Broad reception for coronavirus
Identifieur interne : 000A05 ( Pmc/Checkpoint ); précédent : 000A04; suivant : 000A06Broad reception for coronavirus
Auteurs : Tom Gallagher ; Stanley PerlmanSource :
- Nature [ 0028-0836 ] ; 2013.
Abstract
The discovery that a new coronavirus associated with lethal respiratory infections binds to an evolutionarily conserved receptor on airway cells suggests that direct transmission from bats to humans may occur.
Url:
DOI: 10.1038/495176a
PubMed: 23486053
PubMed Central: 7095116
Affiliations:
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PMC:7095116Le document en format XML
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sortKey="Van Boheemen, S" uniqKey="Van Boheemen S">S van Boheemen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kindler, E" uniqKey="Kindler E">E Kindler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Reguera, J" uniqKey="Reguera J">J Reguera</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, F" uniqKey="Li F">F Li</name></author><author><name sortKey="Li, W" uniqKey="Li W">W Li</name></author><author><name sortKey="Farzan, M" uniqKey="Farzan M">M Farzan</name></author><author><name sortKey="Harrison, Sc" uniqKey="Harrison S">SC Harrison</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kuba, K" uniqKey="Kuba K">K Kuba</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ansorge, S" uniqKey="Ansorge S">S Ansorge</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="brief-report"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Nature</journal-id><journal-id journal-id-type="iso-abbrev">Nature</journal-id><journal-title-group><journal-title>Nature</journal-title></journal-title-group><issn pub-type="ppub">0028-0836</issn><issn pub-type="epub">1476-4687</issn><publisher><publisher-name>Nature Publishing Group UK</publisher-name><publisher-loc>London</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">23486053</article-id><article-id pub-id-type="pmc">7095116</article-id><article-id pub-id-type="publisher-id">BF495176a</article-id><article-id pub-id-type="doi">10.1038/495176a</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Broad reception for coronavirus</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Gallagher</surname><given-names>Tom</given-names></name><address><email>tgallag@lumc.edu</email></address><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Perlman</surname><given-names>Stanley</given-names></name><address><email>stanley-perlman@uiowa.edu</email></address><xref ref-type="aff" rid="Aff2">2</xref></contrib><aff id="Aff1"><label>1</label><institution-wrap><institution-id institution-id-type="GRID">grid.411451.4</institution-id><institution-id institution-id-type="ISNI">0000 0001 2215 0876</institution-id><institution>Tom Gallagher is in the Department of Microbiology and Immunology,</institution><institution>Loyola University Medical Center, Maywood, Illinois 60153, USA.,</institution></institution-wrap>,</aff><aff id="Aff2"><label>2</label><institution-wrap><institution-id institution-id-type="GRID">grid.214572.7</institution-id><institution-id institution-id-type="ISNI">0000 0004 1936 8294</institution-id><institution>Stanley Perlman is in the Department of Microbiology,</institution><institution>University of Iowa, Iowa City, Iowa 52242, USA.,</institution></institution-wrap>,</aff></contrib-group><pub-date pub-type="epub"><day>13</day><month>3</month><year>2013</year></pub-date><pub-date pub-type="ppub"><year>2013</year></pub-date><volume>495</volume><issue>7440</issue><fpage>176</fpage><lpage>177</lpage><permissions><copyright-statement>© Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. 2013</copyright-statement><license><license-p>This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.</license-p></license></permissions><abstract id="Abs1" abstract-type="Standfirst"><p id="Par1">The discovery that a new coronavirus associated with lethal respiratory infections binds to an evolutionarily conserved receptor on airway cells suggests that direct transmission from bats to humans may occur. <bold>See Letter </bold><ext-link ext-link-type="uri" xlink:href="https://www.nature.com/articles/nature12005">p.251</ext-link></p></abstract><abstract id="Abs2" abstract-type="LongSummary"><title>Human receptor for emerging coronavirus</title><p id="Par2">The emerging pathogenic coronavirus hCoV-EMC, first identified in September 2012, has been fatal in about half of the few humans infected so far. Bart Haagmans and colleagues have now identified the receptor that this virus uses to infect cells. In contrast to the related virus SARS-CoV, which uses angiotensin converting enzyme 2, the functional receptor for hCoV-EMC is dipeptidyl peptidase 4 (DPP4, also known as CD26), an exopeptidase found on non-ciliated cells in the lower respiratory tract. This enzyme is highly conserved across different species, and hCoV-EMC can also use bat DPP4 as a functional receptor — a possible clue as to the host range and epidemiological history of this new virus. The findings may also be important for the development of intervention strategies.</p></abstract><kwd-group kwd-group-type="npg-subject"><title>Subject terms</title><kwd>Virology</kwd><kwd>Diseases</kwd><kwd>Epidemiology</kwd></kwd-group><custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name><meta-value>© Springer Nature Limited 2013</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc><affiliations><list></list><tree><noCountry><name sortKey="Gallagher, Tom" sort="Gallagher, Tom" uniqKey="Gallagher T" first="Tom" last="Gallagher">Tom Gallagher</name><name sortKey="Perlman, Stanley" sort="Perlman, Stanley" uniqKey="Perlman S" first="Stanley" last="Perlman">Stanley Perlman</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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