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Clinical Course and Outcomes of Patients with Severe Acute Respiratory Syndrome Coronavirus 2 Infection: a Preliminary Report of the First 28 Patients from the Korean Cohort Study on COVID-19.

Identifieur interne : 000665 ( PubMed/Checkpoint ); précédent : 000664; suivant : 000666

Clinical Course and Outcomes of Patients with Severe Acute Respiratory Syndrome Coronavirus 2 Infection: a Preliminary Report of the First 28 Patients from the Korean Cohort Study on COVID-19.

Auteurs : Eu Suk Kim [Corée du Sud] ; Bum Sik Chin [Corée du Sud] ; Chang Kyung Kang [Corée du Sud] ; Nam Joong Kim [Corée du Sud] ; Yu Min Kang [Corée du Sud] ; Jae Phil Choi [Corée du Sud] ; Dong Hyun Oh [Corée du Sud] ; Jeong Han Kim [Corée du Sud] ; Boram Koh [Corée du Sud] ; Seong Eun Kim [Corée du Sud] ; Na Ra Yun [Corée du Sud] ; Jae Hoon Lee [Corée du Sud] ; Jin Yong Kim [Corée du Sud] ; Yeonjae Kim [Corée du Sud] ; Ji Hwan Bang [Corée du Sud] ; Kyoung Ho Song [Corée du Sud] ; Hong Bin Kim [Corée du Sud] ; Ki Hyun Chung [Corée du Sud] ; Myoung Don Oh [Corée du Sud]

Source :

RBID : pubmed:32242348

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English descriptors

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected pneumonia emerged in Wuhan, China in December 2019. In this retrospective multicenter study, we investigated the clinical course and outcomes of novel coronavirus disease 2019 (COVID-19) from early cases in Republic of Korea.

DOI: 10.3346/jkms.2020.35.e142
PubMed: 32242348


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pubmed:32242348

Le document en format XML

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<name sortKey="Bang, Ji Hwan" sort="Bang, Ji Hwan" uniqKey="Bang J" first="Ji Hwan" last="Bang">Ji Hwan Bang</name>
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<name sortKey="Koh, Boram" sort="Koh, Boram" uniqKey="Koh B" first="Boram" last="Koh">Boram Koh</name>
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<name sortKey="Kim, Seong Eun" sort="Kim, Seong Eun" uniqKey="Kim S" first="Seong Eun" last="Kim">Seong Eun Kim</name>
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<name sortKey="Yun, Na Ra" sort="Yun, Na Ra" uniqKey="Yun N" first="Na Ra" last="Yun">Na Ra Yun</name>
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</author>
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<name sortKey="Lee, Jae Hoon" sort="Lee, Jae Hoon" uniqKey="Lee J" first="Jae Hoon" last="Lee">Jae Hoon Lee</name>
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<nlm:affiliation>Department of Internal Medicine, Wonkwang University School of Medicine, Iksan, Korea.</nlm:affiliation>
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<name sortKey="Kim, Jin Yong" sort="Kim, Jin Yong" uniqKey="Kim J" first="Jin Yong" last="Kim">Jin Yong Kim</name>
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<name sortKey="Kim, Yeonjae" sort="Kim, Yeonjae" uniqKey="Kim Y" first="Yeonjae" last="Kim">Yeonjae Kim</name>
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<settlement type="city">Séoul</settlement>
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<name sortKey="Bang, Ji Hwan" sort="Bang, Ji Hwan" uniqKey="Bang J" first="Ji Hwan" last="Bang">Ji Hwan Bang</name>
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<nlm:affiliation>Division of Infectious Diseases, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul, Korea.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Division of Infectious Diseases, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul</wicri:regionArea>
<placeName>
<settlement type="city">Séoul</settlement>
<region type="capital">Région capitale de Séoul</region>
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<name sortKey="Song, Kyoung Ho" sort="Song, Kyoung Ho" uniqKey="Song K" first="Kyoung Ho" last="Song">Kyoung Ho Song</name>
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<nlm:affiliation>Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam</wicri:regionArea>
<wicri:noRegion>Seongnam</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Kim, Hong Bin" sort="Kim, Hong Bin" uniqKey="Kim H" first="Hong Bin" last="Kim">Hong Bin Kim</name>
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<nlm:affiliation>Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam</wicri:regionArea>
<wicri:noRegion>Seongnam</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Chung, Ki Hyun" sort="Chung, Ki Hyun" uniqKey="Chung K" first="Ki Hyun" last="Chung">Ki Hyun Chung</name>
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<nlm:affiliation>Department of Pediatrics, National Medical Center, Seoul, Korea.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Pediatrics, National Medical Center, Seoul</wicri:regionArea>
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<term>Infections à coronavirus (imagerie diagnostique)</term>
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<div type="abstract" xml:lang="en">Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected pneumonia emerged in Wuhan, China in December 2019. In this retrospective multicenter study, we investigated the clinical course and outcomes of novel coronavirus disease 2019 (COVID-19) from early cases in Republic of Korea.</div>
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<Year>2020</Year>
<Month>04</Month>
<Day>06</Day>
</DateCompleted>
<DateRevised>
<Year>2020</Year>
<Month>04</Month>
<Day>09</Day>
</DateRevised>
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<Journal>
<ISSN IssnType="Electronic">1598-6357</ISSN>
<JournalIssue CitedMedium="Internet">
<Volume>35</Volume>
<Issue>13</Issue>
<PubDate>
<Year>2020</Year>
<Month>Apr</Month>
<Day>06</Day>
</PubDate>
</JournalIssue>
<Title>Journal of Korean medical science</Title>
<ISOAbbreviation>J. Korean Med. Sci.</ISOAbbreviation>
</Journal>
<ArticleTitle>Clinical Course and Outcomes of Patients with Severe Acute Respiratory Syndrome Coronavirus 2 Infection: a Preliminary Report of the First 28 Patients from the Korean Cohort Study on COVID-19.</ArticleTitle>
<Pagination>
<MedlinePgn>e142</MedlinePgn>
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<ELocationID EIdType="doi" ValidYN="Y">10.3346/jkms.2020.35.e142</ELocationID>
<Abstract>
<AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected pneumonia emerged in Wuhan, China in December 2019. In this retrospective multicenter study, we investigated the clinical course and outcomes of novel coronavirus disease 2019 (COVID-19) from early cases in Republic of Korea.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">All of the cases confirmed by real time polymerase chain reaction were enrolled from the 1st to the 28th patient nationwide. Clinical data were collected and analyzed for changes in clinical severity including laboratory, radiological, and virologic dynamics during the progression of illness.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">The median age was 40 years (range, 20-73 years) and 15 (53.6%) patients were male. The most common symptoms were cough (28.6%) and sore throat (28.6%), followed by fever (25.0%). Diarrhea was not common (10.7%). Two patients had no symptoms. Initial chest X-ray (CXR) showed infiltration in 46.4% of the patients, but computed tomography scan confirmed pneumonia in 88.9% (16/18) of the patients. Six patients (21.4%) required supplemental oxygen therapy, but no one needed mechanical ventilation. Lymphopenia was more common in severe cases. Higher level of C-reactive protein and worsening of chest radiographic score was observed during the 5-7 day period after symptom onset. Viral shedding was high from day 1 of illness, especially from the upper respiratory tract (URT).</AbstractText>
<AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">The prodromal symptoms of COVID-19 were mild and most patients did not have limitations of daily activity. Viral shedding from URT was high from the prodromal phase. Radiological pneumonia was common from the early days of illness, but it was frequently not evident in simple CXR. These findings could be plausible explanations for the easy and rapid spread of SARS-CoV-2 in the community.</AbstractText>
<CopyrightInformation>© 2020 The Korean Academy of Medical Sciences.</CopyrightInformation>
</Abstract>
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<Author ValidYN="Y" EqualContrib="Y">
<LastName>Kim</LastName>
<ForeName>Eu Suk</ForeName>
<Initials>ES</Initials>
<Identifier Source="ORCID">https://orcid.org/0000-0001-7132-0157</Identifier>
<AffiliationInfo>
<Affiliation>Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y" EqualContrib="Y">
<LastName>Chin</LastName>
<ForeName>Bum Sik</ForeName>
<Initials>BS</Initials>
<Identifier Source="ORCID">https://orcid.org/0000-0003-3021-1434</Identifier>
<AffiliationInfo>
<Affiliation>Division of Infectious Diseases, Department of Internal Medicine, National Medical Center, Seoul, Korea.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y">
<LastName>Kang</LastName>
<ForeName>Chang Kyung</ForeName>
<Initials>CK</Initials>
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<AffiliationInfo>
<Affiliation>Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.</Affiliation>
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<Author ValidYN="Y">
<LastName>Kim</LastName>
<ForeName>Nam Joong</ForeName>
<Initials>NJ</Initials>
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<AffiliationInfo>
<Affiliation>Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.</Affiliation>
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</Author>
<Author ValidYN="Y">
<LastName>Kang</LastName>
<ForeName>Yu Min</ForeName>
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<Identifier Source="ORCID">https://orcid.org/0000-0002-4368-9878</Identifier>
<AffiliationInfo>
<Affiliation>Department of Infectious Diseases, Myongji Hospital, Goyang, Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Choi</LastName>
<ForeName>Jae Phil</ForeName>
<Initials>JP</Initials>
<Identifier Source="ORCID">https://orcid.org/0000-0003-4805-7930</Identifier>
<AffiliationInfo>
<Affiliation>Department of Internal Medicine, Seoul Medical Center, Seoul, Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Oh</LastName>
<ForeName>Dong Hyun</ForeName>
<Initials>DH</Initials>
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<AffiliationInfo>
<Affiliation>Department of Internal Medicine, Seoul Medical Center, Seoul, Korea.</Affiliation>
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<LastName>Kim</LastName>
<ForeName>Jeong Han</ForeName>
<Initials>JH</Initials>
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<AffiliationInfo>
<Affiliation>Division of Infectious Diseases, Department of Internal Medicine, Armed Forces Capital Hospital, Seongnam, Korea.</Affiliation>
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<LastName>Koh</LastName>
<ForeName>Boram</ForeName>
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<AffiliationInfo>
<Affiliation>Department of Internal Medicine, Gyeonggi Provincial Medical Center Ansung Hospital, Anseong, Korea.</Affiliation>
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<LastName>Kim</LastName>
<ForeName>Seong Eun</ForeName>
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<AffiliationInfo>
<Affiliation>Department of Infectious Diseases, Chonnam National University Medical School, Gwangju, Korea.</Affiliation>
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</Author>
<Author ValidYN="Y">
<LastName>Yun</LastName>
<ForeName>Na Ra</ForeName>
<Initials>NR</Initials>
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<AffiliationInfo>
<Affiliation>Department of Internal Medicine, College of Medicine, Chosun University, Gwangju, Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Lee</LastName>
<ForeName>Jae Hoon</ForeName>
<Initials>JH</Initials>
<Identifier Source="ORCID">https://orcid.org/0000-0002-0897-2838</Identifier>
<AffiliationInfo>
<Affiliation>Department of Internal Medicine, Wonkwang University School of Medicine, Iksan, Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Kim</LastName>
<ForeName>Jin Yong</ForeName>
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<Affiliation>Division of Infectious Diseases, Department of Internal Medicine, Incheon Medical Center, Incheon, Korea.</Affiliation>
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<ForeName>Yeonjae</ForeName>
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<Author ValidYN="Y">
<LastName>Bang</LastName>
<ForeName>Ji Hwan</ForeName>
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<Affiliation>Division of Infectious Diseases, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul, Korea.</Affiliation>
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</Author>
<Author ValidYN="Y">
<LastName>Song</LastName>
<ForeName>Kyoung Ho</ForeName>
<Initials>KH</Initials>
<Identifier Source="ORCID">https://orcid.org/0000-0002-4517-3840</Identifier>
<AffiliationInfo>
<Affiliation>Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.</Affiliation>
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<LastName>Kim</LastName>
<ForeName>Hong Bin</ForeName>
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<Affiliation>Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.</Affiliation>
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<Author ValidYN="Y">
<LastName>Chung</LastName>
<ForeName>Ki Hyun</ForeName>
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<Identifier Source="ORCID">https://orcid.org/0000-0002-7100-2519</Identifier>
<AffiliationInfo>
<Affiliation>Department of Pediatrics, National Medical Center, Seoul, Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Oh</LastName>
<ForeName>Myoung Don</ForeName>
<Initials>MD</Initials>
<Identifier Source="ORCID">https://orcid.org/0000-0002-2344-7695</Identifier>
<AffiliationInfo>
<Affiliation>Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea. mdohmd@snu.ac.kr.</Affiliation>
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</Author>
<Author ValidYN="Y">
<CollectiveName>Korea National Committee for Clinical Management of COVID-19</CollectiveName>
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<Grant>
<GrantID>2740-309-320-01</GrantID>
<Acronym>MHW</Acronym>
<Agency>Ministry of Health and Welfare</Agency>
<Country>Korea</Country>
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