Bilateral Entry and Release of Middle East Respiratory Syndrome Coronavirus Induces Profound Apoptosis of Human Bronchial Epithelial Cells
Identifieur interne : 000A06 ( Pmc/Checkpoint ); précédent : 000A05; suivant : 000A07Bilateral Entry and Release of Middle East Respiratory Syndrome Coronavirus Induces Profound Apoptosis of Human Bronchial Epithelial Cells
Auteurs : Xinrong Tao ; Terence E. Hill ; Chikao Morimoto ; Clarence J. Peters ; Thomas G. Ksiazek ; Chien-Te K. TsengSource :
- Journal of Virology [ 0022-538X ] ; 2013.
Abstract
The newly emerged Middle East respiratory syndrome coronavirus (MERS-CoV) infects human bronchial epithelial Calu-3 cells. Unlike severe acute respiratory syndrome (SARS)-CoV, which exclusively infects and releases through the apical route, this virus can do so through either side of polarized Calu-3 cells. Infection results in profound apoptosis within 24 h irrespective of its production of titers that are lower than those of SARS-CoV. Together, our results provide new insights into the dissemination and pathogenesis of MERS-CoV and may indicate that the virus differs markedly from SARS-CoV.
Url:
DOI: 10.1128/JVI.01562-13
PubMed: 23824802
PubMed Central: 3754134
Affiliations:
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<series><title level="j">Journal of Virology</title>
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<front><div type="abstract" xml:lang="en"><p>The newly emerged Middle East respiratory syndrome coronavirus (MERS-CoV) infects human bronchial epithelial Calu-3 cells. Unlike severe acute respiratory syndrome (SARS)-CoV, which exclusively infects and releases through the apical route, this virus can do so through either side of polarized Calu-3 cells. Infection results in profound apoptosis within 24 h irrespective of its production of titers that are lower than those of SARS-CoV. Together, our results provide new insights into the dissemination and pathogenesis of MERS-CoV and may indicate that the virus differs markedly from SARS-CoV.</p>
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<pmc article-type="brief-report"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Virol</journal-id>
<journal-id journal-id-type="iso-abbrev">J. Virol</journal-id>
<journal-id journal-id-type="hwp">jvi</journal-id>
<journal-id journal-id-type="pmc">jvi</journal-id>
<journal-id journal-id-type="publisher-id">JVI</journal-id>
<journal-title-group><journal-title>Journal of Virology</journal-title>
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<issn pub-type="ppub">0022-538X</issn>
<issn pub-type="epub">1098-5514</issn>
<publisher><publisher-name>American Society for Microbiology</publisher-name>
<publisher-loc>1752 N St., N.W., Washington, DC</publisher-loc>
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<article-meta><article-id pub-id-type="pmid">23824802</article-id>
<article-id pub-id-type="pmc">3754134</article-id>
<article-id pub-id-type="publisher-id">01562-13</article-id>
<article-id pub-id-type="doi">10.1128/JVI.01562-13</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Virus-Cell Interactions</subject>
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<title-group><article-title>Bilateral Entry and Release of Middle East Respiratory Syndrome Coronavirus Induces Profound Apoptosis of Human Bronchial Epithelial Cells</article-title>
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<contrib-group><contrib contrib-type="author"><name><surname>Tao</surname>
<given-names>Xinrong</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>a</sup>
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<contrib contrib-type="author"><name><surname>Hill</surname>
<given-names>Terence E.</given-names>
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<xref ref-type="aff" rid="aff1"><sup>a</sup>
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<contrib contrib-type="author"><name><surname>Morimoto</surname>
<given-names>Chikao</given-names>
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<xref ref-type="aff" rid="aff4"><sup>d</sup>
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<contrib contrib-type="author"><name><surname>Peters</surname>
<given-names>Clarence J.</given-names>
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<xref ref-type="aff" rid="aff1"><sup>a</sup>
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<xref ref-type="aff" rid="aff3"><sup>c</sup>
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<contrib contrib-type="author"><name><surname>Ksiazek</surname>
<given-names>Thomas G.</given-names>
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<xref ref-type="aff" rid="aff2"><sup>b</sup>
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<contrib contrib-type="author" corresp="yes"><name><surname>Tseng</surname>
<given-names>Chien-Te K.</given-names>
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<xref ref-type="aff" rid="aff1"><sup>a</sup>
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<xref ref-type="aff" rid="aff3"><sup>c</sup>
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<aff id="aff1">Departments of Microbiology and Immunology<label>a</label>
</aff>
<aff id="aff2">Pathology<label>b</label>
</aff>
<aff id="aff3">Center for Biodefense and Emerging Infectious Disease,<label>c</label>
University of Texas Medical Branch, Galveston, Texas</aff>
<aff id="aff4">Department of Therapy Development and Innovation for Immune Diseases and Cancer, Juntendo University, Tokyo, Japan<label>d</label>
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<author-notes><corresp id="cor1">Address correspondence to Chien-Te K. Tseng, <email>sktseng@utmb.edu</email>
.</corresp>
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<pub-date pub-type="ppub"><month>9</month>
<year>2013</year>
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<volume>87</volume>
<issue>17</issue>
<fpage>9953</fpage>
<lpage>9958</lpage>
<history><date date-type="received"><day>27</day>
<month>6</month>
<year>2013</year>
</date>
<date date-type="accepted"><day>27</day>
<month>6</month>
<year>2013</year>
</date>
</history>
<permissions><copyright-statement>Copyright © 2013, American Society for Microbiology. All Rights Reserved.</copyright-statement>
<copyright-year>2013</copyright-year>
<copyright-holder>American Society for Microbiology</copyright-holder>
</permissions>
<self-uri xlink:title="pdf" xlink:type="simple" xlink:href="zjv01713009953.pdf"></self-uri>
<abstract><p>The newly emerged Middle East respiratory syndrome coronavirus (MERS-CoV) infects human bronchial epithelial Calu-3 cells. Unlike severe acute respiratory syndrome (SARS)-CoV, which exclusively infects and releases through the apical route, this virus can do so through either side of polarized Calu-3 cells. Infection results in profound apoptosis within 24 h irrespective of its production of titers that are lower than those of SARS-CoV. Together, our results provide new insights into the dissemination and pathogenesis of MERS-CoV and may indicate that the virus differs markedly from SARS-CoV.</p>
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<name sortKey="Ksiazek, Thomas G" sort="Ksiazek, Thomas G" uniqKey="Ksiazek T" first="Thomas G." last="Ksiazek">Thomas G. Ksiazek</name>
<name sortKey="Morimoto, Chikao" sort="Morimoto, Chikao" uniqKey="Morimoto C" first="Chikao" last="Morimoto">Chikao Morimoto</name>
<name sortKey="Peters, Clarence J" sort="Peters, Clarence J" uniqKey="Peters C" first="Clarence J." last="Peters">Clarence J. Peters</name>
<name sortKey="Tao, Xinrong" sort="Tao, Xinrong" uniqKey="Tao X" first="Xinrong" last="Tao">Xinrong Tao</name>
<name sortKey="Tseng, Chien Te K" sort="Tseng, Chien Te K" uniqKey="Tseng C" first="Chien-Te K." last="Tseng">Chien-Te K. Tseng</name>
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