Co-circulation of human metapneumovirus and SARS-associated coronavirus during a major nosocomial SARS outbreak in Hong Kong
Identifieur interne : 000891 ( Pmc/Curation ); précédent : 000890; suivant : 000892Co-circulation of human metapneumovirus and SARS-associated coronavirus during a major nosocomial SARS outbreak in Hong Kong
Auteurs : N. Lee [République populaire de Chine] ; P. K. S. Chan [République populaire de Chine] ; I. T. Yu [République populaire de Chine] ; K. K. Tsoi [République populaire de Chine] ; G. Lui [République populaire de Chine] ; J. J. Y. Sung [République populaire de Chine] ; C. S. Cockram [République populaire de Chine]Source :
- Journal of Clinical Virology [ 1386-6532 ] ; 2007.
Abstract
The clinico-epidemiological significance of human metapneumovirus (hMPV) detected during the SARS outbreak is unknown.
To characterize a nosocomial hMPV outbreak during the 2003 SARS epidemic.
All available nasopharyngeal aspirate (NPA) collected from confirmed patients during the first 8 weeks of the SARS outbreak in 2003 were tested for hMPV by a nested RT-PCR assay targeting the F-gene. Clinico-epidemiological information was used to analyze the relationship of hMPV co-infection to specific risk factors (demographics/symptoms/outcomes; status as health-care workers (HCWs)/patients; history of exposure/contact; ward location). Multivariate logistic regression analysis was performed to determine independent risk factors.
An hMPV outbreak occurred during 6–16 March 2003 (first week of the Hong Kong SARS epidemic). hMPV RNA was detected in 31 of 155 (20%) NPAs from SARS patients. HCW status (OR 2.72, 95% CI 1.11–6.68;
A major nosocomial hMPV outbreak involving HCWs occurred during the early SARS epidemic. Patients with dual hMPV and SARS infection were not sicker than those with SARS infection only.
Url:
DOI: 10.1016/j.jcv.2007.08.015
PubMed: 17936066
PubMed Central: 7108220
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Co-circulation of human metapneumovirus and SARS-associated coronavirus during a major nosocomial SARS outbreak in Hong Kong</title><author><name sortKey="Lee, N" sort="Lee, N" uniqKey="Lee N" first="N." last="Lee">N. Lee</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong</wicri:regionArea></affiliation></author><author><name sortKey="Chan, P K S" sort="Chan, P K S" uniqKey="Chan P" first="P. K. S." last="Chan">P. K. S. Chan</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Microbiology, The Chinese University of Hong Kong, 1/F Clinical Science Building, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Microbiology, The Chinese University of Hong Kong, 1/F Clinical Science Building, Prince of Wales Hospital, Shatin, New Territories, Hong Kong</wicri:regionArea></affiliation></author><author><name sortKey="Yu, I T" sort="Yu, I T" uniqKey="Yu I" first="I. T." last="Yu">I. T. Yu</name><affiliation wicri:level="1"><nlm:aff id="aff3">Department of Community and Family Medicine, The Chinese University of Hong Kong, Hong Kong, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Community and Family Medicine, The Chinese University of Hong Kong, Hong Kong</wicri:regionArea></affiliation></author><author><name sortKey="Tsoi, K K" sort="Tsoi, K K" uniqKey="Tsoi K" first="K. K." last="Tsoi">K. K. Tsoi</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong</wicri:regionArea></affiliation></author><author><name sortKey="Lui, G" sort="Lui, G" uniqKey="Lui G" first="G." last="Lui">G. Lui</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong</wicri:regionArea></affiliation></author><author><name sortKey="Sung, J J Y" sort="Sung, J J Y" uniqKey="Sung J" first="J. J. Y." last="Sung">J. J. Y. Sung</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong</wicri:regionArea></affiliation></author><author><name sortKey="Cockram, C S" sort="Cockram, C S" uniqKey="Cockram C" first="C. S." last="Cockram">C. S. Cockram</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">17936066</idno><idno type="pmc">7108220</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7108220</idno><idno type="RBID">PMC:7108220</idno><idno type="doi">10.1016/j.jcv.2007.08.015</idno><date when="2007">2007</date><idno type="wicri:Area/Pmc/Corpus">000891</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000891</idno><idno type="wicri:Area/Pmc/Curation">000891</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000891</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Co-circulation of human metapneumovirus and SARS-associated coronavirus during a major nosocomial SARS outbreak in Hong Kong</title><author><name sortKey="Lee, N" sort="Lee, N" uniqKey="Lee N" first="N." last="Lee">N. Lee</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong</wicri:regionArea></affiliation></author><author><name sortKey="Chan, P K S" sort="Chan, P K S" uniqKey="Chan P" first="P. K. S." last="Chan">P. K. S. Chan</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Microbiology, The Chinese University of Hong Kong, 1/F Clinical Science Building, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Microbiology, The Chinese University of Hong Kong, 1/F Clinical Science Building, Prince of Wales Hospital, Shatin, New Territories, Hong Kong</wicri:regionArea></affiliation></author><author><name sortKey="Yu, I T" sort="Yu, I T" uniqKey="Yu I" first="I. T." last="Yu">I. T. Yu</name><affiliation wicri:level="1"><nlm:aff id="aff3">Department of Community and Family Medicine, The Chinese University of Hong Kong, Hong Kong, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Community and Family Medicine, The Chinese University of Hong Kong, Hong Kong</wicri:regionArea></affiliation></author><author><name sortKey="Tsoi, K K" sort="Tsoi, K K" uniqKey="Tsoi K" first="K. K." last="Tsoi">K. K. Tsoi</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong</wicri:regionArea></affiliation></author><author><name sortKey="Lui, G" sort="Lui, G" uniqKey="Lui G" first="G." last="Lui">G. Lui</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong</wicri:regionArea></affiliation></author><author><name sortKey="Sung, J J Y" sort="Sung, J J Y" uniqKey="Sung J" first="J. J. Y." last="Sung">J. J. Y. Sung</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong</wicri:regionArea></affiliation></author><author><name sortKey="Cockram, C S" sort="Cockram, C S" uniqKey="Cockram C" first="C. S." last="Cockram">C. S. Cockram</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong</wicri:regionArea></affiliation></author></analytic><series><title level="j">Journal of Clinical Virology</title><idno type="ISSN">1386-6532</idno><idno type="eISSN">1873-5967</idno><imprint><date when="2007">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>The clinico-epidemiological significance of human metapneumovirus (hMPV) detected during the SARS outbreak is unknown.</p></sec><sec><title>Objectives</title><p>To characterize a nosocomial hMPV outbreak during the 2003 SARS epidemic.</p></sec><sec><title>Study design and methods</title><p>All available nasopharyngeal aspirate (NPA) collected from confirmed patients during the first 8 weeks of the SARS outbreak in 2003 were tested for hMPV by a nested RT-PCR assay targeting the F-gene. Clinico-epidemiological information was used to analyze the relationship of hMPV co-infection to specific risk factors (demographics/symptoms/outcomes; status as health-care workers (HCWs)/patients; history of exposure/contact; ward location). Multivariate logistic regression analysis was performed to determine independent risk factors.</p></sec><sec><title>Results</title><p>An hMPV outbreak occurred during 6–16 March 2003 (first week of the Hong Kong SARS epidemic). hMPV RNA was detected in 31 of 155 (20%) NPAs from SARS patients. HCW status (OR 2.72, 95% CI 1.11–6.68; <italic>p</italic> = 0.029) or epidemiological linkage to the SARS outbreak ward (OR 3.59, 95% CI 1.42–9.05; <italic>p</italic> = 0.007) were independent factors associated with hMPV infection. Symptoms of cough and coryza were more common in co-infected individuals (22.6% vs. 15.9%) but this was not statistically significant. Other clinical manifestations and outcomes were not different in co-infected patients.</p></sec><sec><title>Conclusions</title><p>A major nosocomial hMPV outbreak involving HCWs occurred during the early SARS epidemic. Patients with dual hMPV and SARS infection were not sicker than those with SARS infection only.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Bassetti, S" uniqKey="Bassetti S">S. Bassetti</name></author><author><name sortKey="Sherertz, R J" uniqKey="Sherertz R">R.J. Sherertz</name></author><author><name sortKey="Pfaller, M A" uniqKey="Pfaller M">M.A. Pfaller</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bassetti, S" uniqKey="Bassetti S">S. Bassetti</name></author><author><name sortKey="Bischoff, W E" uniqKey="Bischoff W">W.E. Bischoff</name></author><author><name sortKey="Sherertz, R J" uniqKey="Sherertz R">R.J. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">J Clin Virol</journal-id><journal-id journal-id-type="iso-abbrev">J. Clin. Virol</journal-id><journal-title-group><journal-title>Journal of Clinical Virology</journal-title></journal-title-group><issn pub-type="ppub">1386-6532</issn><issn pub-type="epub">1873-5967</issn><publisher><publisher-name>Elsevier B.V.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">17936066</article-id><article-id pub-id-type="pmc">7108220</article-id><article-id pub-id-type="publisher-id">S1386-6532(07)00305-8</article-id><article-id pub-id-type="doi">10.1016/j.jcv.2007.08.015</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Co-circulation of human metapneumovirus and SARS-associated coronavirus during a major nosocomial SARS outbreak in Hong Kong</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Lee</surname><given-names>N.</given-names></name><xref rid="aff1" ref-type="aff">a</xref></contrib><contrib contrib-type="author"><name><surname>Chan</surname><given-names>P.K.S.</given-names></name><email>paulkschan@cuhk.edu.hk</email><xref rid="aff2" ref-type="aff">b</xref><xref rid="cor1" ref-type="corresp">⁎</xref></contrib><contrib contrib-type="author"><name><surname>Yu</surname><given-names>I.T.</given-names></name><xref rid="aff3" ref-type="aff">c</xref></contrib><contrib contrib-type="author"><name><surname>Tsoi</surname><given-names>K.K.</given-names></name><xref rid="aff1" ref-type="aff">a</xref></contrib><contrib contrib-type="author"><name><surname>Lui</surname><given-names>G.</given-names></name><xref rid="aff1" ref-type="aff">a</xref></contrib><contrib contrib-type="author"><name><surname>Sung</surname><given-names>J.J.Y.</given-names></name><xref rid="aff1" ref-type="aff">a</xref></contrib><contrib contrib-type="author"><name><surname>Cockram</surname><given-names>C.S.</given-names></name><xref rid="aff1" ref-type="aff">a</xref></contrib></contrib-group><aff id="aff1"><label>a</label>Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China</aff><aff id="aff2"><label>b</label>Department of Microbiology, The Chinese University of Hong Kong, 1/F Clinical Science Building, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, China</aff><aff id="aff3"><label>c</label>Department of Community and Family Medicine, The Chinese University of Hong Kong, Hong Kong, China</aff><author-notes><corresp id="cor1"><label>⁎</label>Corresponding author. Tel.: +852 2632 2301; fax: +852 2647 3227. <email>paulkschan@cuhk.edu.hk</email></corresp></author-notes><pub-date pub-type="pmc-release"><day>1</day><month>11</month><year>2007</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="ppub"><month>12</month><year>2007</year></pub-date><pub-date pub-type="epub"><day>1</day><month>11</month><year>2007</year></pub-date><volume>40</volume><issue>4</issue><fpage>333</fpage><lpage>337</lpage><history><date date-type="received"><day>13</day><month>6</month><year>2007</year></date><date date-type="rev-recd"><day>17</day><month>8</month><year>2007</year></date><date date-type="accepted"><day>20</day><month>8</month><year>2007</year></date></history><permissions><copyright-statement>Copyright © 2007 Elsevier B.V. All rights reserved.</copyright-statement><copyright-year>2007</copyright-year><copyright-holder>Elsevier B.V.</copyright-holder><license><license-p>Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.</license-p></license></permissions><abstract><sec><title>Background</title><p>The clinico-epidemiological significance of human metapneumovirus (hMPV) detected during the SARS outbreak is unknown.</p></sec><sec><title>Objectives</title><p>To characterize a nosocomial hMPV outbreak during the 2003 SARS epidemic.</p></sec><sec><title>Study design and methods</title><p>All available nasopharyngeal aspirate (NPA) collected from confirmed patients during the first 8 weeks of the SARS outbreak in 2003 were tested for hMPV by a nested RT-PCR assay targeting the F-gene. Clinico-epidemiological information was used to analyze the relationship of hMPV co-infection to specific risk factors (demographics/symptoms/outcomes; status as health-care workers (HCWs)/patients; history of exposure/contact; ward location). Multivariate logistic regression analysis was performed to determine independent risk factors.</p></sec><sec><title>Results</title><p>An hMPV outbreak occurred during 6–16 March 2003 (first week of the Hong Kong SARS epidemic). hMPV RNA was detected in 31 of 155 (20%) NPAs from SARS patients. HCW status (OR 2.72, 95% CI 1.11–6.68; <italic>p</italic> = 0.029) or epidemiological linkage to the SARS outbreak ward (OR 3.59, 95% CI 1.42–9.05; <italic>p</italic> = 0.007) were independent factors associated with hMPV infection. Symptoms of cough and coryza were more common in co-infected individuals (22.6% vs. 15.9%) but this was not statistically significant. Other clinical manifestations and outcomes were not different in co-infected patients.</p></sec><sec><title>Conclusions</title><p>A major nosocomial hMPV outbreak involving HCWs occurred during the early SARS epidemic. Patients with dual hMPV and SARS infection were not sicker than those with SARS infection only.</p></sec></abstract><kwd-group><title>Keywords</title><kwd>Nosocomial outbreak</kwd><kwd>Human metapneumovirus</kwd><kwd>SARS</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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