Animal models in virus research: their utility and limitations.
Identifieur interne : 001230 ( PubMed/Checkpoint ); précédent : 001229; suivant : 001231Animal models in virus research: their utility and limitations.
Auteurs : Derrick Louz [Pays-Bas] ; Hans E. Bergmans ; Birgit P. Loos ; Rob C. HoebenSource :
- Critical reviews in microbiology [ 1549-7828 ] ; 2013.
Descripteurs français
- KwdFr :
- Animaux, Humains, Maladies virales (anatomopathologie), Maladies virales (immunologie), Maladies virales (virologie), Modèles animaux de maladie humaine, Recherche biomédicale (), VIH (Virus de l'Immunodéficience Humaine) (immunologie), VIH (Virus de l'Immunodéficience Humaine) (pathogénicité), Virus de la grippe A (immunologie), Virus de la grippe A (pathogénicité), Virus du SRAS (immunologie), Virus du SRAS (pathogénicité).
- MESH :
- anatomopathologie : Maladies virales.
- immunologie : Maladies virales, VIH (Virus de l'Immunodéficience Humaine), Virus de la grippe A, Virus du SRAS.
- pathogénicité : VIH (Virus de l'Immunodéficience Humaine), Virus de la grippe A, Virus du SRAS.
- virologie : Maladies virales.
- Animaux, Humains, Modèles animaux de maladie humaine, Recherche biomédicale.
English descriptors
- KwdEn :
- Animals, Biomedical Research (methods), Disease Models, Animal, HIV (immunology), HIV (pathogenicity), Humans, Influenza A virus (immunology), Influenza A virus (pathogenicity), SARS Virus (immunology), SARS Virus (pathogenicity), Virus Diseases (immunology), Virus Diseases (pathology), Virus Diseases (virology).
- MESH :
- immunology : HIV, Influenza A virus, SARS Virus, Virus Diseases.
- methods : Biomedical Research.
- pathogenicity : HIV, Influenza A virus, SARS Virus.
- pathology : Virus Diseases.
- virology : Virus Diseases.
- Animals, Disease Models, Animal, Humans.
Abstract
Viral diseases are important threats to public health worldwide. With the number of emerging viral diseases increasing the last decades, there is a growing need for appropriate animal models for virus studies. The relevance of animal models can be limited in terms of mimicking human pathophysiology. In this review, we discuss the utility of animal models for studies of influenza A viruses, HIV and SARS-CoV in light of viral emergence, assessment of infection and transmission risks, and regulatory decision making. We address their relevance and limitations. The susceptibility, immune responses, pathogenesis, and pharmacokinetics may differ between the various animal models. These complexities may thwart translating results from animal experiments to the humans. Within these constraints, animal models are very informative for studying virus immunopathology and transmission modes and for translation of virus research into clinical benefit. Insight in the limitations of the various models may facilitate further improvements of the models.
DOI: 10.3109/1040841X.2012.711740
PubMed: 22978742
Affiliations:
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pubmed:22978742Le document en format XML
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<term>Virus de la grippe A</term>
<term>Virus du SRAS</term>
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<term>Influenza A virus</term>
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<front><div type="abstract" xml:lang="en">Viral diseases are important threats to public health worldwide. With the number of emerging viral diseases increasing the last decades, there is a growing need for appropriate animal models for virus studies. The relevance of animal models can be limited in terms of mimicking human pathophysiology. In this review, we discuss the utility of animal models for studies of influenza A viruses, HIV and SARS-CoV in light of viral emergence, assessment of infection and transmission risks, and regulatory decision making. We address their relevance and limitations. The susceptibility, immune responses, pathogenesis, and pharmacokinetics may differ between the various animal models. These complexities may thwart translating results from animal experiments to the humans. Within these constraints, animal models are very informative for studying virus immunopathology and transmission modes and for translation of virus research into clinical benefit. Insight in the limitations of the various models may facilitate further improvements of the models. </div>
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