><term>Zoonoses</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Disease Vectors</term><term>Ecology</term><term>Models, Theoretical</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Modèles théoriques</term><term>Vecteurs de maladie</term><term>Écologie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Rabies is an acute viral infection that is typically fatal. Most rabies modeling has focused on disease dynamics and control within terrestrial mammals (e.g., raccoons and foxes). As such, rabies in bats has been largely neglected until recently. Because bats have been implicated as natural reservoirs for several emerging zoonotic viruses, including SARS-like corona viruses, henipaviruses, and lyssaviruses, understanding how pathogens are maintained within a population becomes vital. Unfortunately, little is known about maintenance mechanisms for any pathogen in bat populations. We present a mathematical model parameterized with unique data from an extensive study of rabies in a Colorado population of big brown bats (Eptesicus fuscus) to elucidate general maintenance mechanisms. We propose that life history patterns of many species of temperate-zone bats, coupled with sufficiently long incubation periods, allows for rabies virus maintenance. Seasonal variability in bat mortality rates, specifically low mortality during hibernation, allows long-term bat population viability. Within viable bat populations, sufficiently long incubation periods allow enough infected individuals to enter hibernation and survive until the following year, and hence avoid an epizootic fadeout of rabies virus. We hypothesize that the slowing effects of hibernation on metabolic and viral activity maintains infected individuals and their pathogens until susceptibles from the annual birth pulse become infected and continue the cycle. This research provides a context to explore similar host ecology and viral dynamics that may explain seasonal patterns and maintenance of other bat-borne diseases.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">21646516</PMID><DateCompleted><Year>2011</Year><Month>09</Month><Day>29</Day></DateCompleted><DateRevised><Year>2018</Year><Month>11</Month><Day>13</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1091-6490</ISSN><JournalIssue CitedMedium="Internet"><Volume>108</Volume><Issue>25</Issue><PubDate><Year>2011</Year><Month>Jun</Month><Day>21</Day></PubDate></JournalIssue><Title>Proceedings of the National Academy of Sciences of the United States of America</Title><ISOAbbreviation>Proc. Natl. Acad. Sci. 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We present a mathematical model parameterized with unique data from an extensive study of rabies in a Colorado population of big brown bats (Eptesicus fuscus) to elucidate general maintenance mechanisms. We propose that life history patterns of many species of temperate-zone bats, coupled with sufficiently long incubation periods, allows for rabies virus maintenance. Seasonal variability in bat mortality rates, specifically low mortality during hibernation, allows long-term bat population viability. Within viable bat populations, sufficiently long incubation periods allow enough infected individuals to enter hibernation and survive until the following year, and hence avoid an epizootic fadeout of rabies virus. We hypothesize that the slowing effects of hibernation on metabolic and viral activity maintains infected individuals and their pathogens until susceptibles from the annual birth pulse become infected and continue the cycle. This research provides a context to explore similar host ecology and viral dynamics that may explain seasonal patterns and maintenance of other bat-borne diseases.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>George</LastName><ForeName>Dylan B</ForeName><Initials>DB</Initials><AffiliationInfo><Affiliation>Department of Biology, Colorado State University, Fort Collins, CO 80523, USA. dylangeorge@gmail.com</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Webb</LastName><ForeName>Colleen T</ForeName><Initials>CT</Initials></Author><Author ValidYN="Y"><LastName>Farnsworth</LastName><ForeName>Matthew L</ForeName><Initials>ML</Initials></Author><Author ValidYN="Y"><LastName>O'Shea</LastName><ForeName>Thomas J</ForeName><Initials>TJ</Initials></Author><Author ValidYN="Y"><LastName>Bowen</LastName><ForeName>Richard A</ForeName><Initials>RA</Initials></Author><Author ValidYN="Y"><LastName>Smith</LastName><ForeName>David 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Bowen</name><name sortKey="Ellison, Laura E" sort="Ellison, Laura E" uniqKey="Ellison L" first="Laura E" last="Ellison">Laura E. Ellison</name><name sortKey="Farnsworth, Matthew L" sort="Farnsworth, Matthew L" uniqKey="Farnsworth M" first="Matthew L" last="Farnsworth">Matthew L. Farnsworth</name><name sortKey="O Shea, Thomas J" sort="O Shea, Thomas J" uniqKey="O Shea T" first="Thomas J" last="O'Shea">Thomas J. O'Shea</name><name sortKey="Rupprecht, Charles E" sort="Rupprecht, Charles E" uniqKey="Rupprecht C" first="Charles E" last="Rupprecht">Charles E. Rupprecht</name><name sortKey="Smith, David L" sort="Smith, David L" uniqKey="Smith D" first="David L" last="Smith">David L. Smith</name><name sortKey="Stanley, Thomas R" sort="Stanley, Thomas R" uniqKey="Stanley T" first="Thomas R" last="Stanley">Thomas R. Stanley</name><name sortKey="Webb, Colleen T" sort="Webb, Colleen T" uniqKey="Webb C" first="Colleen T" last="Webb">Colleen T. Webb</name></noCountry><country name="États-Unis"><region name="Colorado"><name sortKey="George, Dylan B" sort="George, Dylan B" uniqKey="George D" first="Dylan B" last="George">Dylan B. George</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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