Angiotensin Converting Enzymes
Identifieur interne : 000971 ( Pmc/Curation ); précédent : 000970; suivant : 000972Angiotensin Converting Enzymes
Auteurs : Marty K. S. WongSource :
- Handbook of Hormones ; 2015.
Abstract
Angiotensin converting enzyme (ACE) is well known for its dual actions in converting inactive Ang I to active Ang II and degrade active bradykinin (BK), which play an important role in the control of blood pressure. Since the bottle neck step is the production of pressor Ang II, this was targeted pharmacologically in 1970s and successful ACE inhibitors such as captopril were produced to treat hypertension. Researches on domain specific ACE inhibitors are continuing to produce effective hypertension controlling drugs with fewer side effects. ACE2 was discovered in 2000; it converts Ang II into Ang(1–7), thereby reducing the concentration of Ang II as well as increasing that of Ang(1–7), an important enzyme for Ang(1–7)/Mas receptor signaling. ACE2 also acts as the receptor in the lung for the coronavirus causing the infamous severe acute respiratory syndrome (SARS) in 2003.
Url:
DOI: 10.1016/B978-0-12-801028-0.00254-3
PubMed: NONE
PubMed Central: 7150253
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000971
Links to Exploration step
PMC:7150253Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Angiotensin Converting Enzymes</title><author><name sortKey="Wong, Marty K S" sort="Wong, Marty K S" uniqKey="Wong M" first="Marty K. S." last="Wong">Marty K. S. Wong</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmc">7150253</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7150253</idno><idno type="RBID">PMC:7150253</idno><idno type="doi">10.1016/B978-0-12-801028-0.00254-3</idno><idno type="pmid">NONE</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000971</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000971</idno><idno type="wicri:Area/Pmc/Curation">000971</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000971</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Angiotensin Converting Enzymes</title><author><name sortKey="Wong, Marty K S" sort="Wong, Marty K S" uniqKey="Wong M" first="Marty K. S." last="Wong">Marty K. S. Wong</name></author></analytic><series><title level="j">Handbook of Hormones</title><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Angiotensin converting enzyme (ACE) is well known for its dual actions in converting inactive Ang I to active Ang II and degrade active bradykinin (BK), which play an important role in the control of blood pressure. Since the bottle neck step is the production of pressor Ang II, this was targeted pharmacologically in 1970s and successful ACE inhibitors such as captopril were produced to treat hypertension. Researches on domain specific ACE inhibitors are continuing to produce effective hypertension controlling drugs with fewer side effects. ACE2 was discovered in 2000; it converts Ang II into Ang(1–7), thereby reducing the concentration of Ang II as well as increasing that of Ang(1–7), an important enzyme for Ang(1–7)/Mas receptor signaling. ACE2 also acts as the receptor in the lung for the coronavirus causing the infamous severe acute respiratory syndrome (SARS) in 2003.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Bernstein, K E" uniqKey="Bernstein K">K.E. Bernstein</name></author><author><name sortKey="Ong, F S" uniqKey="Ong F">F.S. Ong</name></author><author><name sortKey="Blackwell, W L" uniqKey="Blackwell W">W.L. Blackwell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tipnis, S R" uniqKey="Tipnis S">S.R. Tipnis</name></author><author><name sortKey="Hooper, N M" uniqKey="Hooper N">N.M. Hooper</name></author><author><name sortKey="Hyde, R" uniqKey="Hyde R">R. Hyde</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Donoghue, M" uniqKey="Donoghue M">M. Donoghue</name></author><author><name sortKey="Hsieh, F" uniqKey="Hsieh F">F. Hsieh</name></author><author><name sortKey="Baronas, E" uniqKey="Baronas E">E. Baronas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Soubrier, F" uniqKey="Soubrier F">F. Soubrier</name></author><author><name sortKey="Wei, L" uniqKey="Wei L">L. Wei</name></author><author><name sortKey="Hubert, C" uniqKey="Hubert C">C. Hubert</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chou, C F" uniqKey="Chou C">C.F. Chou</name></author><author><name sortKey="Loh, C B" uniqKey="Loh C">C.B. Loh</name></author><author><name sortKey="Foo, Y K" uniqKey="Foo Y">Y.K. Foo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, R" uniqKey="Zhang R">R. Zhang</name></author><author><name sortKey="Wu, Y" uniqKey="Wu Y">Y. Wu</name></author><author><name sortKey="Zhao, M" uniqKey="Zhao M">M. Zhao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Erdos, E G" uniqKey="Erdos E">E.G. Erdös</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Georgiadis, D" uniqKey="Georgiadis D">D. Georgiadis</name></author><author><name sortKey="Cuniasse, P" uniqKey="Cuniasse P">P. Cuniasse</name></author><author><name sortKey="Cotton, J" uniqKey="Cotton J">J. Cotton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Clarke, N E" uniqKey="Clarke N">N.E. Clarke</name></author><author><name sortKey="Turner, A J" uniqKey="Turner A">A.J. Turner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cole, J" uniqKey="Cole J">J. Cole</name></author><author><name sortKey="Ertoy, D" uniqKey="Ertoy D">D. Ertoy</name></author><author><name sortKey="Bernstein, K E" uniqKey="Bernstein K">K.E. Bernstein</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="chapter-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Handbook of Hormones</journal-id><journal-title-group><journal-title>Handbook of Hormones</journal-title></journal-title-group></journal-meta><article-meta><article-id pub-id-type="pmc">7150253</article-id><article-id pub-id-type="publisher-id">B978-0-12-801028-0.00254-3</article-id><article-id pub-id-type="doi">10.1016/B978-0-12-801028-0.00254-3</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Angiotensin Converting Enzymes</article-title></title-group><contrib-group><contrib contrib-type="author" id="au0010"><name><surname>Wong</surname><given-names>Marty K.S.</given-names></name></contrib></contrib-group><contrib-group><contrib contrib-type="editor"><name><surname>Takei</surname><given-names>Yoshio</given-names></name></contrib></contrib-group><aff>Atmosphere and Ocean Research Institute, The University of Tokyo, Chiba, Japan</aff><contrib-group><contrib contrib-type="editor"><name><surname>Ando</surname><given-names>Hironori</given-names></name></contrib></contrib-group><aff>Sado Marine Biological Station, Faculty of Science, Niigata University, Niigata, Japan</aff><contrib-group><contrib contrib-type="editor"><name><surname>Tsutsui</surname><given-names>Kazuyoshi</given-names></name></contrib></contrib-group><aff>Department of Biology and Center for Medical Life Science, Waseda University, Tokyo, Japan</aff><pub-date pub-type="pmc-release"><day>4</day><month>9</month><year>2015</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="ppub"><year>2016</year></pub-date><pub-date pub-type="epub"><day>4</day><month>9</month><year>2015</year></pub-date><fpage>263</fpage><lpage>e29D-4</lpage><permissions><copyright-statement>Copyright © 2016 Elsevier Inc. All rights reserved.</copyright-statement><copyright-year>2016</copyright-year><copyright-holder>Elsevier Inc.</copyright-holder><license><license-p>Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.</license-p></license></permissions><abstract id="ab0010"><p>Angiotensin converting enzyme (ACE) is well known for its dual actions in converting inactive Ang I to active Ang II and degrade active bradykinin (BK), which play an important role in the control of blood pressure. Since the bottle neck step is the production of pressor Ang II, this was targeted pharmacologically in 1970s and successful ACE inhibitors such as captopril were produced to treat hypertension. Researches on domain specific ACE inhibitors are continuing to produce effective hypertension controlling drugs with fewer side effects. ACE2 was discovered in 2000; it converts Ang II into Ang(1–7), thereby reducing the concentration of Ang II as well as increasing that of Ang(1–7), an important enzyme for Ang(1–7)/Mas receptor signaling. ACE2 also acts as the receptor in the lung for the coronavirus causing the infamous severe acute respiratory syndrome (SARS) in 2003.</p></abstract><kwd-group><title>Keywords</title><kwd>angiotensin converting enzyme</kwd><kwd>angiotensin converting enzyme inhibitor</kwd><kwd>captopril</kwd><kwd>hypertension</kwd><kwd>severe acute respiratory syndrome (SARS)</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/Pmc/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000971 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd -nk 000971 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= SrasV1
|flux= Pmc
|étape= Curation
|type= RBID
|clé= PMC:7150253
|texte= Angiotensin Converting Enzymes
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Curation/RBID.i -Sk "pubmed:NONE" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd \
| NlmPubMed2Wicri -a SrasV1
| This area was generated with Dilib version V0.6.33. |  |