Molecular advances in the cell biology of SARS-CoV and current disease prevention strategies
Identifieur interne : 001297 ( Pmc/Checkpoint ); précédent : 001296; suivant : 001298Molecular advances in the cell biology of SARS-CoV and current disease prevention strategies
Auteurs : Caren J. Stark ; Cd AtreyaSource :
- Virology Journal [ 1743-422X ] ; 2005.
Abstract
In the aftermath of the SARS epidemic, there has been significant progress in understanding the molecular and cell biology of SARS-CoV. Some of the milestones are the availability of viral genome sequence, identification of the viral receptor, development of an infectious cDNA clone, and the identification of viral antigens that elicit neutralizing antibodies. However, there is still a large gap in our understanding of how SARS-CoV interacts with the host cell and the rapidly changing viral genome adds another variable to this equation. Now the SARS-CoV story has entered a new phase, a search for preventive strategies and a cure for the disease. This review highlights the progress made in identifying molecular aspects of SARS-CoV biology that is relevant in developing disease prevention strategies. Authors conclude that development of successful SARS-CoV vaccines and antivirals depends on the progress we make in these areas in the immediate future.
The online version of this article (doi:10.1186/1743-422X-2-35) contains supplementary material, which is available to authorized users.
Url:
DOI: 10.1186/1743-422X-2-35
PubMed: 15833113
PubMed Central: 1087510
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Molecular advances in the cell biology of SARS-CoV and current disease prevention strategies</title><author><name sortKey="Stark, Caren J" sort="Stark, Caren J" uniqKey="Stark C" first="Caren J" last="Stark">Caren J. Stark</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author><author><name sortKey="Atreya, Cd" sort="Atreya, Cd" uniqKey="Atreya C" first="Cd" last="Atreya">Cd Atreya</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">15833113</idno><idno type="pmc">1087510</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1087510</idno><idno type="RBID">PMC:1087510</idno><idno type="doi">10.1186/1743-422X-2-35</idno><date when="2005">2005</date><idno type="wicri:Area/Pmc/Corpus">000574</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000574</idno><idno type="wicri:Area/Pmc/Curation">000574</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000574</idno><idno type="wicri:Area/Pmc/Checkpoint">001297</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001297</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Molecular advances in the cell biology of SARS-CoV and current disease prevention strategies</title><author><name sortKey="Stark, Caren J" sort="Stark, Caren J" uniqKey="Stark C" first="Caren J" last="Stark">Caren J. Stark</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author><author><name sortKey="Atreya, Cd" sort="Atreya, Cd" uniqKey="Atreya C" first="Cd" last="Atreya">Cd Atreya</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author></analytic><series><title level="j">Virology Journal</title><idno type="eISSN">1743-422X</idno><imprint><date when="2005">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>In the aftermath of the SARS epidemic, there has been significant progress in understanding the molecular and cell biology of SARS-CoV. Some of the milestones are the availability of viral genome sequence, identification of the viral receptor, development of an infectious cDNA clone, and the identification of viral antigens that elicit neutralizing antibodies. However, there is still a large gap in our understanding of how SARS-CoV interacts with the host cell and the rapidly changing viral genome adds another variable to this equation. Now the SARS-CoV story has entered a new phase, a search for preventive strategies and a cure for the disease. This review highlights the progress made in identifying molecular aspects of SARS-CoV biology that is relevant in developing disease prevention strategies. Authors conclude that development of successful SARS-CoV vaccines and antivirals depends on the progress we make in these areas in the immediate future.</p><sec><title>Electronic supplementary material</title><p>The online version of this article (doi:10.1186/1743-422X-2-35) contains supplementary material, which is available to authorized users.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Zhong, Ns" uniqKey="Zhong N">NS Zhong</name></author><author><name sortKey="Zeng, Gq" uniqKey="Zeng G">GQ Zeng</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Nie, Qh" uniqKey="Nie Q">QH Nie</name></author><author><name sortKey="Luo, Xd" uniqKey="Luo X">XD Luo</name></author><author><name sortKey="Zhang, Jz" uniqKey="Zhang J">JZ Zhang</name></author><author><name sortKey="Su, Q" uniqKey="Su Q">Q Su</name></author></analytic></biblStruct><biblStruct><analytic><author><name 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Virol J</journal-id><journal-id journal-id-type="iso-abbrev">Virol. J</journal-id><journal-title-group><journal-title>Virology Journal</journal-title></journal-title-group><issn pub-type="epub">1743-422X</issn><publisher><publisher-name>BioMed Central</publisher-name><publisher-loc>London</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">15833113</article-id><article-id pub-id-type="pmc">1087510</article-id><article-id pub-id-type="publisher-id">50</article-id><article-id pub-id-type="doi">10.1186/1743-422X-2-35</article-id><article-categories><subj-group subj-group-type="heading"><subject>Review</subject></subj-group></article-categories><title-group><article-title>Molecular advances in the cell biology of SARS-CoV and current disease prevention strategies</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Stark</surname><given-names>Caren J</given-names></name><address><email>starkc@cber.fda.gov</email></address><xref ref-type="aff" rid="Aff1"></xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Atreya</surname><given-names>CD</given-names></name><address><email>atreya@cber.fda.gov</email></address><xref ref-type="aff" rid="Aff1"></xref></contrib><aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.417587.8</institution-id><institution-id institution-id-type="ISNI">0000000122433366</institution-id><institution>Division of Viral Products, Center for Biologics Evaluation and Researchss,</institution><institution>US Food and Drug Administration,</institution></institution-wrap>Bethesda, MD 20892 USA</aff></contrib-group><pub-date pub-type="epub"><day>15</day><month>4</month><year>2005</year></pub-date><pub-date pub-type="pmc-release"><day>15</day><month>4</month><year>2005</year></pub-date><pub-date pub-type="collection"><year>2005</year></pub-date><volume>2</volume><elocation-id>35</elocation-id><history><date date-type="received"><day>13</day><month>4</month><year>2005</year></date><date date-type="accepted"><day>15</day><month>4</month><year>2005</year></date></history><permissions><copyright-statement>© Stark and Atreya; licensee BioMed Central Ltd. 2005</copyright-statement><license><license-p>This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.</license-p></license></permissions><abstract id="Abs1"><p>In the aftermath of the SARS epidemic, there has been significant progress in understanding the molecular and cell biology of SARS-CoV. Some of the milestones are the availability of viral genome sequence, identification of the viral receptor, development of an infectious cDNA clone, and the identification of viral antigens that elicit neutralizing antibodies. However, there is still a large gap in our understanding of how SARS-CoV interacts with the host cell and the rapidly changing viral genome adds another variable to this equation. Now the SARS-CoV story has entered a new phase, a search for preventive strategies and a cure for the disease. This review highlights the progress made in identifying molecular aspects of SARS-CoV biology that is relevant in developing disease prevention strategies. Authors conclude that development of successful SARS-CoV vaccines and antivirals depends on the progress we make in these areas in the immediate future.</p><sec><title>Electronic supplementary material</title><p>The online version of this article (doi:10.1186/1743-422X-2-35) contains supplementary material, which is available to authorized users.</p></sec></abstract><kwd-group xml:lang="en"><title>Keywords</title><kwd>Antivirals</kwd><kwd>Cell biology</kwd><kwd>Molecular virology</kwd><kwd>SARS-CoV</kwd><kwd>Vaccines</kwd></kwd-group><custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name><meta-value>© The Author(s) 2005</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc><affiliations><list></list><tree><noCountry><name sortKey="Atreya, Cd" sort="Atreya, Cd" uniqKey="Atreya C" first="Cd" last="Atreya">Cd Atreya</name><name sortKey="Stark, Caren J" sort="Stark, Caren J" uniqKey="Stark C" first="Caren J" last="Stark">Caren J. Stark</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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