SrasV1, Pmc, Checkpoint, bibRecord, 001783

The M Protein of SARS-CoV: Basic Structural and Immunological Properties

Identifieur interne : 001783 ( Pmc/Checkpoint ); précédent : 001782; suivant : 001784

The M Protein of SARS-CoV: Basic Structural and Immunological Properties

Source :

Genomics, Proteomics & Bioinformatics [ 1672-0229 ] ; 2003.

RBID : PMC:5172243

Abstract

We studied structural and immunological properties of the SARS-CoV M (membrane) protein, based on comparative analyses of sequence features, phylogenetic investigation, and experimental results. The M protein is predicted to contain a triple-spanning transmembrane (TM) region, a single N-glycosylation site near its N-terminus that is in the exterior of the virion, and a long C-terminal region in the interior. The M protein harbors a higher substitution rate (0.6% correlated to its size) among viral open reading frames (ORFs) from published data. The four substitutions detected in the M protein, which cause non-synonymous changes, can be classified into three types. One of them results in changes of pI (isoelectric point) and charge, affecting antigenicity. The second changes hydrophobicity of the TM region, and the third one relates to hydrophilicity of the interior structure. Phylogenetic tree building based on the variations of the M protein appears to support the non-human origin of SARS-CoV. To investigate its immunogenicity, we synthesized eight oligopeptides covering 69.2% of the entire ORF and screened them by using ELISA (enzyme-linked immunosorbent assay) with sera from SARS patients. The results confirmed our predictions on antigenic sites.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5172243

DOI: 10.1016/S1672-0229(03)01016-7
PubMed: 15626342
PubMed Central: 5172243

Affiliations:

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Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The M Protein of SARS-CoV: Basic Structural and Immunological Properties</title>
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<author><name sortKey="Tian, Xiangjun" sort="Tian, Xiangjun" uniqKey="Tian X" first="Xiangjun" last="Tian">Xiangjun Tian</name>
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<author><name sortKey="Jiang, Feng" sort="Jiang, Feng" uniqKey="Jiang F" first="Feng" last="Jiang">Feng Jiang</name>
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<author><name sortKey="Zhao, Xiaoqian" sort="Zhao, Xiaoqian" uniqKey="Zhao X" first="Xiaoqian" last="Zhao">Xiaoqian Zhao</name>
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<author><name sortKey="Wang, Jun" sort="Wang, Jun" uniqKey="Wang J" first="Jun" last="Wang">Jun Wang</name>
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<author><name sortKey="Zeng, Changqing" sort="Zeng, Changqing" uniqKey="Zeng C" first="Changqing" last="Zeng">Changqing Zeng</name>
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<author><name sortKey="Wang, Jian" sort="Wang, Jian" uniqKey="Wang J" first="Jian" last="Wang">Jian Wang</name>
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<affiliation wicri:level="1"><nlm:aff id="aff0010">James D. Watson Institute of Genome Sciences, Zhijiang Campus, Zhejiang University and Hangzhou Genomics Institute, Hangzhou 310008, China</nlm:aff>
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<wicri:regionArea>James D. Watson Institute of Genome Sciences, Zhijiang Campus, Zhejiang University and Hangzhou Genomics Institute, Hangzhou 310008</wicri:regionArea>
<placeName><settlement type="city">Hangzhou</settlement>
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<author><name sortKey="Yang, Huanming" sort="Yang, Huanming" uniqKey="Yang H" first="Huanming" last="Yang">Huanming Yang</name>
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<affiliation wicri:level="1"><nlm:aff id="aff0010">James D. Watson Institute of Genome Sciences, Zhijiang Campus, Zhejiang University and Hangzhou Genomics Institute, Hangzhou 310008, China</nlm:aff>
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<idno type="ISSN">1672-0229</idno>
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<front><div type="abstract" xml:lang="en"><p>We studied structural and immunological properties of the SARS-CoV M (membrane) protein, based on comparative analyses of sequence features, phylogenetic investigation, and experimental results. The M protein is predicted to contain a triple-spanning transmembrane (TM) region, a single N-glycosylation site near its N-terminus that is in the exterior of the virion, and a long C-terminal region in the interior. The M protein harbors a higher substitution rate (0.6% correlated to its size) among viral open reading frames (ORFs) from published data. The four substitutions detected in the M protein, which cause non-synonymous changes, can be classified into three types. One of them results in changes of pI (isoelectric point) and charge, affecting antigenicity. The second changes hydrophobicity of the TM region, and the third one relates to hydrophilicity of the interior structure. Phylogenetic tree building based on the variations of the M protein appears to support the non-human origin of SARS-CoV. To investigate its immunogenicity, we synthesized eight oligopeptides covering 69.2% of the entire ORF and screened them by using ELISA (enzyme-linked immunosorbent assay) with sera from SARS patients. The results confirmed our predictions on antigenic sites.</p>
</div>
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<biblStruct><analytic><author><name sortKey="Fleming, J O" uniqKey="Fleming J">J.O. Fleming</name>
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<biblStruct><analytic><author><name sortKey="Armstrong, J" uniqKey="Armstrong J">J. Armstrong</name>
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<biblStruct><analytic><author><name sortKey="Narayanan, K" uniqKey="Narayanan K">K. Narayanan</name>
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  <front><journal-meta><journal-id journal-id-type="nlm-ta">Genomics Proteomics Bioinformatics</journal-id>
<journal-id journal-id-type="iso-abbrev">Genomics Proteomics Bioinformatics</journal-id>
<journal-title-group><journal-title>Genomics, Proteomics & Bioinformatics</journal-title>
</journal-title-group>
<issn pub-type="ppub">1672-0229</issn>
<issn pub-type="epub">2210-3244</issn>
<publisher><publisher-name>Beijing Institute of Genomics, the Chinese Academy of Sciences and the Genetics Society of China. Production and hosting by Elsevier B.V.</publisher-name>
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<article-id pub-id-type="pmc">5172243</article-id>
<article-id pub-id-type="publisher-id">S1672-0229(03)01016-7</article-id>
<article-id pub-id-type="doi">10.1016/S1672-0229(03)01016-7</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
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</article-categories>
<title-group><article-title>The M Protein of SARS-CoV: Basic Structural and Immunological Properties</article-title>
</title-group>
<contrib-group><contrib contrib-type="author" id="au0005"><name><surname>Hu</surname>
<given-names>Yongwu</given-names>
</name>
<xref rid="aff0005" ref-type="aff">1</xref>
<xref rid="aff0010" ref-type="aff">2</xref>
<xref rid="fn1" ref-type="fn">*</xref>
</contrib>
<contrib contrib-type="author" id="au0010"><name><surname>Wen</surname>
<given-names>Jie</given-names>
</name>
<xref rid="aff0005" ref-type="aff">1</xref>
<xref rid="fn1" ref-type="fn">*</xref>
</contrib>
<contrib contrib-type="author" id="au0015"><name><surname>Tang</surname>
<given-names>Lin</given-names>
</name>
<xref rid="aff0005" ref-type="aff">1</xref>
<xref rid="fn1" ref-type="fn">*</xref>
</contrib>
<contrib contrib-type="author" id="au0020"><name><surname>Zhang</surname>
<given-names>Haijun</given-names>
</name>
<xref rid="aff0005" ref-type="aff">1</xref>
<xref rid="fn1" ref-type="fn">*</xref>
</contrib>
<contrib contrib-type="author" id="au0025"><name><surname>Zhang</surname>
<given-names>Xiaowei</given-names>
</name>
<xref rid="aff0005" ref-type="aff">1</xref>
</contrib>
<contrib contrib-type="author" id="au0030"><name><surname>Li</surname>
<given-names>Yan</given-names>
</name>
<xref rid="aff0005" ref-type="aff">1</xref>
</contrib>
<contrib contrib-type="author" id="au0035"><name><surname>Wang</surname>
<given-names>Jing</given-names>
</name>
<xref rid="aff0005" ref-type="aff">1</xref>
<xref rid="aff0015" ref-type="aff">3</xref>
</contrib>
<contrib contrib-type="author" id="au0040"><name><surname>Han</surname>
<given-names>Yujun</given-names>
</name>
<xref rid="aff0005" ref-type="aff">1</xref>
</contrib>
<contrib contrib-type="author" id="au0045"><name><surname>Li</surname>
<given-names>Guoqing</given-names>
</name>
<xref rid="aff0005" ref-type="aff">1</xref>
</contrib>
<contrib contrib-type="author" id="au0050"><name><surname>Shi</surname>
<given-names>Jianping</given-names>
</name>
<xref rid="aff0005" ref-type="aff">1</xref>
</contrib>
<contrib contrib-type="author" id="au0055"><name><surname>Tian</surname>
<given-names>Xiangjun</given-names>
</name>
<xref rid="aff0005" ref-type="aff">1</xref>
<xref rid="aff0010" ref-type="aff">2</xref>
</contrib>
<contrib contrib-type="author" id="au0060"><name><surname>Jiang</surname>
<given-names>Feng</given-names>
</name>
<xref rid="aff0005" ref-type="aff">1</xref>
</contrib>
<contrib contrib-type="author" id="au0065"><name><surname>Zhao</surname>
<given-names>Xiaoqian</given-names>
</name>
<xref rid="aff0005" ref-type="aff">1</xref>
</contrib>
<contrib contrib-type="author" id="au0070"><name><surname>Wang</surname>
<given-names>Jun</given-names>
</name>
<xref rid="aff0005" ref-type="aff">1</xref>
</contrib>
<contrib contrib-type="author" id="au0075"><name><surname>Liu</surname>
<given-names>Siqi</given-names>
</name>
<xref rid="aff0005" ref-type="aff">1</xref>
</contrib>
<contrib contrib-type="author" id="au0080"><name><surname>Zeng</surname>
<given-names>Changqing</given-names>
</name>
<xref rid="aff0005" ref-type="aff">1</xref>
</contrib>
<contrib contrib-type="author" id="au0085"><name><surname>Wang</surname>
<given-names>Jian</given-names>
</name>
<xref rid="aff0005" ref-type="aff">1</xref>
<xref rid="aff0010" ref-type="aff">2</xref>
</contrib>
<contrib contrib-type="author" id="au0090"><name><surname>Yang</surname>
<given-names>Huanming</given-names>
</name>
<email>yanghm@genomics.org.cn</email>
<xref rid="aff0005" ref-type="aff">1</xref>
<xref rid="aff0010" ref-type="aff">2</xref>
<xref rid="cor1" ref-type="corresp">#</xref>
</contrib>
</contrib-group>
<aff id="aff0005"><label>1</label>
Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300, China</aff>
<aff id="aff0010"><label>2</label>
James D. Watson Institute of Genome Sciences, Zhijiang Campus, Zhejiang University and Hangzhou Genomics Institute, Hangzhou 310008, China</aff>
<aff id="aff0015"><label>3</label>
College of Life Sciences, Peking University, Beijing 100871, China</aff>
<author-notes><corresp id="cor1"><label>#</label>
Corresponding author. <email>yanghm@genomics.org.cn</email>
</corresp>
<fn id="fn1"><label>*</label>
<p id="ntp0005">These authors contributed equally to this work.</p>
</fn>
</author-notes>
<pub-date pub-type="pmc-release"><day>28</day>
<month>11</month>
<year>2016</year>
</pub-date>
<pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
      <pub-date pub-type="ppub"><month>5</month>
<year>2003</year>
</pub-date>
<pub-date pub-type="epub"><day>28</day>
<month>11</month>
<year>2016</year>
</pub-date>
<volume>1</volume>
<issue>2</issue>
<fpage>118</fpage>
<lpage>130</lpage>
<permissions><copyright-statement>Copyright © 2003 Beijing Institute of Genomics, the Chinese Academy of Sciences and the Genetics Society of China. Production and hosting by Elsevier B.V.</copyright-statement>
<copyright-year>2003</copyright-year>
<copyright-holder>Beijing Institute of Genomics, the Chinese Academy of Sciences and the Genetics Society of China</copyright-holder>
<license><license-p>Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.</license-p>
</license>
</permissions>
<abstract id="ab0005"><p>We studied structural and immunological properties of the SARS-CoV M (membrane) protein, based on comparative analyses of sequence features, phylogenetic investigation, and experimental results. The M protein is predicted to contain a triple-spanning transmembrane (TM) region, a single N-glycosylation site near its N-terminus that is in the exterior of the virion, and a long C-terminal region in the interior. The M protein harbors a higher substitution rate (0.6% correlated to its size) among viral open reading frames (ORFs) from published data. The four substitutions detected in the M protein, which cause non-synonymous changes, can be classified into three types. One of them results in changes of pI (isoelectric point) and charge, affecting antigenicity. The second changes hydrophobicity of the TM region, and the third one relates to hydrophilicity of the interior structure. Phylogenetic tree building based on the variations of the M protein appears to support the non-human origin of SARS-CoV. To investigate its immunogenicity, we synthesized eight oligopeptides covering 69.2% of the entire ORF and screened them by using ELISA (enzyme-linked immunosorbent assay) with sera from SARS patients. The results confirmed our predictions on antigenic sites.</p>
</abstract>
<kwd-group id="keys0005"><title>Key words</title>
<kwd>SARS-CoV</kwd>
<kwd>the M protein</kwd>
<kwd>enzyme immunoassay</kwd>
<kwd>antigenicity</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
<affiliations><list><country><li>République populaire de Chine</li>
</country>
<region><li>Pékin</li>
<li>Zhejiang</li>
</region>
<settlement><li>Hangzhou</li>
<li>Pékin</li>
</settlement>
<orgName><li>Université de Pékin</li>
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<name sortKey="Jiang, Feng" sort="Jiang, Feng" uniqKey="Jiang F" first="Feng" last="Jiang">Feng Jiang</name>
<name sortKey="Li, Guoqing" sort="Li, Guoqing" uniqKey="Li G" first="Guoqing" last="Li">Guoqing Li</name>
<name sortKey="Li, Yan" sort="Li, Yan" uniqKey="Li Y" first="Yan" last="Li">Yan Li</name>
<name sortKey="Liu, Siqi" sort="Liu, Siqi" uniqKey="Liu S" first="Siqi" last="Liu">Siqi Liu</name>
<name sortKey="Shi, Jianping" sort="Shi, Jianping" uniqKey="Shi J" first="Jianping" last="Shi">Jianping Shi</name>
<name sortKey="Tang, Lin" sort="Tang, Lin" uniqKey="Tang L" first="Lin" last="Tang">Lin Tang</name>
<name sortKey="Tian, Xiangjun" sort="Tian, Xiangjun" uniqKey="Tian X" first="Xiangjun" last="Tian">Xiangjun Tian</name>
<name sortKey="Tian, Xiangjun" sort="Tian, Xiangjun" uniqKey="Tian X" first="Xiangjun" last="Tian">Xiangjun Tian</name>
<name sortKey="Wang, Jian" sort="Wang, Jian" uniqKey="Wang J" first="Jian" last="Wang">Jian Wang</name>
<name sortKey="Wang, Jian" sort="Wang, Jian" uniqKey="Wang J" first="Jian" last="Wang">Jian Wang</name>
<name sortKey="Wang, Jing" sort="Wang, Jing" uniqKey="Wang J" first="Jing" last="Wang">Jing Wang</name>
<name sortKey="Wang, Jing" sort="Wang, Jing" uniqKey="Wang J" first="Jing" last="Wang">Jing Wang</name>
<name sortKey="Wang, Jun" sort="Wang, Jun" uniqKey="Wang J" first="Jun" last="Wang">Jun Wang</name>
<name sortKey="Wen, Jie" sort="Wen, Jie" uniqKey="Wen J" first="Jie" last="Wen">Jie Wen</name>
<name sortKey="Yang, Huanming" sort="Yang, Huanming" uniqKey="Yang H" first="Huanming" last="Yang">Huanming Yang</name>
<name sortKey="Yang, Huanming" sort="Yang, Huanming" uniqKey="Yang H" first="Huanming" last="Yang">Huanming Yang</name>
<name sortKey="Zeng, Changqing" sort="Zeng, Changqing" uniqKey="Zeng C" first="Changqing" last="Zeng">Changqing Zeng</name>
<name sortKey="Zhang, Haijun" sort="Zhang, Haijun" uniqKey="Zhang H" first="Haijun" last="Zhang">Haijun Zhang</name>
<name sortKey="Zhang, Xiaowei" sort="Zhang, Xiaowei" uniqKey="Zhang X" first="Xiaowei" last="Zhang">Xiaowei Zhang</name>
<name sortKey="Zhao, Xiaoqian" sort="Zhao, Xiaoqian" uniqKey="Zhao X" first="Xiaoqian" last="Zhao">Xiaoqian Zhao</name>
</country>
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The M Protein of SARS-CoV: Basic Structural and Immunological Properties

The M Protein of SARS-CoV: Basic Structural and Immunological Properties

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