An evidence-based framework for priority clinical research questions for COVID-19
Identifieur interne : 001145 ( Pmc/Curation ); précédent : 001144; suivant : 001146An evidence-based framework for priority clinical research questions for COVID-19
Auteurs : Carlyn Harris [États-Unis, Royaume-Uni] ; Gail Carson [Royaume-Uni] ; J Kenneth Baillie [Royaume-Uni] ; Peter Horby [Royaume-Uni] ; Harish Nair [Royaume-Uni]Source :
- Journal of Global Health [ 2047-2978 ] ; ????.
Abstract
On 31 December, 2019, the World Health Organization China Country Office was informed of cases of pneumonia of unknown aetiology. Since then, there have been over 75 000 cases globally of the 2019 novel coronavirus (COVID-19), 2000 deaths, and over 14 000 cases recovered. Outbreaks of novel agents represent opportunities for clinical research to inform real-time public health action. In 2018, we conducted a systematic review to identify priority research questions for Severe Acute Respiratory Syndrome-related coronavirus (SARS-CoV) and Middle East Respiratory Syndrome-related coronavirus (MERS-CoV). Here, we review information available on COVID-19 and provide an evidenced-based framework for priority clinical research in the current outbreak.
Three bibliographic databases were searched to identify clinical studies published on SARS-CoV and MERS-CoV in the outbreak setting. Studies were grouped thematically according to clinical research questions addressed. In February 2020, available information on COVID19 was reviewed and compared to the results of the SARS-CoV and MERS-CoV systematic review.
From the research objectives for SARS-CoV and MERS-CoV, ten themes in the literature were identified: Clinical characterisation, prognosis, diagnosis, clinical management, viral pathogenesis, epidemiological characterisation, infection prevention and control/transmission, susceptibility, psychosocial, and aetiology. For COVID19, some information on clinical presentation, diagnostic testing, and aetiology is available but many clinical research gaps have yet to be filled.
Based on a systematic review of other severe coronaviruses, we summarise the state of clinical research for COVID-19, highlight the research gaps, and provide recommendations for the implementation of standardised protocols. Data based on internationally standardised protocols will inform clinical practice real-time.
Url:
DOI: 10.7189/jogh.10-011001
PubMed: 32257173
PubMed Central: 7125419
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :001145
Links to Exploration step
PMC:7125419Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">An evidence-based framework for priority clinical research questions for COVID-19</title>
<author><name sortKey="Harris, Carlyn" sort="Harris, Carlyn" uniqKey="Harris C" first="Carlyn" last="Harris">Carlyn Harris</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Emory University School of Medicine, Atlanta, Georgia, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Emory University School of Medicine, Atlanta, Georgia</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2">Centre for Global Health, Usher Institute, University of Edinburgh, Edinburgh, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Global Health, Usher Institute, University of Edinburgh, Edinburgh</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Carson, Gail" sort="Carson, Gail" uniqKey="Carson G" first="Gail" last="Carson">Gail Carson</name>
<affiliation wicri:level="1"><nlm:aff id="aff3">International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC), Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC), Centre for Tropical Medicine and Global Health, University of Oxford, Oxford</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff4">Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Tropical Medicine and Global Health, University of Oxford, Oxford</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Baillie, J Kenneth" sort="Baillie, J Kenneth" uniqKey="Baillie J" first="J Kenneth" last="Baillie">J Kenneth Baillie</name>
<affiliation wicri:level="1"><nlm:aff id="aff4">Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Tropical Medicine and Global Health, University of Oxford, Oxford</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff5">Centre for Inflammation Research and Roslin Institute, University of Edinburgh, Edinburgh, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Inflammation Research and Roslin Institute, University of Edinburgh, Edinburgh</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Horby, Peter" sort="Horby, Peter" uniqKey="Horby P" first="Peter" last="Horby">Peter Horby</name>
<affiliation wicri:level="1"><nlm:aff id="aff3">International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC), Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC), Centre for Tropical Medicine and Global Health, University of Oxford, Oxford</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff4">Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Tropical Medicine and Global Health, University of Oxford, Oxford</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Nair, Harish" sort="Nair, Harish" uniqKey="Nair H" first="Harish" last="Nair">Harish Nair</name>
<affiliation wicri:level="1"><nlm:aff id="aff2">Centre for Global Health, Usher Institute, University of Edinburgh, Edinburgh, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Global Health, Usher Institute, University of Edinburgh, Edinburgh</wicri:regionArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">32257173</idno>
<idno type="pmc">7125419</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7125419</idno>
<idno type="RBID">PMC:7125419</idno>
<idno type="doi">10.7189/jogh.10-011001</idno>
<date when="????">????</date>
<idno type="wicri:Area/Pmc/Corpus">001145</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001145</idno>
<idno type="wicri:Area/Pmc/Curation">001145</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001145</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">An evidence-based framework for priority clinical research questions for COVID-19</title>
<author><name sortKey="Harris, Carlyn" sort="Harris, Carlyn" uniqKey="Harris C" first="Carlyn" last="Harris">Carlyn Harris</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Emory University School of Medicine, Atlanta, Georgia, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Emory University School of Medicine, Atlanta, Georgia</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2">Centre for Global Health, Usher Institute, University of Edinburgh, Edinburgh, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Global Health, Usher Institute, University of Edinburgh, Edinburgh</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Carson, Gail" sort="Carson, Gail" uniqKey="Carson G" first="Gail" last="Carson">Gail Carson</name>
<affiliation wicri:level="1"><nlm:aff id="aff3">International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC), Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC), Centre for Tropical Medicine and Global Health, University of Oxford, Oxford</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff4">Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Tropical Medicine and Global Health, University of Oxford, Oxford</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Baillie, J Kenneth" sort="Baillie, J Kenneth" uniqKey="Baillie J" first="J Kenneth" last="Baillie">J Kenneth Baillie</name>
<affiliation wicri:level="1"><nlm:aff id="aff4">Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Tropical Medicine and Global Health, University of Oxford, Oxford</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff5">Centre for Inflammation Research and Roslin Institute, University of Edinburgh, Edinburgh, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Inflammation Research and Roslin Institute, University of Edinburgh, Edinburgh</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Horby, Peter" sort="Horby, Peter" uniqKey="Horby P" first="Peter" last="Horby">Peter Horby</name>
<affiliation wicri:level="1"><nlm:aff id="aff3">International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC), Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC), Centre for Tropical Medicine and Global Health, University of Oxford, Oxford</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff4">Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Tropical Medicine and Global Health, University of Oxford, Oxford</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Nair, Harish" sort="Nair, Harish" uniqKey="Nair H" first="Harish" last="Nair">Harish Nair</name>
<affiliation wicri:level="1"><nlm:aff id="aff2">Centre for Global Health, Usher Institute, University of Edinburgh, Edinburgh, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Global Health, Usher Institute, University of Edinburgh, Edinburgh</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Journal of Global Health</title>
<idno type="ISSN">2047-2978</idno>
<idno type="eISSN">2047-2986</idno>
<imprint><date when="????">????</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p>On 31 December, 2019, the World Health Organization China Country Office was informed of cases of pneumonia of unknown aetiology. Since then, there have been over 75 000 cases globally of the 2019 novel coronavirus (COVID-19), 2000 deaths, and over 14 000 cases recovered. Outbreaks of novel agents represent opportunities for clinical research to inform real-time public health action. In 2018, we conducted a systematic review to identify priority research questions for Severe Acute Respiratory Syndrome-related coronavirus (SARS-CoV) and Middle East Respiratory Syndrome-related coronavirus (MERS-CoV). Here, we review information available on COVID-19 and provide an evidenced-based framework for priority clinical research in the current outbreak.</p>
</sec>
<sec><title>Methods</title>
<p>Three bibliographic databases were searched to identify clinical studies published on SARS-CoV and MERS-CoV in the outbreak setting. Studies were grouped thematically according to clinical research questions addressed. In February 2020, available information on COVID19 was reviewed and compared to the results of the SARS-CoV and MERS-CoV systematic review.</p>
</sec>
<sec><title>Results</title>
<p>From the research objectives for SARS-CoV and MERS-CoV, ten themes in the literature were identified: Clinical characterisation, prognosis, diagnosis, clinical management, viral pathogenesis, epidemiological characterisation, infection prevention and control/transmission, susceptibility, psychosocial, and aetiology. For COVID19, some information on clinical presentation, diagnostic testing, and aetiology is available but many clinical research gaps have yet to be filled.</p>
</sec>
<sec><title>Conclusions</title>
<p>Based on a systematic review of other severe coronaviruses, we summarise the state of clinical research for COVID-19, highlight the research gaps, and provide recommendations for the implementation of standardised protocols. Data based on internationally standardised protocols will inform clinical practice real-time.</p>
</sec>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Zhu, N" uniqKey="Zhu N">N Zhu</name>
</author>
<author><name sortKey="Zhang, D" uniqKey="Zhang D">D Zhang</name>
</author>
<author><name sortKey="Wang, W" uniqKey="Wang W">W Wang</name>
</author>
<author><name sortKey="Li, X" uniqKey="Li X">X Li</name>
</author>
<author><name sortKey="Yang, B" uniqKey="Yang B">B Yang</name>
</author>
<author><name sortKey="Song, J" uniqKey="Song J">J Song</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chan, Jf W" uniqKey="Chan J">JF-W Chan</name>
</author>
<author><name sortKey="Yuan, S" uniqKey="Yuan S">S Yuan</name>
</author>
<author><name sortKey="Kok, K H" uniqKey="Kok K">K-H Kok</name>
</author>
<author><name sortKey="To, Kk W" uniqKey="To K">KK-W To</name>
</author>
<author><name sortKey="Chu, H" uniqKey="Chu H">H Chu</name>
</author>
<author><name sortKey="Yang, J" uniqKey="Yang J">J Yang</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Van Kerkove, Md" uniqKey="Van Kerkove M">MD Van Kerkove</name>
</author>
<author><name sortKey="Reveiz, L" uniqKey="Reveiz L">L Reveiz</name>
</author>
<author><name sortKey="Souza, Jp" uniqKey="Souza J">JP Souza</name>
</author>
<author><name sortKey="Jaenisch, T" uniqKey="Jaenisch T">T Jaenisch</name>
</author>
<author><name sortKey="Carson, G" uniqKey="Carson G">G Carson</name>
</author>
<author><name sortKey="Broutet, N" uniqKey="Broutet N">N Broutet</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Huang, C" uniqKey="Huang C">C Huang</name>
</author>
<author><name sortKey="Wang, Y" uniqKey="Wang Y">Y Wang</name>
</author>
<author><name sortKey="Li, X" uniqKey="Li X">X Li</name>
</author>
<author><name sortKey="Ren, L" uniqKey="Ren L">L Ren</name>
</author>
<author><name sortKey="Zhao, J" uniqKey="Zhao J">J Zhao</name>
</author>
<author><name sortKey="Hu, Y" uniqKey="Hu Y">Y Hu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chen, N" uniqKey="Chen N">N Chen</name>
</author>
<author><name sortKey="Zhou, M" uniqKey="Zhou M">M Zhou</name>
</author>
<author><name sortKey="Dong, X" uniqKey="Dong X">X Dong</name>
</author>
<author><name sortKey="Qu, J" uniqKey="Qu J">J Qu</name>
</author>
<author><name sortKey="Gong, F" uniqKey="Gong F">F Gong</name>
</author>
<author><name sortKey="Han, Y" uniqKey="Han Y">Y Han</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wang, D" uniqKey="Wang D">D Wang</name>
</author>
<author><name sortKey="Hu, B" uniqKey="Hu B">B Hu</name>
</author>
<author><name sortKey="Hu, C" uniqKey="Hu C">C Hu</name>
</author>
<author><name sortKey="Zhu, F" uniqKey="Zhu F">F Zhu</name>
</author>
<author><name sortKey="Liu, X" uniqKey="Liu X">X Liu</name>
</author>
<author><name sortKey="Zhang, J" uniqKey="Zhang J">J Zhang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kui, L" uniqKey="Kui L">L Kui</name>
</author>
<author><name sortKey="Fang, Y Y" uniqKey="Fang Y">Y-Y Fang</name>
</author>
<author><name sortKey="Deng, Y" uniqKey="Deng Y">Y Deng</name>
</author>
<author><name sortKey="Liu, W" uniqKey="Liu W">W Liu</name>
</author>
<author><name sortKey="Wang, M F" uniqKey="Wang M">M-F Wang</name>
</author>
<author><name sortKey="Ma, J P" uniqKey="Ma J">J-P Ma</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chen, H" uniqKey="Chen H">H Chen</name>
</author>
<author><name sortKey="Guo, J" uniqKey="Guo J">J Guo</name>
</author>
<author><name sortKey="Wang, C" uniqKey="Wang C">C Wang</name>
</author>
<author><name sortKey="Luo, F" uniqKey="Luo F">F Luo</name>
</author>
<author><name sortKey="Yu, X" uniqKey="Yu X">X Yu</name>
</author>
<author><name sortKey="Zhang, W" uniqKey="Zhang W">W Zhang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wei, M" uniqKey="Wei M">M Wei</name>
</author>
<author><name sortKey="Yuan, J" uniqKey="Yuan J">J Yuan</name>
</author>
<author><name sortKey="Liu, Y" uniqKey="Liu Y">Y Liu</name>
</author>
<author><name sortKey="Fu, T" uniqKey="Fu T">T Fu</name>
</author>
<author><name sortKey="Yu, X" uniqKey="Yu X">X Yu</name>
</author>
<author><name sortKey="Zhang, Z J" uniqKey="Zhang Z">Z-J Zhang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pan, Y" uniqKey="Pan Y">Y Pan</name>
</author>
<author><name sortKey="Guan, H" uniqKey="Guan H">H Guan</name>
</author>
<author><name sortKey="Zhou, S" uniqKey="Zhou S">S Zhou</name>
</author>
<author><name sortKey="Wang, Y" uniqKey="Wang Y">Y Wang</name>
</author>
<author><name sortKey="Li, Q" uniqKey="Li Q">Q Li</name>
</author>
<author><name sortKey="Zhu, T" uniqKey="Zhu T">T Zhu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Xie, X" uniqKey="Xie X">X Xie</name>
</author>
<author><name sortKey="Zhong, Z" uniqKey="Zhong Z">Z Zhong</name>
</author>
<author><name sortKey="Zhao, W" uniqKey="Zhao W">W Zhao</name>
</author>
<author><name sortKey="Zheng, C" uniqKey="Zheng C">C Zheng</name>
</author>
<author><name sortKey="Wang, F" uniqKey="Wang F">F Wang</name>
</author>
<author><name sortKey="Liu, J" uniqKey="Liu J">J Liu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chang, D" uniqKey="Chang D">D Chang</name>
</author>
<author><name sortKey="Lin, M" uniqKey="Lin M">M Lin</name>
</author>
<author><name sortKey="Wei, L" uniqKey="Wei L">L Wei</name>
</author>
<author><name sortKey="Xie, L" uniqKey="Xie L">L Xie</name>
</author>
<author><name sortKey="Zhu, G" uniqKey="Zhu G">G Zhu</name>
</author>
<author><name sortKey="Dela Cruz, Cs" uniqKey="Dela Cruz C">CS Dela Cruz</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Guo, L" uniqKey="Guo L">L Guo</name>
</author>
<author><name sortKey="Wei, D" uniqKey="Wei D">D Wei</name>
</author>
<author><name sortKey="Zhang, X" uniqKey="Zhang X">X Zhang</name>
</author>
<author><name sortKey="Wu, Y" uniqKey="Wu Y">Y Wu</name>
</author>
<author><name sortKey="Li, Q" uniqKey="Li Q">Q Li</name>
</author>
<author><name sortKey="Zhou, M" uniqKey="Zhou M">M Zhou</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wang, C" uniqKey="Wang C">C Wang</name>
</author>
<author><name sortKey="Horby, Pw" uniqKey="Horby P">PW Horby</name>
</author>
<author><name sortKey="Hayden, Fg" uniqKey="Hayden F">FG Hayden</name>
</author>
<author><name sortKey="Gao, Gf" uniqKey="Gao G">GF Gao</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Zou, L" uniqKey="Zou L">L Zou</name>
</author>
<author><name sortKey="Ruan, F" uniqKey="Ruan F">F Ruan</name>
</author>
<author><name sortKey="Huang, M" uniqKey="Huang M">M Huang</name>
</author>
<author><name sortKey="Liang, L" uniqKey="Liang L">L Liang</name>
</author>
<author><name sortKey="Huang, H" uniqKey="Huang H">H Huang</name>
</author>
<author><name sortKey="Hong, Z" uniqKey="Hong Z">Z Hong</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y Zhang</name>
</author>
<author><name sortKey="Chen, C" uniqKey="Chen C">C Chen</name>
</author>
<author><name sortKey="Zhu, S" uniqKey="Zhu S">S Zhu</name>
</author>
<author><name sortKey="Shu, C" uniqKey="Shu C">C Shu</name>
</author>
<author><name sortKey="Wang, D" uniqKey="Wang D">D Wang</name>
</author>
<author><name sortKey="Song, J" uniqKey="Song J">J Song</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Zhang, W" uniqKey="Zhang W">W Zhang</name>
</author>
<author><name sortKey="Du, R H" uniqKey="Du R">R-H Du</name>
</author>
<author><name sortKey="Li, B" uniqKey="Li B">B Li</name>
</author>
<author><name sortKey="Zheng, X S" uniqKey="Zheng X">X-S Zheng</name>
</author>
<author><name sortKey="Yang, X L" uniqKey="Yang X">X-L Yang</name>
</author>
<author><name sortKey="Hu, B" uniqKey="Hu B">B Hu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="To, Kk W" uniqKey="To K">KK-W To</name>
</author>
<author><name sortKey="Tsang, Ot Y" uniqKey="Tsang O">OT-Y Tsang</name>
</author>
<author><name sortKey="Chik Yan Yip, C" uniqKey="Chik Yan Yip C">C Chik-Yan Yip</name>
</author>
<author><name sortKey="Chan, K H" uniqKey="Chan K">K-H Chan</name>
</author>
<author><name sortKey="Wu, T C" uniqKey="Wu T">T-C Wu</name>
</author>
<author><name sortKey="Chan, Jmc" uniqKey="Chan J">JMC Chan</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Heymann, Dl" uniqKey="Heymann D">DL Heymann</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Dunning, Jw" uniqKey="Dunning J">JW Dunning</name>
</author>
<author><name sortKey="Merson, L" uniqKey="Merson L">L Merson</name>
</author>
<author><name sortKey="Rohde, Ggu" uniqKey="Rohde G">GGU Rohde</name>
</author>
<author><name sortKey="Gao, Z" uniqKey="Gao Z">Z Gao</name>
</author>
<author><name sortKey="Semple, Mg" uniqKey="Semple M">MG Semple</name>
</author>
<author><name sortKey="Tran, D" uniqKey="Tran D">D Tran</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fowler, Ra" uniqKey="Fowler R">RA Fowler</name>
</author>
<author><name sortKey="Lapinsky, Se" uniqKey="Lapinsky S">SE Lapinsky</name>
</author>
<author><name sortKey="Hallett, D" uniqKey="Hallett D">D Hallett</name>
</author>
<author><name sortKey="Detsky, As" uniqKey="Detsky A">AS Detsky</name>
</author>
<author><name sortKey="Sibbald, Wj" uniqKey="Sibbald W">WJ Sibbald</name>
</author>
<author><name sortKey="Slutsky, As" uniqKey="Slutsky A">AS Slutsky</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Alraddadi, Bm" uniqKey="Alraddadi B">BM Alraddadi</name>
</author>
<author><name sortKey="Al Salmi, Hs" uniqKey="Al Salmi H">HS Al-Salmi</name>
</author>
<author><name sortKey="Jacobs Slifka, K" uniqKey="Jacobs Slifka K">K Jacobs-Slifka</name>
</author>
<author><name sortKey="Slayton, Rb" uniqKey="Slayton R">RB Slayton</name>
</author>
<author><name sortKey="Estivariz, Cf" uniqKey="Estivariz C">CF Estivariz</name>
</author>
<author><name sortKey="Geller, Ai" uniqKey="Geller A">AI Geller</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tsui, Pt" uniqKey="Tsui P">PT Tsui</name>
</author>
<author><name sortKey="Kwok, Ml" uniqKey="Kwok M">ML Kwok</name>
</author>
<author><name sortKey="Yuen, H" uniqKey="Yuen H">H Yuen</name>
</author>
<author><name sortKey="Lai, St" uniqKey="Lai S">ST Lai</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Wang, Jt" uniqKey="Wang J">JT Wang</name>
</author>
<author><name sortKey="Sheng, Wh" uniqKey="Sheng W">WH Sheng</name>
</author>
<author><name sortKey="Fang, Ct" uniqKey="Fang C">CT Fang</name>
</author>
<author><name sortKey="Chen, Yc" uniqKey="Chen Y">YC Chen</name>
</author>
<author><name sortKey="Wang, Jl" uniqKey="Wang J">JL Wang</name>
</author>
<author><name sortKey="Yu, Cj" uniqKey="Yu C">CJ Yu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Park, J E" uniqKey="Park J">J-E Park</name>
</author>
<author><name sortKey="Jung, S" uniqKey="Jung S">S Jung</name>
</author>
<author><name sortKey="Kim, A" uniqKey="Kim A">A Kim</name>
</author>
<author><name sortKey="Park, J E" uniqKey="Park J">J-E Park</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Mulangu, S" uniqKey="Mulangu S">S Mulangu</name>
</author>
<author><name sortKey="Dodd, Le" uniqKey="Dodd L">LE Dodd</name>
</author>
<author><name sortKey="Davey, Rt" uniqKey="Davey R">RT Davey</name>
</author>
<author><name sortKey="Tshiani Mbaya, O" uniqKey="Tshiani Mbaya O">O Tshiani Mbaya</name>
</author>
<author><name sortKey="Proschan, M" uniqKey="Proschan M">M Proschan</name>
</author>
<author><name sortKey="Mukadi, D" uniqKey="Mukadi D">D Mukadi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Parikh, R" uniqKey="Parikh R">R Parikh</name>
</author>
<author><name sortKey="Mathai, A" uniqKey="Mathai A">A Mathai</name>
</author>
<author><name sortKey="Parikh, S" uniqKey="Parikh S">S Parikh</name>
</author>
<author><name sortKey="Chandra Sekhar, G" uniqKey="Chandra Sekhar G">G Chandra Sekhar</name>
</author>
<author><name sortKey="Thomas, R" uniqKey="Thomas R">R Thomas</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cheng, Pkc" uniqKey="Cheng P">PKC Cheng</name>
</author>
<author><name sortKey="Wong, Da" uniqKey="Wong D">DA Wong</name>
</author>
<author><name sortKey="Tong, Lkl" uniqKey="Tong L">LKL Tong</name>
</author>
<author><name sortKey="Ip, S M" uniqKey="Ip S">S-M Ip</name>
</author>
<author><name sortKey="Lo, Act" uniqKey="Lo A">ACT Lo</name>
</author>
<author><name sortKey="Lau, C S" uniqKey="Lau C">C-S Lau</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chan, Pks" uniqKey="Chan P">PKS Chan</name>
</author>
<author><name sortKey="To, W K" uniqKey="To W">W-K To</name>
</author>
<author><name sortKey="Ng, K C" uniqKey="Ng K">K-C Ng</name>
</author>
<author><name sortKey="Lam, Rky" uniqKey="Lam R">RKY Lam</name>
</author>
<author><name sortKey="Ng, T K" uniqKey="Ng T">T-K Ng</name>
</author>
<author><name sortKey="Chan, Rcw" uniqKey="Chan R">RCW Chan</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Chowell, G" uniqKey="Chowell G">G Chowell</name>
</author>
<author><name sortKey="Abdirizak, F" uniqKey="Abdirizak F">F Abdirizak</name>
</author>
<author><name sortKey="Lee, S" uniqKey="Lee S">S Lee</name>
</author>
<author><name sortKey="Lee, J" uniqKey="Lee J">J Lee</name>
</author>
<author><name sortKey="Jung, E" uniqKey="Jung E">E Jung</name>
</author>
<author><name sortKey="Nishiura, H" uniqKey="Nishiura H">H Nishiura</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Lau, Jtf" uniqKey="Lau J">JTF Lau</name>
</author>
<author><name sortKey="Fung, Ks" uniqKey="Fung K">KS Fung</name>
</author>
<author><name sortKey="Wong, Tw" uniqKey="Wong T">TW Wong</name>
</author>
<author><name sortKey="Kim, Jh" uniqKey="Kim J">JH Kim</name>
</author>
<author><name sortKey="Wong, E" uniqKey="Wong E">E Wong</name>
</author>
<author><name sortKey="Chung, S" uniqKey="Chung S">S Chung</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Oh, Md" uniqKey="Oh M">MD Oh</name>
</author>
<author><name sortKey="Park, Wb" uniqKey="Park W">WB Park</name>
</author>
<author><name sortKey="Park, Sw" uniqKey="Park S">SW Park</name>
</author>
<author><name sortKey="Choe, Pg" uniqKey="Choe P">PG Choe</name>
</author>
<author><name sortKey="Bang, Jh" uniqKey="Bang J">JH Bang</name>
</author>
<author><name sortKey="Song, Kh" uniqKey="Song K">KH Song</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Glob Health</journal-id>
<journal-id journal-id-type="iso-abbrev">J Glob Health</journal-id>
<journal-id journal-id-type="publisher-id">JGH</journal-id>
<journal-title-group><journal-title>Journal of Global Health</journal-title>
</journal-title-group>
<issn pub-type="ppub">2047-2978</issn>
<issn pub-type="epub">2047-2986</issn>
<publisher><publisher-name>International Society of Global Health</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">32257173</article-id>
<article-id pub-id-type="pmc">7125419</article-id>
<article-id pub-id-type="publisher-id">jogh-10-011001</article-id>
<article-id pub-id-type="doi">10.7189/jogh.10-011001</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Research Theme 6: COVID-19 Pandemic</subject>
</subj-group>
</article-categories>
<title-group><article-title>An evidence-based framework for priority clinical research questions for COVID-19</article-title>
<alt-title alt-title-type="running-head">Harris et al. Priority clinical research questions for COVID-19</alt-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Harris</surname>
<given-names>Carlyn</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Carson</surname>
<given-names>Gail</given-names>
</name>
<xref ref-type="aff" rid="aff3"><sup>3</sup>
</xref>
<xref ref-type="aff" rid="aff4"><sup>4</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Baillie</surname>
<given-names>J Kenneth</given-names>
</name>
<xref ref-type="aff" rid="aff4"><sup>4</sup>
</xref>
<xref ref-type="aff" rid="aff5"><sup>5</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Horby</surname>
<given-names>Peter</given-names>
</name>
<xref ref-type="aff" rid="aff3"><sup>3</sup>
</xref>
<xref ref-type="aff" rid="aff4"><sup>4</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Nair</surname>
<given-names>Harish</given-names>
</name>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
</contrib>
<aff id="aff1"><label>1</label>
Emory University School of Medicine, Atlanta, Georgia, USA</aff>
<aff id="aff2"><label>2</label>
Centre for Global Health, Usher Institute, University of Edinburgh, Edinburgh, UK</aff>
<aff id="aff3"><label>3</label>
International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC), Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, UK</aff>
<aff id="aff4"><label>4</label>
Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, UK</aff>
<aff id="aff5"><label>5</label>
Centre for Inflammation Research and Roslin Institute, University of Edinburgh, Edinburgh, UK</aff>
</contrib-group>
<author-notes><corresp id="cor1"><bold>Correspondence to:</bold>
Prof Harish Nair, PhD, MBBS
Centre for Global Health
Usher Institute
University of Edinburgh
Old Medical School
Teviot Place
Edinburgh, EH8 9AG
UK
<email xlink:href="Harish.Nair@ed.ac.uk">Harish.Nair@ed.ac.uk</email>
</corresp>
</author-notes>
<pub-date date-type="pub" publication-format="print"><month>6</month>
<year>2020</year>
</pub-date>
<pub-date date-type="pub" publication-format="electronic"><day>31</day>
<month>3</month>
<year>2020</year>
</pub-date>
<volume>10</volume>
<issue>1</issue>
<elocation-id>011001</elocation-id>
<permissions><copyright-statement>Copyright © 2020 by the Journal of Global Health. All rights reserved.</copyright-statement>
<copyright-year>2020</copyright-year>
<license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/4.0/"><license-p>This work is licensed under a Creative Commons Attribution 4.0 International License.</license-p>
</license>
</permissions>
<abstract><sec><title>Background</title>
<p>On 31 December, 2019, the World Health Organization China Country Office was informed of cases of pneumonia of unknown aetiology. Since then, there have been over 75 000 cases globally of the 2019 novel coronavirus (COVID-19), 2000 deaths, and over 14 000 cases recovered. Outbreaks of novel agents represent opportunities for clinical research to inform real-time public health action. In 2018, we conducted a systematic review to identify priority research questions for Severe Acute Respiratory Syndrome-related coronavirus (SARS-CoV) and Middle East Respiratory Syndrome-related coronavirus (MERS-CoV). Here, we review information available on COVID-19 and provide an evidenced-based framework for priority clinical research in the current outbreak.</p>
</sec>
<sec><title>Methods</title>
<p>Three bibliographic databases were searched to identify clinical studies published on SARS-CoV and MERS-CoV in the outbreak setting. Studies were grouped thematically according to clinical research questions addressed. In February 2020, available information on COVID19 was reviewed and compared to the results of the SARS-CoV and MERS-CoV systematic review.</p>
</sec>
<sec><title>Results</title>
<p>From the research objectives for SARS-CoV and MERS-CoV, ten themes in the literature were identified: Clinical characterisation, prognosis, diagnosis, clinical management, viral pathogenesis, epidemiological characterisation, infection prevention and control/transmission, susceptibility, psychosocial, and aetiology. For COVID19, some information on clinical presentation, diagnostic testing, and aetiology is available but many clinical research gaps have yet to be filled.</p>
</sec>
<sec><title>Conclusions</title>
<p>Based on a systematic review of other severe coronaviruses, we summarise the state of clinical research for COVID-19, highlight the research gaps, and provide recommendations for the implementation of standardised protocols. Data based on internationally standardised protocols will inform clinical practice real-time.</p>
</sec>
</abstract>
<counts><fig-count count="0"></fig-count>
<table-count count="3"></table-count>
<equation-count count="0"></equation-count>
<ref-count count="49"></ref-count>
<page-count count="10"></page-count>
</counts>
</article-meta>
</front>
</pmc>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/Pmc/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001145 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd -nk 001145 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= SrasV1 |flux= Pmc |étape= Curation |type= RBID |clé= PMC:7125419 |texte= An evidence-based framework for priority clinical research questions for COVID-19 }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Curation/RBID.i -Sk "pubmed:32257173" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd \ | NlmPubMed2Wicri -a SrasV1
![]() | This area was generated with Dilib version V0.6.33. | ![]() |