Co‐infection of respiratory bacterium with severe acute respiratory syndrome coronavirus induces an exacerbated pneumonia in mice
Identifieur interne : 000E35 ( Pmc/Checkpoint ); précédent : 000E34; suivant : 000E36Co‐infection of respiratory bacterium with severe acute respiratory syndrome coronavirus induces an exacerbated pneumonia in mice
Auteurs : Yasushi Ami ; Noriyo Nagata ; Kazuya Shirato ; Rie Watanabe ; Naoko Iwata ; Keiko Nakagaki ; Shuetsu Fukushi ; Masayuki Saijo ; Shigeru Morikawa ; Fumihiro TaguchiSource :
- Microbiology and Immunology [ 0385-5600 ] ; 2008.
Abstract
SARS‐CoV grows in a variety of tissues that express its receptor, although the mechanism for high replication in the lungs and severe respiratory illness is not well understood. We recently showed that elastase enhances SARS‐CoV infection in cultured cells, which suggests that SARS development may be due to elastase‐mediated, enhanced SARS‐CoV infection in the lungs. To explore this possibility, we examined whether co‐infection of mice with SARS‐CoV and
Url:
DOI: 10.1111/j.1348-0421.2008.00011.x
PubMed: NONE
PubMed Central: 7168413
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
PMC:7168413Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Co‐infection of respiratory bacterium with severe acute respiratory syndrome coronavirus induces an exacerbated pneumonia in mice</title>
<author><name sortKey="Ami, Yasushi" sort="Ami, Yasushi" uniqKey="Ami Y" first="Yasushi" last="Ami">Yasushi Ami</name>
<affiliation><nlm:aff id="a1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Nagata, Noriyo" sort="Nagata, Noriyo" uniqKey="Nagata N" first="Noriyo" last="Nagata">Noriyo Nagata</name>
<affiliation><nlm:aff id="a1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Shirato, Kazuya" sort="Shirato, Kazuya" uniqKey="Shirato K" first="Kazuya" last="Shirato">Kazuya Shirato</name>
<affiliation><nlm:aff id="a1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Watanabe, Rie" sort="Watanabe, Rie" uniqKey="Watanabe R" first="Rie" last="Watanabe">Rie Watanabe</name>
<affiliation><nlm:aff id="a1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Iwata, Naoko" sort="Iwata, Naoko" uniqKey="Iwata N" first="Naoko" last="Iwata">Naoko Iwata</name>
<affiliation><nlm:aff id="a1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Nakagaki, Keiko" sort="Nakagaki, Keiko" uniqKey="Nakagaki K" first="Keiko" last="Nakagaki">Keiko Nakagaki</name>
<affiliation><nlm:aff id="a1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Fukushi, Shuetsu" sort="Fukushi, Shuetsu" uniqKey="Fukushi S" first="Shuetsu" last="Fukushi">Shuetsu Fukushi</name>
<affiliation><nlm:aff id="a1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Saijo, Masayuki" sort="Saijo, Masayuki" uniqKey="Saijo M" first="Masayuki" last="Saijo">Masayuki Saijo</name>
<affiliation><nlm:aff id="a1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Morikawa, Shigeru" sort="Morikawa, Shigeru" uniqKey="Morikawa S" first="Shigeru" last="Morikawa">Shigeru Morikawa</name>
<affiliation><nlm:aff id="a1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Taguchi, Fumihiro" sort="Taguchi, Fumihiro" uniqKey="Taguchi F" first="Fumihiro" last="Taguchi">Fumihiro Taguchi</name>
<affiliation><nlm:aff id="a1"></nlm:aff>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmc">7168413</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7168413</idno>
<idno type="RBID">PMC:7168413</idno>
<idno type="doi">10.1111/j.1348-0421.2008.00011.x</idno>
<idno type="pmid">NONE</idno>
<date when="2008">2008</date>
<idno type="wicri:Area/Pmc/Corpus">000A55</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000A55</idno>
<idno type="wicri:Area/Pmc/Curation">000A55</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000A55</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000E35</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000E35</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Co‐infection of respiratory bacterium with severe acute respiratory syndrome coronavirus induces an exacerbated pneumonia in mice</title>
<author><name sortKey="Ami, Yasushi" sort="Ami, Yasushi" uniqKey="Ami Y" first="Yasushi" last="Ami">Yasushi Ami</name>
<affiliation><nlm:aff id="a1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Nagata, Noriyo" sort="Nagata, Noriyo" uniqKey="Nagata N" first="Noriyo" last="Nagata">Noriyo Nagata</name>
<affiliation><nlm:aff id="a1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Shirato, Kazuya" sort="Shirato, Kazuya" uniqKey="Shirato K" first="Kazuya" last="Shirato">Kazuya Shirato</name>
<affiliation><nlm:aff id="a1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Watanabe, Rie" sort="Watanabe, Rie" uniqKey="Watanabe R" first="Rie" last="Watanabe">Rie Watanabe</name>
<affiliation><nlm:aff id="a1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Iwata, Naoko" sort="Iwata, Naoko" uniqKey="Iwata N" first="Naoko" last="Iwata">Naoko Iwata</name>
<affiliation><nlm:aff id="a1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Nakagaki, Keiko" sort="Nakagaki, Keiko" uniqKey="Nakagaki K" first="Keiko" last="Nakagaki">Keiko Nakagaki</name>
<affiliation><nlm:aff id="a1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Fukushi, Shuetsu" sort="Fukushi, Shuetsu" uniqKey="Fukushi S" first="Shuetsu" last="Fukushi">Shuetsu Fukushi</name>
<affiliation><nlm:aff id="a1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Saijo, Masayuki" sort="Saijo, Masayuki" uniqKey="Saijo M" first="Masayuki" last="Saijo">Masayuki Saijo</name>
<affiliation><nlm:aff id="a1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Morikawa, Shigeru" sort="Morikawa, Shigeru" uniqKey="Morikawa S" first="Shigeru" last="Morikawa">Shigeru Morikawa</name>
<affiliation><nlm:aff id="a1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Taguchi, Fumihiro" sort="Taguchi, Fumihiro" uniqKey="Taguchi F" first="Fumihiro" last="Taguchi">Fumihiro Taguchi</name>
<affiliation><nlm:aff id="a1"></nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">Microbiology and Immunology</title>
<idno type="ISSN">0385-5600</idno>
<idno type="eISSN">1348-0421</idno>
<imprint><date when="2008">2008</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><title>ABSTRACT</title>
<p>SARS‐CoV grows in a variety of tissues that express its receptor, although the mechanism for high replication in the lungs and severe respiratory illness is not well understood. We recently showed that elastase enhances SARS‐CoV infection in cultured cells, which suggests that SARS development may be due to elastase‐mediated, enhanced SARS‐CoV infection in the lungs. To explore this possibility, we examined whether co‐infection of mice with SARS‐CoV and <italic>Pp,</italic>
a low‐pathogenic bacterium which elicits elastase production in the lungs, induces exacerbation of pneumonia. Mice co‐infected with SARS‐CoV and <italic>Pp</italic>
developed severe respiratory disease with extensive weight loss, resulting in a 33∼90% mortality rate. Mice with exacerbated pneumonia showed enhanced virus infection in the lungs and histopathological lesions similar to those found in human SARS cases. Intranasal administration of LPS, another elastase inducer, showed an effect similar to that of <italic>Pp</italic>
infection. Thus, this study shows that exacerbated pneumonia in mice results from co‐infection with SARS‐CoV and a respiratory bacterium that induces elastase production in the lungs, suggesting a possible role for elastase in the exacerbation of pneumonia.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<pmc article-type="editorial"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Microbiol Immunol</journal-id>
<journal-id journal-id-type="iso-abbrev">Microbiol. Immunol</journal-id>
<journal-id journal-id-type="doi">10.1111/(ISSN)1348-0421</journal-id>
<journal-id journal-id-type="publisher-id">MIM</journal-id>
<journal-title-group><journal-title>Microbiology and Immunology</journal-title>
</journal-title-group>
<issn pub-type="ppub">0385-5600</issn>
<issn pub-type="epub">1348-0421</issn>
<publisher><publisher-name>Blackwell Publishing Asia</publisher-name>
<publisher-loc>Melbourne, Australia</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmc">7168413</article-id>
<article-id pub-id-type="doi">10.1111/j.1348-0421.2008.00011.x</article-id>
<article-id pub-id-type="publisher-id">MIM011</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Editor Communicated Papers</subject>
</subj-group>
</article-categories>
<title-group><article-title>Co‐infection of respiratory bacterium with severe acute respiratory syndrome coronavirus induces an exacerbated pneumonia in mice</article-title>
<alt-title alt-title-type="left-running-head">Y. Ami <italic>et al.</italic>
</alt-title>
<alt-title alt-title-type="right-running-head">Mouse SARS by SARS‐CoV and <italic>Pp</italic>
Infection</alt-title>
</title-group>
<contrib-group><contrib id="cr1" contrib-type="author"><name><surname>Ami</surname>
<given-names>Yasushi</given-names>
</name>
<xref ref-type="aff" rid="a1"><sup>1</sup>
</xref>
</contrib>
<contrib id="cr2" contrib-type="author"><name><surname>Nagata</surname>
<given-names>Noriyo</given-names>
</name>
<xref ref-type="aff" rid="a1"><sup>1</sup>
</xref>
</contrib>
<contrib id="cr3" contrib-type="author"><name><surname>Shirato</surname>
<given-names>Kazuya</given-names>
</name>
<xref ref-type="aff" rid="a1"><sup>1</sup>
</xref>
</contrib>
<contrib id="cr4" contrib-type="author"><name><surname>Watanabe</surname>
<given-names>Rie</given-names>
</name>
<xref ref-type="aff" rid="a1"><sup>1</sup>
</xref>
</contrib>
<contrib id="cr5" contrib-type="author"><name><surname>Iwata</surname>
<given-names>Naoko</given-names>
</name>
<xref ref-type="aff" rid="a1"><sup>1</sup>
</xref>
</contrib>
<contrib id="cr6" contrib-type="author"><name><surname>Nakagaki</surname>
<given-names>Keiko</given-names>
</name>
<xref ref-type="aff" rid="a1"><sup>1</sup>
</xref>
</contrib>
<contrib id="cr7" contrib-type="author"><name><surname>Fukushi</surname>
<given-names>Shuetsu</given-names>
</name>
<xref ref-type="aff" rid="a1"><sup>1</sup>
</xref>
</contrib>
<contrib id="cr8" contrib-type="author"><name><surname>Saijo</surname>
<given-names>Masayuki</given-names>
</name>
<xref ref-type="aff" rid="a1"><sup>1</sup>
</xref>
</contrib>
<contrib id="cr9" contrib-type="author"><name><surname>Morikawa</surname>
<given-names>Shigeru</given-names>
</name>
<xref ref-type="aff" rid="a1"><sup>1</sup>
</xref>
</contrib>
<contrib id="cr10" contrib-type="author"><name><surname>Taguchi</surname>
<given-names>Fumihiro</given-names>
</name>
<xref ref-type="aff" rid="a1"><sup>1</sup>
</xref>
</contrib>
</contrib-group>
<aff id="a1"><label><sup>1</sup>
</label>
National Institute of Infectious Diseases, Murayama Branch, 4‐7‐1 Gakuen, Musashi‐Murayama, Tokyo 208‐0011, Japan</aff>
<author-notes><corresp id="correspondenceTo"><bold>Correspondence</bold>
Fumihiro Taguchi, Department of Virology III, Division of Respiratory Virus Diseases, National Institute of Infectious Diseases, 4‐7‐1 Gakuen, Musashi‐Murayama, Tokyo 208‐0011, Japan. Tel: +81‐42‐561‐0771 (ext. 533); email: <email>ftaguchi@nih.go.jp</email>
</corresp>
</author-notes>
<pub-date pub-type="epub"><day>01</day>
<month>4</month>
<year>2008</year>
</pub-date>
<pub-date pub-type="ppub"><month>2</month>
<year>2008</year>
</pub-date>
<volume>52</volume>
<issue>2</issue>
<issue-id pub-id-type="doi">10.1111/mim.2008.52.issue-2</issue-id>
<fpage>118</fpage>
<lpage>127</lpage>
<history><pmc-comment>supplied string: Received: 4 December 2007; accepted: 6 December 2007</pmc-comment>
<date date-type="received"><day>4</day>
<month>12</month>
<year>2007</year>
</date>
<date date-type="accepted"><day>6</day>
<month>12</month>
<year>2007</year>
</date>
</history>
<permissions><copyright-statement content-type="article-copyright">©2008 The Societies and Blackwell Publishing Asia Pty Ltd</copyright-statement>
<license><license-p>This article is being made freely available through PubMed Central as part of the COVID-19 public health emergency response. It can be used for unrestricted research re-use and analysis in any form or by any means with acknowledgement of the original source, for the duration of the public health emergency.</license-p>
</license>
</permissions>
<self-uri content-type="pdf" xlink:href="file:MIM-52-118.pdf"></self-uri>
<abstract><title>ABSTRACT</title>
<p>SARS‐CoV grows in a variety of tissues that express its receptor, although the mechanism for high replication in the lungs and severe respiratory illness is not well understood. We recently showed that elastase enhances SARS‐CoV infection in cultured cells, which suggests that SARS development may be due to elastase‐mediated, enhanced SARS‐CoV infection in the lungs. To explore this possibility, we examined whether co‐infection of mice with SARS‐CoV and <italic>Pp,</italic>
a low‐pathogenic bacterium which elicits elastase production in the lungs, induces exacerbation of pneumonia. Mice co‐infected with SARS‐CoV and <italic>Pp</italic>
developed severe respiratory disease with extensive weight loss, resulting in a 33∼90% mortality rate. Mice with exacerbated pneumonia showed enhanced virus infection in the lungs and histopathological lesions similar to those found in human SARS cases. Intranasal administration of LPS, another elastase inducer, showed an effect similar to that of <italic>Pp</italic>
infection. Thus, this study shows that exacerbated pneumonia in mice results from co‐infection with SARS‐CoV and a respiratory bacterium that induces elastase production in the lungs, suggesting a possible role for elastase in the exacerbation of pneumonia.</p>
</abstract>
<kwd-group><kwd id="k1">coronavirus</kwd>
<kwd id="k2">elastase</kwd>
<kwd id="k3">mouse</kwd>
<kwd id="k4">SARS</kwd>
</kwd-group>
<counts><count count-type="links-crossref" count="78"></count>
<fig-count count="6"></fig-count>
<table-count count="0"></table-count>
<equation-count count="0"></equation-count>
<ref-count count="38"></ref-count>
<page-count count="10"></page-count>
</counts>
<custom-meta-group><custom-meta><meta-name>source-schema-version-number</meta-name>
<meta-value>2.0</meta-value>
</custom-meta>
<custom-meta><meta-name>cover-date</meta-name>
<meta-value>February 2008</meta-value>
</custom-meta>
<custom-meta><meta-name>details-of-publishers-convertor</meta-name>
<meta-value>Converter:WILEY_ML3GV2_TO_JATSPMC version:5.8.0 mode:remove_FC converted:15.04.2020</meta-value>
</custom-meta>
</custom-meta-group>
</article-meta>
</front>
</pmc>
<affiliations><list></list>
<tree><noCountry><name sortKey="Ami, Yasushi" sort="Ami, Yasushi" uniqKey="Ami Y" first="Yasushi" last="Ami">Yasushi Ami</name>
<name sortKey="Fukushi, Shuetsu" sort="Fukushi, Shuetsu" uniqKey="Fukushi S" first="Shuetsu" last="Fukushi">Shuetsu Fukushi</name>
<name sortKey="Iwata, Naoko" sort="Iwata, Naoko" uniqKey="Iwata N" first="Naoko" last="Iwata">Naoko Iwata</name>
<name sortKey="Morikawa, Shigeru" sort="Morikawa, Shigeru" uniqKey="Morikawa S" first="Shigeru" last="Morikawa">Shigeru Morikawa</name>
<name sortKey="Nagata, Noriyo" sort="Nagata, Noriyo" uniqKey="Nagata N" first="Noriyo" last="Nagata">Noriyo Nagata</name>
<name sortKey="Nakagaki, Keiko" sort="Nakagaki, Keiko" uniqKey="Nakagaki K" first="Keiko" last="Nakagaki">Keiko Nakagaki</name>
<name sortKey="Saijo, Masayuki" sort="Saijo, Masayuki" uniqKey="Saijo M" first="Masayuki" last="Saijo">Masayuki Saijo</name>
<name sortKey="Shirato, Kazuya" sort="Shirato, Kazuya" uniqKey="Shirato K" first="Kazuya" last="Shirato">Kazuya Shirato</name>
<name sortKey="Taguchi, Fumihiro" sort="Taguchi, Fumihiro" uniqKey="Taguchi F" first="Fumihiro" last="Taguchi">Fumihiro Taguchi</name>
<name sortKey="Watanabe, Rie" sort="Watanabe, Rie" uniqKey="Watanabe R" first="Rie" last="Watanabe">Rie Watanabe</name>
</noCountry>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/Pmc/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000E35 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Checkpoint/biblio.hfd -nk 000E35 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= SrasV1 |flux= Pmc |étape= Checkpoint |type= RBID |clé= PMC:7168413 |texte= Co‐infection of respiratory bacterium with severe acute respiratory syndrome coronavirus induces an exacerbated pneumonia in mice }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Checkpoint/RBID.i -Sk "pubmed:NONE" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Checkpoint/biblio.hfd \ | NlmPubMed2Wicri -a SrasV1
![]() | This area was generated with Dilib version V0.6.33. | ![]() |