Broad-spectrum coronavirus antiviral drug discovery.
Identifieur interne : 000924 ( PubMed/Checkpoint ); précédent : 000923; suivant : 000925Broad-spectrum coronavirus antiviral drug discovery.
Auteurs : Allison L. Totura [États-Unis] ; Sina Bavari [États-Unis]Source :
- Expert opinion on drug discovery [ 1746-045X ] ; 2019.
Descripteurs français
- KwdFr :
- Animaux, Antiviraux (effets indésirables), Antiviraux (pharmacologie), Coronavirus du syndrome respiratoire du Moyen-Orient (), Coronavirus du syndrome respiratoire du Moyen-Orient (isolement et purification), Découverte de médicament (), Humains, Infections à coronavirus (traitement médicamenteux), Infections à coronavirus (virologie), Modèles animaux de maladie humaine, Syndrome respiratoire aigu sévère (traitement médicamenteux), Syndrome respiratoire aigu sévère (virologie), Virus du SRAS (), Virus du SRAS (isolement et purification).
- MESH :
- effets indésirables : Antiviraux.
- isolement et purification : Coronavirus du syndrome respiratoire du Moyen-Orient, Virus du SRAS.
- pharmacologie : Antiviraux.
- traitement médicamenteux : Infections à coronavirus, Syndrome respiratoire aigu sévère.
- virologie : Infections à coronavirus, Syndrome respiratoire aigu sévère.
- Animaux, Coronavirus du syndrome respiratoire du Moyen-Orient, Découverte de médicament, Humains, Modèles animaux de maladie humaine, Virus du SRAS.
English descriptors
- KwdEn :
- Animals, Antiviral Agents (adverse effects), Antiviral Agents (pharmacology), Coronavirus Infections (drug therapy), Coronavirus Infections (virology), Disease Models, Animal, Drug Discovery (methods), Humans, Middle East Respiratory Syndrome Coronavirus (drug effects), Middle East Respiratory Syndrome Coronavirus (isolation & purification), SARS Virus (drug effects), SARS Virus (isolation & purification), Severe Acute Respiratory Syndrome (drug therapy), Severe Acute Respiratory Syndrome (virology).
- MESH :
- chemical , adverse effects : Antiviral Agents.
- chemical , pharmacology : Antiviral Agents.
- drug effects : Middle East Respiratory Syndrome Coronavirus, SARS Virus.
- drug therapy : Coronavirus Infections, Severe Acute Respiratory Syndrome.
- isolation & purification : Middle East Respiratory Syndrome Coronavirus, SARS Virus.
- methods : Drug Discovery.
- virology : Coronavirus Infections, Severe Acute Respiratory Syndrome.
- Animals, Disease Models, Animal, Humans.
Abstract
The highly pathogenic coronaviruses severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) are lethal zoonotic viruses that have emerged into human populations these past 15 years. These coronaviruses are associated with novel respiratory syndromes that spread from person-to-person via close contact, resulting in high morbidity and mortality caused by the progression to Acute Respiratory Distress Syndrome (ARDS). Areas covered: The risks of re-emergence of SARS-CoV from bat reservoir hosts, the persistence of MERS-CoV circulation, and the potential for future emergence of novel coronaviruses indicate antiviral drug discovery will require activity against multiple coronaviruses. In this review, approaches that antagonize viral nonstructural proteins, neutralize structural proteins, or modulate essential host elements of viral infection with varying levels of efficacy in models of highly pathogenic coronavirus disease are discussed. Expert opinion: Treatment of SARS and MERS in outbreak settings has focused on therapeutics with general antiviral activity and good safety profiles rather than efficacy data provided by cellular, rodent, or nonhuman primate models of highly pathogenic coronavirus infection. Based on lessons learned from SARS and MERS outbreaks, lack of drugs capable of pan-coronavirus antiviral activity increases the vulnerability of public health systems to a highly pathogenic coronavirus pandemic.
DOI: 10.1080/17460441.2019.1581171
PubMed: 30849247
Affiliations:
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SRAS</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The highly pathogenic coronaviruses severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) are lethal zoonotic viruses that have emerged into human populations these past 15 years. These coronaviruses are associated with novel respiratory syndromes that spread from person-to-person via close contact, resulting in high morbidity and mortality caused by the progression to Acute Respiratory Distress Syndrome (ARDS). Areas covered: The risks of re-emergence of SARS-CoV from bat reservoir hosts, the persistence of MERS-CoV circulation, and the potential for future emergence of novel coronaviruses indicate antiviral drug discovery will require activity against multiple coronaviruses. In this review, approaches that antagonize viral nonstructural proteins, neutralize structural proteins, or modulate essential host elements of viral infection with varying levels of efficacy in models of highly pathogenic coronavirus disease are discussed. Expert opinion: Treatment of SARS and MERS in outbreak settings has focused on therapeutics with general antiviral activity and good safety profiles rather than efficacy data provided by cellular, rodent, or nonhuman primate models of highly pathogenic coronavirus infection. Based on lessons learned from SARS and MERS outbreaks, lack of drugs capable of pan-coronavirus antiviral activity increases the vulnerability of public health systems to a highly pathogenic coronavirus pandemic.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">30849247</PMID><DateCompleted><Year>2020</Year><Month>03</Month><Day>04</Day></DateCompleted><DateRevised><Year>2020</Year><Month>04</Month><Day>01</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1746-045X</ISSN><JournalIssue CitedMedium="Internet"><Volume>14</Volume><Issue>4</Issue><PubDate><Year>2019</Year><Month>04</Month></PubDate></JournalIssue><Title>Expert opinion on drug discovery</Title><ISOAbbreviation>Expert Opin Drug Discov</ISOAbbreviation></Journal><ArticleTitle>Broad-spectrum coronavirus antiviral drug discovery.</ArticleTitle><Pagination><MedlinePgn>397-412</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1080/17460441.2019.1581171</ELocationID><Abstract><AbstractText Label="INTRODUCTION">The highly pathogenic coronaviruses severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) are lethal zoonotic viruses that have emerged into human populations these past 15 years. These coronaviruses are associated with novel respiratory syndromes that spread from person-to-person via close contact, resulting in high morbidity and mortality caused by the progression to Acute Respiratory Distress Syndrome (ARDS). Areas covered: The risks of re-emergence of SARS-CoV from bat reservoir hosts, the persistence of MERS-CoV circulation, and the potential for future emergence of novel coronaviruses indicate antiviral drug discovery will require activity against multiple coronaviruses. In this review, approaches that antagonize viral nonstructural proteins, neutralize structural proteins, or modulate essential host elements of viral infection with varying levels of efficacy in models of highly pathogenic coronavirus disease are discussed. Expert opinion: Treatment of SARS and MERS in outbreak settings has focused on therapeutics with general antiviral activity and good safety profiles rather than efficacy data provided by cellular, rodent, or nonhuman primate models of highly pathogenic coronavirus infection. Based on lessons learned from SARS and MERS outbreaks, lack of drugs capable of pan-coronavirus antiviral activity increases the vulnerability of public health systems to a highly pathogenic coronavirus pandemic.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Totura</LastName><ForeName>Allison L</ForeName><Initials>AL</Initials><Identifier Source="ORCID">0000-0001-6827-0523</Identifier><AffiliationInfo><Affiliation>a Division of Molecular and Translational Sciences , United States Army Medical Research Institute of Infectious Diseases , Fort Detrick , MD , USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bavari</LastName><ForeName>Sina</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>a Division of Molecular and Translational Sciences , United States Army Medical Research Institute of Infectious Diseases , Fort Detrick , MD , USA.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013486">Research Support, U.S. Gov't, Non-P.H.S.</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2019</Year><Month>03</Month><Day>08</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Expert Opin Drug Discov</MedlineTA><NlmUniqueID>101295755</NlmUniqueID><ISSNLinking>1746-0441</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000998">Antiviral Agents</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000998" MajorTopicYN="N">Antiviral 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