Posttraumatic stress disorder in convalescent severe acute respiratory syndrome patients: a 4-year follow-up study☆
Identifieur interne : 001019 ( Pmc/Corpus ); précédent : 001018; suivant : 001020Posttraumatic stress disorder in convalescent severe acute respiratory syndrome patients: a 4-year follow-up study☆
Auteurs : Xia Hong ; Glenn W. Currier ; Xiaohui Zhao ; Yinan Jiang ; Wei Zhou ; Jing WeiSource :
- General Hospital Psychiatry [ 0163-8343 ] ; 2009.
Abstract
To measure the incidence and impact of posttraumatic stress disorder (PTSD) in a cohort of 70 subjects with severe acute respiratory syndrome (SARS).
Clinical assessments of PTSD were conducted at 2, 7, 10, 20 and 46 months after discharge from medical hospitalization for treatment of SARS. Diagnoses of PTSD were established by a trained psychiatrist using the
Of the 68 subjects who finished at least two follow-up interviews, 30 developed PTSD over the study period (44.1%). Scores on IES, SAS, SDS and SCL-90 (
PTSD occurs in a significant percentage of subjects who recover from SARS, and the occurrence of PTSD predicts persistent psychological distress and diminished social functioning in the 4 years after SARS treatment.
Url:
DOI: 10.1016/j.genhosppsych.2009.06.008
PubMed: 19892213
PubMed Central: 7112559
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PMC:7112559Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Posttraumatic stress disorder in convalescent severe acute respiratory syndrome patients: a 4-year follow-up study<sup><xref ref-type="fn" rid="d32e2490">☆</xref></sup></title><author><name sortKey="Hong, Xia" sort="Hong, Xia" uniqKey="Hong X" first="Xia" last="Hong">Xia Hong</name><affiliation><nlm:aff id="aff1">Department of Psychological Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China</nlm:aff></affiliation><affiliation><nlm:aff id="aff2">Department of Psychiatry, University of Rochester Medical Center, Rochester, NY 14642, USA</nlm:aff></affiliation></author><author><name sortKey="Currier, Glenn W" sort="Currier, Glenn W" uniqKey="Currier G" first="Glenn W." last="Currier">Glenn W. Currier</name><affiliation><nlm:aff id="aff2">Department of Psychiatry, University of Rochester Medical Center, Rochester, NY 14642, USA</nlm:aff></affiliation><affiliation><nlm:aff id="aff3">Department of Emergency Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA</nlm:aff></affiliation></author><author><name sortKey="Zhao, Xiaohui" sort="Zhao, Xiaohui" uniqKey="Zhao X" first="Xiaohui" last="Zhao">Xiaohui Zhao</name><affiliation><nlm:aff id="aff1">Department of Psychological Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China</nlm:aff></affiliation></author><author><name sortKey="Jiang, Yinan" sort="Jiang, Yinan" uniqKey="Jiang Y" first="Yinan" last="Jiang">Yinan Jiang</name><affiliation><nlm:aff id="aff4">Department of Internal Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China</nlm:aff></affiliation></author><author><name sortKey="Zhou, Wei" sort="Zhou, Wei" uniqKey="Zhou W" first="Wei" last="Zhou">Wei Zhou</name><affiliation><nlm:aff id="aff1">Department of Psychological Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China</nlm:aff></affiliation></author><author><name sortKey="Wei, Jing" sort="Wei, Jing" uniqKey="Wei J" first="Jing" last="Wei">Jing Wei</name><affiliation><nlm:aff id="aff1">Department of Psychological Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">19892213</idno><idno type="pmc">7112559</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7112559</idno><idno type="RBID">PMC:7112559</idno><idno type="doi">10.1016/j.genhosppsych.2009.06.008</idno><date when="2009">2009</date><idno type="wicri:Area/Pmc/Corpus">001019</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001019</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Posttraumatic stress disorder in convalescent severe acute respiratory syndrome patients: a 4-year follow-up study<sup><xref ref-type="fn" rid="d32e2490">☆</xref></sup></title><author><name sortKey="Hong, Xia" sort="Hong, Xia" uniqKey="Hong X" first="Xia" last="Hong">Xia Hong</name><affiliation><nlm:aff id="aff1">Department of Psychological Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China</nlm:aff></affiliation><affiliation><nlm:aff id="aff2">Department of Psychiatry, University of Rochester Medical Center, Rochester, NY 14642, USA</nlm:aff></affiliation></author><author><name sortKey="Currier, Glenn W" sort="Currier, Glenn W" uniqKey="Currier G" first="Glenn W." last="Currier">Glenn W. Currier</name><affiliation><nlm:aff id="aff2">Department of Psychiatry, University of Rochester Medical Center, Rochester, NY 14642, USA</nlm:aff></affiliation><affiliation><nlm:aff id="aff3">Department of Emergency Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA</nlm:aff></affiliation></author><author><name sortKey="Zhao, Xiaohui" sort="Zhao, Xiaohui" uniqKey="Zhao X" first="Xiaohui" last="Zhao">Xiaohui Zhao</name><affiliation><nlm:aff id="aff1">Department of Psychological Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China</nlm:aff></affiliation></author><author><name sortKey="Jiang, Yinan" sort="Jiang, Yinan" uniqKey="Jiang Y" first="Yinan" last="Jiang">Yinan Jiang</name><affiliation><nlm:aff id="aff4">Department of Internal Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China</nlm:aff></affiliation></author><author><name sortKey="Zhou, Wei" sort="Zhou, Wei" uniqKey="Zhou W" first="Wei" last="Zhou">Wei Zhou</name><affiliation><nlm:aff id="aff1">Department of Psychological Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China</nlm:aff></affiliation></author><author><name sortKey="Wei, Jing" sort="Wei, Jing" uniqKey="Wei J" first="Jing" last="Wei">Jing Wei</name><affiliation><nlm:aff id="aff1">Department of Psychological Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China</nlm:aff></affiliation></author></analytic><series><title level="j">General Hospital Psychiatry</title><idno type="ISSN">0163-8343</idno><idno type="eISSN">1873-7714</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Objective</title><p>To measure the incidence and impact of posttraumatic stress disorder (PTSD) in a cohort of 70 subjects with severe acute respiratory syndrome (SARS).</p></sec><sec><title>Methods</title><p>Clinical assessments of PTSD were conducted at 2, 7, 10, 20 and 46 months after discharge from medical hospitalization for treatment of SARS. Diagnoses of PTSD were established by a trained psychiatrist using the <italic>Chinese Classification of Mental Disorders</italic> (<italic>CCMD-III</italic>) and <italic>Diagnostic and Statistical Manual of Mental Disorders, 4th Edition</italic> (<italic>DSM-IV</italic>) criteria. To study the impact of PTSD, we used the Impact of Event Scale (IES), Zung Self-Rating Anxiety Scale (SAS), Zung Self-Rating Depression Scale (SDS), Symptom Checklist 90 (SCL-90), Short Form-36 (SF-36 Health Survey) and Social Disability Screening Schedule (SDSS).</p></sec><sec><title>Results</title><p>Of the 68 subjects who finished at least two follow-up interviews, 30 developed PTSD over the study period (44.1%). Scores on IES, SAS, SDS and SCL-90 (<italic>P</italic><.0001) were higher, and functional impairment as measured by SF-36 (<italic>P</italic><.0001) and SDSS was more severe (<italic>P</italic>=.0073) for subjects with PTSD.</p></sec><sec><title>Conclusion</title><p>PTSD occurs in a significant percentage of subjects who recover from SARS, and the occurrence of PTSD predicts persistent psychological distress and diminished social functioning in the 4 years after SARS treatment.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="World Health Organization" uniqKey="World Health Organization">World Health Organization</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="World Health Organization" uniqKey="World Health Organization">World Health Organization</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liang, W" uniqKey="Liang W">W. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Gen Hosp Psychiatry</journal-id><journal-id journal-id-type="iso-abbrev">Gen Hosp Psychiatry</journal-id><journal-title-group><journal-title>General Hospital Psychiatry</journal-title></journal-title-group><issn pub-type="ppub">0163-8343</issn><issn pub-type="epub">1873-7714</issn><publisher><publisher-name>Published by Elsevier Inc.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">19892213</article-id><article-id pub-id-type="pmc">7112559</article-id><article-id pub-id-type="publisher-id">S0163-8343(09)00134-0</article-id><article-id pub-id-type="doi">10.1016/j.genhosppsych.2009.06.008</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Posttraumatic stress disorder in convalescent severe acute respiratory syndrome patients: a 4-year follow-up study<sup><xref ref-type="fn" rid="d32e2490">☆</xref></sup></article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Hong</surname><given-names>Xia</given-names></name><degrees>M.D., Ph.D.</degrees><xref rid="aff1" ref-type="aff">a</xref><xref rid="aff2" ref-type="aff">b</xref></contrib><contrib contrib-type="author"><name><surname>Currier</surname><given-names>Glenn W.</given-names></name><degrees>M.D.</degrees><xref rid="aff2" ref-type="aff">b</xref><xref rid="aff3" ref-type="aff">c</xref></contrib><contrib contrib-type="author"><name><surname>Zhao</surname><given-names>Xiaohui</given-names></name><degrees>M.D.</degrees><xref rid="aff1" ref-type="aff">a</xref></contrib><contrib contrib-type="author"><name><surname>Jiang</surname><given-names>Yinan</given-names></name><degrees>M.D.</degrees><xref rid="aff4" ref-type="aff">d</xref></contrib><contrib contrib-type="author"><name><surname>Zhou</surname><given-names>Wei</given-names></name><degrees>M.D.</degrees><xref rid="aff1" ref-type="aff">a</xref></contrib><contrib contrib-type="author"><name><surname>Wei</surname><given-names>Jing</given-names></name><degrees>M.D.</degrees><email>weijing@pumch.cn</email><xref rid="aff1" ref-type="aff">a</xref><xref rid="cor1" ref-type="corresp">⁎</xref></contrib></contrib-group><aff id="aff1"><label>a</label>Department of Psychological Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China</aff><aff id="aff2"><label>b</label>Department of Psychiatry, University of Rochester Medical Center, Rochester, NY 14642, USA</aff><aff id="aff3"><label>c</label>Department of Emergency Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA</aff><aff id="aff4"><label>d</label>Department of Internal Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China</aff><author-notes><corresp id="cor1"><label>⁎</label>Corresponding author. Tel.: +86 10 65296066; fax: +86 10 65296066. <email>weijing@pumch.cn</email></corresp></author-notes><pub-date pub-type="pmc-release"><day>27</day><month>8</month><year>2009</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="ppub" iso-8601-date="2009-12-01"><season>November-December</season><year>2009</year></pub-date><pub-date pub-type="epub"><day>27</day><month>8</month><year>2009</year></pub-date><volume>31</volume><issue>6</issue><fpage>546</fpage><lpage>554</lpage><history><date date-type="received"><day>13</day><month>1</month><year>2009</year></date><date date-type="accepted"><day>29</day><month>6</month><year>2009</year></date></history><permissions><copyright-statement>Copyright © 2009 Published by Elsevier Inc.</copyright-statement><copyright-year>2009</copyright-year><copyright-holder></copyright-holder><license><license-p>Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.</license-p></license></permissions><abstract><sec><title>Objective</title><p>To measure the incidence and impact of posttraumatic stress disorder (PTSD) in a cohort of 70 subjects with severe acute respiratory syndrome (SARS).</p></sec><sec><title>Methods</title><p>Clinical assessments of PTSD were conducted at 2, 7, 10, 20 and 46 months after discharge from medical hospitalization for treatment of SARS. Diagnoses of PTSD were established by a trained psychiatrist using the <italic>Chinese Classification of Mental Disorders</italic> (<italic>CCMD-III</italic>) and <italic>Diagnostic and Statistical Manual of Mental Disorders, 4th Edition</italic> (<italic>DSM-IV</italic>) criteria. To study the impact of PTSD, we used the Impact of Event Scale (IES), Zung Self-Rating Anxiety Scale (SAS), Zung Self-Rating Depression Scale (SDS), Symptom Checklist 90 (SCL-90), Short Form-36 (SF-36 Health Survey) and Social Disability Screening Schedule (SDSS).</p></sec><sec><title>Results</title><p>Of the 68 subjects who finished at least two follow-up interviews, 30 developed PTSD over the study period (44.1%). Scores on IES, SAS, SDS and SCL-90 (<italic>P</italic><.0001) were higher, and functional impairment as measured by SF-36 (<italic>P</italic><.0001) and SDSS was more severe (<italic>P</italic>=.0073) for subjects with PTSD.</p></sec><sec><title>Conclusion</title><p>PTSD occurs in a significant percentage of subjects who recover from SARS, and the occurrence of PTSD predicts persistent psychological distress and diminished social functioning in the 4 years after SARS treatment.</p></sec></abstract><kwd-group><title>Keywords</title><kwd>Posttraumatic stress disorder</kwd><kwd>Severe acute respiratory syndrome</kwd><kwd>Follow-up study</kwd></kwd-group></article-meta></front><body><sec id="section0005"><label>1</label><title>Introduction</title><p id="para0005">Severe acute respiratory syndrome (SARS) was the first severe and readily transmissible new infectious disease to emerge in the 21st century. SARS initially developed in southern China, where the first cases are now known to have occurred in late November 2002 <xref rid="bib1" ref-type="bibr">[1]</xref>. Since then, the cumulative number of reported probable cases of SARS worldwide for the period November 16, 2002, to August 7, 2003, was 8422 <xref rid="bib2" ref-type="bibr">[2]</xref>.</p><p id="para0010">The largest outbreak of SARS struck Beijing in spring 2003. Infected individuals from several outlying provinces sought clinical care in Beijing, resulting in viral dissemination to local health care facilities. Beijing's outbreak began in March 5; by late April, daily hospital admissions for SARS exceeded 100 for several days, with the onset of the last probable case on May 29, 2003 <xref rid="bib3" ref-type="bibr">[3]</xref>, <xref rid="bib4" ref-type="bibr">[4]</xref>. In total, 2521 cases of probable SARS occurred, with total of 192 deaths and a case fatality rate of 7.6% <xref rid="bib4" ref-type="bibr">[4]</xref>.</p><p id="para0015">Initial public health management of the outbreak relied heavily on quarantine. Patients diagnosed with SARS were isolated in several hospitals, with specific secondary referral hospitals serving as central receiving facilities as the outbreak emerged. Unaffected individuals with known contact with SARS patients were isolated in their own homes to interrupt the transmission of the syndrome. The public was terrified, with widespread media attention concerning the severity of the epidemic. SARS is normally transmitted through droplet spread from one person to another, clustered among family groups. The transmission rate among close contacts was 6.3% (range by Beijing local government districts, 2.9–9.7%). Transmission increased with the age of close contacts, from 5.0% in children younger than 10 years to 27.6% in adults aged 60 to 69 years. The attack rate was highest among spouses (15.4%), other household members (8.8%) and nonhousehold relatives (11.6%) <xref rid="bib5" ref-type="bibr">[5]</xref>.</p><p id="para0020">Posttraumatic stress disorder (PTSD) is a stress-related disorder that can occur after the experience of a traumatic event. The estimated lifetime prevalence of PTSD is 7.8% in the US population <xref rid="bib6" ref-type="bibr">[6]</xref>. The 12-month prevalence of PTSD was 0.2% in metropolitan population in China (Beijing and Shanghai) <xref rid="bib7" ref-type="bibr">[7]</xref>. Several studies report the incidence of PTSD in victims of natural disaster (8.6% to 24.2%) or traumatic accident (10.6%) in China <xref rid="bib8" ref-type="bibr">[8]</xref>, <xref rid="bib9" ref-type="bibr">[9]</xref>, <xref rid="bib10" ref-type="bibr">[10]</xref>. However, differences in study design, outcome measures and clinical populations provided make it difficult to compare these results.</p><p id="para0025">The psychosocial and functional impact of PTSD can be severe. Individuals with PTSD often manifest greater psychological and social impairment. PTSD can damage interpersonal relationships and functional capacity, leading to increased depression and related impairment <xref rid="bib11" ref-type="bibr">[11]</xref>. More generally, chronic stress has been associated with a variety of adverse medical outcomes, including chronic diseases such as diabetes, hypertension and heart disease <xref rid="bib12" ref-type="bibr">[12]</xref>.</p><p id="para0030">One specific serious medical outcome of treatment related to SARS can adversely affect long-term functional capacity. As a side-effect of drugs (such as glucocorticoids) used in treatment, femoral head necrosis (FHN) was reported to occur in 15% to 30% of Chinese SARS patients in follow-up studies <xref rid="bib13" ref-type="bibr">[13]</xref>, <xref rid="bib14" ref-type="bibr">[14]</xref>.</p><p id="para0035">There were 10 articles published after 2003 examining the psychological impact of SARS on survivors <xref rid="bib15" ref-type="bibr">[15]</xref>, <xref rid="bib16" ref-type="bibr">[16]</xref>, <xref rid="bib17" ref-type="bibr">[17]</xref>, <xref rid="bib18" ref-type="bibr">[18]</xref>, <xref rid="bib19" ref-type="bibr">[19]</xref>, <xref rid="bib20" ref-type="bibr">[20]</xref>, <xref rid="bib21" ref-type="bibr">[21]</xref>, <xref rid="bib22" ref-type="bibr">[22]</xref>, <xref rid="bib23" ref-type="bibr">[23]</xref>, <xref rid="bib24" ref-type="bibr">[24]</xref>. In one study of 63 survivors of SARS at 3 months postdischarge from hospital in Singapore, the rate of possible PTSD, inferred from an Impact of Event Scale (IES) Score of >26, was 41.7% <xref rid="bib15" ref-type="bibr">[15]</xref>. In a study of 195 survivors of SARS at 1 month postdischarge from hospital in Hong Kong, 10% to 18% of them reported symptoms related to PTSD <xref rid="bib16" ref-type="bibr">[16]</xref>. In another study in Hong Kong, among 131 survivors, 4% at 1 month and 5% at 3 months postdischarge endorsed symptoms consistent with PTSD <xref rid="bib17" ref-type="bibr">[17]</xref>. However, these articles were limited by use of self-reported ratings of PTSD, and no specific PTSD measures were included. Several studies suggest that SARS survivors still had elevated levels of general psychological distress 1, 3, 12 and 18 months after hospital discharge, but the rate of PTSD is unspecified in these studies <xref rid="bib18" ref-type="bibr">[18]</xref>, <xref rid="bib19" ref-type="bibr">[19]</xref>, <xref rid="bib20" ref-type="bibr">[20]</xref>, <xref rid="bib21" ref-type="bibr">[21]</xref>, <xref rid="bib22" ref-type="bibr">[22]</xref>, <xref rid="bib23" ref-type="bibr">[23]</xref>, <xref rid="bib24" ref-type="bibr">[24]</xref>. The increased psychological burden of FHN in conjunction with SARS has not been evaluated. Furthermore, several articles published in Chinese focused on the incidence of PTSD on SARS survivors in Beijing, Shanxi and Tianjin in mainland China, and the incidence rate of PTSD was reported to be 9.8%, 30.7% and 46.2% at 3 months postdischarge <xref rid="bib25" ref-type="bibr">[25]</xref>, <xref rid="bib26" ref-type="bibr">[26]</xref>, <xref rid="bib27" ref-type="bibr">[27]</xref>.</p><p id="para0040">The aim of our study was therefore to determine the incidence of PTSD in survivors of SARS up to 4 years after initial medical treatment. We aimed to describe changes in psychological and functional outcomes for subjects with and without PTSD diagnoses over the same time frame and to consider the impact of FHN on severity of PTSD.</p></sec><sec id="section0010"><label>2</label><title>Methods</title><sec id="section0015"><label>2.1</label><title>Participants</title><p id="para0045">Participants were recruited from the free outpatient medical clinic for convalescent patients of SARS at Peking Union Medical College Hospital (PUMCH). Infectious, respiratory and psychological services were available in the clinic. Subjects from several inpatient SARS treatment facilities received subsequent care at PUMCH on a voluntary basis. The study sample was enrolled between June 24, 2003, and November 30, 2003. All subjects qualifying for the study had received a SARS diagnosis in accordance with the Ministry of Health of the People's Republic of China criteria for “infectious atypical pneumonia” and were determined to be adequately treated, appropriate for discharge and isolated for 1 week in their own home after hospital discharge <xref rid="bib28" ref-type="bibr">[28]</xref>. The protocol of this study was approved by the PUMCH Ethics Committee, and written informed consent was obtained from all participants.</p><p id="para0050">All adult subjects who came to the free outpatient clinic for convalescent patients of SARS at PUMCH were consecutively screened over a period of 6 months. All subjects who were approached agreed to participate. The initial interview (T1) was performed an average of 53 days (S.D.=31, range=9 to 186 days) after hospital discharge. Follow-up interviews were conducted approximately 7 months (T2, average=204 days, S.D.=35 days), 10 months (T3, average=314 days, S.D.=32 days), 20 months (T4, average=618 days, S.D.=50 days) and 46 months (T5, average=1380 days, S.D.=27 days) after discharge from hospital. Interviews consisted of a variety of rater-administered, self-report measures and open interview, and lasted on average approximately 60 min.</p></sec><sec id="section0020"><label>2.2</label><title>Measures</title><p id="para0055">All rater-administered and self-report measures were translated into Chinese and have been published.<list list-type="simple" id="list0005"><list-item id="list-item0005"><label>1.</label><p id="para0060">Sociodemographic data, including age, sex, marital status, occupation, employment status prior to SARS, educational level, living status, number of relatives who contracted or died from SARS.</p></list-item><list-item id="list-item0010"><label>2.</label><p id="para0065">Medical and psychiatric history, as well family history of psychiatric disorder, was included. “If you were found to suffer from femoral head necrosis” and “if you have any body discomfort” were added in T3, T4 and T5. Chest computed tomography (CT) was available in T1. The abnormality of chest radiography was scored from 0 (<italic>not at all</italic>) to 4 (<italic>very severe</italic>) by a radiologist. Magnetic resonance imaging (MRI) of the hip joint was available in T3. Self-reported FHN and results of MRI were used together to judge whether subjects suffered from FHN.</p></list-item><list-item id="list-item0015"><label>3.</label><p id="para0070">Scales used to assess the impact of PTSD:<list list-type="simple" id="list0010"><list-item id="list-item0020"><label>a.</label><p id="para0075">The Impact of Event Scale (IES) is a 15-item self-report questionnaire designed to assess symptoms of intrusive thoughts and avoidance resulting from traumatic life events. The scale measured frequency with which each of the PTSD symptom has occurred over the past week; scores of 0, 1, 3 and 5 correspond with responses of “not at all,” “rarely,” “sometimes” and “often,” respectively; and a summed score ranges from 0 to 75 <xref rid="bib29" ref-type="bibr">[29]</xref>, <xref rid="bib30" ref-type="bibr">[30]</xref>.</p></list-item><list-item id="list-item0025"><label>b.</label><p id="para0080">Zung's Self-Rating Depression Scale (SDS <xref rid="bib31" ref-type="bibr">[31]</xref>) and Zung's Self-Rating Anxiety Scale (SAS <xref rid="bib32" ref-type="bibr">[32]</xref>) are two 20-item self-report questionnaires designed to assess symptoms of depression and anxiety, with scores ranging from 0 to 80 <xref rid="bib31" ref-type="bibr">[31]</xref>, <xref rid="bib32" ref-type="bibr">[32]</xref>, <xref rid="bib33" ref-type="bibr">[33]</xref>, <xref rid="bib34" ref-type="bibr">[34]</xref>.</p></list-item><list-item id="list-item0030"><label>c.</label><p id="para0085">Symptom Checklist 90 (SCL-90) is a 90-item self-report inventory designed to screen for psychopathological symptoms. Each item is scored from 0 (<italic>not at all</italic>) to 4 (<italic>extremely</italic>). It includes nine symptom dimensions: somatization, obsessive–compulsiveness, interpersonal sensitivity, depression, anxiety, hostility, phobic anxiety, paranoid ideation and psychoticism <xref rid="bib35" ref-type="bibr">[35]</xref>, <xref rid="bib36" ref-type="bibr">[36]</xref>.</p></list-item><list-item id="list-item0035"><label>d.</label><p id="para0090">Short Form-36 (SF-36) Health Survey was conducted in T3 to T5. The SF-36 includes eight subscales: physical functioning (PF), role limitation due to reduced physical functioning (RP), body pain (BP), general health (GH), vitality (VT), social functioning (SF), mental health (MH) and role limitation due to emotional problems (RE). Scale scores were transformed and standardized on a scale ranging from 0 to 100, with lower scores representing poorer health functioning <xref rid="bib37" ref-type="bibr">[37]</xref>. SF-36 has been translated into Chinese and normed on Chinese populations <xref rid="bib38" ref-type="bibr">[38]</xref>.</p></list-item><list-item id="list-item0040"><label>e.</label><p id="para0095">Social Disability Screening Schedule (SDSS) was conducted in T3 to T5. SDSS is a 10-item rater-administered scale used to access the function in a variety of occupational, social, marital and family roles. Item scores of 0, 1 and 2 correspond with absent, moderate or serious dysfunction, respectively. This scale was translated into Chinese and modified according to the Disability Assessment Schedule <xref rid="bib39" ref-type="bibr">[39]</xref>, <xref rid="bib40" ref-type="bibr">[40]</xref>.</p></list-item></list></p></list-item></list></p><p id="para0100">T1 interviews were conducted at the outpatient clinic. T2 to T5 interviews were completed in a variety of venues, including at PUMCH, the patient's home or by mail with telephone follow-up if live interviews were not possible. Self-rating scales were finished by the subjects themselves according to written direction. Other rating scales were conducted by the same interviewer during each visit.</p></sec><sec id="section0025"><label>2.3</label><title>Diagnostic criteria</title><p id="para0105">The diagnosis of PTSD was made by a senior psychiatric doctor according to <italic>CCMD-III</italic><xref rid="bib41" ref-type="bibr">[41]</xref> criteria. The <italic>CCMD-III</italic> differs from the <italic>DSM-IV</italic> classification <xref rid="bib42" ref-type="bibr">[42]</xref> by requiring a longer duration for symptoms, and therefore all subjects met <italic>DSM-IV</italic> criteria as well. Diagnoses were classified into four types:<list list-type="simple" id="list0015"><list-item id="list-item0045"><label>1.</label><p id="para0110">Current PTSD: Subjects fulfilled the criteria of PTSD at the follow-up interview.</p></list-item><list-item id="list-item0050"><label>2.</label><p id="para0115">Prior PTSD: Subjects endorsed past symptoms consistent with PTSD and met the diagnostic criteria, but the symptoms were alleviated and did not meet the criteria at the current follow-up interview.</p></list-item><list-item id="list-item0055"><label>3.</label><p id="para0120">No PTSD.</p></list-item><list-item id="list-item0060"><label>4.</label><p id="para0125">Unable to confirm: Insufficient data available to make PTSD diagnosis.</p></list-item></list></p></sec><sec id="section0030"><label>2.4</label><title>Statistical analysis</title><p id="para0130">Statistical analyses were conducted with SAS 9.1/SPSS 15.0. Group comparisons of dimensional variables were performed with independent-samples <italic>t</italic> tests. For categorical variables, chi-squared tests were used, including Fisher's exact test if the expected count was less than five in more than 20% of cells. For ordinal variable (chest CT), nonparametric Wilcoxon signed-rank test was used. Linear mixed-effects models were used to examine whether the impact of PTSD as measured by IES, SAS, SDS, SCL-90, SF-36 and SDSS was different with no-PTSD subjects, and whether there were some changes over time. The models contained scores on IES, SASS, SDS, SCL-90, SF-36 and SDSS as response variables (<italic>y</italic>), and PTSD (<italic>x</italic>) and follow-up time (years postdischarge, <italic>t</italic>) as the primary fixed effects of interest. PTSD was included as a time variant variable with a value of 0 for any time point before and a value of 1 after diagnosis. The models included <italic>x</italic>, <italic>t</italic> and the interaction between <italic>x</italic> and <italic>t</italic> (model of <italic>y</italic> on <italic>x</italic>, <italic>t</italic>, <italic>x</italic>⁎<italic>t</italic>).</p></sec></sec><sec id="section0035"><label>3</label><title>Results</title><sec id="section0040"><label>3.1</label><title>Sample</title><p id="para0135">Sociodemographic characteristics and medical condition of the sample are presented in <xref rid="tbl1" ref-type="table">Table 1</xref>. The majority of subjects were females, and the mean age was 38.5 years. The age distribution did not differ from overall Beijing SARS cases <xref rid="bib3" ref-type="bibr">[3]</xref> (chi-square=10.02, <italic>P</italic>=.1236). One subject had a positive history of depression and had been prescribed fluoxetine for 1 year, although he/she was not taking antidepressants before the onset of SARS. Subjects with PTSD were more likely to be older, female, married, have higher numbers of close relatives who suffered and/or died from SARS, and to have FHN. There was no significant difference between those with PTSD and those without PTSD on chest CT findings in T1 (<italic>P</italic>=.0600).<table-wrap position="float" id="tbl1"><label>Table 1</label><caption><p>Sociodemographic characteristics and medical condition of the sample</p></caption><table frame="hsides" rules="groups"><thead><tr><th valign="top">Variable</th><th valign="top">Total (<italic>N</italic>=70)</th><th valign="top">No PTSD (<italic>n</italic>=38)</th><th valign="top">PTSD (<italic>n</italic>=30)</th><th valign="top">Chi-square or <italic>t</italic></th><th valign="top"><italic>P</italic></th></tr></thead><tbody><tr><td valign="top">Age (years), mean (S.D)</td><td valign="top">38.5 (12.3)</td><td valign="top">35.0 (13.4)</td><td valign="top">42.9 (9.7)</td><td align="char" valign="top">2.729</td><td align="char" valign="top">.0081<xref rid="tblfn1" ref-type="table-fn">⁎</xref></td></tr><tr><td colspan="6" valign="top">Gender, <italic>n</italic> (%)</td></tr><tr><td valign="top"> Male</td><td valign="top">23 (32.9)</td><td valign="top">17 (44.7)</td><td valign="top">6 (20.0)</td><td valign="top"></td><td valign="top"></td></tr><tr><td valign="top"> Female</td><td valign="top">47 (67.1)</td><td valign="top">21 (55.3)</td><td valign="top">24 (80.0)</td><td align="char" valign="top">4.583</td><td align="char" valign="top">.0323<xref rid="tblfn1" ref-type="table-fn">⁎</xref></td></tr><tr><td colspan="6" valign="top">Marital status, <italic>n</italic> (%)</td></tr><tr><td valign="top"> Single</td><td valign="top">17 (24.3)</td><td valign="top">16 (42.1)</td><td valign="top">1 ( 3.3)</td><td valign="top"></td><td valign="top"></td></tr><tr><td valign="top"> Married</td><td valign="top">47 (67.1)</td><td valign="top">21 (55.3)</td><td valign="top">24 (80.0)</td><td valign="top"></td><td valign="top"></td></tr><tr><td valign="top"> Divorced</td><td valign="top">3 ( 4.3)</td><td valign="top">1 ( 2.6)</td><td valign="top">2 ( 6.7)</td><td valign="top"></td><td valign="top"></td></tr><tr><td valign="top"> Widowed</td><td valign="top">3 ( 4.3)</td><td valign="top">0 ( 0.0)</td><td valign="top">3 (10.0)</td><td align="char" valign="top">16.050</td><td align="char" valign="top">.0011<xref rid="tblfn1" ref-type="table-fn">⁎</xref></td></tr><tr><td colspan="6" valign="top">Occupation, <italic>n</italic> (%)</td></tr><tr><td valign="top"> Professional/managerial</td><td valign="top">50 (71.5)</td><td valign="top">27 (71.1)</td><td valign="top">22 (73.3)</td><td valign="top"></td><td valign="top"></td></tr><tr><td valign="top"> Laborer</td><td valign="top">20 (28.5)</td><td valign="top">11 (28.9)</td><td valign="top">8 (26.7)</td><td align="char" valign="top">0.043</td><td align="char" valign="top">.8351</td></tr><tr><td valign="top">Educational years in school, mean (S.D)</td><td valign="top">13.5 (2.7)</td><td valign="top">13.8 (2.9)</td><td valign="top">13.1 (2.4)</td><td align="char" valign="top">1.098</td><td align="char" valign="top">.2763</td></tr><tr><td colspan="6" valign="top">Employment status before SARS, <italic>n</italic> (%)</td></tr><tr><td valign="top"> Paid work</td><td valign="top">56 (80.0)</td><td valign="top">27 (71.1)</td><td valign="top">27 (90.0)</td><td valign="top"></td><td valign="top"></td></tr><tr><td valign="top"> No paid work</td><td valign="top">14 (20.0)</td><td valign="top">11 (28.9)</td><td valign="top">3 (10.0)</td><td valign="top"></td><td align="char" valign="top">.0729</td></tr><tr><td valign="top">Persons in home, mean (S.D)</td><td valign="top">3.0 (0.9)</td><td valign="top">3.1 (1.0)</td><td valign="top">2.7 (0.7)</td><td align="char" valign="top">1.833</td><td align="char" valign="top">.0713</td></tr><tr><td valign="top">Number of close relatives who suffered from SARS, mean (S.D.)</td><td valign="top">1.3 (2.7)</td><td valign="top">0.5 (1.6)</td><td valign="top">2.3 (3.5)</td><td align="char" valign="top">2.689</td><td align="char" valign="top">.0106<xref rid="tblfn1" ref-type="table-fn">⁎</xref></td></tr><tr><td valign="top">Number of close relatives who died from SARS, mean (S.D.)</td><td valign="top">0.4 (1.0)</td><td valign="top">0.1 (0.5)</td><td valign="top">0.7 (1.3)</td><td align="char" valign="top">2.409</td><td align="char" valign="top">.0211<xref rid="tblfn1" ref-type="table-fn">⁎</xref></td></tr><tr><td valign="top">Positive history of psychiatric disease, <italic>n</italic> (%)</td><td valign="top">1 (1.4)</td><td valign="top">0 (0 )</td><td valign="top">1 (3.3%)</td><td valign="top"></td><td align="char" valign="top">.4410</td></tr><tr><td valign="top">Positive family history of psychiatric disease, <italic>n</italic> (%)</td><td valign="top">2 (2.8)</td><td valign="top">1 (2.6)</td><td valign="top">1 (3.3%)</td><td valign="top"></td><td align="char" valign="top">1.0000</td></tr><tr><td valign="top">Femoral head necrosis, <italic>n</italic> (%)</td><td valign="top">(<italic>n</italic>=61)</td><td valign="top">(<italic>n</italic>=34)</td><td valign="top">(<italic>n</italic>=27)</td><td valign="top"></td><td valign="top"></td></tr><tr><td valign="top"> Yes</td><td valign="top">12 (17.1)</td><td valign="top">3 ( 7.9)</td><td valign="top">9 (30.0)</td><td valign="top"></td><td valign="top"></td></tr><tr><td valign="top"> No</td><td valign="top">49 (70.0)</td><td valign="top">31 (81.6)</td><td valign="top">18 (60.0)</td><td valign="top"></td><td align="char" valign="top">.0238<xref rid="tblfn1" ref-type="table-fn">⁎</xref></td></tr><tr><td valign="top">Chest CT, <italic>n</italic> (%)</td><td valign="top">(<italic>n</italic>=54)</td><td valign="top">(<italic>n</italic>=29)</td><td valign="top">(<italic>n</italic>=24)</td><td valign="top"></td><td valign="top"></td></tr><tr><td valign="top"> 0</td><td valign="top">23 (42.6)</td><td valign="top">17 (58.6)</td><td valign="top">5 (20.8)</td><td valign="top"></td><td valign="top"></td></tr><tr><td valign="top"> 1</td><td valign="top">11 (20.4)</td><td valign="top">3 (10.3)</td><td valign="top">8 (33.3)</td><td valign="top"></td><td valign="top"></td></tr><tr><td valign="top"> 2</td><td valign="top">8 (14.8)</td><td valign="top">2 (6.9)</td><td valign="top">6 (25.0)</td><td valign="top"></td><td valign="top"></td></tr><tr><td valign="top"> 3</td><td valign="top">9 (16.7)</td><td valign="top">6 (20.7)</td><td valign="top">3 (12.5)</td><td valign="top"></td><td valign="top"></td></tr><tr><td valign="top"> 4</td><td valign="top">3 ( 5.6)</td><td valign="top">1 (3.5)</td><td valign="top">2 (8.3)</td><td align="char" valign="top">3.539</td><td align="char" valign="top">.0600</td></tr></tbody></table><table-wrap-foot><fn id="tblfn1"><label>⁎</label><p>Significant difference between no-PTSD and PTSD groups (<italic>P</italic><.05).</p></fn></table-wrap-foot></table-wrap></p><p id="para0140">Follow-up status is shown in <xref rid="fig1" ref-type="fig">Fig. 1</xref>. Seventy, 68, 65 and 57 subjects finished at least one, two, three and four interviews, respectively. Forty-three finished all five interviews. Some subjects who missed earlier interviews were captured in later assessments. Among all visits, 82.2% were finished at the outpatient clinic, 3.9% via home interviews and 13.9% via mailing and telephone.<fig id="fig1"><label>Fig. 1</label><caption><p>Follow-up status of the sample.</p></caption><graphic xlink:href="gr1_lrg"></graphic></fig></p></sec><sec id="section0045"><label>3.2</label><title>Rates of PTSD</title><p id="para0145">Thirty subjects (44.1%) met the diagnostic criteria for PTSD in at least one of the five follow-up visits. The incidence rates were 26.1% (6/23) for males, 53.3% (24/45) for females, 15% (3/20) for subjects under 30 years of age, 46.4% (13/28) for subjects 30 to 45 years of age and 70.0% (14/20) for subjects over 45 years of age.</p><p id="para0150">As shown in <xref rid="fig1" ref-type="fig">Fig. 1</xref>, 28 met the criteria initially; one subject who did not demonstrate PTSD in T1 to T3 developed onset of PTSD at T4 but recovered at T5, and one subject who did not demonstrate PTSD in T1 to T4 developed onset of PTSD at T5. Two subjects who fulfilled the symptom criteria, severity criteria, but not the course criteria for PTSD in the T1 visit (interval between T1 and hospital discharge was 18 and 65 days, respectively), were then dropped. Therefore we were unable to confirm the diagnoses of these two subjects. Three subjects, whose diagnosis was PTSD in both the T1 and T2 visits, did not fulfill the diagnostic criteria thereafter, suggesting recovery from PTSD. Thirty-eight subjects never met the diagnostic criteria. One participant, who went abroad at T2, did respond to questionnaires while unavailable for interview; the diagnosis was unable to confirm at T1 and T2. Upon return to China at T4, this subject did not meet the criteria for PTSD. No other subject who missed an assessment changed his/her PTSD status on the next available assessment.</p><p id="para0155">The prevalence of PTSD over time is shown in <xref rid="tbl2" ref-type="table">Table 2</xref>. Twenty-three (82.1%) of the 28 cases of PTSD established at T1 still met the diagnostic criteria at T5.<table-wrap position="float" id="tbl2"><label>Table 2</label><caption><p>Point prevalence of PTSD at each specific visit</p></caption><table frame="hsides" rules="groups"><thead><tr><th valign="top">Interview</th><th valign="top"><italic>n</italic></th><th valign="top">PTSD (%)</th><th valign="top">No PTSD (%)</th><th valign="top">Unable to confirm (%)</th></tr></thead><tbody><tr><td valign="top">T<sub>1</sub></td><td align="char" valign="top">70</td><td align="char" valign="top">28 (40.0)</td><td align="char" valign="top">39 (55.7)</td><td valign="top">3 (4.3)</td></tr><tr><td valign="top">T<sub>2</sub></td><td align="char" valign="top">61</td><td align="char" valign="top">25 (41.0)</td><td align="char" valign="top">35 (57.4)</td><td valign="top">1 (1.6)</td></tr><tr><td valign="top">T<sub>3</sub></td><td align="char" valign="top">57</td><td align="char" valign="top">22 (38.6)</td><td align="char" valign="top">35 (61.4)</td><td valign="top">0</td></tr><tr><td valign="top">T<sub>4</sub></td><td align="char" valign="top">58</td><td align="char" valign="top">23 (39.7)</td><td align="char" valign="top">35 (60.3)</td><td valign="top">0</td></tr><tr><td valign="top">T<sub>5</sub></td><td align="char" valign="top">57</td><td align="char" valign="top">24 (42.1)</td><td align="char" valign="top">33 (57.9)</td><td valign="top">0</td></tr></tbody></table></table-wrap></p><p id="para0160">Compared with subjects with no PTSD, subjects given a diagnosis of PTSD had significantly higher scores on IES, SAS, SDS, SCL-90 and SDSS, and a significantly lower score on SF-36 at all time points (<xref rid="tbl3" ref-type="table">Table 3</xref>). <xref rid="tbl4" ref-type="table">Table 4</xref>shows the differences in mean score on scales from linear mixed models for the PTSD vs. the no-PTSD group. All PTSD terms were significant (<italic>P</italic><.05), indicating that there were significant differences in the scores on scales for the PTSD vs. the no-PTSD group. Time terms were significant in IES (−2.8, <italic>P</italic>=.0025), SDS (−2.5, <italic>P</italic><.0001) and VT (3.5, <italic>P</italic>=.0135), suggesting that there was a significant decrease in scores on IES and SDS, and an increase in scores on VT as follow-up time increased for both the PTSD and the no-PTSD groups. PTSD×Time interaction terms were not significant (<italic>P</italic>>.05), indicating that there were no significant differences in the changes over time in the scores on scales for the PTSD vs. the no-PTSD group.<table-wrap position="float" id="tbl3"><label>Table 3</label><caption><p>IES, RFI, SAS, SDS, SCL-90, SF-36 and SDSS in the PTSD and no-PTSD group</p></caption><table frame="hsides" rules="groups"><thead><tr><th valign="top">Scales</th><th valign="top">No PTSD</th><th valign="top">PTSD</th><th valign="top"><italic>t</italic></th><th valign="top"><italic>P</italic></th></tr></thead><tbody><tr><td colspan="5" valign="top">IES</td></tr><tr><td valign="top"> T<sub>1</sub> (<italic>n</italic>=67)</td><td align="char" valign="top">22.4±12.7</td><td align="char" valign="top">45.3±16.6</td><td align="char" valign="top">6.390</td><td align="char" valign="top"><.001<xref rid="tblfn2" ref-type="table-fn">⁎</xref></td></tr><tr><td valign="top"> T<sub>2</sub> (<italic>n</italic>=60)</td><td align="char" valign="top">15.8±11.5</td><td align="char" valign="top">39.0±12.6</td><td align="char" valign="top">7.386</td><td align="char" valign="top"><.001<xref rid="tblfn2" ref-type="table-fn">⁎</xref></td></tr><tr><td valign="top"> T<sub>3</sub> (<italic>n</italic>=57)</td><td align="char" valign="top">15.1±11.0</td><td align="char" valign="top">46.7±14.6</td><td align="char" valign="top">9.274</td><td align="char" valign="top"><.001<xref rid="tblfn2" ref-type="table-fn">⁎</xref></td></tr><tr><td valign="top"> T<sub>4</sub> (<italic>n</italic>=58)</td><td align="char" valign="top">9.9±9.9</td><td align="char" valign="top">41.2±16.6</td><td align="char" valign="top">8.145</td><td align="char" valign="top"><.001<xref rid="tblfn2" ref-type="table-fn">⁎</xref></td></tr><tr><td valign="top"> T<sub>5</sub> (<italic>n</italic>=57)</td><td align="char" valign="top">9.8±10.2</td><td align="char" valign="top">39.0±20.9</td><td align="char" valign="top">5.355</td><td align="char" valign="top"><.001<xref rid="tblfn2" ref-type="table-fn">⁎</xref></td></tr><tr><td colspan="5" valign="top">SAS</td></tr><tr><td valign="top"> T<sub>1</sub> (<italic>n</italic>=67)</td><td align="char" valign="top">26.3±10.9</td><td align="char" valign="top">43.0±16.7</td><td align="char" valign="top">4.610</td><td align="char" valign="top"><.001<xref rid="tblfn2" ref-type="table-fn">⁎</xref></td></tr><tr><td valign="top"> T<sub>2</sub> (<italic>n</italic>=60)</td><td align="char" valign="top">25.5±7.4</td><td align="char" valign="top">37.5±15.6</td><td align="char" valign="top">3.988</td><td align="char" valign="top"><.001<xref rid="tblfn2" ref-type="table-fn">⁎</xref></td></tr><tr><td valign="top"> T<sub>3</sub> (<italic>n</italic>=57)</td><td align="char" valign="top">25.6±5.9</td><td align="char" valign="top">42.9±16.2</td><td align="char" valign="top">4.807</td><td align="char" valign="top"><.001<xref rid="tblfn2" ref-type="table-fn">⁎</xref></td></tr><tr><td valign="top"> T<sub>4</sub> (<italic>n</italic>=58)</td><td align="char" valign="top">23.6±8.3</td><td align="char" valign="top">37.1±15.6</td><td align="char" valign="top">3.859</td><td align="char" valign="top"><.001<xref rid="tblfn2" ref-type="table-fn">⁎</xref></td></tr><tr><td valign="top"> T<sub>5</sub> (<italic>n</italic>=57)</td><td align="char" valign="top">22.7±7.7</td><td align="char" valign="top">37.2±21.0</td><td align="char" valign="top">3.215</td><td align="char" valign="top">.003<xref rid="tblfn2" ref-type="table-fn">⁎</xref></td></tr><tr><td colspan="5" valign="top">SDS</td></tr><tr><td valign="top"> T<sub>1</sub> (<italic>n</italic>=67)</td><td align="char" valign="top">33.9±10.3</td><td align="char" valign="top">47.4±11.2</td><td align="char" valign="top">5.103</td><td align="char" valign="top"><.001<xref rid="tblfn2" ref-type="table-fn">⁎</xref></td></tr><tr><td valign="top"> T<sub>2</sub> (<italic>n</italic>=60)</td><td align="char" valign="top">35.1±13.2</td><td align="char" valign="top">44.3±10.9</td><td align="char" valign="top">2.858</td><td align="char" valign="top">.006<xref rid="tblfn2" ref-type="table-fn">⁎</xref></td></tr><tr><td valign="top"> T<sub>3</sub> (<italic>n</italic>=57)</td><td align="char" valign="top">31.5±8.7</td><td align="char" valign="top">47.0±13.5</td><td align="char" valign="top">4.788</td><td align="char" valign="top"><.001<xref rid="tblfn2" ref-type="table-fn">⁎</xref></td></tr><tr><td valign="top"> T<sub>4</sub> (<italic>n</italic>=58)</td><td align="char" valign="top">26.1±7.2</td><td align="char" valign="top">43.7±12.2</td><td align="char" valign="top">6.238</td><td align="char" valign="top"><.001<xref rid="tblfn2" ref-type="table-fn">⁎</xref></td></tr><tr><td valign="top"> T<sub>5</sub> (<italic>n</italic>=57)</td><td align="char" valign="top">26.1±7.7</td><td align="char" valign="top">41.1±18.1</td><td align="char" valign="top">3.715</td><td align="char" valign="top">.001<xref rid="tblfn2" ref-type="table-fn">⁎</xref></td></tr><tr><td colspan="5" valign="top">SCL-90</td></tr><tr><td valign="top"> T<sub>1</sub> (<italic>n</italic>=67)</td><td align="char" valign="top">36.0±26.9</td><td align="char" valign="top">124.5±81.7</td><td align="char" valign="top">5.529</td><td align="char" valign="top"><.001<xref rid="tblfn2" ref-type="table-fn">⁎</xref></td></tr><tr><td valign="top"> T<sub>2</sub> (<italic>n</italic>=60)</td><td align="char" valign="top">37.4±55.1</td><td align="char" valign="top">104.7±80.9</td><td align="char" valign="top">4.065</td><td align="char" valign="top"><.001<xref rid="tblfn2" ref-type="table-fn">⁎</xref></td></tr><tr><td valign="top"> T<sub>3</sub> (<italic>n</italic>=57)</td><td align="char" valign="top">26.8±26.7</td><td align="char" valign="top">126.0±89.1</td><td align="char" valign="top">5.077</td><td align="char" valign="top"><.001<xref rid="tblfn2" ref-type="table-fn">⁎</xref></td></tr><tr><td valign="top"> T<sub>4</sub> (<italic>n</italic>=58)</td><td align="char" valign="top">23.7±27.7</td><td align="char" valign="top">95.7±81.7</td><td align="char" valign="top">4.078</td><td align="char" valign="top"><.001<xref rid="tblfn2" ref-type="table-fn">⁎</xref></td></tr><tr><td valign="top"> T<sub>5</sub> (<italic>n</italic>=57)</td><td align="char" valign="top">21.8±27.7</td><td align="char" valign="top">98.4±90.8</td><td align="char" valign="top">2.798</td><td align="char" valign="top">.010<xref rid="tblfn2" ref-type="table-fn">⁎</xref></td></tr><tr><td colspan="5" valign="top">SF-36 T<sub>3</sub> (<italic>n</italic>=57)</td></tr><tr><td valign="top"> Physical functioning</td><td align="char" valign="top">80.88±31.22</td><td align="char" valign="top">62.37±27.40</td><td align="char" valign="top">3.368</td><td align="char" valign="top">.001<xref rid="tblfn2" ref-type="table-fn">⁎</xref></td></tr><tr><td valign="top"> Role limitation due to reduced physical functioning</td><td align="char" valign="top">74.26±39.64</td><td align="char" valign="top">32.89±40.87</td><td align="char" valign="top">3.377</td><td align="char" valign="top">.001<xref rid="tblfn2" ref-type="table-fn">⁎</xref></td></tr><tr><td valign="top"> Body pain</td><td align="char" valign="top">75.03±24.53</td><td align="char" valign="top">47.66±25.16</td><td align="char" valign="top">3.861</td><td align="char" valign="top"><.001<xref rid="tblfn2" ref-type="table-fn">⁎</xref></td></tr><tr><td valign="top"> General health</td><td align="char" valign="top">62.79±27.99</td><td align="char" valign="top">33.42±20.20</td><td align="char" valign="top">4.402</td><td align="char" valign="top"><.001<xref rid="tblfn2" ref-type="table-fn">⁎</xref></td></tr><tr><td valign="top"> Vitality</td><td align="char" valign="top">69.26±24.46</td><td align="char" valign="top">41.32±21.53</td><td align="char" valign="top">4.157</td><td align="char" valign="top"><.001<xref rid="tblfn2" ref-type="table-fn">⁎</xref></td></tr><tr><td valign="top"> Social functioning</td><td align="char" valign="top">80.15±25.58</td><td align="char" valign="top">50.66±31.31</td><td align="char" valign="top">3.309</td><td align="char" valign="top">.001<xref rid="tblfn2" ref-type="table-fn">⁎</xref></td></tr><tr><td valign="top"> Mental health</td><td align="char" valign="top">80.00±15.94</td><td align="char" valign="top">54.11±19.43</td><td align="char" valign="top">5.240</td><td align="char" valign="top"><.001<xref rid="tblfn2" ref-type="table-fn">⁎</xref></td></tr><tr><td valign="top"> Role limitation due to emotional problems</td><td align="char" valign="top">89.22±26.87</td><td align="char" valign="top">33.33±41.57</td><td align="char" valign="top">4.584</td><td align="char" valign="top"><.001<xref rid="tblfn2" ref-type="table-fn">⁎</xref></td></tr><tr><td colspan="5" valign="top">SDSS</td></tr><tr><td valign="top"> T<sub>3</sub> (<italic>n</italic>=57)</td><td align="char" valign="top">0.76±1.64</td><td align="char" valign="top">2.05±2.55</td><td align="char" valign="top">2.355</td><td align="char" valign="top">.019<xref rid="tblfn2" ref-type="table-fn">⁎</xref></td></tr><tr><td valign="top"> T<sub>4</sub> (<italic>n</italic>=58)</td><td align="char" valign="top">1.14±2.78</td><td align="char" valign="top">6.30±5.65</td><td align="char" valign="top">4.109</td><td align="char" valign="top"><.001<xref rid="tblfn2" ref-type="table-fn">⁎</xref></td></tr><tr><td valign="top"> T<sub>5</sub> (<italic>n</italic>=57)</td><td align="char" valign="top">1.28±2.34</td><td align="char" valign="top">6.65±5.87</td><td align="char" valign="top">5.980</td><td align="char" valign="top"><.001<xref rid="tblfn2" ref-type="table-fn">⁎</xref></td></tr></tbody></table><table-wrap-foot><fn id="tblfn2"><label>⁎</label><p>Significant difference between the no-PTSD and PTSD groups (<italic>P</italic><.05).</p></fn></table-wrap-foot></table-wrap><table-wrap position="float" id="tbl4"><label>Table 4</label><caption><p>Impact of PTSD as measured by IES, SAS, SDS, SCL-90, SF-36 and SDSS on the linear mixed-effects models<xref rid="tblfn3" ref-type="table-fn">a</xref></p></caption><table frame="hsides" rules="groups"><thead><tr><th valign="top"></th><th valign="top">Estimate</th><th valign="top">S.E.</th><th valign="top"><italic>P</italic></th><th valign="top"></th><th valign="top">Estimate</th><th valign="top">S.E.</th><th valign="top"><italic>P</italic></th></tr></thead><tbody><tr><td colspan="4" valign="top">IES</td><td colspan="4" valign="top">SAS</td></tr><tr><td valign="top"> Intercept</td><td align="char" valign="top">21.2</td><td align="char" valign="top">1.9</td><td align="char" valign="top"><.0001<xref rid="tblfn4" ref-type="table-fn">⁎</xref></td><td valign="top"> Intercept</td><td align="char" valign="top">27.5</td><td align="char" valign="top">1.7</td><td align="char" valign="top"><.0001<xref rid="tblfn4" ref-type="table-fn">⁎</xref></td></tr><tr><td valign="top"> PTSD (reference: no PTSD)</td><td align="char" valign="top">20.6</td><td align="char" valign="top">2.7</td><td align="char" valign="top"><.0001<xref rid="tblfn4" ref-type="table-fn">⁎</xref></td><td valign="top"> PTSD (reference: no PTSD)</td><td align="char" valign="top">13.3</td><td align="char" valign="top">2.4</td><td align="char" valign="top"><.0001<xref rid="tblfn4" ref-type="table-fn">⁎</xref></td></tr><tr><td valign="top"> Follow-up time (years)</td><td align="char" valign="top">−2.8</td><td align="char" valign="top">0.9</td><td align="char" valign="top">.0025<xref rid="tblfn4" ref-type="table-fn">⁎</xref></td><td valign="top"> Follow-up time (years)</td><td align="char" valign="top">−1.2</td><td align="char" valign="top">0.6</td><td align="char" valign="top">.0607</td></tr><tr><td valign="top"> PTSD×Time</td><td align="char" valign="top">0.6</td><td align="char" valign="top">1.4</td><td align="char" valign="top">.6761</td><td valign="top"> PTSD×Time</td><td align="char" valign="top">0.1</td><td align="char" valign="top">1.0</td><td align="char" valign="top">.9158</td></tr><tr><td colspan="4" valign="top">SDS</td><td colspan="4" valign="top">SCL-90</td></tr><tr><td valign="top"> Intercept</td><td align="char" valign="top">35.3</td><td align="char" valign="top">1.4</td><td align="char" valign="top"><.0001<xref rid="tblfn4" ref-type="table-fn">⁎</xref></td><td valign="top"> Intercept</td><td align="char" valign="top">44.2</td><td align="char" valign="top">8.1</td><td align="char" valign="top"><.0001<xref rid="tblfn4" ref-type="table-fn">⁎</xref></td></tr><tr><td valign="top"> PTSD (reference: no PTSD)</td><td align="char" valign="top">10.3</td><td align="char" valign="top">2.1</td><td align="char" valign="top"><.0001<xref rid="tblfn4" ref-type="table-fn">⁎</xref></td><td valign="top"> PTSD (reference: no PTSD)</td><td align="char" valign="top">62.2</td><td align="char" valign="top">11.3</td><td align="char" valign="top"><.0001<xref rid="tblfn4" ref-type="table-fn">⁎</xref></td></tr><tr><td valign="top"> Follow-up time (years)</td><td align="char" valign="top">−2.5</td><td align="char" valign="top">0.6</td><td align="char" valign="top"><.0001<xref rid="tblfn4" ref-type="table-fn">⁎</xref></td><td valign="top"> Follow-up time (years)</td><td align="char" valign="top">−4.0</td><td align="char" valign="top">2.8</td><td align="char" valign="top">.1528</td></tr><tr><td valign="top"> PTSD×Time</td><td align="char" valign="top">1.1</td><td align="char" valign="top">0.9</td><td align="char" valign="top">.2203</td><td valign="top"> PTSD×Time</td><td align="char" valign="top">0.7</td><td align="char" valign="top">4.2</td><td align="char" valign="top">.8769</td></tr><tr><td colspan="4" valign="top">SDSS</td><td colspan="4" valign="top"></td></tr><tr><td valign="top"> Intercept</td><td align="char" valign="top">1.0</td><td align="char" valign="top">0.5</td><td align="char" valign="top">.0853</td><td valign="top"></td><td valign="top"></td><td valign="top"></td><td valign="top"></td></tr><tr><td valign="top"> PTSD (reference: no PTSD)</td><td align="char" valign="top">2.5</td><td align="char" valign="top">0.9</td><td align="char" valign="top">.0073<xref rid="tblfn4" ref-type="table-fn">⁎</xref></td><td valign="top"></td><td valign="top"></td><td valign="top"></td><td valign="top"></td></tr><tr><td valign="top"> Follow-up time (years)</td><td align="char" valign="top">−0.1</td><td align="char" valign="top">0.2</td><td align="char" valign="top">.7912</td><td valign="top"></td><td valign="top"></td><td valign="top"></td><td valign="top"></td></tr><tr><td valign="top"> PTSD×Time</td><td align="char" valign="top">0.4</td><td align="char" valign="top">0.3</td><td align="char" valign="top">.2385</td><td valign="top"></td><td valign="top"></td><td valign="top"></td><td valign="top"></td></tr><tr><td colspan="8" valign="top">
</td></tr><tr><td colspan="8" valign="top"><italic>SF-36</italic></td></tr><tr><td valign="top">PF</td><td valign="top"></td><td valign="top"></td><td valign="top"></td><td valign="top">RP</td><td valign="top"></td><td valign="top"></td><td valign="top"></td></tr><tr><td valign="top"> Chinese norm</td><td align="char" valign="top">82.2</td><td align="char" valign="top">19.8</td><td valign="top"></td><td valign="top"> Chinese norm</td><td align="char" valign="top">81.2</td><td align="char" valign="top">33.6</td><td valign="top"></td></tr><tr><td valign="top"> Intercept</td><td align="char" valign="top">84.5</td><td align="char" valign="top">4.3</td><td align="char" valign="top"><.0001<xref rid="tblfn4" ref-type="table-fn">⁎</xref></td><td valign="top"> Intercept</td><td align="char" valign="top">72.1</td><td align="char" valign="top">6.9</td><td align="char" valign="top"><.0001<xref rid="tblfn4" ref-type="table-fn">⁎</xref></td></tr><tr><td valign="top"> PTSD (reference: no PTSD)</td><td align="char" valign="top">−23.7</td><td align="char" valign="top">6.6</td><td align="char" valign="top">.0010<xref rid="tblfn4" ref-type="table-fn">⁎</xref></td><td valign="top"> PTSD (reference: no PTSD)</td><td align="char" valign="top">−42.2</td><td align="char" valign="top">11.3</td><td align="char" valign="top">.0006<xref rid="tblfn4" ref-type="table-fn">⁎</xref></td></tr><tr><td valign="top"> Follow-up time (years)</td><td align="char" valign="top">0.3</td><td align="char" valign="top">1.4</td><td align="char" valign="top">.8150</td><td valign="top"> Follow-up time (years)</td><td align="char" valign="top">4.1</td><td align="char" valign="top">2.3</td><td align="char" valign="top">.0783</td></tr><tr><td valign="top"> PTSD×Time</td><td align="char" valign="top">0.6</td><td align="char" valign="top">2.2</td><td align="char" valign="top">.7939</td><td valign="top"> PTSD×Time</td><td align="char" valign="top">1.9</td><td align="char" valign="top">3.6</td><td align="char" valign="top">.6109</td></tr><tr><td valign="top">BP</td><td valign="top"></td><td valign="top"></td><td valign="top"></td><td valign="top">GH</td><td valign="top"></td><td valign="top"></td><td valign="top"></td></tr><tr><td valign="top"> Chinese norm</td><td align="char" valign="top">81.5</td><td align="char" valign="top">20.5</td><td valign="top"></td><td valign="top"> Chinese norm</td><td align="char" valign="top">56.7</td><td align="char" valign="top">20.2</td><td valign="top"></td></tr><tr><td valign="top"> Intercept</td><td align="char" valign="top">70.3</td><td align="char" valign="top">4.9</td><td align="char" valign="top"><.0001<xref rid="tblfn4" ref-type="table-fn">⁎</xref></td><td valign="top"> Intercept</td><td align="char" valign="top">61.5</td><td align="char" valign="top">4.5</td><td align="char" valign="top"><.0001<xref rid="tblfn4" ref-type="table-fn">⁎</xref></td></tr><tr><td valign="top"> PTSD (reference: no PTSD)</td><td align="char" valign="top">−26.6</td><td align="char" valign="top">7.3</td><td align="char" valign="top">.0019<xref rid="tblfn4" ref-type="table-fn">⁎</xref></td><td valign="top"> PTSD (reference: no PTSD)</td><td align="char" valign="top">−27.8</td><td align="char" valign="top">6.9</td><td align="char" valign="top">.0003<xref rid="tblfn4" ref-type="table-fn">⁎</xref></td></tr><tr><td valign="top"> Follow-up time (years)</td><td align="char" valign="top">1.3</td><td align="char" valign="top">1.5</td><td align="char" valign="top">.3679</td><td valign="top"> Follow-up time (years)</td><td align="char" valign="top">2.2</td><td align="char" valign="top">1.3</td><td align="char" valign="top">.0954</td></tr><tr><td valign="top"> PTSD×Time</td><td align="char" valign="top">−2.5</td><td align="char" valign="top">2.3</td><td align="char" valign="top">.2826</td><td valign="top"> PTSD×Time</td><td align="char" valign="top">0.6</td><td align="char" valign="top">2.0</td><td align="char" valign="top">.7627</td></tr><tr><td valign="top">VT</td><td valign="top"></td><td valign="top"></td><td valign="top"></td><td valign="top">SF</td><td valign="top"></td><td valign="top"></td><td valign="top"></td></tr><tr><td valign="top"> Chinese norm</td><td align="char" valign="top">52.0</td><td align="char" valign="top">20.9</td><td valign="top"></td><td valign="top"> Chinese norm</td><td align="char" valign="top">83.0</td><td align="char" valign="top">17.8</td><td valign="top"></td></tr><tr><td valign="top"> Intercept</td><td align="char" valign="top">65.3</td><td align="char" valign="top">4.6</td><td align="char" valign="top"><.0001<xref rid="tblfn4" ref-type="table-fn">⁎</xref></td><td valign="top"> Intercept</td><td align="char" valign="top">80.4</td><td align="char" valign="top">5.3</td><td align="char" valign="top"><.0001<xref rid="tblfn4" ref-type="table-fn">⁎</xref></td></tr><tr><td valign="top"> PTSD (reference: no PTSD)</td><td align="char" valign="top">−20.2</td><td align="char" valign="top">7.1</td><td align="char" valign="top">.0076<xref rid="tblfn4" ref-type="table-fn">⁎</xref></td><td valign="top"> PTSD (reference: no PTSD)</td><td align="char" valign="top">−30.1</td><td align="char" valign="top">8.5</td><td align="char" valign="top">.0012<xref rid="tblfn4" ref-type="table-fn">⁎</xref></td></tr><tr><td valign="top"> Follow-up time (years)</td><td align="char" valign="top">3.5</td><td align="char" valign="top">1.4</td><td align="char" valign="top">.0135<xref rid="tblfn4" ref-type="table-fn">⁎</xref></td><td valign="top"> Follow-up time (years)</td><td align="char" valign="top">3.4</td><td align="char" valign="top">1.8</td><td align="char" valign="top">.0749</td></tr><tr><td valign="top"> PTSD×Time</td><td align="char" valign="top">−3.6</td><td align="char" valign="top">2.2</td><td align="char" valign="top">.1054</td><td valign="top"> PTSD×Time</td><td align="char" valign="top">−2.3</td><td align="char" valign="top">2.9</td><td align="char" valign="top">.4252</td></tr><tr><td valign="top">RE</td><td valign="top"></td><td valign="top"></td><td valign="top"></td><td valign="top">MH</td><td valign="top"></td><td valign="top"></td><td valign="top"></td></tr><tr><td valign="top"> Chinese norm</td><td align="char" valign="top">84.4</td><td align="char" valign="top">32.4</td><td valign="top"></td><td valign="top"> Chinese norm</td><td align="char" valign="top">59.7</td><td align="char" valign="top">22.7</td><td valign="top"></td></tr><tr><td valign="top"> Intercept</td><td align="char" valign="top">87.0</td><td align="char" valign="top">6.1</td><td align="char" valign="top"><.0001<xref rid="tblfn4" ref-type="table-fn">⁎</xref></td><td valign="top"> Intercept</td><td align="char" valign="top">78.3</td><td align="char" valign="top">3.4</td><td align="char" valign="top"><.0001<xref rid="tblfn4" ref-type="table-fn">⁎</xref></td></tr><tr><td valign="top"> PTSD (reference: no PTSD)</td><td align="char" valign="top">−58.7</td><td align="char" valign="top">10.0</td><td align="char" valign="top"><.0001<xref rid="tblfn4" ref-type="table-fn">⁎</xref></td><td valign="top"> PTSD (reference: no PTSD)</td><td align="char" valign="top">−23.4</td><td align="char" valign="top">5.5</td><td align="char" valign="top">.0001<xref rid="tblfn4" ref-type="table-fn">⁎</xref></td></tr><tr><td valign="top"> Follow-up time (years)</td><td align="char" valign="top">1.6</td><td align="char" valign="top">2.2</td><td align="char" valign="top">.4643</td><td valign="top"> Follow-up time (years)</td><td align="char" valign="top">1.9</td><td align="char" valign="top">1.3</td><td align="char" valign="top">.1356</td></tr><tr><td valign="top"> PTSD×Time</td><td align="char" valign="top">4.8</td><td align="char" valign="top">3.5</td><td align="char" valign="top">.1768</td><td valign="top"> PTSD×Time</td><td align="char" valign="top">−1.3</td><td align="char" valign="top">2.0</td><td align="char" valign="top">.5135</td></tr></tbody></table><table-wrap-foot><fn id="tblfn3"><label>a</label><p>All Chinese norms were from Li et al. <xref rid="bib38" ref-type="bibr">[38]</xref>.</p></fn></table-wrap-foot><table-wrap-foot><fn id="tblfn4"><label>⁎</label><p><italic>P</italic><.05.</p></fn></table-wrap-foot></table-wrap></p></sec></sec><sec id="section0050"><label>4</label><title>Discussion</title><p id="para0165">The incidence of PTSD is 44.1% in SARS survivors in our 4-year follow-up study, suggesting PTSD is common in SARS survivors. This incidence rate is similar to that reported for 63 survivors of SARS at 3 months after discharge from hospital in Singapore, where the rate of possible PTSD was 41.7% <xref rid="bib15" ref-type="bibr">[15]</xref>. Great variations in rates of PTSD have been reported after impersonal events such as serious motor vehicle accidents and natural disasters, with reported ranges of 10% to 43% <xref rid="bib43" ref-type="bibr">[43]</xref>, <xref rid="bib44" ref-type="bibr">[44]</xref>, <xref rid="bib45" ref-type="bibr">[45]</xref>. Focusing on another life-threatening condition, Davydow et al. <xref rid="bib46" ref-type="bibr">[46]</xref> reviewed 10 observational studies among survivors of acute respiratory distress syndrome and found that the psychiatrist-diagnosed PTSD prevalence at hospital discharge, 5 years and 8 years was 44%, 25% and 24%, respectively. In this study, we use the <italic>CCMD-III</italic> criteria <xref rid="bib41" ref-type="bibr">[41]</xref>, which is a more conservative measure of PTSD than <italic>DSM-IV</italic><xref rid="bib42" ref-type="bibr">[42]</xref>, with a 3-month vs. a 1-month requirement for symptom duration. In the survey, two subjects fulfilled the symptom criteria, severity criteria, but not the course criteria for <italic>CCMD-III</italic> in the T1 visit (interval between T1 and hospital discharge was 18 and 65 days, respectively) and were not located thereafter. Had we used <italic>DSM-IV</italic> criteria only, the latter subject (interviewed at 65 days after hospital discharge) would have been diagnosed with PTSD. It is unlikely that we overestimated the incidence of PTSD by using stricter diagnostic criteria.</p><p id="para0170">A critical question is whether the 70 survivors enrolled in the study are representative of the 2329 SARS survivors in Beijing. The average age in our cohort was 38.5 years, which is close to the median age of Beijing SARS cases (33 years), with no significant difference in age distribution between those two groups (<italic>P</italic>=.420). Females were overrepresented in our sample (67.1%), which may reflect differences in help-seeking behavior between genders <xref rid="bib47" ref-type="bibr">[47]</xref>, <xref rid="bib48" ref-type="bibr">[48]</xref>. Females with mental health problems are more likely to seek help from medical professionals <xref rid="bib47" ref-type="bibr">[47]</xref>, although in the current study, participants also sought help from Departments of Infectious Disease and Respiratory Medicine.</p><p id="para0175">Four (4/30, 13.3%) SARS survivors who exhibited PTSD in our cohort recovered during follow-up. Most subjects (23/28, 82.1%) who were diagnosed with PTSD at the beginning of our study retained the diagnosis through the end of the study, suggesting that the median recovery time of this cohort is more than 46 months. The score on IES in subjects with PTSD showed the same trends, with only a slight decrease over time (<xref rid="tbl3" ref-type="table">Table 3</xref>, <xref rid="tbl4" ref-type="table">Table 4</xref>). This is consistent with other studies, including the 1996 Detroit Area Survey of Trauma, where the median time for PTSD to remit was 24.9 months and where in more than one third of cases PTSD persisted for more than 60 months. Previous research suggests that PTSD persists longer in women (median duration is 48.1 months) than in men (12.0 months) and persists longer in cases resulting from traumas experienced directly (median duration is 48.1 months) compared with learning about traumas to a loved one or the sudden unexpected death of a loved one (12.1 months) <xref rid="bib49" ref-type="bibr">[49]</xref>. Subjects in our study were SARS survivors who experienced the trauma directly, and 67.1% were females, possibly explaining the long duration of PTSD in our group.</p><p id="para0180">As shown by linear mixed-effects modeling, after excluding the effect of time and PTSD×Time interaction variables, compared with subjects with no PTSD, subjects given a diagnosis of PTSD had significantly higher scores on IES, SAS, SDS, SCL-90 and SDSS and a significantly lower score on SF-36 (<xref rid="tbl4" ref-type="table">Table 4</xref>). These findings suggest that the impact of PTSD was severe and persistent in our cohort, adversely affecting not only mental but also physical health. These results are consistent with findings in the studies of survivors of acute respiratory distress syndrome <xref rid="bib50" ref-type="bibr">[50]</xref> and of general intensive care unit survivors <xref rid="bib51" ref-type="bibr">[51]</xref>. Symptoms of PTSD in those survivors were associated with lower quality of life, and physical outcomes were significantly impacted by the presence of PTSD <xref rid="bib51" ref-type="bibr">[51]</xref>, <xref rid="bib52" ref-type="bibr">[52]</xref>.</p><p id="para0185">A traumatic event's severity, duration and physical proximity are the most important factors affecting the likelihood of developing PTSD <xref rid="bib42" ref-type="bibr">[42]</xref>. In our cohort, while subjects from several inpatient SARS treatment facilities were enrolled, we have no data about their clinical course during active SARS infection. Chest radiography postdischarge may be an indirect indicator for the clinical severity of the disease. There was no significant difference between those with PTSD and those without PTSD on chest CT findings in T1. But the marginal significance (<italic>P</italic>=.060) suggested the necessity of larger sample size to clarify the correlation. The number of close relatives who suffered or died from SARS may be an important indicator of the event severity. FHN, a specific serious adverse medical outcome related to SARS treatment, may be a chronic stressor to these survivors. Subjects with PTSD were more likely to have FHN and to have higher numbers of close relatives who suffered and/or died from SARS than the no-PTSD group. These results supported the hypothesis we mentioned above.</p><p id="para0190">This study has several potential limitations, including primarily a limited sample size. The diagnosis of PTSD according to the criteria of <italic>DSM-IV</italic><xref rid="bib42" ref-type="bibr">[42]</xref> by a trained psychiatrist using a standardized interview technique may be regarded as the clinical “gold standard” for the measurement of PTSD. Therefore, the subjects were interviewed by an experienced psychiatrist in our cohort. Had we employed the Structured Clinical Interview for DSM-IV to establish the PTSD diagnosis, the criterion validity would have been greater. Third, our subjects came from several inpatient SARS treatment facilities, and data about subject's severity of SARS, treatment method and drug dose were unavailable for analysis.</p></sec><sec id="section0055"><label>5</label><title>Conclusion</title><p id="para0195">PTSD could be detected in almost half of SARS survivors in the 4 years after successful medical treatment. Once established, PTSD tended to endure and had a significant deleterious impact in terms of both psychiatric symptoms and function. 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support.</p></ack><fn-group><fn id="d32e2490"><label>☆</label><p>This study was supported by Peking Union Medical College Hospital (HX, ZXH, JYN, ZW, WJ); the National Institutes of Health, Fogarty International Center (D43TW005814) (E.D. Caine, PI) (HX); and the National Institute of Mental Health Center (P20MH071897) (E.D. Caine, PI) (GC).</p></fn></fn-group></back></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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