SARS-Cov-2 infection: response of human immune system and possible implications for the rapid test and treatment
Identifieur interne : 000886 ( Pmc/Curation ); précédent : 000885; suivant : 000887SARS-Cov-2 infection: response of human immune system and possible implications for the rapid test and treatment
Auteurs : Di Mauro Gabriella ; Scavone Cristina ; Rafaniello Concetta ; Rossi Francesco ; Capuano AnnalisaSource :
- International Immunopharmacology [ 1567-5769 ] ; 2020.
Abstract
The new coronavirus outbreak is an ongoing pandemic that is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The new coronavirus SARS-Cov-2 belongs to the subfamily of β−coronaviruses and shares 79.5% of the genetic sequence of SARS-CoV, the causative agent of the epidemic that started in 2002 and ended in 2004.
Considering the clinical impact of the new outbreak, it is highly important to study the potential responses of the human immune system during the SARS-CoV-2 infection as well as the role of virus-specific T cells and by B-lymphocytes. Moreover, specific data on the production of IgG and IgM is crucial to allow the rapid identification of the infection. In this paper we also described the importance of sensitive and specific rapid test for SARS-CoV-2. Indeed, this test represents an important immunological tool aimed at identifying the precise phase of the infection in order to undertake a more appropriate pharmacological treatment. Lastly, we provided an overview of pharmacological treatments aimed to reduce inflammatory processes underlying the infection and the need for the discovery of a new vaccine against SARS-CoV-2.
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DOI: 10.1016/j.intimp.2020.106519
PubMed: NONE
PubMed Central: 7161502
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The new coronavirus SARS-Cov-2 belongs to the subfamily of β−coronaviruses and shares 79.5% of the genetic sequence of SARS-CoV, the causative agent of the epidemic that started in 2002 and ended in 2004.</p><p>Considering the clinical impact of the new outbreak, it is highly important to study the potential responses of the human immune system during the SARS-CoV-2 infection as well as the role of virus-specific T cells and by B-lymphocytes. Moreover, specific data on the production of IgG and IgM is crucial to allow the rapid identification of the infection. In this paper we also described the importance of sensitive and specific rapid test for SARS-CoV-2. Indeed, this test represents an important immunological tool aimed at identifying the precise phase of the infection in order to undertake a more appropriate pharmacological treatment. Lastly, we provided an overview of pharmacological treatments aimed to reduce inflammatory processes underlying the infection and the need for the discovery of a new vaccine against SARS-CoV-2.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Yin, Y" uniqKey="Yin Y">Y. Yin</name></author><author><name sortKey="Wunderink, R G" uniqKey="Wunderink R">R.G. Wunderink</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guo, Y R" uniqKey="Guo Y">Y.R. Guo</name></author><author><name sortKey="Cao, Q D" uniqKey="Cao Q">Q.D. Cao</name></author><author><name sortKey="Hong, Z S" uniqKey="Hong Z">Z.S. Hong</name></author><author><name sortKey="Tan, Y Y" uniqKey="Tan Y">Y.Y. Tan</name></author><author><name sortKey="Chen, S D" uniqKey="Chen S">S.D. Chen</name></author><author><name sortKey="Jin, H J" uniqKey="Jin H">H.J. Jin</name></author><author><name sortKey="Tan, K S" uniqKey="Tan K">K.S. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Int Immunopharmacol</journal-id><journal-id journal-id-type="iso-abbrev">Int. Immunopharmacol</journal-id><journal-title-group><journal-title>International Immunopharmacology</journal-title></journal-title-group><issn pub-type="ppub">1567-5769</issn><issn pub-type="epub">1878-1705</issn><publisher><publisher-name>The Authors. Published by Elsevier B.V.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmc">7161502</article-id><article-id pub-id-type="publisher-id">S1567-5769(20)30930-9</article-id><article-id pub-id-type="doi">10.1016/j.intimp.2020.106519</article-id><article-id pub-id-type="publisher-id">106519</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>SARS-Cov-2 infection: response of human immune system and possible implications for the rapid test and treatment</article-title></title-group><contrib-group><contrib contrib-type="author" id="au005"><name><surname>Gabriella</surname><given-names>di Mauro</given-names></name><email>gabriella.dimauro@unicampania.it</email><xref rid="cor1" ref-type="corresp">⁎</xref><xref rid="fn1" ref-type="fn">1</xref></contrib><contrib contrib-type="author" id="au010"><name><surname>Cristina</surname><given-names>Scavone</given-names></name><xref rid="fn1" ref-type="fn">1</xref></contrib><contrib contrib-type="author" id="au015"><name><surname>Concetta</surname><given-names>Rafaniello</given-names></name></contrib><contrib contrib-type="author" id="au020"><name><surname>Francesco</surname><given-names>Rossi</given-names></name><xref rid="fn2" ref-type="fn">2</xref></contrib><contrib contrib-type="author" id="au025"><name><surname>Annalisa</surname><given-names>Capuano</given-names></name><xref rid="fn2" ref-type="fn">2</xref></contrib></contrib-group><aff id="af005">Department of Experimental Medicine, University of Campania “Luigi Vanvitelli”, Regional Centre of Pharmacovigilance, Campania Region, Naples, Italy</aff><author-notes><corresp id="cor1"><label>⁎</label>Corresponding author. <email>gabriella.dimauro@unicampania.it</email></corresp><fn id="fn1"><label>1</label><p id="np005">These authors have equally contributed.</p></fn><fn id="fn2"><label>2</label><p id="np010">These authors are both lead authors.</p></fn></author-notes><pub-date pub-type="pmc-release"><day>16</day><month>4</month><year>2020</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="epub"><day>16</day><month>4</month><year>2020</year></pub-date><elocation-id>106519</elocation-id><history><date date-type="received"><day>26</day><month>3</month><year>2020</year></date><date date-type="accepted"><day>14</day><month>4</month><year>2020</year></date></history><permissions><copyright-statement>© 2020 The Authors. Published by Elsevier B.V.</copyright-statement><copyright-year>2020</copyright-year><copyright-holder></copyright-holder><license><license-p>Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.</license-p></license></permissions><abstract id="ab005"><p>The new coronavirus outbreak is an ongoing pandemic that is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The new coronavirus SARS-Cov-2 belongs to the subfamily of β−coronaviruses and shares 79.5% of the genetic sequence of SARS-CoV, the causative agent of the epidemic that started in 2002 and ended in 2004.</p><p>Considering the clinical impact of the new outbreak, it is highly important to study the potential responses of the human immune system during the SARS-CoV-2 infection as well as the role of virus-specific T cells and by B-lymphocytes. Moreover, specific data on the production of IgG and IgM is crucial to allow the rapid identification of the infection. In this paper we also described the importance of sensitive and specific rapid test for SARS-CoV-2. Indeed, this test represents an important immunological tool aimed at identifying the precise phase of the infection in order to undertake a more appropriate pharmacological treatment. Lastly, we provided an overview of pharmacological treatments aimed to reduce inflammatory processes underlying the infection and the need for the discovery of a new vaccine against SARS-CoV-2.</p></abstract><kwd-group id="kg005"><title>Keywords</title><kwd>SARS-Cov-2 infection</kwd><kwd>human immune system</kwd><kwd>rapid test</kwd><kwd>pharmacological treatments</kwd><kwd>outbreak</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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