Small Molecules Blocking the Entry of Severe Acute Respiratory Syndrome Coronavirus into Host Cells
Identifieur interne : 001465 ( Pmc/Checkpoint ); précédent : 001464; suivant : 001466Small Molecules Blocking the Entry of Severe Acute Respiratory Syndrome Coronavirus into Host Cells
Auteurs : Ling Yi ; Zhengquan Li ; Kehu Yuan ; Xiuxia Qu ; Jian Chen ; Guangwen Wang ; Hong Zhang ; Hongpeng Luo ; Lili Zhu ; Pengfei Jiang ; Lirong Chen ; Yan Shen ; Min Luo ; Guoying Zuo ; Jianhe Hu ; Deliang Duan ; Yuchun Nie ; Xuanling Shi ; Wei Wang ; Yang Han ; Taisheng Li ; Yuqing Liu ; Mingxiao Ding ; Hongkui Deng ; Xiaojie XuSource :
- Journal of Virology [ 0022-538X ] ; 2004.
Abstract
Severe acute respiratory syndrome coronavirus (SARS-CoV) is the pathogen of SARS, which caused a global panic in 2003. We describe here the screening of Chinese herbal medicine-based, novel small molecules that bind avidly with the surface spike protein of SARS-CoV and thus can interfere with the entry of the virus to its host cells. We achieved this by using a two-step screening method consisting of frontal affinity chromatography-mass spectrometry coupled with a viral infection assay based on a human immunodeficiency virus (HIV)-luc/SARS pseudotyped virus. Two small molecules, tetra-
Url:
DOI: 10.1128/JVI.78.20.11334-11339.2004
PubMed: 15452254
PubMed Central: 521800
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Small Molecules Blocking the Entry of Severe Acute Respiratory Syndrome Coronavirus into Host Cells</title><author><name sortKey="Yi, Ling" sort="Yi, Ling" uniqKey="Yi L" first="Ling" last="Yi">Ling Yi</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Li, Zhengquan" sort="Li, Zhengquan" uniqKey="Li Z" first="Zhengquan" last="Li">Zhengquan Li</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Yuan, Kehu" sort="Yuan, Kehu" uniqKey="Yuan K" first="Kehu" last="Yuan">Kehu Yuan</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Qu, Xiuxia" sort="Qu, Xiuxia" uniqKey="Qu X" first="Xiuxia" last="Qu">Xiuxia Qu</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Chen, Jian" sort="Chen, Jian" uniqKey="Chen J" first="Jian" last="Chen">Jian Chen</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Wang, Guangwen" sort="Wang, Guangwen" uniqKey="Wang G" first="Guangwen" last="Wang">Guangwen Wang</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Zhang, Hong" sort="Zhang, Hong" uniqKey="Zhang H" first="Hong" last="Zhang">Hong Zhang</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Luo, Hongpeng" sort="Luo, Hongpeng" uniqKey="Luo H" first="Hongpeng" last="Luo">Hongpeng Luo</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Zhu, Lili" sort="Zhu, Lili" uniqKey="Zhu L" first="Lili" last="Zhu">Lili Zhu</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Jiang, Pengfei" sort="Jiang, Pengfei" uniqKey="Jiang P" first="Pengfei" last="Jiang">Pengfei Jiang</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Chen, Lirong" sort="Chen, Lirong" uniqKey="Chen L" first="Lirong" last="Chen">Lirong Chen</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Shen, Yan" sort="Shen, Yan" uniqKey="Shen Y" first="Yan" last="Shen">Yan Shen</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Luo, Min" sort="Luo, Min" uniqKey="Luo M" first="Min" last="Luo">Min Luo</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Zuo, Guoying" sort="Zuo, Guoying" uniqKey="Zuo G" first="Guoying" last="Zuo">Guoying Zuo</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Hu, Jianhe" sort="Hu, Jianhe" uniqKey="Hu J" first="Jianhe" last="Hu">Jianhe Hu</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Duan, Deliang" sort="Duan, Deliang" uniqKey="Duan D" 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type="RBID">PMC:521800</idno><idno type="doi">10.1128/JVI.78.20.11334-11339.2004</idno><date when="2004">2004</date><idno type="wicri:Area/Pmc/Corpus">000685</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000685</idno><idno type="wicri:Area/Pmc/Curation">000685</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000685</idno><idno type="wicri:Area/Pmc/Checkpoint">001465</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001465</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Small Molecules Blocking the Entry of Severe Acute Respiratory Syndrome Coronavirus into Host Cells</title><author><name sortKey="Yi, Ling" sort="Yi, Ling" uniqKey="Yi L" first="Ling" last="Yi">Ling Yi</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Li, Zhengquan" sort="Li, Zhengquan" uniqKey="Li Z" first="Zhengquan" last="Li">Zhengquan Li</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Yuan, Kehu" sort="Yuan, Kehu" uniqKey="Yuan K" first="Kehu" last="Yuan">Kehu Yuan</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Qu, Xiuxia" sort="Qu, Xiuxia" uniqKey="Qu X" first="Xiuxia" last="Qu">Xiuxia Qu</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Chen, Jian" sort="Chen, Jian" uniqKey="Chen J" first="Jian" last="Chen">Jian Chen</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Wang, Guangwen" sort="Wang, Guangwen" uniqKey="Wang G" first="Guangwen" last="Wang">Guangwen Wang</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Zhang, Hong" sort="Zhang, Hong" uniqKey="Zhang H" first="Hong" last="Zhang">Hong Zhang</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Luo, Hongpeng" sort="Luo, Hongpeng" uniqKey="Luo H" first="Hongpeng" last="Luo">Hongpeng Luo</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Zhu, Lili" sort="Zhu, Lili" uniqKey="Zhu L" first="Lili" last="Zhu">Lili Zhu</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Jiang, Pengfei" sort="Jiang, Pengfei" uniqKey="Jiang P" first="Pengfei" last="Jiang">Pengfei Jiang</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Chen, Lirong" sort="Chen, Lirong" uniqKey="Chen L" first="Lirong" last="Chen">Lirong Chen</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Shen, Yan" sort="Shen, Yan" uniqKey="Shen Y" first="Yan" last="Shen">Yan Shen</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Luo, Min" sort="Luo, Min" uniqKey="Luo M" first="Min" last="Luo">Min Luo</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Zuo, Guoying" sort="Zuo, Guoying" uniqKey="Zuo G" first="Guoying" last="Zuo">Guoying Zuo</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Hu, Jianhe" sort="Hu, Jianhe" uniqKey="Hu J" first="Jianhe" last="Hu">Jianhe Hu</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Duan, Deliang" sort="Duan, Deliang" uniqKey="Duan D" first="Deliang" last="Duan">Deliang Duan</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Nie, Yuchun" sort="Nie, Yuchun" uniqKey="Nie Y" first="Yuchun" last="Nie">Yuchun Nie</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Shi, Xuanling" sort="Shi, Xuanling" uniqKey="Shi X" first="Xuanling" last="Shi">Xuanling Shi</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Wang, Wei" sort="Wang, Wei" uniqKey="Wang W" first="Wei" last="Wang">Wei Wang</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Han, Yang" sort="Han, Yang" uniqKey="Han Y" first="Yang" last="Han">Yang Han</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Li, Taisheng" sort="Li, Taisheng" uniqKey="Li T" first="Taisheng" last="Li">Taisheng Li</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Liu, Yuqing" sort="Liu, Yuqing" uniqKey="Liu Y" first="Yuqing" last="Liu">Yuqing Liu</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Ding, Mingxiao" sort="Ding, Mingxiao" uniqKey="Ding M" first="Mingxiao" last="Ding">Mingxiao Ding</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Deng, Hongkui" sort="Deng, Hongkui" uniqKey="Deng H" first="Hongkui" last="Deng">Hongkui Deng</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Xu, Xiaojie" sort="Xu, Xiaojie" uniqKey="Xu X" first="Xiaojie" last="Xu">Xiaojie Xu</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author></analytic><series><title level="j">Journal of Virology</title><idno type="ISSN">0022-538X</idno><idno type="eISSN">1098-5514</idno><imprint><date when="2004">2004</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Severe acute respiratory syndrome coronavirus (SARS-CoV) is the pathogen of SARS, which caused a global panic in 2003. We describe here the screening of Chinese herbal medicine-based, novel small molecules that bind avidly with the surface spike protein of SARS-CoV and thus can interfere with the entry of the virus to its host cells. We achieved this by using a two-step screening method consisting of frontal affinity chromatography-mass spectrometry coupled with a viral infection assay based on a human immunodeficiency virus (HIV)-luc/SARS pseudotyped virus. Two small molecules, tetra-<italic>O</italic>-galloyl-β-<sc>d</sc>-glucose (TGG) and luteolin, were identified, whose anti-SARS-CoV activities were confirmed by using a wild-type SARS-CoV infection system. TGG exhibits prominent anti-SARS-CoV activity with a 50% effective concentration of 4.5 μM and a selective index of 240.0. The two-step screening method described here yielded several small molecules that can be used for developing new classes of anti-SARS-CoV drugs and is potentially useful for the high-throughput screening of drugs inhibiting the entry of HIV, hepatitis C virus, and other insidious viruses into their host cells.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Virol</journal-id><journal-id journal-id-type="publisher-id">jvi</journal-id><journal-title>Journal of Virology</journal-title><issn pub-type="ppub">0022-538X</issn><issn pub-type="epub">1098-5514</issn><publisher><publisher-name>American Society for Microbiology</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">15452254</article-id><article-id pub-id-type="pmc">521800</article-id><article-id pub-id-type="publisher-id">0206-04</article-id><article-id pub-id-type="doi">10.1128/JVI.78.20.11334-11339.2004</article-id><article-categories><subj-group subj-group-type="heading"><subject>Vaccines and Antiviral Agents</subject></subj-group></article-categories><title-group><article-title>Small Molecules Blocking the Entry of Severe Acute Respiratory Syndrome Coronavirus into Host Cells</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Yi</surname><given-names>Ling</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="fn" rid="fn1">†</xref></contrib><contrib contrib-type="author"><name><surname>Li</surname><given-names>Zhengquan</given-names></name><xref ref-type="aff" rid="aff1">2</xref><xref ref-type="fn" rid="fn1">†</xref></contrib><contrib contrib-type="author"><name><surname>Yuan</surname><given-names>Kehu</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="fn" rid="fn1">†</xref></contrib><contrib contrib-type="author"><name><surname>Qu</surname><given-names>Xiuxia</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Chen</surname><given-names>Jian</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Wang</surname><given-names>Guangwen</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Zhang</surname><given-names>Hong</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Luo</surname><given-names>Hongpeng</given-names></name><xref ref-type="aff" rid="aff1">2</xref></contrib><contrib contrib-type="author"><name><surname>Zhu</surname><given-names>Lili</given-names></name><xref ref-type="aff" rid="aff1">2</xref></contrib><contrib contrib-type="author"><name><surname>Jiang</surname><given-names>Pengfei</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Chen</surname><given-names>Lirong</given-names></name><xref ref-type="aff" rid="aff1">2</xref></contrib><contrib contrib-type="author"><name><surname>Shen</surname><given-names>Yan</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Luo</surname><given-names>Min</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Zuo</surname><given-names>Guoying</given-names></name><xref ref-type="aff" rid="aff1">2</xref></contrib><contrib contrib-type="author"><name><surname>Hu</surname><given-names>Jianhe</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Duan</surname><given-names>Deliang</given-names></name><xref ref-type="aff" rid="aff1">2</xref></contrib><contrib contrib-type="author"><name><surname>Nie</surname><given-names>Yuchun</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Shi</surname><given-names>Xuanling</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Wang</surname><given-names>Wei</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Han</surname><given-names>Yang</given-names></name><xref ref-type="aff" rid="aff1">3</xref></contrib><contrib contrib-type="author"><name><surname>Li</surname><given-names>Taisheng</given-names></name><xref ref-type="aff" rid="aff1">3</xref></contrib><contrib contrib-type="author"><name><surname>Liu</surname><given-names>Yuqing</given-names></name><xref ref-type="aff" rid="aff1">4</xref></contrib><contrib contrib-type="author"><name><surname>Ding</surname><given-names>Mingxiao</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Deng</surname><given-names>Hongkui</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="corresp" rid="cor1">*</xref></contrib><contrib contrib-type="author"><name><surname>Xu</surname><given-names>Xiaojie</given-names></name><xref ref-type="aff" rid="aff1">2</xref><xref ref-type="corresp" rid="cor1">*</xref></contrib></contrib-group><aff id="aff1">Department of Cell Biology and Genetics, College of Life Sciences,<label>1</label> College of Chemistry and Molecular Engineering, Peking University,<label>2</label> Department of Infectious Disease, PUMC Hospital, CAMS and PUMC, Beijing,<label>3</label> Centre for the Study of Liver Disease and Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong, Peoples Republic of China<label>4</label></aff><author-notes><fn id="cor1"><label>*</label><p>Corresponding author. Mailing address for H. Deng: Department of Cell Biology and Genetics, College of Life Sciences, Peking University, Beijing 100871, Peoples Republic of China. Phone: 8610-6275-6474. Fax: 8610-6275-6474. E-mail: <email>hongkui_deng@pku.edu.cn</email>. Mailing address for X. Xu: College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, Peoples Republic of China. Phone: 8610-6275-7456. Fax: 8610-6275-1708. E-mail: <email>xiaojxu@chem.pku.edu.cn</email>.</p></fn><fn id="fn1"><label>†</label><p>L.Y., Z.L., and K.Y. contributed equally to this study.</p></fn></author-notes><pub-date pub-type="ppub"><month>10</month><year>2004</year></pub-date><volume>78</volume><issue>20</issue><fpage>11334</fpage><lpage>11339</lpage><history><date date-type="received"><day>30</day><month>1</month><year>2004</year></date><date date-type="accepted"><day>14</day><month>6</month><year>2004</year></date></history><copyright-statement>Copyright © 2004, American Society for Microbiology</copyright-statement><copyright-year>2004</copyright-year><abstract><p>Severe acute respiratory syndrome coronavirus (SARS-CoV) is the pathogen of SARS, which caused a global panic in 2003. We describe here the screening of Chinese herbal medicine-based, novel small molecules that bind avidly with the surface spike protein of SARS-CoV and thus can interfere with the entry of the virus to its host cells. We achieved this by using a two-step screening method consisting of frontal affinity chromatography-mass spectrometry coupled with a viral infection assay based on a human immunodeficiency virus (HIV)-luc/SARS pseudotyped virus. Two small molecules, tetra-<italic>O</italic>-galloyl-β-<sc>d</sc>-glucose (TGG) and luteolin, were identified, whose anti-SARS-CoV activities were confirmed by using a wild-type SARS-CoV infection system. TGG exhibits prominent anti-SARS-CoV activity with a 50% effective concentration of 4.5 μM and a selective index of 240.0. The two-step screening method described here yielded several small molecules that can be used for developing new classes of anti-SARS-CoV drugs and is potentially useful for the high-throughput screening of drugs inhibiting the entry of HIV, hepatitis C virus, and other insidious viruses into their host cells.</p></abstract></article-meta></front></pmc><affiliations><list></list><tree><noCountry><name sortKey="Chen, Jian" sort="Chen, Jian" uniqKey="Chen J" first="Jian" last="Chen">Jian Chen</name><name sortKey="Chen, Lirong" sort="Chen, Lirong" uniqKey="Chen L" first="Lirong" last="Chen">Lirong Chen</name><name sortKey="Deng, Hongkui" sort="Deng, Hongkui" uniqKey="Deng H" first="Hongkui" last="Deng">Hongkui Deng</name><name sortKey="Ding, Mingxiao" sort="Ding, Mingxiao" uniqKey="Ding M" first="Mingxiao" last="Ding">Mingxiao Ding</name><name sortKey="Duan, Deliang" sort="Duan, Deliang" uniqKey="Duan D" first="Deliang" last="Duan">Deliang Duan</name><name sortKey="Han, Yang" sort="Han, Yang" uniqKey="Han Y" first="Yang" last="Han">Yang Han</name><name sortKey="Hu, Jianhe" sort="Hu, Jianhe" uniqKey="Hu J" first="Jianhe" last="Hu">Jianhe Hu</name><name sortKey="Jiang, Pengfei" sort="Jiang, Pengfei" uniqKey="Jiang P" first="Pengfei" last="Jiang">Pengfei Jiang</name><name sortKey="Li, Taisheng" sort="Li, Taisheng" uniqKey="Li T" first="Taisheng" last="Li">Taisheng Li</name><name sortKey="Li, Zhengquan" sort="Li, Zhengquan" uniqKey="Li Z" first="Zhengquan" last="Li">Zhengquan Li</name><name sortKey="Liu, Yuqing" sort="Liu, Yuqing" uniqKey="Liu Y" first="Yuqing" last="Liu">Yuqing Liu</name><name sortKey="Luo, Hongpeng" sort="Luo, Hongpeng" uniqKey="Luo H" first="Hongpeng" last="Luo">Hongpeng Luo</name><name sortKey="Luo, Min" sort="Luo, Min" uniqKey="Luo M" first="Min" last="Luo">Min Luo</name><name sortKey="Nie, Yuchun" sort="Nie, Yuchun" uniqKey="Nie Y" first="Yuchun" last="Nie">Yuchun Nie</name><name sortKey="Qu, Xiuxia" sort="Qu, Xiuxia" uniqKey="Qu X" first="Xiuxia" last="Qu">Xiuxia Qu</name><name sortKey="Shen, Yan" sort="Shen, Yan" uniqKey="Shen Y" first="Yan" last="Shen">Yan Shen</name><name sortKey="Shi, Xuanling" sort="Shi, Xuanling" uniqKey="Shi X" first="Xuanling" last="Shi">Xuanling Shi</name><name sortKey="Wang, Guangwen" sort="Wang, Guangwen" uniqKey="Wang G" first="Guangwen" last="Wang">Guangwen Wang</name><name sortKey="Wang, Wei" sort="Wang, Wei" uniqKey="Wang W" first="Wei" last="Wang">Wei Wang</name><name sortKey="Xu, Xiaojie" sort="Xu, Xiaojie" uniqKey="Xu X" first="Xiaojie" last="Xu">Xiaojie Xu</name><name sortKey="Yi, Ling" sort="Yi, Ling" uniqKey="Yi L" first="Ling" last="Yi">Ling Yi</name><name sortKey="Yuan, Kehu" sort="Yuan, Kehu" uniqKey="Yuan K" first="Kehu" last="Yuan">Kehu Yuan</name><name sortKey="Zhang, Hong" sort="Zhang, Hong" uniqKey="Zhang H" first="Hong" last="Zhang">Hong Zhang</name><name sortKey="Zhu, Lili" sort="Zhu, Lili" uniqKey="Zhu L" first="Lili" last="Zhu">Lili Zhu</name><name sortKey="Zuo, Guoying" sort="Zuo, Guoying" uniqKey="Zuo G" first="Guoying" last="Zuo">Guoying Zuo</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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