Coronavirus reverse genetic systems: Infectious clones and replicons
Identifieur interne : 000912 ( Pmc/Checkpoint ); précédent : 000911; suivant : 000913Coronavirus reverse genetic systems: Infectious clones and replicons
Auteurs : Fernando Almazán ; Isabel Sola ; Sonia Zu Iga ; Silvia Marquez-Jurado ; Lucia Morales ; Martina Becares ; Luis EnjuanesSource :
- Virus Research [ 0168-1702 ] ; 2014.
Abstract
The four different reverse genetic systems developed for CoVs are reviewed and discussed. These systems were based on the use of BACs, in vitro ligation and vaccinia virus as a vector. CoV reverse genetics is an essential tool for the study of CoV replication, virus–host interaction and pathogenesis. These reverse genetic systems allow the development of genetically defined vaccines and the analysis of antiviral drugs.
Url:
DOI: 10.1016/j.virusres.2014.05.026
PubMed: 24930446
PubMed Central: 4727449
Affiliations:
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PMC:4727449Le document en format XML
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<author><name sortKey="Sola, Isabel" sort="Sola, Isabel" uniqKey="Sola I" first="Isabel" last="Sola">Isabel Sola</name>
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<author><name sortKey="Zu Iga, Sonia" sort="Zu Iga, Sonia" uniqKey="Zu Iga S" first="Sonia" last="Zu Iga">Sonia Zu Iga</name>
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<author><name sortKey="Marquez Jurado, Silvia" sort="Marquez Jurado, Silvia" uniqKey="Marquez Jurado S" first="Silvia" last="Marquez-Jurado">Silvia Marquez-Jurado</name>
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<author><name sortKey="Morales, Lucia" sort="Morales, Lucia" uniqKey="Morales L" first="Lucia" last="Morales">Lucia Morales</name>
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<author><name sortKey="Becares, Martina" sort="Becares, Martina" uniqKey="Becares M" first="Martina" last="Becares">Martina Becares</name>
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<author><name sortKey="Enjuanes, Luis" sort="Enjuanes, Luis" uniqKey="Enjuanes L" first="Luis" last="Enjuanes">Luis Enjuanes</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Coronavirus reverse genetic systems: Infectious clones and replicons</title>
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<author><name sortKey="Sola, Isabel" sort="Sola, Isabel" uniqKey="Sola I" first="Isabel" last="Sola">Isabel Sola</name>
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<author><name sortKey="Zu Iga, Sonia" sort="Zu Iga, Sonia" uniqKey="Zu Iga S" first="Sonia" last="Zu Iga">Sonia Zu Iga</name>
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<author><name sortKey="Marquez Jurado, Silvia" sort="Marquez Jurado, Silvia" uniqKey="Marquez Jurado S" first="Silvia" last="Marquez-Jurado">Silvia Marquez-Jurado</name>
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<author><name sortKey="Morales, Lucia" sort="Morales, Lucia" uniqKey="Morales L" first="Lucia" last="Morales">Lucia Morales</name>
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<author><name sortKey="Becares, Martina" sort="Becares, Martina" uniqKey="Becares M" first="Martina" last="Becares">Martina Becares</name>
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<series><title level="j">Virus Research</title>
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<front><div type="abstract" xml:lang="en"><title>Highlights</title>
<p><list list-type="simple" id="lis0005"><list-item id="lsti0005"><label>•</label>
<p id="par0005">The four different reverse genetic systems developed for CoVs are reviewed and discussed.</p>
</list-item>
<list-item id="lsti0010"><label>•</label>
<p id="par0010">These systems were based on the use of BACs, in vitro ligation and vaccinia virus as a vector.</p>
</list-item>
<list-item id="lsti0015"><label>•</label>
<p id="par0015">CoV reverse genetics is an essential tool for the study of CoV replication, virus–host interaction and pathogenesis.</p>
</list-item>
<list-item id="lsti0020"><label>•</label>
<p id="par0020">These reverse genetic systems allow the development of genetically defined vaccines and the analysis of antiviral drugs.</p>
</list-item>
</list>
</p>
</div>
</front>
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</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y. Zhang</name>
</author>
<author><name sortKey="Buchholz, F" uniqKey="Buchholz F">F. Buchholz</name>
</author>
<author><name sortKey="Muyrers, J P P" uniqKey="Muyrers J">J.P.P. Muyrers</name>
</author>
<author><name sortKey="Stewart, A F" uniqKey="Stewart A">A.F. Stewart</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ziebuhr, J" uniqKey="Ziebuhr J">J. Ziebuhr</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zimmer, G" uniqKey="Zimmer G">G. Zimmer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zu Iga, S" uniqKey="Zu Iga S">S. Zuñiga</name>
</author>
<author><name sortKey="Cruz, J L" uniqKey="Cruz J">J.L. Cruz</name>
</author>
<author><name sortKey="Sola, I" uniqKey="Sola I">I. Sola</name>
</author>
<author><name sortKey="Mateos Gomez, P A" uniqKey="Mateos Gomez P">P.A. Mateos-Gomez</name>
</author>
<author><name sortKey="Palacio, L" uniqKey="Palacio L">L. Palacio</name>
</author>
<author><name sortKey="Enjuanes, L" uniqKey="Enjuanes L">L. Enjuanes</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Virus Res</journal-id>
<journal-id journal-id-type="iso-abbrev">Virus Res</journal-id>
<journal-title-group><journal-title>Virus Research</journal-title>
</journal-title-group>
<issn pub-type="ppub">0168-1702</issn>
<issn pub-type="epub">1872-7492</issn>
<publisher><publisher-name>Elsevier B.V.</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">24930446</article-id>
<article-id pub-id-type="pmc">4727449</article-id>
<article-id pub-id-type="publisher-id">S0168-1702(14)00240-8</article-id>
<article-id pub-id-type="doi">10.1016/j.virusres.2014.05.026</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Coronavirus reverse genetic systems: Infectious clones and replicons</article-title>
</title-group>
<contrib-group><contrib contrib-type="author" id="aut0005"><name><surname>Almazán</surname>
<given-names>Fernando</given-names>
</name>
</contrib>
<contrib contrib-type="author" id="aut0010"><name><surname>Sola</surname>
<given-names>Isabel</given-names>
</name>
</contrib>
<contrib contrib-type="author" id="aut0015"><name><surname>Zuñiga</surname>
<given-names>Sonia</given-names>
</name>
</contrib>
<contrib contrib-type="author" id="aut0020"><name><surname>Marquez-Jurado</surname>
<given-names>Silvia</given-names>
</name>
</contrib>
<contrib contrib-type="author" id="aut0025"><name><surname>Morales</surname>
<given-names>Lucia</given-names>
</name>
</contrib>
<contrib contrib-type="author" id="aut0030"><name><surname>Becares</surname>
<given-names>Martina</given-names>
</name>
</contrib>
<contrib contrib-type="author" id="aut0035"><name><surname>Enjuanes</surname>
<given-names>Luis</given-names>
</name>
<email>L.Enjuanes@cnb.csic.es</email>
<xref rid="cor0005" ref-type="corresp">⁎</xref>
</contrib>
</contrib-group>
<aff id="aff0005">Department of Molecular and Cell Biology. Centro Nacional de Biotecnología (CNB-CSIC), Campus Universidad Autónoma de Madrid, C/ Darwin 3, Cantoblanco, 28049 Madrid, Spain</aff>
<author-notes><corresp id="cor0005"><label>⁎</label>
Corresponding author. Tel.: +34 915854555; fax: +34 915854506. <email>L.Enjuanes@cnb.csic.es</email>
</corresp>
</author-notes>
<pub-date pub-type="pmc-release"><day>12</day>
<month>6</month>
<year>2014</year>
</pub-date>
<pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="ppub"><day>30</day>
<month>8</month>
<year>2014</year>
</pub-date>
<pub-date pub-type="epub"><day>12</day>
<month>6</month>
<year>2014</year>
</pub-date>
<volume>189</volume>
<fpage>262</fpage>
<lpage>270</lpage>
<permissions><copyright-statement>Copyright © 2014 Elsevier B.V. All rights reserved.</copyright-statement>
<copyright-year>2014</copyright-year>
<copyright-holder>Elsevier B.V.</copyright-holder>
<license><license-p>Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.</license-p>
</license>
</permissions>
<abstract abstract-type="author-highlights" id="abs0005"><title>Highlights</title>
<p><list list-type="simple" id="lis0005"><list-item id="lsti0005"><label>•</label>
<p id="par0005">The four different reverse genetic systems developed for CoVs are reviewed and discussed.</p>
</list-item>
<list-item id="lsti0010"><label>•</label>
<p id="par0010">These systems were based on the use of BACs, in vitro ligation and vaccinia virus as a vector.</p>
</list-item>
<list-item id="lsti0015"><label>•</label>
<p id="par0015">CoV reverse genetics is an essential tool for the study of CoV replication, virus–host interaction and pathogenesis.</p>
</list-item>
<list-item id="lsti0020"><label>•</label>
<p id="par0020">These reverse genetic systems allow the development of genetically defined vaccines and the analysis of antiviral drugs.</p>
</list-item>
</list>
</p>
</abstract>
<abstract id="abs0010"><p>Coronaviruses (CoVs) infect humans and many animal species, and are associated with respiratory, enteric, hepatic, and central nervous system diseases. The large size of the CoV genome and the instability of some CoV replicase gene sequences during its propagation in bacteria, represent serious obstacles for the development of reverse genetic systems similar to those used for smaller positive sense RNA viruses. To overcome these limitations, several alternatives to more conventional plasmid-based approaches have been established in the last 13 years. In this report, we briefly review and discuss the different reverse genetic systems developed for CoVs, paying special attention to the severe acute respiratory syndrome CoV (SARS-CoV).</p>
</abstract>
<kwd-group id="kwd0005"><title>Keywords</title>
<kwd>Coronavirus</kwd>
<kwd>Reverse genetics</kwd>
<kwd>Infectious clones</kwd>
<kwd>Replicons</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
<affiliations><list></list>
<tree><noCountry><name sortKey="Almazan, Fernando" sort="Almazan, Fernando" uniqKey="Almazan F" first="Fernando" last="Almazán">Fernando Almazán</name>
<name sortKey="Becares, Martina" sort="Becares, Martina" uniqKey="Becares M" first="Martina" last="Becares">Martina Becares</name>
<name sortKey="Enjuanes, Luis" sort="Enjuanes, Luis" uniqKey="Enjuanes L" first="Luis" last="Enjuanes">Luis Enjuanes</name>
<name sortKey="Marquez Jurado, Silvia" sort="Marquez Jurado, Silvia" uniqKey="Marquez Jurado S" first="Silvia" last="Marquez-Jurado">Silvia Marquez-Jurado</name>
<name sortKey="Morales, Lucia" sort="Morales, Lucia" uniqKey="Morales L" first="Lucia" last="Morales">Lucia Morales</name>
<name sortKey="Sola, Isabel" sort="Sola, Isabel" uniqKey="Sola I" first="Isabel" last="Sola">Isabel Sola</name>
<name sortKey="Zu Iga, Sonia" sort="Zu Iga, Sonia" uniqKey="Zu Iga S" first="Sonia" last="Zu Iga">Sonia Zu Iga</name>
</noCountry>
</tree>
</affiliations>
</record>
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