Orchitis: A Complication of Severe Acute Respiratory Syndrome (SARS)1
Identifieur interne : 001089 ( Pmc/Checkpoint ); précédent : 001088; suivant : 001090Orchitis: A Complication of Severe Acute Respiratory Syndrome (SARS)1
Auteurs : Jian Xu [République populaire de Chine] ; Lihua Qi [République populaire de Chine] ; Xiaochun Chi [République populaire de Chine] ; Jingjing Yang [République populaire de Chine] ; Xiaohong Wei [République populaire de Chine] ; Encong Gong [République populaire de Chine] ; Suatcheng Peh [République populaire de Chine] ; Jiang Gu [République populaire de Chine]Source :
- Biology of Reproduction [ 0006-3363 ] ; 2006.
Abstract
Severe acute respiratory syndrome (SARS) coronavirus has been known to damage multiple organs; however, little is known about its impact on the reproductive system. In the present study, we analyzed the pathological changes of testes from six patients who died of SARS. Results suggested that SARS caused orchitis. All SARS testes displayed widespread germ cell destruction, few or no spermatozoon in the seminiferous tubule, thickened basement membrane, and leukocyte infiltration. The numbers of CD3+ T lymphocytes and CD68+ macrophages increased significantly in the interstitial tissue compared with the control group (
Url:
DOI: 10.1095/biolreprod.105.044776
PubMed: 16237152
PubMed Central: 7109827
Affiliations:
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uniqKey="Qi L" first="Lihua" last="Qi">Lihua Qi</name><affiliation wicri:level="4"><nlm:aff id="aff1">Departments of Anatomy, Histology, and Embryology, School of Basic Medical Sciences, Peking University, Beijing 100083, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Departments of Anatomy, Histology, and Embryology, School of Basic Medical Sciences, Peking University, Beijing 100083</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName><orgName type="university">Université de Pékin</orgName><placeName><settlement type="city">Pékin</settlement><region type="capitale">Pékin</region></placeName></affiliation></author><author><name sortKey="Chi, Xiaochun" sort="Chi, Xiaochun" uniqKey="Chi X" first="Xiaochun" last="Chi">Xiaochun Chi</name><affiliation wicri:level="4"><nlm:aff id="aff1">Departments of Anatomy, Histology, and Embryology, School of Basic Medical Sciences, Peking University, Beijing 100083, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Departments of Anatomy, Histology, and Embryology, School of Basic Medical Sciences, Peking University, Beijing 100083</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName><orgName type="university">Université de Pékin</orgName><placeName><settlement type="city">Pékin</settlement><region type="capitale">Pékin</region></placeName></affiliation></author><author><name sortKey="Yang, Jingjing" sort="Yang, Jingjing" uniqKey="Yang J" first="Jingjing" last="Yang">Jingjing Yang</name><affiliation wicri:level="4"><nlm:aff id="aff1">Departments of Anatomy, Histology, and Embryology, School of Basic Medical Sciences, Peking University, Beijing 100083, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Departments of Anatomy, Histology, and Embryology, School of Basic Medical Sciences, Peking University, Beijing 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of Severe Acute Respiratory Syndrome (SARS)<xref ref-type="author-notes" rid="fn1"><sup>1</sup></xref></title><author><name sortKey="Xu, Jian" sort="Xu, Jian" uniqKey="Xu J" first="Jian" last="Xu">Jian Xu</name><affiliation wicri:level="4"><nlm:aff id="aff1">Departments of Anatomy, Histology, and Embryology, School of Basic Medical Sciences, Peking University, Beijing 100083, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Departments of Anatomy, Histology, and Embryology, School of Basic Medical Sciences, Peking University, Beijing 100083</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName><orgName type="university">Université de Pékin</orgName><placeName><settlement type="city">Pékin</settlement><region type="capitale">Pékin</region></placeName></affiliation></author><author><name sortKey="Qi, Lihua" sort="Qi, Lihua" uniqKey="Qi L" first="Lihua" last="Qi">Lihua Qi</name><affiliation wicri:level="4"><nlm:aff id="aff1">Departments of Anatomy, Histology, and Embryology, School of Basic Medical Sciences, Peking University, Beijing 100083, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Departments of Anatomy, Histology, and Embryology, School of Basic Medical Sciences, Peking University, Beijing 100083</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName><orgName type="university">Université de Pékin</orgName><placeName><settlement type="city">Pékin</settlement><region type="capitale">Pékin</region></placeName></affiliation></author><author><name sortKey="Chi, Xiaochun" sort="Chi, Xiaochun" uniqKey="Chi X" first="Xiaochun" last="Chi">Xiaochun Chi</name><affiliation wicri:level="4"><nlm:aff id="aff1">Departments of Anatomy, Histology, and Embryology, School of Basic Medical Sciences, Peking University, Beijing 100083, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Departments of Anatomy, Histology, and Embryology, School of Basic Medical Sciences, Peking University, Beijing 100083</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName><orgName type="university">Université de Pékin</orgName><placeName><settlement type="city">Pékin</settlement><region type="capitale">Pékin</region></placeName></affiliation></author><author><name sortKey="Yang, Jingjing" sort="Yang, Jingjing" uniqKey="Yang J" first="Jingjing" last="Yang">Jingjing Yang</name><affiliation wicri:level="4"><nlm:aff id="aff1">Departments of Anatomy, Histology, and Embryology, School of Basic Medical Sciences, Peking University, Beijing 100083, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Departments of Anatomy, Histology, and Embryology, School of Basic Medical Sciences, Peking University, Beijing 100083</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName><orgName type="university">Université de Pékin</orgName><placeName><settlement type="city">Pékin</settlement><region type="capitale">Pékin</region></placeName></affiliation></author><author><name sortKey="Wei, Xiaohong" sort="Wei, Xiaohong" uniqKey="Wei X" first="Xiaohong" last="Wei">Xiaohong Wei</name><affiliation wicri:level="4"><nlm:aff id="aff1">Departments of Anatomy, Histology, and Embryology, School of Basic Medical Sciences, Peking University, Beijing 100083, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Departments of Anatomy, Histology, and Embryology, School of Basic Medical Sciences, Peking University, Beijing 100083</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName><orgName type="university">Université de Pékin</orgName><placeName><settlement type="city">Pékin</settlement><region type="capitale">Pékin</region></placeName></affiliation></author><author><name sortKey="Gong, Encong" sort="Gong, Encong" uniqKey="Gong E" first="Encong" last="Gong">Encong Gong</name><affiliation wicri:level="4"><nlm:aff id="aff2">Pathology, School of Basic Medical Sciences, Peking University, Beijing 100083, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Pathology, School of Basic Medical Sciences, Peking University, Beijing 100083</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName><orgName type="university">Université de Pékin</orgName><placeName><settlement type="city">Pékin</settlement><region type="capitale">Pékin</region></placeName></affiliation></author><author><name sortKey="Peh, Suatcheng" sort="Peh, Suatcheng" uniqKey="Peh S" first="Suatcheng" last="Peh">Suatcheng Peh</name><affiliation wicri:level="4"><nlm:aff id="aff2">Pathology, School of Basic Medical Sciences, Peking University, Beijing 100083, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Pathology, School of Basic Medical Sciences, Peking University, Beijing 100083</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName><orgName type="university">Université de Pékin</orgName><placeName><settlement type="city">Pékin</settlement><region type="capitale">Pékin</region></placeName></affiliation></author><author><name sortKey="Gu, Jiang" sort="Gu, Jiang" uniqKey="Gu J" first="Jiang" last="Gu">Jiang Gu</name><affiliation wicri:level="4"><nlm:aff id="aff2">Pathology, School of Basic Medical Sciences, Peking University, Beijing 100083, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Pathology, School of Basic Medical Sciences, Peking University, Beijing 100083</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName><orgName type="university">Université de Pékin</orgName><placeName><settlement type="city">Pékin</settlement><region type="capitale">Pékin</region></placeName></affiliation></author></analytic><series><title level="j">Biology of Reproduction</title><idno type="ISSN">0006-3363</idno><idno type="eISSN">1529-7268</idno><imprint><date when="2006">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Abstract</title><p>Severe acute respiratory syndrome (SARS) coronavirus has been known to damage multiple organs; however, little is known about its impact on the reproductive system. In the present study, we analyzed the pathological changes of testes from six patients who died of SARS. Results suggested that SARS caused orchitis. All SARS testes displayed widespread germ cell destruction, few or no spermatozoon in the seminiferous tubule, thickened basement membrane, and leukocyte infiltration. The numbers of CD3+ T lymphocytes and CD68+ macrophages increased significantly in the interstitial tissue compared with the control group (<italic>P</italic> < 0.05). SARS viral genomic sequences were not detected in the testes by in situ hybridization. Immunohistochemistry demonstrated abundant IgG precipitation in the seminiferous epithelium of SARS testes, indicating possible immune response as the cause for the damage. Our findings indicated that orchitis is a complication of SARS. It further suggests that the reproductive functions should be followed and evaluated in recovered male SARS patients.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Ksiazek, Tg" uniqKey="Ksiazek T">TG Ksiazek</name></author><author><name sortKey="Erdman, D" uniqKey="Erdman D">D Erdman</name></author><author><name sortKey="Goldsmith, Cs" uniqKey="Goldsmith C">CS Goldsmith</name></author><author><name sortKey="Zaki, Sr" uniqKey="Zaki S">SR Zaki</name></author><author><name sortKey="Peret, T" uniqKey="Peret T">T Peret</name></author><author><name sortKey="Emery, S" uniqKey="Emery S">S Emery</name></author><author><name sortKey="Tong, S" uniqKey="Tong S">S Tong</name></author><author><name sortKey="Urbani, C" uniqKey="Urbani C">C Urbani</name></author><author><name sortKey="Comer, Ja" uniqKey="Comer J">JA Comer</name></author><author><name sortKey="Lim, W" uniqKey="Lim W">W Lim</name></author><author><name sortKey="Rollin, Pe" uniqKey="Rollin P">PE Rollin</name></author><author><name sortKey="Dowell, Sf" uniqKey="Dowell S">SF Dowell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Drosten, C" uniqKey="Drosten C">C Drosten</name></author><author><name sortKey="Gunther, S" uniqKey="Gunther S">S Gunther</name></author><author><name sortKey="Preiser, W" uniqKey="Preiser W">W Preiser</name></author><author><name sortKey="Van Der Werf, S" uniqKey="Van Der Werf S">S van der Werf</name></author><author><name sortKey="Brodt, Hr" uniqKey="Brodt H">HR Brodt</name></author><author><name sortKey="Becker, S" uniqKey="Becker S">S Becker</name></author><author><name sortKey="Rabenau, H" uniqKey="Rabenau H">H Rabenau</name></author><author><name sortKey="Panning, M" uniqKey="Panning M">M Panning</name></author><author><name sortKey="Kolesnikova, L" uniqKey="Kolesnikova L">L Kolesnikova</name></author><author><name sortKey="Fouchier, Ra" uniqKey="Fouchier R">RA Fouchier</name></author><author><name sortKey="Berger, A" uniqKey="Berger A">A Berger</name></author><author><name sortKey="Burguiere, Am" uniqKey="Burguiere A">AM Burguiere</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Marra, Ma" uniqKey="Marra M">MA Marra</name></author><author><name sortKey="Jones, Sj" uniqKey="Jones S">SJ Jones</name></author><author><name sortKey="Astell, Cr" uniqKey="Astell C">CR Astell</name></author><author><name sortKey="Holt, Ra" uniqKey="Holt R">RA Holt</name></author><author><name sortKey="Brooks Wilson, A" uniqKey="Brooks Wilson A">A Brooks-Wilson</name></author><author><name sortKey="Butterfield, Ys" uniqKey="Butterfield Y">YS Butterfield</name></author><author><name sortKey="Khattra, J" uniqKey="Khattra J">J Khattra</name></author><author><name sortKey="Asano, Jk" uniqKey="Asano J">JK Asano</name></author><author><name sortKey="Barber, Sa" uniqKey="Barber S">SA Barber</name></author><author><name sortKey="Chan, Sy" uniqKey="Chan S">SY Chan</name></author><author><name sortKey="Cloutier, A" uniqKey="Cloutier A">A Cloutier</name></author><author><name sortKey="Caughlin, Sm" uniqKey="Caughlin S">SM Caughlin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, J" uniqKey="Chen J">J Chen</name></author><author><name sortKey="Zhang, Ht" uniqKey="Zhang H">HT Zhang</name></author><author><name sortKey="Xie, Yq" uniqKey="Xie Y">YQ Xie</name></author><author><name sortKey="Wan, Jw" uniqKey="Wan J">JW Wan</name></author><author><name sortKey="Lu, Zh" uniqKey="Lu Z">ZH Lu</name></author><author><name sortKey="Wang, Dt" uniqKey="Wang D">DT Wang</name></author><author><name sortKey="Wang, Qz" uniqKey="Wang Q">QZ Wang</name></author><author><name sortKey="Xue, Xh" uniqKey="Xue X">XH Xue</name></author><author><name sortKey="Si, Wx" uniqKey="Si W">WX Si</name></author><author><name sortKey="Luo, Yf" uniqKey="Luo Y">YF Luo</name></author><author><name sortKey="Qiu, Hm" uniqKey="Qiu H">HM Qiu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tse, Gm" uniqKey="Tse G">GM Tse</name></author><author><name sortKey="To, Kf" uniqKey="To K">KF To</name></author><author><name sortKey="Chan, Pk" uniqKey="Chan P">PK Chan</name></author><author><name sortKey="Lo, Aw" uniqKey="Lo A">AW Lo</name></author><author><name sortKey="Ng, Kc" uniqKey="Ng K">KC Ng</name></author><author><name sortKey="Wu, A" uniqKey="Wu A">A Wu</name></author><author><name sortKey="Lee, N" uniqKey="Lee N">N Lee</name></author><author><name sortKey="Wong, Hc" uniqKey="Wong H">HC Wong</name></author><author><name sortKey="Mak, Sm" uniqKey="Mak S">SM Mak</name></author><author><name sortKey="Chan, Kf" uniqKey="Chan K">KF Chan</name></author><author><name sortKey="Hui, Ds" uniqKey="Hui D">DS Hui</name></author><author><name sortKey="Sung, Jj" uniqKey="Sung J">JJ Sung</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gu, J" uniqKey="Gu J">J Gu</name></author><author><name sortKey="Gong, E" uniqKey="Gong E">E Gong</name></author><author><name sortKey="Zhang, B" uniqKey="Zhang B">B Zhang</name></author><author><name sortKey="Zheng, J" uniqKey="Zheng J">J Zheng</name></author><author><name sortKey="Gao, Z" uniqKey="Gao Z">Z Gao</name></author><author><name sortKey="Zhong, Y" uniqKey="Zhong Y">Y Zhong</name></author><author><name sortKey="Zou, W" uniqKey="Zou W">W Zou</name></author><author><name sortKey="Zhan, J" uniqKey="Zhan J">J Zhan</name></author><author><name sortKey="Wang, S" uniqKey="Wang S">S Wang</name></author><author><name sortKey="Xie, Z" uniqKey="Xie Z">Z Xie</name></author><author><name sortKey="Zhuang, H" uniqKey="Zhuang H">H Zhuang</name></author><author><name sortKey="Wu, B" uniqKey="Wu B">B Wu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ding, Y" uniqKey="Ding Y">Y Ding</name></author><author><name sortKey="Wang, H" uniqKey="Wang H">H Wang</name></author><author><name sortKey="Shen, H" uniqKey="Shen H">H Shen</name></author><author><name sortKey="Li, Z" uniqKey="Li Z">Z Li</name></author><author><name sortKey="Geng, J" uniqKey="Geng J">J Geng</name></author><author><name sortKey="Han, H" uniqKey="Han H">H Han</name></author><author><name sortKey="Cai, J" uniqKey="Cai J">J Cai</name></author><author><name sortKey="Li, X" uniqKey="Li X">X Li</name></author><author><name sortKey="Kang, W" uniqKey="Kang W">W Kang</name></author><author><name sortKey="Weng, D" uniqKey="Weng D">D Weng</name></author><author><name sortKey="Lu, Y" uniqKey="Lu Y">Y Lu</name></author><author><name sortKey="Wu, D" uniqKey="Wu D">D Wu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhao, Jm" uniqKey="Zhao J">JM Zhao</name></author><author><name sortKey="Zhou, Gd" uniqKey="Zhou G">GD Zhou</name></author><author><name sortKey="Sun, Yl" uniqKey="Sun Y">YL Sun</name></author><author><name sortKey="Wang, Ss" uniqKey="Wang S">SS Wang</name></author><author><name sortKey="Yang, Jf" uniqKey="Yang J">JF Yang</name></author><author><name sortKey="Meng, Eh" uniqKey="Meng E">EH Meng</name></author><author><name sortKey="Pan, D" uniqKey="Pan D">D Pan</name></author><author><name sortKey="Li, Ws" uniqKey="Li W">WS Li</name></author><author><name sortKey="Zhou, Xs" uniqKey="Zhou X">XS Zhou</name></author><author><name sortKey="Wang, Yd" uniqKey="Wang Y">YD Wang</name></author><author><name sortKey="Lu, Jy" uniqKey="Lu J">JY Lu</name></author><author><name sortKey="Li, N" uniqKey="Li N">N Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ding, Y" uniqKey="Ding Y">Y Ding</name></author><author><name sortKey="He, L" uniqKey="He L">L He</name></author><author><name sortKey="Zhang, Q" uniqKey="Zhang Q">Q Zhang</name></author><author><name sortKey="Huang, Z" uniqKey="Huang Z">Z Huang</name></author><author><name sortKey="Che, X" uniqKey="Che X">X Che</name></author><author><name sortKey="Hou, J" uniqKey="Hou J">J Hou</name></author><author><name sortKey="Wang, H" uniqKey="Wang H">H Wang</name></author><author><name sortKey="Shen, H" uniqKey="Shen H">H Shen</name></author><author><name sortKey="Qui, L" uniqKey="Qui L">L Qui</name></author><author><name sortKey="Li, Z" uniqKey="Li Z">Z Li</name></author><author><name sortKey="Geng, J" uniqKey="Geng J">J Geng</name></author><author><name sortKey="Cai, J" uniqKey="Cai J">J Cai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dejucq, N" uniqKey="Dejucq N">N Dejucq</name></author><author><name sortKey="Jegou, B" uniqKey="Jegou B">B Jégou</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Shi, X" uniqKey="Shi X">X Shi</name></author><author><name sortKey="Gong, E" uniqKey="Gong E">E Gong</name></author><author><name sortKey="Gao, D" uniqKey="Gao D">D Gao</name></author><author><name sortKey="Zhang, B" uniqKey="Zhang B">B Zhang</name></author><author><name sortKey="Zheng, J" uniqKey="Zheng J">J Zheng</name></author><author><name sortKey="Gao, Z" uniqKey="Gao Z">Z Gao</name></author><author><name sortKey="Zhong, Y" uniqKey="Zhong Y">Y Zhong</name></author><author><name sortKey="Zou, W" uniqKey="Zou W">W Zou</name></author><author><name sortKey="Wu, B" uniqKey="Wu B">B Wu</name></author><author><name sortKey="Fang, W" uniqKey="Fang W">W Fang</name></author><author><name sortKey="Liao, S" uniqKey="Liao S">S Liao</name></author><author><name sortKey="Wang, S" uniqKey="Wang S">S Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Poretsky, L" uniqKey="Poretsky L">L Poretsky</name></author><author><name sortKey="Can, S" uniqKey="Can S">S Can</name></author><author><name sortKey="Zumoff, B" uniqKey="Zumoff B">B Zumoff</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pudney, J" uniqKey="Pudney J">J Pudney</name></author><author><name sortKey="Anderson, D" uniqKey="Anderson D">D Anderson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tessler, An" uniqKey="Tessler A">AN Tessler</name></author><author><name sortKey="Catanese, A" uniqKey="Catanese A">A Catanese</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Oliver, Rt" uniqKey="Oliver R">RT Oliver</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Feichtinger, H" uniqKey="Feichtinger H">H Feichtinger</name></author><author><name sortKey="Kaaya, E" uniqKey="Kaaya E">E Kaaya</name></author><author><name sortKey="Putkonen, P" uniqKey="Putkonen P">P Putkonen</name></author><author><name sortKey="Li, Sl" uniqKey="Li S">SL Li</name></author><author><name sortKey="Ekman, M" uniqKey="Ekman M">M Ekman</name></author><author><name sortKey="Gendelman, R" uniqKey="Gendelman R">R Gendelman</name></author><author><name sortKey="Biberfeld, G" uniqKey="Biberfeld G">G Biberfeld</name></author><author><name sortKey="Biberfeld, P" uniqKey="Biberfeld P">P Biberfeld</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chabon, Ab" uniqKey="Chabon A">AB Chabon</name></author><author><name sortKey="Stenger, Rj" uniqKey="Stenger R">RJ Stenger</name></author><author><name sortKey="Grabstald, H" uniqKey="Grabstald H">H Grabstald</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rogers, C" uniqKey="Rogers C">C Rogers</name></author><author><name sortKey="Klatt, Ec" uniqKey="Klatt E">EC Klatt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yoshikawa, Y" uniqKey="Yoshikawa Y">Y Yoshikawa</name></author><author><name sortKey="Truong, Ld" uniqKey="Truong L">LD Truong</name></author><author><name sortKey="Fraire, Ae" uniqKey="Fraire A">AE Fraire</name></author><author><name sortKey="Kim, Hs" uniqKey="Kim H">HS Kim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Freeman, R" uniqKey="Freeman R">R Freeman</name></author><author><name sortKey="Hambling, Mh" uniqKey="Hambling M">MH Hambling</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bjorvatn, B" uniqKey="Bjorvatn B">B Bjorvatn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Charny, Cw" uniqKey="Charny C">CW Charny</name></author><author><name sortKey="Meranze, Dr" uniqKey="Meranze D">DR Meranze</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xu, J" uniqKey="Xu J">J Xu</name></author><author><name sortKey="Xu, Z" uniqKey="Xu Z">Z Xu</name></author><author><name sortKey="Jiang, Y" uniqKey="Jiang Y">Y Jiang</name></author><author><name sortKey="Qian, X" uniqKey="Qian X">X Qian</name></author><author><name sortKey="Huang, Y" uniqKey="Huang Y">Y Huang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Oliver, Rt" uniqKey="Oliver R">RT Oliver</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gao, Hb" uniqKey="Gao H">HB Gao</name></author><author><name sortKey="Tong, Mh" uniqKey="Tong M">MH Tong</name></author><author><name sortKey="Hu, Yq" uniqKey="Hu Y">YQ Hu</name></author><author><name sortKey="Guo, Qs" uniqKey="Guo Q">QS Guo</name></author><author><name sortKey="Ge, R" uniqKey="Ge R">R Ge</name></author><author><name sortKey="Hardy, Mp" uniqKey="Hardy M">MP Hardy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Adamopoulos, Da" uniqKey="Adamopoulos D">DA Adamopoulos</name></author><author><name sortKey="Lawrence, Dm" uniqKey="Lawrence D">DM Lawrence</name></author><author><name sortKey="Vassilopoulos, P" uniqKey="Vassilopoulos P">P Vassilopoulos</name></author><author><name sortKey="Contoyiannis, Pa" uniqKey="Contoyiannis P">PA Contoyiannis</name></author><author><name sortKey="Swyer, Gi" uniqKey="Swyer G">GI Swyer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Croxson, Ts" uniqKey="Croxson T">TS Croxson</name></author><author><name sortKey="Chapman, We" uniqKey="Chapman W">WE Chapman</name></author><author><name sortKey="Miller, Lk" uniqKey="Miller L">LK Miller</name></author><author><name sortKey="Levit, Cd" uniqKey="Levit C">CD Levit</name></author><author><name sortKey="Senie, R" uniqKey="Senie R">R Senie</name></author><author><name sortKey="Zumoff, B" uniqKey="Zumoff B">B Zumoff</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, W" uniqKey="Li W">W Li</name></author><author><name sortKey="Moore, Mj" uniqKey="Moore M">MJ Moore</name></author><author><name sortKey="Vasilieva, N" uniqKey="Vasilieva N">N Vasilieva</name></author><author><name sortKey="Sui, J" uniqKey="Sui J">J Sui</name></author><author><name sortKey="Wong, Sk" uniqKey="Wong S">SK Wong</name></author><author><name sortKey="Berne, Ma" uniqKey="Berne M">MA Berne</name></author><author><name sortKey="Somasundaran, M" uniqKey="Somasundaran M">M Somasundaran</name></author><author><name sortKey="Sullivan, Jl" uniqKey="Sullivan J">JL Sullivan</name></author><author><name sortKey="Luzuriaga, K" uniqKey="Luzuriaga K">K Luzuriaga</name></author><author><name sortKey="Greenough, Tc" uniqKey="Greenough T">TC Greenough</name></author><author><name sortKey="Choe, H" uniqKey="Choe H">H Choe</name></author><author><name sortKey="Farzan, M" uniqKey="Farzan M">M Farzan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Harmer, D" uniqKey="Harmer D">D Harmer</name></author><author><name sortKey="Gilbert, M" uniqKey="Gilbert M">M Gilbert</name></author><author><name sortKey="Borman, R" uniqKey="Borman R">R Borman</name></author><author><name sortKey="Clark, Kl" uniqKey="Clark K">KL Clark</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tipnis, Sr" uniqKey="Tipnis S">SR Tipnis</name></author><author><name sortKey="Hooper, Nm" uniqKey="Hooper N">NM Hooper</name></author><author><name sortKey="Hyde, R" uniqKey="Hyde R">R Hyde</name></author><author><name sortKey="Karran, E" uniqKey="Karran E">E Karran</name></author><author><name sortKey="Christie, G" uniqKey="Christie G">G Christie</name></author><author><name sortKey="Turner, Aj" uniqKey="Turner A">AJ Turner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Donoghue, M" uniqKey="Donoghue M">M Donoghue</name></author><author><name sortKey="Hsieh, F" uniqKey="Hsieh F">F Hsieh</name></author><author><name sortKey="Baronas, E" uniqKey="Baronas E">E Baronas</name></author><author><name sortKey="Godbout, K" uniqKey="Godbout K">K Godbout</name></author><author><name sortKey="Gosselin, M" uniqKey="Gosselin M">M Gosselin</name></author><author><name sortKey="Stagliano, N" uniqKey="Stagliano N">N Stagliano</name></author><author><name sortKey="Donovan, M" uniqKey="Donovan M">M Donovan</name></author><author><name sortKey="Wodf, B" uniqKey="Wodf B">B Wodf</name></author><author><name sortKey="Robinson, K" uniqKey="Robinson K">K Robinson</name></author><author><name sortKey="Jeyaseelan, R" uniqKey="Jeyaseelan R">R Jeyaseelan</name></author><author><name sortKey="Breitbart, Re" uniqKey="Breitbart R">RE Breitbart</name></author><author><name sortKey="Acton, S" uniqKey="Acton S">S Acton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hedger, Mp" uniqKey="Hedger M">MP Hedger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Itoh, M" uniqKey="Itoh M">M Itoh</name></author><author><name sortKey="Hiramine, C" uniqKey="Hiramine C">C Hiramine</name></author><author><name sortKey="Tokunaga, Y" uniqKey="Tokunaga Y">Y Tokunaga</name></author><author><name sortKey="Mukasa, A" uniqKey="Mukasa A">A Mukasa</name></author><author><name sortKey="Hojo, K" uniqKey="Hojo K">K Hojo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kohno, S" uniqKey="Kohno S">S Kohno</name></author><author><name sortKey="Munoz, Ja" uniqKey="Munoz J">JA Munoz</name></author><author><name sortKey="Williams, Tm" uniqKey="Williams T">TM Williams</name></author><author><name sortKey="Teuscher, C" uniqKey="Teuscher C">C Teuscher</name></author><author><name sortKey="Bernard, Cc" uniqKey="Bernard C">CC Bernard</name></author><author><name sortKey="Tung, Ks" uniqKey="Tung K">KS Tung</name></author></analytic></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Biol Reprod</journal-id><journal-id journal-id-type="iso-abbrev">Biol. Reprod</journal-id><journal-id journal-id-type="publisher-id">biolreprod</journal-id><journal-title-group><journal-title>Biology of Reproduction</journal-title></journal-title-group><issn pub-type="ppub">0006-3363</issn><issn pub-type="epub">1529-7268</issn><publisher><publisher-name>Oxford University Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">16237152</article-id><article-id pub-id-type="pmc">7109827</article-id><article-id pub-id-type="doi">10.1095/biolreprod.105.044776</article-id><article-categories><subj-group subj-group-type="heading"><subject>Testis</subject></subj-group></article-categories><title-group><article-title>Orchitis: A Complication of Severe Acute Respiratory Syndrome (SARS)<xref ref-type="author-notes" rid="fn1"><sup>1</sup></xref></article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Xu</surname><given-names>Jian</given-names></name><xref ref-type="aff" rid="aff1">3</xref></contrib><contrib contrib-type="author"><name><surname>Qi</surname><given-names>Lihua</given-names></name><xref ref-type="aff" rid="aff1">3</xref></contrib><contrib contrib-type="author"><name><surname>Chi</surname><given-names>Xiaochun</given-names></name><xref ref-type="aff" rid="aff1">3</xref></contrib><contrib contrib-type="author"><name><surname>Yang</surname><given-names>Jingjing</given-names></name><xref ref-type="aff" rid="aff1">3</xref></contrib><contrib contrib-type="author"><name><surname>Wei</surname><given-names>Xiaohong</given-names></name><xref ref-type="aff" rid="aff1">3</xref></contrib><contrib contrib-type="author"><name><surname>Gong</surname><given-names>Encong</given-names></name><xref ref-type="aff" rid="aff2">4</xref></contrib><contrib contrib-type="author"><name><surname>Peh</surname><given-names>Suatcheng</given-names></name><xref ref-type="aff" rid="aff2">4</xref></contrib><contrib contrib-type="author"><name><surname>Gu</surname><given-names>Jiang</given-names></name><pmc-comment>jgu@privatedoctor.org </pmc-comment>
<xref ref-type="corresp" rid="cor1"></xref><xref ref-type="aff" rid="aff2">4</xref></contrib></contrib-group><aff id="aff1"><label>3</label>Departments of Anatomy, Histology, and Embryology, School of Basic Medical Sciences, Peking University, Beijing 100083, China</aff><aff id="aff2"><label>4</label>Pathology, School of Basic Medical Sciences, Peking University, Beijing 100083, China</aff><author-notes><fn id="fn1"><label><sup>1</sup></label><p>Supported by National 863 project (2003AA208107).</p></fn><corresp id="cor1"><label>2</label>Correspondence: Jiang Gu, Department of Pathology, School of Basic Medical Sciences, Peking University, 38 Xueyuan Road, Haidian District, Beijing 100083, China. FAX: 86 10 82801237;</corresp></author-notes><pub-date pub-type="ppub"><day>01</day><month>2</month><year>2006</year></pub-date><volume>74</volume><issue>2</issue><fpage>410</fpage><lpage>416</lpage><history><date date-type="accepted"><day>18</day><month>10</month><year>2005</year></date><date date-type="received"><day>21</day><month>6</month><year>2005</year></date><date date-type="rev-recd"><day>05</day><month>7</month><year>2005</year></date></history><permissions><copyright-statement>© 2006 by the Society for the Study of Reproduction, Inc.</copyright-statement><copyright-year>2006</copyright-year><license><license-p>This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.</license-p></license></permissions><self-uri xlink:href="biolreprod0410.pdf"></self-uri><abstract><title>Abstract</title><p>Severe acute respiratory syndrome (SARS) coronavirus has been known to damage multiple organs; however, little is known about its impact on the reproductive system. In the present study, we analyzed the pathological changes of testes from six patients who died of SARS. Results suggested that SARS caused orchitis. All SARS testes displayed widespread germ cell destruction, few or no spermatozoon in the seminiferous tubule, thickened basement membrane, and leukocyte infiltration. The numbers of CD3+ T lymphocytes and CD68+ macrophages increased significantly in the interstitial tissue compared with the control group (<italic>P</italic> < 0.05). SARS viral genomic sequences were not detected in the testes by in situ hybridization. Immunohistochemistry demonstrated abundant IgG precipitation in the seminiferous epithelium of SARS testes, indicating possible immune response as the cause for the damage. Our findings indicated that orchitis is a complication of SARS. It further suggests that the reproductive functions should be followed and evaluated in recovered male SARS patients.</p></abstract><kwd-group><kwd>immunohistochemistry</kwd><kwd>in situ hybridization</kwd><kwd>orchitis</kwd><kwd>SARS</kwd><kwd>spermatogenesis</kwd><kwd>testis</kwd></kwd-group></article-meta></front></pmc><affiliations><list><country><li>République populaire de Chine</li></country><region><li>Pékin</li></region><settlement><li>Pékin</li></settlement><orgName><li>Université de Pékin</li></orgName></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Xu, Jian" sort="Xu, Jian" uniqKey="Xu J" first="Jian" last="Xu">Jian Xu</name></noRegion><name sortKey="Chi, Xiaochun" sort="Chi, Xiaochun" uniqKey="Chi X" first="Xiaochun" last="Chi">Xiaochun Chi</name><name sortKey="Gong, Encong" sort="Gong, Encong" uniqKey="Gong E" first="Encong" last="Gong">Encong Gong</name><name sortKey="Gu, Jiang" sort="Gu, Jiang" uniqKey="Gu J" first="Jiang" last="Gu">Jiang Gu</name><name sortKey="Peh, Suatcheng" sort="Peh, Suatcheng" uniqKey="Peh S" first="Suatcheng" last="Peh">Suatcheng Peh</name><name sortKey="Qi, Lihua" sort="Qi, Lihua" uniqKey="Qi L" first="Lihua" last="Qi">Lihua Qi</name><name sortKey="Wei, Xiaohong" sort="Wei, Xiaohong" uniqKey="Wei X" first="Xiaohong" last="Wei">Xiaohong Wei</name><name sortKey="Yang, Jingjing" sort="Yang, Jingjing" uniqKey="Yang J" first="Jingjing" last="Yang">Jingjing Yang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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