Transcriptional profiling of Vero E6 cells over-expressing SARS-CoV S2 subunit: Insights on viral regulation of apoptosis and proliferation
Identifieur interne : 001561 ( Pmc/Curation ); précédent : 001560; suivant : 001562Transcriptional profiling of Vero E6 cells over-expressing SARS-CoV S2 subunit: Insights on viral regulation of apoptosis and proliferation
Auteurs : Yin-Shan Yeung ; Chi-Wai Yip ; Chung-Chau Hon ; Ken Y. C. Chow ; Iris C. M. Ma ; Fanya Zeng ; Frederick C. C. LeungSource :
- Virology [ 0042-6822 ] ; 2007.
Abstract
We have previously demonstrated that over-expression of spike protein (S) of severe acute respiratory syndrome coronavirus (SARS-CoV) or its C-terminal subunit (S2) is sufficient to induce apoptosis
Url:
DOI: 10.1016/j.virol.2007.09.016
PubMed: 17961624
PubMed Central: 7103328
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<author><name sortKey="Yeung, Yin Shan" sort="Yeung, Yin Shan" uniqKey="Yeung Y" first="Yin-Shan" last="Yeung">Yin-Shan Yeung</name>
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<author><name sortKey="Yip, Chi Wai" sort="Yip, Chi Wai" uniqKey="Yip C" first="Chi-Wai" last="Yip">Chi-Wai Yip</name>
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<author><name sortKey="Hon, Chung Chau" sort="Hon, Chung Chau" uniqKey="Hon C" first="Chung-Chau" last="Hon">Chung-Chau Hon</name>
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<author><name sortKey="Chow, Ken Y C" sort="Chow, Ken Y C" uniqKey="Chow K" first="Ken Y. C." last="Chow">Ken Y. C. Chow</name>
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<author><name sortKey="Ma, Iris C M" sort="Ma, Iris C M" uniqKey="Ma I" first="Iris C. M." last="Ma">Iris C. M. Ma</name>
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<author><name sortKey="Zeng, Fanya" sort="Zeng, Fanya" uniqKey="Zeng F" first="Fanya" last="Zeng">Fanya Zeng</name>
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<author><name sortKey="Leung, Frederick C C" sort="Leung, Frederick C C" uniqKey="Leung F" first="Frederick C. C." last="Leung">Frederick C. C. Leung</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Transcriptional profiling of Vero E6 cells over-expressing SARS-CoV S2 subunit: Insights on viral regulation of apoptosis and proliferation</title>
<author><name sortKey="Yeung, Yin Shan" sort="Yeung, Yin Shan" uniqKey="Yeung Y" first="Yin-Shan" last="Yeung">Yin-Shan Yeung</name>
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<author><name sortKey="Yip, Chi Wai" sort="Yip, Chi Wai" uniqKey="Yip C" first="Chi-Wai" last="Yip">Chi-Wai Yip</name>
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<author><name sortKey="Hon, Chung Chau" sort="Hon, Chung Chau" uniqKey="Hon C" first="Chung-Chau" last="Hon">Chung-Chau Hon</name>
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<author><name sortKey="Chow, Ken Y C" sort="Chow, Ken Y C" uniqKey="Chow K" first="Ken Y. C." last="Chow">Ken Y. C. Chow</name>
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<author><name sortKey="Ma, Iris C M" sort="Ma, Iris C M" uniqKey="Ma I" first="Iris C. M." last="Ma">Iris C. M. Ma</name>
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<author><name sortKey="Zeng, Fanya" sort="Zeng, Fanya" uniqKey="Zeng F" first="Fanya" last="Zeng">Fanya Zeng</name>
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<author><name sortKey="Leung, Frederick C C" sort="Leung, Frederick C C" uniqKey="Leung F" first="Frederick C. C." last="Leung">Frederick C. C. Leung</name>
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<series><title level="j">Virology</title>
<idno type="ISSN">0042-6822</idno>
<idno type="eISSN">1096-0341</idno>
<imprint><date when="2007">2007</date>
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<front><div type="abstract" xml:lang="en"><p>We have previously demonstrated that over-expression of spike protein (S) of severe acute respiratory syndrome coronavirus (SARS-CoV) or its C-terminal subunit (S2) is sufficient to induce apoptosis <italic>in vitro</italic>
. To further investigate the possible roles of S2 in SARS-CoV-induced apoptosis and pathogenesis of SARS, we characterized the host expression profiles induced upon S2 over-expression in Vero E6 cells by oligonucleotide microarray analysis. Possible activation of mitochondrial apoptotic pathway in S2 expressing cells was suggested, as evidenced by the up-regulation of cytochrome <italic>c</italic>
and down-regulation of the Bcl-2 family anti-apoptotic members. Inhibition of Bcl-2-related anti-apoptotic pathway was further supported by the diminution of S2-induced apoptosis in Vero E6 cells over-expressing Bcl-xL. In addition, modulation of CCN E2 and CDKN 1A implied the possible control of cell cycle arrest at G1/S phase. This study is expected to extend our understanding on the pathogenesis of SARS at a molecular level.</p>
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</TEI>
<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Virology</journal-id>
<journal-id journal-id-type="iso-abbrev">Virology</journal-id>
<journal-title-group><journal-title>Virology</journal-title>
</journal-title-group>
<issn pub-type="ppub">0042-6822</issn>
<issn pub-type="epub">1096-0341</issn>
<publisher><publisher-name>Elsevier Inc.</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">17961624</article-id>
<article-id pub-id-type="pmc">7103328</article-id>
<article-id pub-id-type="publisher-id">S0042-6822(07)00617-4</article-id>
<article-id pub-id-type="doi">10.1016/j.virol.2007.09.016</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Transcriptional profiling of Vero E6 cells over-expressing SARS-CoV S2 subunit: Insights on viral regulation of apoptosis and proliferation</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Yeung</surname>
<given-names>Yin-Shan</given-names>
</name>
<email>ysyeung@graduate.hku.hk</email>
</contrib>
<contrib contrib-type="author"><name><surname>Yip</surname>
<given-names>Chi-Wai</given-names>
</name>
<email>h0024004@hkusua.hku.hk</email>
</contrib>
<contrib contrib-type="author"><name><surname>Hon</surname>
<given-names>Chung-Chau</given-names>
</name>
<email>h9826299@hkusua.hku.hk</email>
</contrib>
<contrib contrib-type="author"><name><surname>Chow</surname>
<given-names>Ken Y.C.</given-names>
</name>
<email>chow@pasteur.fr</email>
</contrib>
<contrib contrib-type="author"><name><surname>Ma</surname>
<given-names>Iris C.M.</given-names>
</name>
<email>h0105962@hkusua.hku.hk</email>
</contrib>
<contrib contrib-type="author"><name><surname>Zeng</surname>
<given-names>Fanya</given-names>
</name>
<email>fzeng@hkucc.hku.hk</email>
</contrib>
<contrib contrib-type="author"><name><surname>Leung</surname>
<given-names>Frederick C.C.</given-names>
</name>
<email>fcleung@hkucc.hku.hk</email>
<xref rid="cor1" ref-type="corresp">⁎</xref>
</contrib>
</contrib-group>
<aff>Department of Zoology, Kadoorie Biological Science Building, The University of Hong Kong, Hong Kong</aff>
<author-notes><corresp id="cor1"><label>⁎</label>
Corresponding author. Fax: +852 28574672. <email>fcleung@hkucc.hku.hk</email>
</corresp>
</author-notes>
<pub-date pub-type="pmc-release"><day>25</day>
<month>10</month>
<year>2007</year>
</pub-date>
<pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="ppub"><day>5</day>
<month>2</month>
<year>2008</year>
</pub-date>
<pub-date pub-type="epub"><day>25</day>
<month>10</month>
<year>2007</year>
</pub-date>
<volume>371</volume>
<issue>1</issue>
<fpage>32</fpage>
<lpage>43</lpage>
<history><date date-type="received"><day>3</day>
<month>4</month>
<year>2007</year>
</date>
<date date-type="rev-recd"><day>30</day>
<month>4</month>
<year>2007</year>
</date>
<date date-type="accepted"><day>14</day>
<month>9</month>
<year>2007</year>
</date>
</history>
<permissions><copyright-statement>Copyright © 2007 Elsevier Inc. All rights reserved.</copyright-statement>
<copyright-year>2007</copyright-year>
<copyright-holder>Elsevier Inc.</copyright-holder>
<license><license-p>Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.</license-p>
</license>
</permissions>
<abstract><p>We have previously demonstrated that over-expression of spike protein (S) of severe acute respiratory syndrome coronavirus (SARS-CoV) or its C-terminal subunit (S2) is sufficient to induce apoptosis <italic>in vitro</italic>
. To further investigate the possible roles of S2 in SARS-CoV-induced apoptosis and pathogenesis of SARS, we characterized the host expression profiles induced upon S2 over-expression in Vero E6 cells by oligonucleotide microarray analysis. Possible activation of mitochondrial apoptotic pathway in S2 expressing cells was suggested, as evidenced by the up-regulation of cytochrome <italic>c</italic>
and down-regulation of the Bcl-2 family anti-apoptotic members. Inhibition of Bcl-2-related anti-apoptotic pathway was further supported by the diminution of S2-induced apoptosis in Vero E6 cells over-expressing Bcl-xL. In addition, modulation of CCN E2 and CDKN 1A implied the possible control of cell cycle arrest at G1/S phase. This study is expected to extend our understanding on the pathogenesis of SARS at a molecular level.</p>
</abstract>
<kwd-group><title>Keywords</title>
<kwd>Severe acute respiratory syndrome coronavirus</kwd>
<kwd>Spike protein</kwd>
<kwd>Apoptosis</kwd>
<kwd>Proliferation</kwd>
<kwd>Microarray</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
</record>
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