SrasV1, PubMed, Corpus, bibRecord, 001306

Animal models in virus research: their utility and limitations.

Identifieur interne : 001306 ( PubMed/Corpus ); précédent : 001305; suivant : 001307

Animal models in virus research: their utility and limitations.

Auteurs : Derrick Louz ; Hans E. Bergmans ; Birgit P. Loos ; Rob C. Hoeben

Source :

Critical reviews in microbiology [ 1549-7828 ] ; 2013.

RBID : pubmed:22978742

English descriptors

KwdEn :
- Animals, Biomedical Research (methods), Disease Models, Animal, HIV (immunology), HIV (pathogenicity), Humans, Influenza A virus (immunology), Influenza A virus (pathogenicity), SARS Virus (immunology), SARS Virus (pathogenicity), Virus Diseases (immunology), Virus Diseases (pathology), Virus Diseases (virology).
MESH :
- immunology : HIV, Influenza A virus, SARS Virus, Virus Diseases.
- methods : Biomedical Research.
- pathogenicity : HIV, Influenza A virus, SARS Virus.
- pathology : Virus Diseases.
- virology : Virus Diseases.
- Animals, Disease Models, Animal, Humans.

Abstract

Viral diseases are important threats to public health worldwide. With the number of emerging viral diseases increasing the last decades, there is a growing need for appropriate animal models for virus studies. The relevance of animal models can be limited in terms of mimicking human pathophysiology. In this review, we discuss the utility of animal models for studies of influenza A viruses, HIV and SARS-CoV in light of viral emergence, assessment of infection and transmission risks, and regulatory decision making. We address their relevance and limitations. The susceptibility, immune responses, pathogenesis, and pharmacokinetics may differ between the various animal models. These complexities may thwart translating results from animal experiments to the humans. Within these constraints, animal models are very informative for studying virus immunopathology and transmission modes and for translation of virus research into clinical benefit. Insight in the limitations of the various models may facilitate further improvements of the models.

DOI: 10.3109/1040841X.2012.711740
PubMed: 22978742

Links to Exploration step

pubmed:22978742

Le document en format XML

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<author><name sortKey="Louz, Derrick" sort="Louz, Derrick" uniqKey="Louz D" first="Derrick" last="Louz">Derrick Louz</name>
<affiliation><nlm:affiliation>National Institute for Public Health and the Environment (RIVM), GMO Office , Bilthoven , The Netherlands.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Bergmans, Hans E" sort="Bergmans, Hans E" uniqKey="Bergmans H" first="Hans E" last="Bergmans">Hans E. Bergmans</name>
</author>
<author><name sortKey="Loos, Birgit P" sort="Loos, Birgit P" uniqKey="Loos B" first="Birgit P" last="Loos">Birgit P. Loos</name>
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<author><name sortKey="Hoeben, Rob C" sort="Hoeben, Rob C" uniqKey="Hoeben R" first="Rob C" last="Hoeben">Rob C. Hoeben</name>
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<author><name sortKey="Bergmans, Hans E" sort="Bergmans, Hans E" uniqKey="Bergmans H" first="Hans E" last="Bergmans">Hans E. Bergmans</name>
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<author><name sortKey="Loos, Birgit P" sort="Loos, Birgit P" uniqKey="Loos B" first="Birgit P" last="Loos">Birgit P. Loos</name>
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<author><name sortKey="Hoeben, Rob C" sort="Hoeben, Rob C" uniqKey="Hoeben R" first="Rob C" last="Hoeben">Rob C. Hoeben</name>
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<term>Biomedical Research (methods)</term>
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<term>HIV (immunology)</term>
<term>HIV (pathogenicity)</term>
<term>Humans</term>
<term>Influenza A virus (immunology)</term>
<term>Influenza A virus (pathogenicity)</term>
<term>SARS Virus (immunology)</term>
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<front><div type="abstract" xml:lang="en">Viral diseases are important threats to public health worldwide. With the number of emerging viral diseases increasing the last decades, there is a growing need for appropriate animal models for virus studies. The relevance of animal models can be limited in terms of mimicking human pathophysiology. In this review, we discuss the utility of animal models for studies of influenza A viruses, HIV and SARS-CoV in light of viral emergence, assessment of infection and transmission risks, and regulatory decision making. We address their relevance and limitations. The susceptibility, immune responses, pathogenesis, and pharmacokinetics may differ between the various animal models. These complexities may thwart translating results from animal experiments to the humans. Within these constraints, animal models are very informative for studying virus immunopathology and transmission modes and for translation of virus research into clinical benefit. Insight in the limitations of the various models may facilitate further improvements of the models. </div>
</front>
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<DateCompleted><Year>2014</Year>
<Month>04</Month>
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<DateRevised><Year>2013</Year>
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<Title>Critical reviews in microbiology</Title>
<ISOAbbreviation>Crit. Rev. Microbiol.</ISOAbbreviation>
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<ArticleTitle>Animal models in virus research: their utility and limitations.</ArticleTitle>
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<Abstract><AbstractText>Viral diseases are important threats to public health worldwide. With the number of emerging viral diseases increasing the last decades, there is a growing need for appropriate animal models for virus studies. The relevance of animal models can be limited in terms of mimicking human pathophysiology. In this review, we discuss the utility of animal models for studies of influenza A viruses, HIV and SARS-CoV in light of viral emergence, assessment of infection and transmission risks, and regulatory decision making. We address their relevance and limitations. The susceptibility, immune responses, pathogenesis, and pharmacokinetics may differ between the various animal models. These complexities may thwart translating results from animal experiments to the humans. Within these constraints, animal models are very informative for studying virus immunopathology and transmission modes and for translation of virus research into clinical benefit. Insight in the limitations of the various models may facilitate further improvements of the models. </AbstractText>
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<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
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<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
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Animal models in virus research: their utility and limitations.

Animal models in virus research: their utility and limitations.

Source :

English descriptors

Abstract

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki