Evolution of SARS Coronavirus and the Relevance of Modern Molecular Epidemiology
Identifieur interne : 000970 ( Pmc/Curation ); précédent : 000969; suivant : 000971Evolution of SARS Coronavirus and the Relevance of Modern Molecular Epidemiology
Auteurs : Z. Shi [République populaire de Chine] ; L.-F. Wang [Singapour]Source :
- Genetics and Evolution of Infectious Diseases ; 2017.
Abstract
The severe acute respiratory syndrome (SARS) is the first major zoonotic infectious disease of the 21st Century. The disease, originally termed “atypical pneumonia,” was first recognized in November 2002 in Guangdong Province, China, which spread rapidly to 26 countries within 5 months and eventually led to 8096 human infection cases and 774 deaths. A previously unrecognized coronavirus, named SARS coronavirus (SARS-CoV), was later identified as the causative agent of SARS. Subsequent investigation indicated that the source of the human infections originated most likely from infected wildlife animals traded in the live animal markets, with masked palm civets considered the most prominent and important carrier. Large-scale culling of civets appeared to be effective in preventing further outbreaks in the region. Subsequent epidemiological studies showed that civets are intermediate host of SARS-CoV and bats are the likely natural reservoir of SARS-CoV and a large number of SARS-like coronaviruses (SL-CoVs). Detailed analysis of the massive SARS-CoV genomic sequence data indicated that SARS-CoV experienced a strong selection pressure during different outbreak phases in humans as well as interspecies transmission from animals to humans. The spike glycoprotein (S) of SARS-CoV plays a key role in virus–host interaction and hence is a key determinant of interspecies transmission. It has been shown that minor changes of amino acid (aa) residues in the S protein could lead to dramatic changes in virus susceptibility in animal and human hosts. This chapter focuses on the genetics and evolution of SARS-CoVs and SL-CoVs in humans, civets, and bats. The events of SARS outbreaks and the accompanying response activities highlight the importance of modern molecular epidemiology in disease investigation and the urgent need to broaden the screening and investigation of unknown viruses in wildlife animals.
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DOI: 10.1016/B978-0-12-799942-5.00026-3
PubMed: NONE
PubMed Central: 7150232
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Evolution of SARS Coronavirus and the Relevance of Modern Molecular Epidemiology</title><author><name sortKey="Shi, Z" sort="Shi, Z" uniqKey="Shi Z" first="Z." last="Shi">Z. Shi</name><affiliation wicri:level="1"><nlm:aff id="aff1">Chinese Academy of Sciences (CAS), Wuhan, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Chinese Academy of Sciences (CAS), Wuhan</wicri:regionArea></affiliation></author><author><name sortKey="Wang, L F" sort="Wang, L F" uniqKey="Wang L" first="L.-F." last="Wang">L.-F. Wang</name><affiliation wicri:level="1"><nlm:aff id="aff2">Duke-NUS Medical School, Singapore, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Duke-NUS Medical School, Singapore</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmc">7150232</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7150232</idno><idno type="RBID">PMC:7150232</idno><idno type="doi">10.1016/B978-0-12-799942-5.00026-3</idno><idno type="pmid">NONE</idno><date when="2017">2017</date><idno type="wicri:Area/Pmc/Corpus">000970</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000970</idno><idno type="wicri:Area/Pmc/Curation">000970</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000970</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Evolution of SARS Coronavirus and the Relevance of Modern Molecular Epidemiology</title><author><name sortKey="Shi, Z" sort="Shi, Z" uniqKey="Shi Z" first="Z." last="Shi">Z. Shi</name><affiliation wicri:level="1"><nlm:aff id="aff1">Chinese Academy of Sciences (CAS), Wuhan, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Chinese Academy of Sciences (CAS), Wuhan</wicri:regionArea></affiliation></author><author><name sortKey="Wang, L F" sort="Wang, L F" uniqKey="Wang L" first="L.-F." last="Wang">L.-F. Wang</name><affiliation wicri:level="1"><nlm:aff id="aff2">Duke-NUS Medical School, Singapore, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Duke-NUS Medical School, Singapore</wicri:regionArea></affiliation></author></analytic><series><title level="j">Genetics and Evolution of Infectious Diseases</title><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The severe acute respiratory syndrome (SARS) is the first major zoonotic infectious disease of the 21st Century. The disease, originally termed “atypical pneumonia,” was first recognized in November 2002 in Guangdong Province, China, which spread rapidly to 26 countries within 5 months and eventually led to 8096 human infection cases and 774 deaths. A previously unrecognized coronavirus, named SARS coronavirus (SARS-CoV), was later identified as the causative agent of SARS. Subsequent investigation indicated that the source of the human infections originated most likely from infected wildlife animals traded in the live animal markets, with masked palm civets considered the most prominent and important carrier. Large-scale culling of civets appeared to be effective in preventing further outbreaks in the region. Subsequent epidemiological studies showed that civets are intermediate host of SARS-CoV and bats are the likely natural reservoir of SARS-CoV and a large number of SARS-like coronaviruses (SL-CoVs). Detailed analysis of the massive SARS-CoV genomic sequence data indicated that SARS-CoV experienced a strong selection pressure during different outbreak phases in humans as well as interspecies transmission from animals to humans. The spike glycoprotein (S) of SARS-CoV plays a key role in virus–host interaction and hence is a key determinant of interspecies transmission. It has been shown that minor changes of amino acid (aa) residues in the S protein could lead to dramatic changes in virus susceptibility in animal and human hosts. This chapter focuses on the genetics and evolution of SARS-CoVs and SL-CoVs in humans, civets, and bats. The events of SARS outbreaks and the accompanying response activities highlight the importance of modern molecular epidemiology in disease investigation and the urgent need to broaden the screening and investigation of unknown viruses in wildlife animals.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Chinese Sars Molecular Epidemiology Consortium" uniqKey="Chinese Sars Molecular Epidemiology Consortium">Chinese SARS Molecular Epidemiology Consortium</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhao, G P" uniqKey="Zhao G">G.P. Zhao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, M" uniqKey="Wang M">M. Wang</name></author><author><name sortKey="Yan, M" uniqKey="Yan M">M. Yan</name></author><author><name sortKey="Xu, H" uniqKey="Xu H">H. Xu</name></author><author><name sortKey="Liang, W" uniqKey="Liang W">W. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Genetics and Evolution of Infectious Diseases</journal-id><journal-title-group><journal-title>Genetics and Evolution of Infectious Diseases</journal-title></journal-title-group></journal-meta><article-meta><article-id pub-id-type="pmc">7150232</article-id><article-id pub-id-type="publisher-id">B978-0-12-799942-5.00026-3</article-id><article-id pub-id-type="doi">10.1016/B978-0-12-799942-5.00026-3</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Evolution of SARS Coronavirus and the Relevance of Modern Molecular Epidemiology</article-title></title-group><contrib-group><contrib contrib-type="author" id="au1"><name><surname>Shi</surname><given-names>Z.</given-names></name><xref rid="aff1" ref-type="aff">1</xref></contrib><contrib contrib-type="author" id="au2"><name><surname>Wang</surname><given-names>L.-F.</given-names></name><xref rid="aff2" ref-type="aff">2</xref></contrib></contrib-group><aff id="aff1"><label>1</label>Chinese Academy of Sciences (CAS), Wuhan, China</aff><aff id="aff2"><label>2</label>Duke-NUS Medical School, Singapore, Singapore</aff><pub-date pub-type="pmc-release"><day>20</day><month>1</month><year>2017</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="ppub"><year>2017</year></pub-date><pub-date pub-type="epub"><day>20</day><month>1</month><year>2017</year></pub-date><fpage>601</fpage><lpage>619</lpage><permissions><copyright-statement>Copyright © 2017 Elsevier Inc. All rights reserved.</copyright-statement><copyright-year>2017</copyright-year><copyright-holder>Elsevier Inc.</copyright-holder><license><license-p>Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.</license-p></license></permissions><abstract id="abs0010"><p>The severe acute respiratory syndrome (SARS) is the first major zoonotic infectious disease of the 21st Century. The disease, originally termed “atypical pneumonia,” was first recognized in November 2002 in Guangdong Province, China, which spread rapidly to 26 countries within 5 months and eventually led to 8096 human infection cases and 774 deaths. A previously unrecognized coronavirus, named SARS coronavirus (SARS-CoV), was later identified as the causative agent of SARS. Subsequent investigation indicated that the source of the human infections originated most likely from infected wildlife animals traded in the live animal markets, with masked palm civets considered the most prominent and important carrier. Large-scale culling of civets appeared to be effective in preventing further outbreaks in the region. Subsequent epidemiological studies showed that civets are intermediate host of SARS-CoV and bats are the likely natural reservoir of SARS-CoV and a large number of SARS-like coronaviruses (SL-CoVs). Detailed analysis of the massive SARS-CoV genomic sequence data indicated that SARS-CoV experienced a strong selection pressure during different outbreak phases in humans as well as interspecies transmission from animals to humans. The spike glycoprotein (S) of SARS-CoV plays a key role in virus–host interaction and hence is a key determinant of interspecies transmission. It has been shown that minor changes of amino acid (aa) residues in the S protein could lead to dramatic changes in virus susceptibility in animal and human hosts. This chapter focuses on the genetics and evolution of SARS-CoVs and SL-CoVs in humans, civets, and bats. The events of SARS outbreaks and the accompanying response activities highlight the importance of modern molecular epidemiology in disease investigation and the urgent need to broaden the screening and investigation of unknown viruses in wildlife animals.</p></abstract><kwd-group id="kwrds0010"><title>Keywords</title><kwd>Genetic evolution</kwd><kwd>Interspecies transmission</kwd><kwd>Molecular epidemiology</kwd><kwd>SARS</kwd><kwd>SARS-like CoV</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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