The ADP-ribose-1''-monophosphatase domains of severe acute respiratory syndrome coronavirus and human coronavirus 229E mediate resistance to antiviral interferon responses.
Identifieur interne : 001421 ( PubMed/Checkpoint ); précédent : 001420; suivant : 001422The ADP-ribose-1''-monophosphatase domains of severe acute respiratory syndrome coronavirus and human coronavirus 229E mediate resistance to antiviral interferon responses.
Auteurs : Thomas Kuri [Allemagne] ; Klara K. Eriksson [Suisse] ; Akos Putics [Allemagne] ; Roland Züst [Suisse] ; Eric J. Snijder [Pays-Bas] ; Andrew D. Davidson [Royaume-Uni] ; Stuart G. Siddell [Royaume-Uni] ; Volker Thiel [Suisse] ; John Ziebuhr [Allemagne] ; Friedemann Weber [Allemagne]Source :
- The Journal of general virology [ 1465-2099 ] ; 2011.
Descripteurs français
- KwdFr :
- Alignement de séquences, Antiviraux (immunologie), Coronavirus humain 229E (), Coronavirus humain 229E (enzymologie), Coronavirus humain 229E (génétique), Coronavirus humain 229E (immunologie), Données de séquences moléculaires, Humains, Infections à coronavirus (génétique), Infections à coronavirus (immunologie), Infections à coronavirus (virologie), Interféron alpha (génétique), Interféron alpha (immunologie), Lignée cellulaire, Phosphoric monoester hydrolases (), Phosphoric monoester hydrolases (génétique), Phosphoric monoester hydrolases (immunologie), Protéines virales (), Protéines virales (génétique), Protéines virales (immunologie), Structure tertiaire des protéines, Syndrome respiratoire aigu sévère (génétique), Syndrome respiratoire aigu sévère (immunologie), Syndrome respiratoire aigu sévère (virologie), Séquence d'acides aminés, Virus du SRAS (), Virus du SRAS (enzymologie), Virus du SRAS (génétique).
- MESH :
- enzymologie : Coronavirus humain 229E, Virus du SRAS.
- génétique : Coronavirus humain 229E, Infections à coronavirus, Interféron alpha, Phosphoric monoester hydrolases, Protéines virales, Syndrome respiratoire aigu sévère, Virus du SRAS.
- immunologie : Antiviraux, Coronavirus humain 229E, Infections à coronavirus, Interféron alpha, Phosphoric monoester hydrolases, Protéines virales, Syndrome respiratoire aigu sévère.
- virologie : Infections à coronavirus, Syndrome respiratoire aigu sévère.
- Alignement de séquences, Coronavirus humain 229E, Données de séquences moléculaires, Humains, Lignée cellulaire, Phosphoric monoester hydrolases, Protéines virales, Structure tertiaire des protéines, Séquence d'acides aminés, Virus du SRAS.
English descriptors
- KwdEn :
- Amino Acid Sequence, Antiviral Agents (immunology), Cell Line, Coronavirus 229E, Human (chemistry), Coronavirus 229E, Human (enzymology), Coronavirus 229E, Human (genetics), Coronavirus 229E, Human (immunology), Coronavirus Infections (genetics), Coronavirus Infections (immunology), Coronavirus Infections (virology), Humans, Interferon-alpha (genetics), Interferon-alpha (immunology), Molecular Sequence Data, Phosphoric Monoester Hydrolases (chemistry), Phosphoric Monoester Hydrolases (genetics), Phosphoric Monoester Hydrolases (immunology), Protein Structure, Tertiary, SARS Virus (chemistry), SARS Virus (drug effects), SARS Virus (enzymology), SARS Virus (genetics), Sequence Alignment, Severe Acute Respiratory Syndrome (genetics), Severe Acute Respiratory Syndrome (immunology), Severe Acute Respiratory Syndrome (virology), Viral Proteins (chemistry), Viral Proteins (genetics), Viral Proteins (immunology).
- MESH :
- chemical , chemistry : Phosphoric Monoester Hydrolases, Viral Proteins.
- chemical , genetics : Interferon-alpha, Phosphoric Monoester Hydrolases, Viral Proteins.
- chemical , immunology : Antiviral Agents, Interferon-alpha, Phosphoric Monoester Hydrolases, Viral Proteins.
- chemistry : Coronavirus 229E, Human, SARS Virus.
- drug effects : SARS Virus.
- enzymology : Coronavirus 229E, Human, SARS Virus.
- genetics : Coronavirus 229E, Human, Coronavirus Infections, SARS Virus, Severe Acute Respiratory Syndrome.
- immunology : Coronavirus 229E, Human, Coronavirus Infections, Severe Acute Respiratory Syndrome.
- virology : Coronavirus Infections, Severe Acute Respiratory Syndrome.
- Amino Acid Sequence, Cell Line, Humans, Molecular Sequence Data, Protein Structure, Tertiary, Sequence Alignment.
Abstract
Several plus-strand RNA viruses encode proteins containing macrodomains. These domains possess ADP-ribose-1″-phosphatase (ADRP) activity and/or bind poly(ADP-ribose), poly(A) or poly(G). The relevance of these activities in the viral life cycle has not yet been resolved. Here, we report that genetically engineered mutants of severe acute respiratory syndrome coronavirus (SARS-CoV) and human coronavirus 229E (HCoV-229E) expressing ADRP-deficient macrodomains displayed an increased sensitivity to the antiviral effect of alpha interferon compared with their wild-type counterparts. The data suggest that macrodomain-associated ADRP activities may have a role in viral escape from the innate immune responses of the host.
DOI: 10.1099/vir.0.031856-0
PubMed: 21525212
Affiliations:
- Allemagne, Pays-Bas, Royaume-Uni, Suisse
- Bade-Wurtemberg, Bavière, District de Basse-Franconie, District de Fribourg-en-Brisgau, District de Giessen, Hesse (Land), Hollande-Méridionale
- Fribourg-en-Brisgau, Leyde, Marbourg, Wurtzbourg
Links toward previous steps (curation, corpus...)
Links to Exploration step
pubmed:21525212Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The ADP-ribose-1''-monophosphatase domains of severe acute respiratory syndrome coronavirus and human coronavirus 229E mediate resistance to antiviral interferon responses.</title>
<author><name sortKey="Kuri, Thomas" sort="Kuri, Thomas" uniqKey="Kuri T" first="Thomas" last="Kuri">Thomas Kuri</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Virology, University of Freiburg, D-79008 Freiburg, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Virology, University of Freiburg, D-79008 Freiburg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Fribourg-en-Brisgau</region>
<settlement type="city">Fribourg-en-Brisgau</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Eriksson, Klara K" sort="Eriksson, Klara K" uniqKey="Eriksson K" first="Klara K" last="Eriksson">Klara K. Eriksson</name>
<affiliation wicri:level="1"><nlm:affiliation>Research Department, Kantonal Hospital St Gallen, St Gallen, Switzerland.</nlm:affiliation>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Research Department, Kantonal Hospital St Gallen, St Gallen</wicri:regionArea>
<wicri:noRegion>St Gallen</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Putics, Akos" sort="Putics, Akos" uniqKey="Putics A" first="Akos" last="Putics">Akos Putics</name>
<affiliation wicri:level="3"><nlm:affiliation>Institute of Virology and Immunology, University of Würzburg, D-97078 Würzburg, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Virology and Immunology, University of Würzburg, D-97078 Würzburg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Basse-Franconie</region>
<settlement type="city">Wurtzbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zust, Roland" sort="Zust, Roland" uniqKey="Zust R" first="Roland" last="Züst">Roland Züst</name>
<affiliation wicri:level="1"><nlm:affiliation>Research Department, Kantonal Hospital St Gallen, St Gallen, Switzerland.</nlm:affiliation>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Research Department, Kantonal Hospital St Gallen, St Gallen</wicri:regionArea>
<wicri:noRegion>St Gallen</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Snijder, Eric J" sort="Snijder, Eric J" uniqKey="Snijder E" first="Eric J" last="Snijder">Eric J. Snijder</name>
<affiliation wicri:level="3"><nlm:affiliation>Molecular Virology Laboratory, Department of Medical Microbiology, Center of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Molecular Virology Laboratory, Department of Medical Microbiology, Center of Infectious Diseases, Leiden University Medical Center, Leiden</wicri:regionArea>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Davidson, Andrew D" sort="Davidson, Andrew D" uniqKey="Davidson A" first="Andrew D" last="Davidson">Andrew D. Davidson</name>
<affiliation wicri:level="1"><nlm:affiliation>Division of Virology, Department of Cellular and Molecular Medicine, School of Medical and Veterinary Sciences, University of Bristol, Bristol, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Division of Virology, Department of Cellular and Molecular Medicine, School of Medical and Veterinary Sciences, University of Bristol, Bristol</wicri:regionArea>
<wicri:noRegion>Bristol</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Siddell, Stuart G" sort="Siddell, Stuart G" uniqKey="Siddell S" first="Stuart G" last="Siddell">Stuart G. Siddell</name>
<affiliation wicri:level="1"><nlm:affiliation>Division of Virology, Department of Cellular and Molecular Medicine, School of Medical and Veterinary Sciences, University of Bristol, Bristol, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Division of Virology, Department of Cellular and Molecular Medicine, School of Medical and Veterinary Sciences, University of Bristol, Bristol</wicri:regionArea>
<wicri:noRegion>Bristol</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Thiel, Volker" sort="Thiel, Volker" uniqKey="Thiel V" first="Volker" last="Thiel">Volker Thiel</name>
<affiliation wicri:level="1"><nlm:affiliation>Research Department, Kantonal Hospital St Gallen, St Gallen, Switzerland.</nlm:affiliation>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Research Department, Kantonal Hospital St Gallen, St Gallen</wicri:regionArea>
<wicri:noRegion>St Gallen</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ziebuhr, John" sort="Ziebuhr, John" uniqKey="Ziebuhr J" first="John" last="Ziebuhr">John Ziebuhr</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Medical Virology, Justus Liebig University Giessen, D-35392 Giessen, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Medical Virology, Justus Liebig University Giessen, D-35392 Giessen</wicri:regionArea>
<wicri:noRegion>35392 Giessen</wicri:noRegion>
<wicri:noRegion>35392 Giessen</wicri:noRegion>
<wicri:noRegion>D-35392 Giessen</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Weber, Friedemann" sort="Weber, Friedemann" uniqKey="Weber F" first="Friedemann" last="Weber">Friedemann Weber</name>
<affiliation wicri:level="3"><nlm:affiliation>Institute for Virology, Philipps-University Marburg, D-35043 Marburg, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute for Virology, Philipps-University Marburg, D-35043 Marburg</wicri:regionArea>
<placeName><region type="land" nuts="1">Hesse (Land)</region>
<region type="district" nuts="2">District de Giessen</region>
<settlement type="city">Marbourg</settlement>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2011">2011</date>
<idno type="RBID">pubmed:21525212</idno>
<idno type="pmid">21525212</idno>
<idno type="doi">10.1099/vir.0.031856-0</idno>
<idno type="wicri:Area/PubMed/Corpus">001523</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001523</idno>
<idno type="wicri:Area/PubMed/Curation">001523</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001523</idno>
<idno type="wicri:Area/PubMed/Checkpoint">001421</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001421</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">The ADP-ribose-1''-monophosphatase domains of severe acute respiratory syndrome coronavirus and human coronavirus 229E mediate resistance to antiviral interferon responses.</title>
<author><name sortKey="Kuri, Thomas" sort="Kuri, Thomas" uniqKey="Kuri T" first="Thomas" last="Kuri">Thomas Kuri</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Virology, University of Freiburg, D-79008 Freiburg, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Virology, University of Freiburg, D-79008 Freiburg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Fribourg-en-Brisgau</region>
<settlement type="city">Fribourg-en-Brisgau</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Eriksson, Klara K" sort="Eriksson, Klara K" uniqKey="Eriksson K" first="Klara K" last="Eriksson">Klara K. Eriksson</name>
<affiliation wicri:level="1"><nlm:affiliation>Research Department, Kantonal Hospital St Gallen, St Gallen, Switzerland.</nlm:affiliation>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Research Department, Kantonal Hospital St Gallen, St Gallen</wicri:regionArea>
<wicri:noRegion>St Gallen</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Putics, Akos" sort="Putics, Akos" uniqKey="Putics A" first="Akos" last="Putics">Akos Putics</name>
<affiliation wicri:level="3"><nlm:affiliation>Institute of Virology and Immunology, University of Würzburg, D-97078 Würzburg, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Virology and Immunology, University of Würzburg, D-97078 Würzburg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Basse-Franconie</region>
<settlement type="city">Wurtzbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zust, Roland" sort="Zust, Roland" uniqKey="Zust R" first="Roland" last="Züst">Roland Züst</name>
<affiliation wicri:level="1"><nlm:affiliation>Research Department, Kantonal Hospital St Gallen, St Gallen, Switzerland.</nlm:affiliation>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Research Department, Kantonal Hospital St Gallen, St Gallen</wicri:regionArea>
<wicri:noRegion>St Gallen</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Snijder, Eric J" sort="Snijder, Eric J" uniqKey="Snijder E" first="Eric J" last="Snijder">Eric J. Snijder</name>
<affiliation wicri:level="3"><nlm:affiliation>Molecular Virology Laboratory, Department of Medical Microbiology, Center of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Molecular Virology Laboratory, Department of Medical Microbiology, Center of Infectious Diseases, Leiden University Medical Center, Leiden</wicri:regionArea>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Davidson, Andrew D" sort="Davidson, Andrew D" uniqKey="Davidson A" first="Andrew D" last="Davidson">Andrew D. Davidson</name>
<affiliation wicri:level="1"><nlm:affiliation>Division of Virology, Department of Cellular and Molecular Medicine, School of Medical and Veterinary Sciences, University of Bristol, Bristol, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Division of Virology, Department of Cellular and Molecular Medicine, School of Medical and Veterinary Sciences, University of Bristol, Bristol</wicri:regionArea>
<wicri:noRegion>Bristol</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Siddell, Stuart G" sort="Siddell, Stuart G" uniqKey="Siddell S" first="Stuart G" last="Siddell">Stuart G. Siddell</name>
<affiliation wicri:level="1"><nlm:affiliation>Division of Virology, Department of Cellular and Molecular Medicine, School of Medical and Veterinary Sciences, University of Bristol, Bristol, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Division of Virology, Department of Cellular and Molecular Medicine, School of Medical and Veterinary Sciences, University of Bristol, Bristol</wicri:regionArea>
<wicri:noRegion>Bristol</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Thiel, Volker" sort="Thiel, Volker" uniqKey="Thiel V" first="Volker" last="Thiel">Volker Thiel</name>
<affiliation wicri:level="1"><nlm:affiliation>Research Department, Kantonal Hospital St Gallen, St Gallen, Switzerland.</nlm:affiliation>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Research Department, Kantonal Hospital St Gallen, St Gallen</wicri:regionArea>
<wicri:noRegion>St Gallen</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ziebuhr, John" sort="Ziebuhr, John" uniqKey="Ziebuhr J" first="John" last="Ziebuhr">John Ziebuhr</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Medical Virology, Justus Liebig University Giessen, D-35392 Giessen, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Medical Virology, Justus Liebig University Giessen, D-35392 Giessen</wicri:regionArea>
<wicri:noRegion>35392 Giessen</wicri:noRegion>
<wicri:noRegion>35392 Giessen</wicri:noRegion>
<wicri:noRegion>D-35392 Giessen</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Weber, Friedemann" sort="Weber, Friedemann" uniqKey="Weber F" first="Friedemann" last="Weber">Friedemann Weber</name>
<affiliation wicri:level="3"><nlm:affiliation>Institute for Virology, Philipps-University Marburg, D-35043 Marburg, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute for Virology, Philipps-University Marburg, D-35043 Marburg</wicri:regionArea>
<placeName><region type="land" nuts="1">Hesse (Land)</region>
<region type="district" nuts="2">District de Giessen</region>
<settlement type="city">Marbourg</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">The Journal of general virology</title>
<idno type="eISSN">1465-2099</idno>
<imprint><date when="2011" type="published">2011</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence</term>
<term>Antiviral Agents (immunology)</term>
<term>Cell Line</term>
<term>Coronavirus 229E, Human (chemistry)</term>
<term>Coronavirus 229E, Human (enzymology)</term>
<term>Coronavirus 229E, Human (genetics)</term>
<term>Coronavirus 229E, Human (immunology)</term>
<term>Coronavirus Infections (genetics)</term>
<term>Coronavirus Infections (immunology)</term>
<term>Coronavirus Infections (virology)</term>
<term>Humans</term>
<term>Interferon-alpha (genetics)</term>
<term>Interferon-alpha (immunology)</term>
<term>Molecular Sequence Data</term>
<term>Phosphoric Monoester Hydrolases (chemistry)</term>
<term>Phosphoric Monoester Hydrolases (genetics)</term>
<term>Phosphoric Monoester Hydrolases (immunology)</term>
<term>Protein Structure, Tertiary</term>
<term>SARS Virus (chemistry)</term>
<term>SARS Virus (drug effects)</term>
<term>SARS Virus (enzymology)</term>
<term>SARS Virus (genetics)</term>
<term>Sequence Alignment</term>
<term>Severe Acute Respiratory Syndrome (genetics)</term>
<term>Severe Acute Respiratory Syndrome (immunology)</term>
<term>Severe Acute Respiratory Syndrome (virology)</term>
<term>Viral Proteins (chemistry)</term>
<term>Viral Proteins (genetics)</term>
<term>Viral Proteins (immunology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Alignement de séquences</term>
<term>Antiviraux (immunologie)</term>
<term>Coronavirus humain 229E ()</term>
<term>Coronavirus humain 229E (enzymologie)</term>
<term>Coronavirus humain 229E (génétique)</term>
<term>Coronavirus humain 229E (immunologie)</term>
<term>Données de séquences moléculaires</term>
<term>Humains</term>
<term>Infections à coronavirus (génétique)</term>
<term>Infections à coronavirus (immunologie)</term>
<term>Infections à coronavirus (virologie)</term>
<term>Interféron alpha (génétique)</term>
<term>Interféron alpha (immunologie)</term>
<term>Lignée cellulaire</term>
<term>Phosphoric monoester hydrolases ()</term>
<term>Phosphoric monoester hydrolases (génétique)</term>
<term>Phosphoric monoester hydrolases (immunologie)</term>
<term>Protéines virales ()</term>
<term>Protéines virales (génétique)</term>
<term>Protéines virales (immunologie)</term>
<term>Structure tertiaire des protéines</term>
<term>Syndrome respiratoire aigu sévère (génétique)</term>
<term>Syndrome respiratoire aigu sévère (immunologie)</term>
<term>Syndrome respiratoire aigu sévère (virologie)</term>
<term>Séquence d'acides aminés</term>
<term>Virus du SRAS ()</term>
<term>Virus du SRAS (enzymologie)</term>
<term>Virus du SRAS (génétique)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Phosphoric Monoester Hydrolases</term>
<term>Viral Proteins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Interferon-alpha</term>
<term>Phosphoric Monoester Hydrolases</term>
<term>Viral Proteins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antiviral Agents</term>
<term>Interferon-alpha</term>
<term>Phosphoric Monoester Hydrolases</term>
<term>Viral Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Coronavirus 229E, Human</term>
<term>SARS Virus</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>SARS Virus</term>
</keywords>
<keywords scheme="MESH" qualifier="enzymologie" xml:lang="fr"><term>Coronavirus humain 229E</term>
<term>Virus du SRAS</term>
</keywords>
<keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Coronavirus 229E, Human</term>
<term>SARS Virus</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Coronavirus 229E, Human</term>
<term>Coronavirus Infections</term>
<term>SARS Virus</term>
<term>Severe Acute Respiratory Syndrome</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Coronavirus humain 229E</term>
<term>Infections à coronavirus</term>
<term>Interféron alpha</term>
<term>Phosphoric monoester hydrolases</term>
<term>Protéines virales</term>
<term>Syndrome respiratoire aigu sévère</term>
<term>Virus du SRAS</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Antiviraux</term>
<term>Coronavirus humain 229E</term>
<term>Infections à coronavirus</term>
<term>Interféron alpha</term>
<term>Phosphoric monoester hydrolases</term>
<term>Protéines virales</term>
<term>Syndrome respiratoire aigu sévère</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Coronavirus 229E, Human</term>
<term>Coronavirus Infections</term>
<term>Severe Acute Respiratory Syndrome</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections à coronavirus</term>
<term>Syndrome respiratoire aigu sévère</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coronavirus Infections</term>
<term>Severe Acute Respiratory Syndrome</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term>
<term>Cell Line</term>
<term>Humans</term>
<term>Molecular Sequence Data</term>
<term>Protein Structure, Tertiary</term>
<term>Sequence Alignment</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Alignement de séquences</term>
<term>Coronavirus humain 229E</term>
<term>Données de séquences moléculaires</term>
<term>Humains</term>
<term>Lignée cellulaire</term>
<term>Phosphoric monoester hydrolases</term>
<term>Protéines virales</term>
<term>Structure tertiaire des protéines</term>
<term>Séquence d'acides aminés</term>
<term>Virus du SRAS</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Several plus-strand RNA viruses encode proteins containing macrodomains. These domains possess ADP-ribose-1″-phosphatase (ADRP) activity and/or bind poly(ADP-ribose), poly(A) or poly(G). The relevance of these activities in the viral life cycle has not yet been resolved. Here, we report that genetically engineered mutants of severe acute respiratory syndrome coronavirus (SARS-CoV) and human coronavirus 229E (HCoV-229E) expressing ADRP-deficient macrodomains displayed an increased sensitivity to the antiviral effect of alpha interferon compared with their wild-type counterparts. The data suggest that macrodomain-associated ADRP activities may have a role in viral escape from the innate immune responses of the host.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">21525212</PMID>
<DateCompleted><Year>2011</Year>
<Month>09</Month>
<Day>19</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>02</Month>
<Day>28</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1465-2099</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>92</Volume>
<Issue>Pt 8</Issue>
<PubDate><Year>2011</Year>
<Month>Aug</Month>
</PubDate>
</JournalIssue>
<Title>The Journal of general virology</Title>
<ISOAbbreviation>J. Gen. Virol.</ISOAbbreviation>
</Journal>
<ArticleTitle>The ADP-ribose-1''-monophosphatase domains of severe acute respiratory syndrome coronavirus and human coronavirus 229E mediate resistance to antiviral interferon responses.</ArticleTitle>
<Pagination><MedlinePgn>1899-1905</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1099/vir.0.031856-0</ELocationID>
<Abstract><AbstractText>Several plus-strand RNA viruses encode proteins containing macrodomains. These domains possess ADP-ribose-1″-phosphatase (ADRP) activity and/or bind poly(ADP-ribose), poly(A) or poly(G). The relevance of these activities in the viral life cycle has not yet been resolved. Here, we report that genetically engineered mutants of severe acute respiratory syndrome coronavirus (SARS-CoV) and human coronavirus 229E (HCoV-229E) expressing ADRP-deficient macrodomains displayed an increased sensitivity to the antiviral effect of alpha interferon compared with their wild-type counterparts. The data suggest that macrodomain-associated ADRP activities may have a role in viral escape from the innate immune responses of the host.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Kuri</LastName>
<ForeName>Thomas</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Department of Virology, University of Freiburg, D-79008 Freiburg, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Eriksson</LastName>
<ForeName>Klara K</ForeName>
<Initials>KK</Initials>
<AffiliationInfo><Affiliation>Research Department, Kantonal Hospital St Gallen, St Gallen, Switzerland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Putics</LastName>
<ForeName>Akos</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Institute of Virology and Immunology, University of Würzburg, D-97078 Würzburg, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Züst</LastName>
<ForeName>Roland</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Research Department, Kantonal Hospital St Gallen, St Gallen, Switzerland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Snijder</LastName>
<ForeName>Eric J</ForeName>
<Initials>EJ</Initials>
<AffiliationInfo><Affiliation>Molecular Virology Laboratory, Department of Medical Microbiology, Center of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Davidson</LastName>
<ForeName>Andrew D</ForeName>
<Initials>AD</Initials>
<AffiliationInfo><Affiliation>Division of Virology, Department of Cellular and Molecular Medicine, School of Medical and Veterinary Sciences, University of Bristol, Bristol, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Siddell</LastName>
<ForeName>Stuart G</ForeName>
<Initials>SG</Initials>
<AffiliationInfo><Affiliation>Division of Virology, Department of Cellular and Molecular Medicine, School of Medical and Veterinary Sciences, University of Bristol, Bristol, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Thiel</LastName>
<ForeName>Volker</ForeName>
<Initials>V</Initials>
<AffiliationInfo><Affiliation>Research Department, Kantonal Hospital St Gallen, St Gallen, Switzerland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ziebuhr</LastName>
<ForeName>John</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Institute of Medical Virology, Justus Liebig University Giessen, D-35392 Giessen, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Weber</LastName>
<ForeName>Friedemann</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>Institute for Virology, Philipps-University Marburg, D-35043 Marburg, Germany.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Virology, University of Freiburg, D-79008 Freiburg, Germany.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>BB/G012067/1</GrantID>
<Agency>Biotechnology and Biological Sciences Research Council</Agency>
<Country>United Kingdom</Country>
</Grant>
</GrantList>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2011</Year>
<Month>04</Month>
<Day>27</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>J Gen Virol</MedlineTA>
<NlmUniqueID>0077340</NlmUniqueID>
<ISSNLinking>0022-1317</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000998">Antiviral Agents</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D016898">Interferon-alpha</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D014764">Viral Proteins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 3.1.3.2</RegistryNumber>
<NameOfSubstance UI="D010744">Phosphoric Monoester Hydrolases</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000595" MajorTopicYN="N">Amino Acid Sequence</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000998" MajorTopicYN="N">Antiviral Agents</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002460" MajorTopicYN="N">Cell Line</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D028941" MajorTopicYN="N">Coronavirus 229E, Human</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
<QualifierName UI="Q000201" MajorTopicYN="Y">enzymology</QualifierName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016898" MajorTopicYN="N">Interferon-alpha</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008969" MajorTopicYN="N">Molecular Sequence Data</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010744" MajorTopicYN="N">Phosphoric Monoester Hydrolases</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017434" MajorTopicYN="N">Protein Structure, Tertiary</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D045473" MajorTopicYN="N">SARS Virus</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
<QualifierName UI="Q000201" MajorTopicYN="Y">enzymology</QualifierName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016415" MajorTopicYN="N">Sequence Alignment</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D045169" MajorTopicYN="N">Severe Acute Respiratory Syndrome</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014764" MajorTopicYN="N">Viral Proteins</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2011</Year>
<Month>4</Month>
<Day>29</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2011</Year>
<Month>4</Month>
<Day>29</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2011</Year>
<Month>9</Month>
<Day>20</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">21525212</ArticleId>
<ArticleId IdType="doi">10.1099/vir.0.031856-0</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>Allemagne</li>
<li>Pays-Bas</li>
<li>Royaume-Uni</li>
<li>Suisse</li>
</country>
<region><li>Bade-Wurtemberg</li>
<li>Bavière</li>
<li>District de Basse-Franconie</li>
<li>District de Fribourg-en-Brisgau</li>
<li>District de Giessen</li>
<li>Hesse (Land)</li>
<li>Hollande-Méridionale</li>
</region>
<settlement><li>Fribourg-en-Brisgau</li>
<li>Leyde</li>
<li>Marbourg</li>
<li>Wurtzbourg</li>
</settlement>
</list>
<tree><country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Kuri, Thomas" sort="Kuri, Thomas" uniqKey="Kuri T" first="Thomas" last="Kuri">Thomas Kuri</name>
</region>
<name sortKey="Putics, Akos" sort="Putics, Akos" uniqKey="Putics A" first="Akos" last="Putics">Akos Putics</name>
<name sortKey="Weber, Friedemann" sort="Weber, Friedemann" uniqKey="Weber F" first="Friedemann" last="Weber">Friedemann Weber</name>
<name sortKey="Ziebuhr, John" sort="Ziebuhr, John" uniqKey="Ziebuhr J" first="John" last="Ziebuhr">John Ziebuhr</name>
</country>
<country name="Suisse"><noRegion><name sortKey="Eriksson, Klara K" sort="Eriksson, Klara K" uniqKey="Eriksson K" first="Klara K" last="Eriksson">Klara K. Eriksson</name>
</noRegion>
<name sortKey="Thiel, Volker" sort="Thiel, Volker" uniqKey="Thiel V" first="Volker" last="Thiel">Volker Thiel</name>
<name sortKey="Zust, Roland" sort="Zust, Roland" uniqKey="Zust R" first="Roland" last="Züst">Roland Züst</name>
</country>
<country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="Snijder, Eric J" sort="Snijder, Eric J" uniqKey="Snijder E" first="Eric J" last="Snijder">Eric J. Snijder</name>
</region>
</country>
<country name="Royaume-Uni"><noRegion><name sortKey="Davidson, Andrew D" sort="Davidson, Andrew D" uniqKey="Davidson A" first="Andrew D" last="Davidson">Andrew D. Davidson</name>
</noRegion>
<name sortKey="Siddell, Stuart G" sort="Siddell, Stuart G" uniqKey="Siddell S" first="Stuart G" last="Siddell">Stuart G. Siddell</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/PubMed/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001421 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd -nk 001421 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= SrasV1 |flux= PubMed |étape= Checkpoint |type= RBID |clé= pubmed:21525212 |texte= The ADP-ribose-1''-monophosphatase domains of severe acute respiratory syndrome coronavirus and human coronavirus 229E mediate resistance to antiviral interferon responses. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/RBID.i -Sk "pubmed:21525212" \ | HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd \ | NlmPubMed2Wicri -a SrasV1
![]() | This area was generated with Dilib version V0.6.33. | ![]() |