The ADP-ribose-1''-monophosphatase domains of severe acute respiratory syndrome coronavirus and human coronavirus 229E mediate resistance to antiviral interferon responses.
Identifieur interne : 001523 ( PubMed/Corpus ); précédent : 001522; suivant : 001524The ADP-ribose-1''-monophosphatase domains of severe acute respiratory syndrome coronavirus and human coronavirus 229E mediate resistance to antiviral interferon responses.
Auteurs : Thomas Kuri ; Klara K. Eriksson ; Akos Putics ; Roland Züst ; Eric J. Snijder ; Andrew D. Davidson ; Stuart G. Siddell ; Volker Thiel ; John Ziebuhr ; Friedemann WeberSource :
- The Journal of general virology [ 1465-2099 ] ; 2011.
English descriptors
- KwdEn :
- Amino Acid Sequence, Antiviral Agents (immunology), Cell Line, Coronavirus 229E, Human (chemistry), Coronavirus 229E, Human (enzymology), Coronavirus 229E, Human (genetics), Coronavirus 229E, Human (immunology), Coronavirus Infections (genetics), Coronavirus Infections (immunology), Coronavirus Infections (virology), Humans, Interferon-alpha (genetics), Interferon-alpha (immunology), Molecular Sequence Data, Phosphoric Monoester Hydrolases (chemistry), Phosphoric Monoester Hydrolases (genetics), Phosphoric Monoester Hydrolases (immunology), Protein Structure, Tertiary, SARS Virus (chemistry), SARS Virus (drug effects), SARS Virus (enzymology), SARS Virus (genetics), Sequence Alignment, Severe Acute Respiratory Syndrome (genetics), Severe Acute Respiratory Syndrome (immunology), Severe Acute Respiratory Syndrome (virology), Viral Proteins (chemistry), Viral Proteins (genetics), Viral Proteins (immunology).
- MESH :
- chemical , chemistry : Phosphoric Monoester Hydrolases, Viral Proteins.
- chemical , genetics : Interferon-alpha, Phosphoric Monoester Hydrolases, Viral Proteins.
- chemical , immunology : Antiviral Agents, Interferon-alpha, Phosphoric Monoester Hydrolases, Viral Proteins.
- chemistry : Coronavirus 229E, Human, SARS Virus.
- drug effects : SARS Virus.
- enzymology : Coronavirus 229E, Human, SARS Virus.
- genetics : Coronavirus 229E, Human, Coronavirus Infections, SARS Virus, Severe Acute Respiratory Syndrome.
- immunology : Coronavirus 229E, Human, Coronavirus Infections, Severe Acute Respiratory Syndrome.
- virology : Coronavirus Infections, Severe Acute Respiratory Syndrome.
- Amino Acid Sequence, Cell Line, Humans, Molecular Sequence Data, Protein Structure, Tertiary, Sequence Alignment.
Abstract
Several plus-strand RNA viruses encode proteins containing macrodomains. These domains possess ADP-ribose-1″-phosphatase (ADRP) activity and/or bind poly(ADP-ribose), poly(A) or poly(G). The relevance of these activities in the viral life cycle has not yet been resolved. Here, we report that genetically engineered mutants of severe acute respiratory syndrome coronavirus (SARS-CoV) and human coronavirus 229E (HCoV-229E) expressing ADRP-deficient macrodomains displayed an increased sensitivity to the antiviral effect of alpha interferon compared with their wild-type counterparts. The data suggest that macrodomain-associated ADRP activities may have a role in viral escape from the innate immune responses of the host.
DOI: 10.1099/vir.0.031856-0
PubMed: 21525212
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Eriksson</name><affiliation><nlm:affiliation>Research Department, Kantonal Hospital St Gallen, St Gallen, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Putics, Akos" sort="Putics, Akos" uniqKey="Putics A" first="Akos" last="Putics">Akos Putics</name><affiliation><nlm:affiliation>Institute of Virology and Immunology, University of Würzburg, D-97078 Würzburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Zust, Roland" sort="Zust, Roland" uniqKey="Zust R" first="Roland" last="Züst">Roland Züst</name><affiliation><nlm:affiliation>Research Department, Kantonal Hospital St Gallen, St Gallen, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Snijder, Eric J" sort="Snijder, Eric J" uniqKey="Snijder E" first="Eric J" last="Snijder">Eric J. Snijder</name><affiliation><nlm:affiliation>Molecular Virology Laboratory, Department of Medical Microbiology, Center of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Davidson, Andrew D" sort="Davidson, Andrew D" uniqKey="Davidson A" first="Andrew D" last="Davidson">Andrew D. Davidson</name><affiliation><nlm:affiliation>Division of Virology, Department of Cellular and Molecular Medicine, School of Medical and Veterinary Sciences, University of Bristol, Bristol, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Siddell, Stuart G" sort="Siddell, Stuart G" uniqKey="Siddell S" first="Stuart G" last="Siddell">Stuart G. 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Eriksson</name><affiliation><nlm:affiliation>Research Department, Kantonal Hospital St Gallen, St Gallen, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Putics, Akos" sort="Putics, Akos" uniqKey="Putics A" first="Akos" last="Putics">Akos Putics</name><affiliation><nlm:affiliation>Institute of Virology and Immunology, University of Würzburg, D-97078 Würzburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Zust, Roland" sort="Zust, Roland" uniqKey="Zust R" first="Roland" last="Züst">Roland Züst</name><affiliation><nlm:affiliation>Research Department, Kantonal Hospital St Gallen, St Gallen, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Snijder, Eric J" sort="Snijder, Eric J" uniqKey="Snijder E" first="Eric J" last="Snijder">Eric J. Snijder</name><affiliation><nlm:affiliation>Molecular Virology Laboratory, Department of Medical Microbiology, Center of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Davidson, Andrew D" sort="Davidson, Andrew D" uniqKey="Davidson A" first="Andrew D" last="Davidson">Andrew D. Davidson</name><affiliation><nlm:affiliation>Division of Virology, Department of Cellular and Molecular Medicine, School of Medical and Veterinary Sciences, University of Bristol, Bristol, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Siddell, Stuart G" sort="Siddell, Stuart G" uniqKey="Siddell S" first="Stuart G" last="Siddell">Stuart G. Siddell</name><affiliation><nlm:affiliation>Division of Virology, Department of Cellular and Molecular Medicine, School of Medical and Veterinary Sciences, University of Bristol, Bristol, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Thiel, Volker" sort="Thiel, Volker" uniqKey="Thiel V" first="Volker" last="Thiel">Volker Thiel</name><affiliation><nlm:affiliation>Research Department, Kantonal Hospital St Gallen, St Gallen, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Ziebuhr, John" sort="Ziebuhr, John" uniqKey="Ziebuhr J" first="John" last="Ziebuhr">John Ziebuhr</name><affiliation><nlm:affiliation>Institute of Medical Virology, Justus Liebig University Giessen, D-35392 Giessen, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Weber, Friedemann" sort="Weber, Friedemann" uniqKey="Weber F" first="Friedemann" last="Weber">Friedemann Weber</name><affiliation><nlm:affiliation>Institute for Virology, Philipps-University Marburg, D-35043 Marburg, Germany.</nlm:affiliation></affiliation></author></analytic><series><title level="j">The Journal of general virology</title><idno type="eISSN">1465-2099</idno><imprint><date when="2011" type="published">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence</term><term>Antiviral Agents (immunology)</term><term>Cell Line</term><term>Coronavirus 229E, Human (chemistry)</term><term>Coronavirus 229E, Human (enzymology)</term><term>Coronavirus 229E, Human (genetics)</term><term>Coronavirus 229E, Human (immunology)</term><term>Coronavirus Infections (genetics)</term><term>Coronavirus Infections (immunology)</term><term>Coronavirus Infections (virology)</term><term>Humans</term><term>Interferon-alpha (genetics)</term><term>Interferon-alpha (immunology)</term><term>Molecular Sequence Data</term><term>Phosphoric Monoester Hydrolases (chemistry)</term><term>Phosphoric Monoester Hydrolases (genetics)</term><term>Phosphoric Monoester Hydrolases (immunology)</term><term>Protein Structure, Tertiary</term><term>SARS Virus (chemistry)</term><term>SARS Virus (drug effects)</term><term>SARS Virus (enzymology)</term><term>SARS Virus (genetics)</term><term>Sequence Alignment</term><term>Severe Acute Respiratory Syndrome (genetics)</term><term>Severe Acute Respiratory Syndrome (immunology)</term><term>Severe Acute Respiratory Syndrome (virology)</term><term>Viral Proteins (chemistry)</term><term>Viral Proteins (genetics)</term><term>Viral Proteins (immunology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Phosphoric Monoester Hydrolases</term><term>Viral Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Interferon-alpha</term><term>Phosphoric Monoester Hydrolases</term><term>Viral Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antiviral Agents</term><term>Interferon-alpha</term><term>Phosphoric Monoester Hydrolases</term><term>Viral Proteins</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Coronavirus 229E, Human</term><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Coronavirus 229E, Human</term><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Coronavirus 229E, Human</term><term>Coronavirus Infections</term><term>SARS Virus</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Coronavirus 229E, Human</term><term>Coronavirus Infections</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coronavirus Infections</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term><term>Cell Line</term><term>Humans</term><term>Molecular Sequence Data</term><term>Protein Structure, Tertiary</term><term>Sequence Alignment</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Several plus-strand RNA viruses encode proteins containing macrodomains. These domains possess ADP-ribose-1″-phosphatase (ADRP) activity and/or bind poly(ADP-ribose), poly(A) or poly(G). The relevance of these activities in the viral life cycle has not yet been resolved. Here, we report that genetically engineered mutants of severe acute respiratory syndrome coronavirus (SARS-CoV) and human coronavirus 229E (HCoV-229E) expressing ADRP-deficient macrodomains displayed an increased sensitivity to the antiviral effect of alpha interferon compared with their wild-type counterparts. The data suggest that macrodomain-associated ADRP activities may have a role in viral escape from the innate immune responses of the host.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">21525212</PMID><DateCompleted><Year>2011</Year><Month>09</Month><Day>19</Day></DateCompleted><DateRevised><Year>2020</Year><Month>02</Month><Day>28</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1465-2099</ISSN><JournalIssue CitedMedium="Internet"><Volume>92</Volume><Issue>Pt 8</Issue><PubDate><Year>2011</Year><Month>Aug</Month></PubDate></JournalIssue><Title>The Journal of general virology</Title><ISOAbbreviation>J. Gen. Virol.</ISOAbbreviation></Journal><ArticleTitle>The ADP-ribose-1''-monophosphatase domains of severe acute respiratory syndrome coronavirus and human coronavirus 229E mediate resistance to antiviral interferon responses.</ArticleTitle><Pagination><MedlinePgn>1899-1905</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1099/vir.0.031856-0</ELocationID><Abstract><AbstractText>Several plus-strand RNA viruses encode proteins containing macrodomains. These domains possess ADP-ribose-1″-phosphatase (ADRP) activity and/or bind poly(ADP-ribose), poly(A) or poly(G). The relevance of these activities in the viral life cycle has not yet been resolved. Here, we report that genetically engineered mutants of severe acute respiratory syndrome coronavirus (SARS-CoV) and human coronavirus 229E (HCoV-229E) expressing ADRP-deficient macrodomains displayed an increased sensitivity to the antiviral effect of alpha interferon compared with their wild-type counterparts. The data suggest that macrodomain-associated ADRP activities may have a role in viral escape from the innate immune responses of the host.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Kuri</LastName><ForeName>Thomas</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Virology, University of Freiburg, D-79008 Freiburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Eriksson</LastName><ForeName>Klara K</ForeName><Initials>KK</Initials><AffiliationInfo><Affiliation>Research Department, Kantonal Hospital St Gallen, St Gallen, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Putics</LastName><ForeName>Akos</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Institute of Virology and Immunology, University of Würzburg, D-97078 Würzburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Züst</LastName><ForeName>Roland</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Research Department, Kantonal Hospital St Gallen, St Gallen, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Snijder</LastName><ForeName>Eric J</ForeName><Initials>EJ</Initials><AffiliationInfo><Affiliation>Molecular Virology Laboratory, Department of Medical Microbiology, Center of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Davidson</LastName><ForeName>Andrew D</ForeName><Initials>AD</Initials><AffiliationInfo><Affiliation>Division of Virology, Department of Cellular and Molecular Medicine, School of Medical and Veterinary Sciences, University of Bristol, Bristol, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Siddell</LastName><ForeName>Stuart G</ForeName><Initials>SG</Initials><AffiliationInfo><Affiliation>Division of Virology, Department of Cellular and Molecular Medicine, School of Medical and Veterinary Sciences, University of Bristol, Bristol, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Thiel</LastName><ForeName>Volker</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Research Department, Kantonal Hospital St Gallen, St Gallen, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ziebuhr</LastName><ForeName>John</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Institute of Medical Virology, Justus Liebig University Giessen, D-35392 Giessen, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Weber</LastName><ForeName>Friedemann</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Institute for Virology, Philipps-University Marburg, D-35043 Marburg, Germany.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Virology, University of Freiburg, D-79008 Freiburg, Germany.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>BB/G012067/1</GrantID><Agency>Biotechnology and Biological Sciences Research Council</Agency><Country>United Kingdom</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2011</Year><Month>04</Month><Day>27</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>J Gen Virol</MedlineTA><NlmUniqueID>0077340</NlmUniqueID><ISSNLinking>0022-1317</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000998">Antiviral Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D016898">Interferon-alpha</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014764">Viral Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.1.3.2</RegistryNumber><NameOfSubstance UI="D010744">Phosphoric Monoester Hydrolases</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000595" MajorTopicYN="N">Amino Acid Sequence</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000998" MajorTopicYN="N">Antiviral Agents</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002460" MajorTopicYN="N">Cell Line</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D028941" MajorTopicYN="N">Coronavirus 229E, Human</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000201" MajorTopicYN="Y">enzymology</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016898" MajorTopicYN="N">Interferon-alpha</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008969" MajorTopicYN="N">Molecular 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