Houttuynia cordata blocks HSV infection through inhibition of NF-κB activation.
Identifieur interne : 001492 ( PubMed/Checkpoint ); précédent : 001491; suivant : 001493Houttuynia cordata blocks HSV infection through inhibition of NF-κB activation.
Auteurs : Xiaoqing Chen [République populaire de Chine] ; Zhongxia Wang ; Ziying Yang ; Jingjing Wang ; Yunxia Xu ; Ren-Xiang Tan ; Erguang LiSource :
- Antiviral research [ 1872-9096 ] ; 2011.
Descripteurs français
- KwdFr :
- Animaux, Antiviraux (isolement et purification), Antiviraux (pharmacologie), Cellules HeLa, Cellules Vero, Charge virale, Concentration inhibitrice 50, Extraits de plantes (isolement et purification), Extraits de plantes (pharmacologie), Facteur de transcription NF-kappa B (antagonistes et inhibiteurs), Herpèsvirus humain de type 2 (croissance et développement), Houttuynia (), Humains, Méthode des plages virales, Réplication virale ().
- MESH :
- antagonistes et inhibiteurs : Facteur de transcription NF-kappa B.
- croissance et développement : Herpèsvirus humain de type 2.
- isolement et purification : Antiviraux, Extraits de plantes.
- pharmacologie : Antiviraux, Extraits de plantes.
- Animaux, Cellules HeLa, Cellules Vero, Charge virale, Concentration inhibitrice 50, Houttuynia, Humains, Méthode des plages virales, Réplication virale.
English descriptors
- KwdEn :
- Animals, Antiviral Agents (isolation & purification), Antiviral Agents (pharmacology), Chlorocebus aethiops, HeLa Cells, Herpesvirus 2, Human (growth & development), Houttuynia (chemistry), Humans, Inhibitory Concentration 50, NF-kappa B (antagonists & inhibitors), Plant Extracts (isolation & purification), Plant Extracts (pharmacology), Vero Cells, Viral Load, Viral Plaque Assay, Virus Replication (drug effects).
- MESH :
- chemical , antagonists & inhibitors : NF-kappa B.
- chemical , isolation & purification : Antiviral Agents, Plant Extracts.
- chemical , pharmacology : Antiviral Agents, Plant Extracts.
- chemistry : Houttuynia.
- drug effects : Virus Replication.
- growth & development : Herpesvirus 2, Human.
- Animals, Chlorocebus aethiops, HeLa Cells, Humans, Inhibitory Concentration 50, Vero Cells, Viral Load, Viral Plaque Assay.
Abstract
Houttuynia cordata Thunb. is a medicinal plant widely used in folk medicine in several Asian countries. It has been reported that a water extract of H. cordata exhibits activity against herpes simplex virus (HSV) and the virus of severe acute respiratory syndrome (SARS), although the mechanisms are not fully understood yet. Previous studies have demonstrated absolute requirement of NF-κB activation for efficient replication of HSV-1 and HSV-2 and inhibition of NF-κB activation has been shown to suppress HSV infection. Here we show that a hot water extract of H. cordata (HCWE) inhibits HSV-2 infection through inhibition of NF-κB activation. The IC(50) was estimated at 50 μg/ml of lyophilized HCWE powder. At 150 and 450 μg/ml, HCWE blocked infectious HSV-2 production by more than 3 and 4 logs, respectively. The inhibitory activity was concomitant with an inhibition of NF-κB activation by HSV-2 infection. Although activation of NF-κB and Erk MAPK has been implicated for HSV replication and growth, HCWE showed no effect on HSV-2-induced Erk activation. Furthermore, we show that treatment with quercetin, quercitrin or isoquercitrin, major water extractable flavonoids from H. cordata, significantly blocked HSV-2 infection. These results together demonstrated that H. cordata blocks HSV-2 infection through inhibition of NF-κB activation.
DOI: 10.1016/j.antiviral.2011.09.005
PubMed: 21951655
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
pubmed:21951655Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Houttuynia cordata blocks HSV infection through inhibition of NF-κB activation.</title><author><name sortKey="Chen, Xiaoqing" sort="Chen, Xiaoqing" uniqKey="Chen X" first="Xiaoqing" last="Chen">Xiaoqing Chen</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, 22 Hankou Road, Nanjing, Jiangsu Province 210093, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, 22 Hankou Road, Nanjing, Jiangsu Province 210093</wicri:regionArea><wicri:noRegion>Jiangsu Province 210093</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Zhongxia" sort="Wang, Zhongxia" uniqKey="Wang Z" first="Zhongxia" last="Wang">Zhongxia Wang</name></author><author><name sortKey="Yang, Ziying" sort="Yang, Ziying" uniqKey="Yang Z" first="Ziying" last="Yang">Ziying Yang</name></author><author><name sortKey="Wang, Jingjing" sort="Wang, Jingjing" uniqKey="Wang J" first="Jingjing" last="Wang">Jingjing Wang</name></author><author><name sortKey="Xu, Yunxia" sort="Xu, Yunxia" uniqKey="Xu Y" first="Yunxia" last="Xu">Yunxia Xu</name></author><author><name sortKey="Tan, Ren Xiang" sort="Tan, Ren Xiang" uniqKey="Tan R" first="Ren-Xiang" last="Tan">Ren-Xiang Tan</name></author><author><name sortKey="Li, Erguang" sort="Li, Erguang" uniqKey="Li E" first="Erguang" last="Li">Erguang Li</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2011">2011</date><idno type="RBID">pubmed:21951655</idno><idno type="pmid">21951655</idno><idno type="doi">10.1016/j.antiviral.2011.09.005</idno><idno type="wicri:Area/PubMed/Corpus">001467</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001467</idno><idno type="wicri:Area/PubMed/Curation">001467</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001467</idno><idno type="wicri:Area/PubMed/Checkpoint">001492</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001492</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Houttuynia cordata blocks HSV infection through inhibition of NF-κB activation.</title><author><name sortKey="Chen, Xiaoqing" sort="Chen, Xiaoqing" uniqKey="Chen X" first="Xiaoqing" last="Chen">Xiaoqing Chen</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, 22 Hankou Road, Nanjing, Jiangsu Province 210093, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, 22 Hankou Road, Nanjing, Jiangsu Province 210093</wicri:regionArea><wicri:noRegion>Jiangsu Province 210093</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Zhongxia" sort="Wang, Zhongxia" uniqKey="Wang Z" first="Zhongxia" last="Wang">Zhongxia Wang</name></author><author><name sortKey="Yang, Ziying" sort="Yang, Ziying" uniqKey="Yang Z" first="Ziying" last="Yang">Ziying Yang</name></author><author><name sortKey="Wang, Jingjing" sort="Wang, Jingjing" uniqKey="Wang J" first="Jingjing" last="Wang">Jingjing Wang</name></author><author><name sortKey="Xu, Yunxia" sort="Xu, Yunxia" uniqKey="Xu Y" first="Yunxia" last="Xu">Yunxia Xu</name></author><author><name sortKey="Tan, Ren Xiang" sort="Tan, Ren Xiang" uniqKey="Tan R" first="Ren-Xiang" last="Tan">Ren-Xiang Tan</name></author><author><name sortKey="Li, Erguang" sort="Li, Erguang" uniqKey="Li E" first="Erguang" last="Li">Erguang Li</name></author></analytic><series><title level="j">Antiviral research</title><idno type="eISSN">1872-9096</idno><imprint><date when="2011" type="published">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antiviral Agents (isolation & purification)</term><term>Antiviral Agents (pharmacology)</term><term>Chlorocebus aethiops</term><term>HeLa Cells</term><term>Herpesvirus 2, Human (growth & development)</term><term>Houttuynia (chemistry)</term><term>Humans</term><term>Inhibitory Concentration 50</term><term>NF-kappa B (antagonists & inhibitors)</term><term>Plant Extracts (isolation & purification)</term><term>Plant Extracts (pharmacology)</term><term>Vero Cells</term><term>Viral Load</term><term>Viral Plaque Assay</term><term>Virus Replication (drug effects)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Antiviraux (isolement et purification)</term><term>Antiviraux (pharmacologie)</term><term>Cellules HeLa</term><term>Cellules Vero</term><term>Charge virale</term><term>Concentration inhibitrice 50</term><term>Extraits de plantes (isolement et purification)</term><term>Extraits de plantes (pharmacologie)</term><term>Facteur de transcription NF-kappa B (antagonistes et inhibiteurs)</term><term>Herpèsvirus humain de type 2 (croissance et développement)</term><term>Houttuynia ()</term><term>Humains</term><term>Méthode des plages virales</term><term>Réplication virale ()</term></keywords><keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>NF-kappa B</term></keywords><keywords scheme="MESH" type="chemical" qualifier="isolation & purification" xml:lang="en"><term>Antiviral Agents</term><term>Plant Extracts</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antiviral Agents</term><term>Plant Extracts</term></keywords><keywords scheme="MESH" qualifier="antagonistes et inhibiteurs" xml:lang="fr"><term>Facteur de transcription NF-kappa B</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Houttuynia</term></keywords><keywords scheme="MESH" qualifier="croissance et développement" xml:lang="fr"><term>Herpèsvirus humain de type 2</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Virus Replication</term></keywords><keywords scheme="MESH" qualifier="growth & development" xml:lang="en"><term>Herpesvirus 2, Human</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Antiviraux</term><term>Extraits de plantes</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antiviraux</term><term>Extraits de plantes</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Chlorocebus aethiops</term><term>HeLa Cells</term><term>Humans</term><term>Inhibitory Concentration 50</term><term>Vero Cells</term><term>Viral Load</term><term>Viral Plaque Assay</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Cellules HeLa</term><term>Cellules Vero</term><term>Charge virale</term><term>Concentration inhibitrice 50</term><term>Houttuynia</term><term>Humains</term><term>Méthode des plages virales</term><term>Réplication virale</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Houttuynia cordata Thunb. is a medicinal plant widely used in folk medicine in several Asian countries. It has been reported that a water extract of H. cordata exhibits activity against herpes simplex virus (HSV) and the virus of severe acute respiratory syndrome (SARS), although the mechanisms are not fully understood yet. Previous studies have demonstrated absolute requirement of NF-κB activation for efficient replication of HSV-1 and HSV-2 and inhibition of NF-κB activation has been shown to suppress HSV infection. Here we show that a hot water extract of H. cordata (HCWE) inhibits HSV-2 infection through inhibition of NF-κB activation. The IC(50) was estimated at 50 μg/ml of lyophilized HCWE powder. At 150 and 450 μg/ml, HCWE blocked infectious HSV-2 production by more than 3 and 4 logs, respectively. The inhibitory activity was concomitant with an inhibition of NF-κB activation by HSV-2 infection. Although activation of NF-κB and Erk MAPK has been implicated for HSV replication and growth, HCWE showed no effect on HSV-2-induced Erk activation. Furthermore, we show that treatment with quercetin, quercitrin or isoquercitrin, major water extractable flavonoids from H. cordata, significantly blocked HSV-2 infection. These results together demonstrated that H. cordata blocks HSV-2 infection through inhibition of NF-κB activation.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">21951655</PMID><DateCompleted><Year>2012</Year><Month>02</Month><Day>08</Day></DateCompleted><DateRevised><Year>2020</Year><Month>04</Month><Day>03</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1872-9096</ISSN><JournalIssue CitedMedium="Internet"><Volume>92</Volume><Issue>2</Issue><PubDate><Year>2011</Year><Month>Nov</Month></PubDate></JournalIssue><Title>Antiviral research</Title><ISOAbbreviation>Antiviral Res.</ISOAbbreviation></Journal><ArticleTitle>Houttuynia cordata blocks HSV infection through inhibition of NF-κB activation.</ArticleTitle><Pagination><MedlinePgn>341-5</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.antiviral.2011.09.005</ELocationID><Abstract><AbstractText>Houttuynia cordata Thunb. is a medicinal plant widely used in folk medicine in several Asian countries. It has been reported that a water extract of H. cordata exhibits activity against herpes simplex virus (HSV) and the virus of severe acute respiratory syndrome (SARS), although the mechanisms are not fully understood yet. Previous studies have demonstrated absolute requirement of NF-κB activation for efficient replication of HSV-1 and HSV-2 and inhibition of NF-κB activation has been shown to suppress HSV infection. Here we show that a hot water extract of H. cordata (HCWE) inhibits HSV-2 infection through inhibition of NF-κB activation. The IC(50) was estimated at 50 μg/ml of lyophilized HCWE powder. At 150 and 450 μg/ml, HCWE blocked infectious HSV-2 production by more than 3 and 4 logs, respectively. The inhibitory activity was concomitant with an inhibition of NF-κB activation by HSV-2 infection. Although activation of NF-κB and Erk MAPK has been implicated for HSV replication and growth, HCWE showed no effect on HSV-2-induced Erk activation. Furthermore, we show that treatment with quercetin, quercitrin or isoquercitrin, major water extractable flavonoids from H. cordata, significantly blocked HSV-2 infection. These results together demonstrated that H. cordata blocks HSV-2 infection through inhibition of NF-κB activation.</AbstractText><CopyrightInformation>Copyright © 2011 Elsevier B.V. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Xiaoqing</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, 22 Hankou Road, Nanjing, Jiangsu Province 210093, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Zhongxia</ForeName><Initials>Z</Initials></Author><Author ValidYN="Y"><LastName>Yang</LastName><ForeName>Ziying</ForeName><Initials>Z</Initials></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Jingjing</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Xu</LastName><ForeName>Yunxia</ForeName><Initials>Y</Initials></Author><Author ValidYN="Y"><LastName>Tan</LastName><ForeName>Ren-Xiang</ForeName><Initials>RX</Initials></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Erguang</ForeName><Initials>E</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2011</Year><Month>09</Month><Day>17</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Antiviral Res</MedlineTA><NlmUniqueID>8109699</NlmUniqueID><ISSNLinking>0166-3542</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000998">Antiviral Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D016328">NF-kappa B</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010936">Plant Extracts</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000998" MajorTopicYN="N">Antiviral Agents</DescriptorName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002522" MajorTopicYN="N">Chlorocebus aethiops</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006367" MajorTopicYN="N">HeLa Cells</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018258" MajorTopicYN="N">Herpesvirus 2, Human</DescriptorName><QualifierName UI="Q000254" MajorTopicYN="Y">growth & development</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D052859" MajorTopicYN="N">Houttuynia</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020128" MajorTopicYN="N">Inhibitory Concentration 50</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016328" MajorTopicYN="N">NF-kappa B</DescriptorName><QualifierName UI="Q000037" MajorTopicYN="Y">antagonists & inhibitors</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010936" MajorTopicYN="N">Plant Extracts</DescriptorName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014709" MajorTopicYN="N">Vero Cells</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019562" MajorTopicYN="N">Viral Load</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010948" MajorTopicYN="N">Viral Plaque Assay</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014779" MajorTopicYN="N">Virus Replication</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2011</Year><Month>04</Month><Day>08</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2011</Year><Month>08</Month><Day>17</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2011</Year><Month>09</Month><Day>07</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2011</Year><Month>9</Month><Day>29</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2011</Year><Month>9</Month><Day>29</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2012</Year><Month>2</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">21951655</ArticleId><ArticleId IdType="pii">S0166-3542(11)00443-8</ArticleId><ArticleId IdType="doi">10.1016/j.antiviral.2011.09.005</ArticleId><ArticleId IdType="pmc">PMC7114259</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>J Virol. 2005 Jul;79(13):8348-60</Citation><ArticleIdList><ArticleId IdType="pubmed">15956580</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Antiviral Res. 2005 Aug;67(2):107-19</Citation><ArticleIdList><ArticleId IdType="pubmed">16040137</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>J Immunol Methods. 1983 Dec 16;65(1-2):55-63</Citation><ArticleIdList><ArticleId IdType="pubmed">6606682</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Antiviral Res. 2010 Nov;88(2):227-35</Citation><ArticleIdList><ArticleId IdType="pubmed">20826184</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Biochem Pharmacol. 2005 Sep 1;70(5):700-13</Citation><ArticleIdList><ArticleId IdType="pubmed">16023083</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>J Med Virol. 1985 Jan;15(1):71-9</Citation><ArticleIdList><ArticleId IdType="pubmed">2981979</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>J Ethnopharmacol. 2008 Jun 19;118(1):79-85</Citation><ArticleIdList><ArticleId IdType="pubmed">18479853</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Antiviral Res. 2006 Sep;71(2-3):301-6</Citation><ArticleIdList><ArticleId IdType="pubmed">16488488</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Virology. 2005 Nov 25;342(2):297-310</Citation><ArticleIdList><ArticleId IdType="pubmed">16150474</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>J Biol Chem. 2001 Aug 3;276(31):28759-66</Citation><ArticleIdList><ArticleId IdType="pubmed">11387335</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>J Antimicrob Chemother. 2009 Jul;64(1):1-4</Citation><ArticleIdList><ArticleId IdType="pubmed">19420020</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Am J Chin Med. 2003;31(3):355-62</Citation><ArticleIdList><ArticleId IdType="pubmed">12943167</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>J Biol Chem. 1999 Feb 19;274(8):5097-103</Citation><ArticleIdList><ArticleId IdType="pubmed">9988758</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>J Virol. 1989 Sep;63(9):4097-100</Citation><ArticleIdList><ArticleId IdType="pubmed">2527315</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Virology. 1998 Aug 1;247(2):212-22</Citation><ArticleIdList><ArticleId IdType="pubmed">9705914</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Chem Pharm Bull (Tokyo). 2009 Nov;57(11):1227-30</Citation><ArticleIdList><ArticleId IdType="pubmed">19881272</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Arch Pharm Res. 2005 Nov;28(11):1293-301</Citation><ArticleIdList><ArticleId IdType="pubmed">16350858</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>J Virol. 2004 Dec;78(24):13582-90</Citation><ArticleIdList><ArticleId IdType="pubmed">15564469</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>J Clin Invest. 2001 Jan;107(2):143-51</Citation><ArticleIdList><ArticleId IdType="pubmed">11160127</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>J Virol. 2004 Jul;78(14):7508-17</Citation><ArticleIdList><ArticleId IdType="pubmed">15220424</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>J Virol. 2000 Nov;74(22):10417-29</Citation><ArticleIdList><ArticleId IdType="pubmed">11044086</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>J Virol. 2002 Feb;76(3):1435-49</Citation><ArticleIdList><ArticleId IdType="pubmed">11773417</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Virology. 2008 Apr 10;373(2):239-47</Citation><ArticleIdList><ArticleId IdType="pubmed">18191976</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>J Virol. 2008 Oct;82(20):9880-9</Citation><ArticleIdList><ArticleId IdType="pubmed">18701591</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>J Virol. 2003 Jul;77(13):7261-80</Citation><ArticleIdList><ArticleId IdType="pubmed">12805425</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Talanta. 2006 Jan 15;68(3):759-64</Citation><ArticleIdList><ArticleId IdType="pubmed">18970387</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>J Gen Virol. 1968 May;2(3):357-64</Citation><ArticleIdList><ArticleId IdType="pubmed">4300104</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Virus Res. 2010 Jun;150(1-2):22-7</Citation><ArticleIdList><ArticleId IdType="pubmed">20172001</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Virology. 2004 Nov 10;329(1):142-56</Citation><ArticleIdList><ArticleId IdType="pubmed">15476882</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Eur J Pharm Sci. 2009 Jun 28;37(3-4):329-33</Citation><ArticleIdList><ArticleId IdType="pubmed">19491023</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Planta Med. 1995 Jun;61(3):237-41</Citation><ArticleIdList><ArticleId IdType="pubmed">7617766</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Antiviral Res. 2006 Dec;72(3):242-51</Citation><ArticleIdList><ArticleId IdType="pubmed">16876885</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>J Biol Chem. 2006 Mar 17;281(11):7110-7</Citation><ArticleIdList><ArticleId IdType="pubmed">16407234</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><noCountry><name sortKey="Li, Erguang" sort="Li, Erguang" uniqKey="Li E" first="Erguang" last="Li">Erguang Li</name><name sortKey="Tan, Ren Xiang" sort="Tan, Ren Xiang" uniqKey="Tan R" first="Ren-Xiang" last="Tan">Ren-Xiang Tan</name><name sortKey="Wang, Jingjing" sort="Wang, Jingjing" uniqKey="Wang J" first="Jingjing" last="Wang">Jingjing Wang</name><name sortKey="Wang, Zhongxia" sort="Wang, Zhongxia" uniqKey="Wang Z" first="Zhongxia" last="Wang">Zhongxia Wang</name><name sortKey="Xu, Yunxia" sort="Xu, Yunxia" uniqKey="Xu Y" first="Yunxia" last="Xu">Yunxia Xu</name><name sortKey="Yang, Ziying" sort="Yang, Ziying" uniqKey="Yang Z" first="Ziying" last="Yang">Ziying Yang</name></noCountry><country name="République populaire de Chine"><noRegion><name sortKey="Chen, Xiaoqing" sort="Chen, Xiaoqing" uniqKey="Chen X" first="Xiaoqing" last="Chen">Xiaoqing Chen</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/PubMed/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001492 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd -nk 001492 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= SrasV1
|flux= PubMed
|étape= Checkpoint
|type= RBID
|clé= pubmed:21951655
|texte= Houttuynia cordata blocks HSV infection through inhibition of NF-κB activation.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/RBID.i -Sk "pubmed:21951655" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd \
| NlmPubMed2Wicri -a SrasV1
| This area was generated with Dilib version V0.6.33. |  |