COVID-19: Knowns, Unknowns, and Questions
Identifieur interne : 000359 ( Pmc/Checkpoint ); précédent : 000358; suivant : 000360COVID-19: Knowns, Unknowns, and Questions
Auteurs : Stuart Weston [États-Unis] ; Matthew B. Frieman [États-Unis]Source :
- mSphere [ 2379-5042 ] ; 2020.
Abstract
The recent emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from the Hubei province in China in late 2019 demonstrates the epidemic potential of coronaviruses. The rapid spread of this virus across the world in only 2 months highlights the transmissibility of this family of viruses and the significant morbidity and mortality that they can cause. We highlight the current state of knowledge of coronavirus biology while answering questions concerning the current outbreak of SARS-CoV-2.
Url:
DOI: 10.1128/mSphere.00203-20
PubMed: 32188753
PubMed Central: 7082143
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">COVID-19: Knowns, Unknowns, and Questions</title><author><name sortKey="Weston, Stuart" sort="Weston, Stuart" uniqKey="Weston S" first="Stuart" last="Weston">Stuart Weston</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Frieman, Matthew B" sort="Frieman, Matthew B" uniqKey="Frieman M" first="Matthew B." last="Frieman">Matthew B. Frieman</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">32188753</idno><idno type="pmc">7082143</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7082143</idno><idno type="RBID">PMC:7082143</idno><idno type="doi">10.1128/mSphere.00203-20</idno><date when="2020">2020</date><idno type="wicri:Area/Pmc/Corpus">000798</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000798</idno><idno type="wicri:Area/Pmc/Curation">000798</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000798</idno><idno type="wicri:Area/Pmc/Checkpoint">000359</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000359</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">COVID-19: Knowns, Unknowns, and Questions</title><author><name sortKey="Weston, Stuart" sort="Weston, Stuart" uniqKey="Weston S" first="Stuart" last="Weston">Stuart Weston</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Frieman, Matthew B" sort="Frieman, Matthew B" uniqKey="Frieman M" first="Matthew B." last="Frieman">Matthew B. Frieman</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author></analytic><series><title level="j">mSphere</title><idno type="eISSN">2379-5042</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The recent emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from the Hubei province in China in late 2019 demonstrates the epidemic potential of coronaviruses. The rapid spread of this virus across the world in only 2 months highlights the transmissibility of this family of viruses and the significant morbidity and mortality that they can cause. We highlight the current state of knowledge of coronavirus biology while answering questions concerning the current outbreak of SARS-CoV-2.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="De Wit, E" uniqKey="De Wit E">E de Wit</name></author><author><name sortKey="Van Doremalen, N" uniqKey="Van Doremalen N">N van Doremalen</name></author><author><name sortKey="Falzarano, D" uniqKey="Falzarano D">D Falzarano</name></author><author><name sortKey="Munster, Vj" uniqKey="Munster V">VJ Munster</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gralinski, Le" uniqKey="Gralinski L">LE Gralinski</name></author><author><name sortKey="Menachery, Vd" uniqKey="Menachery V">VD Menachery</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhou, P" uniqKey="Zhou P">P Zhou</name></author><author><name sortKey="Yang, X L" uniqKey="Yang X">X-L Yang</name></author><author><name sortKey="Wang, X G" uniqKey="Wang X">X-G Wang</name></author><author><name sortKey="Hu, B" uniqKey="Hu B">B Hu</name></author><author><name sortKey="Zhang, L" uniqKey="Zhang L">L Zhang</name></author><author><name sortKey="Zhang, W" uniqKey="Zhang W">W Zhang</name></author><author><name sortKey="Si, H R" uniqKey="Si H">H-R Si</name></author><author><name sortKey="Zhu, Y" uniqKey="Zhu Y">Y Zhu</name></author><author><name sortKey="Li, B" uniqKey="Li B">B Li</name></author><author><name sortKey="Huang, C L" uniqKey="Huang C">C-L Huang</name></author><author><name sortKey="Chen, H D" uniqKey="Chen H">H-D Chen</name></author><author><name sortKey="Chen, J" uniqKey="Chen J">J Chen</name></author><author><name sortKey="Luo, Y" uniqKey="Luo Y">Y Luo</name></author><author><name sortKey="Guo, H" uniqKey="Guo H">H Guo</name></author><author><name sortKey="Jiang, R D" uniqKey="Jiang R">R-D Jiang</name></author><author><name sortKey="Liu, M Q" uniqKey="Liu M">M-Q Liu</name></author><author><name sortKey="Chen, Y" uniqKey="Chen Y">Y Chen</name></author><author><name sortKey="Shen, X R" uniqKey="Shen X">X-R Shen</name></author><author><name sortKey="Wang, X" uniqKey="Wang X">X Wang</name></author><author><name sortKey="Zheng, X S" uniqKey="Zheng X">X-S Zheng</name></author><author><name sortKey="Zhao, K" uniqKey="Zhao K">K Zhao</name></author><author><name sortKey="Chen, Q J" uniqKey="Chen Q">Q-J Chen</name></author><author><name sortKey="Deng, F" uniqKey="Deng F">F Deng</name></author><author><name sortKey="Liu, L L" uniqKey="Liu L">L-L Liu</name></author><author><name sortKey="Yan, B" uniqKey="Yan B">B Yan</name></author><author><name sortKey="Zhan, F X" uniqKey="Zhan F">F-X Zhan</name></author><author><name sortKey="Wang, Y Y" uniqKey="Wang Y">Y-Y Wang</name></author><author><name sortKey="Xiao, G" uniqKey="Xiao G">G Xiao</name></author><author><name sortKey="Shi, Z L" uniqKey="Shi Z">Z-L Shi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, W" uniqKey="Li W">W Li</name></author><author><name sortKey="Moore, Mj" uniqKey="Moore M">MJ Moore</name></author><author><name sortKey="Vasilieva, N" uniqKey="Vasilieva N">N Vasilieva</name></author><author><name sortKey="Sui, J" uniqKey="Sui J">J Sui</name></author><author><name sortKey="Wong, Sk" uniqKey="Wong S">SK Wong</name></author><author><name sortKey="Berne, Ma" uniqKey="Berne M">MA Berne</name></author><author><name sortKey="Somasundaran, M" uniqKey="Somasundaran M">M Somasundaran</name></author><author><name sortKey="Sullivan, Jl" uniqKey="Sullivan J">JL Sullivan</name></author><author><name sortKey="Luzuriaga, K" uniqKey="Luzuriaga K">K Luzuriaga</name></author><author><name sortKey="Greenough, Tc" uniqKey="Greenough T">TC Greenough</name></author><author><name sortKey="Choe, H" uniqKey="Choe H">H Choe</name></author><author><name sortKey="Farzan, M" uniqKey="Farzan M">M Farzan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liu, Y" uniqKey="Liu Y">Y Liu</name></author><author><name sortKey="Gayle, Aa" uniqKey="Gayle A">AA Gayle</name></author><author><name sortKey="Wilder Smith, A" uniqKey="Wilder Smith A">A Wilder-Smith</name></author><author><name sortKey="Rocklov, J" uniqKey="Rocklov J">J Rocklöv</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y Zhang</name></author><author><name sortKey="Chen, C" uniqKey="Chen C">C Chen</name></author><author><name sortKey="Zhu, S" uniqKey="Zhu S">S Zhu</name></author><author><name sortKey="Shu, C" uniqKey="Shu C">C Shu</name></author><author><name sortKey="Wang, D" uniqKey="Wang D">D Wang</name></author><author><name sortKey="Song, J" uniqKey="Song J">J Song</name></author><author><name sortKey="Song, Y" uniqKey="Song Y">Y Song</name></author><author><name sortKey="Zhen, W" uniqKey="Zhen W">W Zhen</name></author><author><name sortKey="Zijian, F" uniqKey="Zijian F">F Zijian</name></author><author><name sortKey="Wu, G" uniqKey="Wu G">G Wu</name></author><author><name sortKey="Xu, J" uniqKey="Xu J">J Xu</name></author><author><name sortKey="Xu, W" uniqKey="Xu W">W Xu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tsan Yuk Lam, T" uniqKey="Tsan Yuk Lam T">T Tsan-Yuk Lam</name></author><author><name sortKey="Ho Hin Shum, M" uniqKey="Ho Hin Shum M">M Ho-Hin Shum</name></author><author><name sortKey="Zhu, H C" uniqKey="Zhu H">H-C Zhu</name></author><author><name sortKey="Tong, Y G" uniqKey="Tong Y">Y-G Tong</name></author><author><name sortKey="Ni, B" uniqKey="Ni B">B Ni</name></author><author><name sortKey="Liao, Y S" uniqKey="Liao Y">Y-S Liao</name></author><author><name sortKey="Wei, W" uniqKey="Wei W">W Wei</name></author><author><name sortKey="Yiu Man Cheung, W" uniqKey="Yiu Man Cheung W">W Yiu-Man Cheung</name></author><author><name sortKey="Li, W J" uniqKey="Li W">W-J Li</name></author><author><name sortKey="Leung, Gm" uniqKey="Leung G">GM Leung</name></author><author><name sortKey="Holmes, Ec" uniqKey="Holmes E">EC Holmes</name></author><author><name sortKey="Hu, Y L" uniqKey="Hu Y">Y-L Hu</name></author><author><name sortKey="Guan, Y" uniqKey="Guan Y">Y Guan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Haagmans, Bl" uniqKey="Haagmans B">BL Haagmans</name></author><author><name sortKey="Van Den Brand, Jma" uniqKey="Van Den Brand J">JMA Van Den Brand</name></author><author><name sortKey="Raj, Vs" uniqKey="Raj V">VS Raj</name></author><author><name sortKey="Volz, A" uniqKey="Volz A">A Volz</name></author><author><name sortKey="Wohlsein, P" uniqKey="Wohlsein P">P Wohlsein</name></author><author><name sortKey="Smits, Sl" uniqKey="Smits S">SL Smits</name></author><author><name sortKey="Schipper, D" uniqKey="Schipper D">D Schipper</name></author><author><name sortKey="Bestebroer, Tm" uniqKey="Bestebroer T">TM Bestebroer</name></author><author><name sortKey="Okba, N" uniqKey="Okba N">N Okba</name></author><author><name sortKey="Fux, R" uniqKey="Fux R">R Fux</name></author><author><name sortKey="Bensaid, A" uniqKey="Bensaid A">A Bensaid</name></author><author><name sortKey="Foz, Ds" uniqKey="Foz D">DS Foz</name></author><author><name sortKey="Kuiken, T" uniqKey="Kuiken T">T Kuiken</name></author><author><name sortKey="Baumg Rtner, W" uniqKey="Baumg Rtner W">W Baumgärtner</name></author><author><name sortKey="Segales, J" uniqKey="Segales J">J Segalés</name></author><author><name sortKey="Sutter, G" uniqKey="Sutter G">G Sutter</name></author><author><name sortKey="Osterhaus, A" uniqKey="Osterhaus A">A Osterhaus</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Alharbi, Nk" uniqKey="Alharbi N">NK Alharbi</name></author><author><name sortKey="Qasim, I" uniqKey="Qasim I">I Qasim</name></author><author><name sortKey="Almasoud, A" uniqKey="Almasoud A">A Almasoud</name></author><author><name sortKey="Aljami, Ha" uniqKey="Aljami H">HA Aljami</name></author><author><name sortKey="Alenazi, Mw" uniqKey="Alenazi M">MW Alenazi</name></author><author><name sortKey="Alhafufi, A" uniqKey="Alhafufi A">A Alhafufi</name></author><author><name sortKey="Aldibasi, Os" uniqKey="Aldibasi O">OS Aldibasi</name></author><author><name sortKey="Hashem, Am" uniqKey="Hashem A">AM Hashem</name></author><author><name sortKey="Kasem, S" uniqKey="Kasem S">S Kasem</name></author><author><name sortKey="Albrahim, R" uniqKey="Albrahim R">R Albrahim</name></author><author><name sortKey="Aldubaib, M" uniqKey="Aldubaib M">M Aldubaib</name></author><author><name sortKey="Almansour, A" uniqKey="Almansour A">A Almansour</name></author><author><name sortKey="Temperton, Nj" uniqKey="Temperton N">NJ Temperton</name></author><author><name sortKey="Kupke, A" uniqKey="Kupke A">A Kupke</name></author><author><name sortKey="Becker, S" uniqKey="Becker S">S Becker</name></author><author><name sortKey="Abu Obaidah, A" uniqKey="Abu Obaidah A">A Abu-Obaidah</name></author><author><name sortKey="Alkarar, A" uniqKey="Alkarar A">A Alkarar</name></author><author><name sortKey="Yoon, Ik" uniqKey="Yoon I">IK Yoon</name></author><author><name sortKey="Azhar, E" uniqKey="Azhar E">E Azhar</name></author><author><name sortKey="Lambe, T" uniqKey="Lambe T">T Lambe</name></author><author><name sortKey="Bayoumi, F" uniqKey="Bayoumi F">F Bayoumi</name></author><author><name sortKey="Aldowerij, A" uniqKey="Aldowerij A">A Aldowerij</name></author><author><name sortKey="Ibrahim, Oh" uniqKey="Ibrahim O">OH Ibrahim</name></author><author><name sortKey="Gilbert, Sc" uniqKey="Gilbert S">SC Gilbert</name></author><author><name sortKey="Balkhy, Hh" uniqKey="Balkhy H">HH Balkhy</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Imai, N" uniqKey="Imai N">N Imai</name></author><author><name sortKey="Dorigatti, I" uniqKey="Dorigatti I">I Dorigatti</name></author><author><name sortKey="Cori, A" uniqKey="Cori A">A Cori</name></author><author><name sortKey="Donnelly, C" uniqKey="Donnelly C">C Donnelly</name></author><author><name sortKey="Riley, S" uniqKey="Riley S">S Riley</name></author><author><name sortKey="Ferguson, Nm" uniqKey="Ferguson N">NM Ferguson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Roberts, A" uniqKey="Roberts A">A Roberts</name></author><author><name sortKey="Paddock, C" uniqKey="Paddock C">C Paddock</name></author><author><name sortKey="Vogel, L" uniqKey="Vogel L">L Vogel</name></author><author><name sortKey="Butler, E" uniqKey="Butler E">E Butler</name></author><author><name sortKey="Zaki, S" uniqKey="Zaki S">S Zaki</name></author><author><name sortKey="Subbarao, K" uniqKey="Subbarao K">K Subbarao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Frieman, M" uniqKey="Frieman M">M Frieman</name></author><author><name sortKey="Yount, B" uniqKey="Yount B">B Yount</name></author><author><name sortKey="Agnihothram, S" uniqKey="Agnihothram S">S Agnihothram</name></author><author><name sortKey="Page, C" uniqKey="Page C">C Page</name></author><author><name sortKey="Donaldson, E" uniqKey="Donaldson E">E Donaldson</name></author><author><name sortKey="Roberts, A" uniqKey="Roberts A">A Roberts</name></author><author><name sortKey="Vogel, L" uniqKey="Vogel L">L Vogel</name></author><author><name sortKey="Woodruff, B" uniqKey="Woodruff B">B Woodruff</name></author><author><name sortKey="Scorpio, D" uniqKey="Scorpio D">D Scorpio</name></author><author><name sortKey="Subbarao, K" uniqKey="Subbarao K">K Subbarao</name></author><author><name sortKey="Baric, Rs" uniqKey="Baric R">RS Baric</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, J" uniqKey="Chen J">J Chen</name></author><author><name sortKey="Subbarao, K" uniqKey="Subbarao K">K Subbarao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Matsuyama, R" uniqKey="Matsuyama R">R Matsuyama</name></author><author><name sortKey="Nishiura, H" uniqKey="Nishiura H">H Nishiura</name></author><author><name sortKey="Kutsuna, S" uniqKey="Kutsuna S">S Kutsuna</name></author><author><name sortKey="Hayakawa, K" uniqKey="Hayakawa K">K Hayakawa</name></author><author><name sortKey="Ohmagari, N" uniqKey="Ohmagari N">N Ohmagari</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Alraddadi, Bm" uniqKey="Alraddadi B">BM Alraddadi</name></author><author><name sortKey="Watson, Jt" uniqKey="Watson J">JT Watson</name></author><author><name sortKey="Almarashi, A" uniqKey="Almarashi A">A Almarashi</name></author><author><name sortKey="Abedi, Gr" uniqKey="Abedi G">GR Abedi</name></author><author><name sortKey="Turkistani, A" uniqKey="Turkistani A">A Turkistani</name></author><author><name sortKey="Sadran, M" uniqKey="Sadran M">M Sadran</name></author><author><name sortKey="Housa, A" uniqKey="Housa A">A Housa</name></author><author><name sortKey="Almazroa, Ma" uniqKey="Almazroa M">MA Almazroa</name></author><author><name sortKey="Alraihan, N" uniqKey="Alraihan N">N Alraihan</name></author><author><name sortKey="Banjar, A" uniqKey="Banjar A">A Banjar</name></author><author><name sortKey="Albalawi, E" uniqKey="Albalawi E">E Albalawi</name></author><author><name sortKey="Alhindi, H" uniqKey="Alhindi H">H Alhindi</name></author><author><name sortKey="Choudhry, Aj" uniqKey="Choudhry A">AJ Choudhry</name></author><author><name sortKey="Meiman, Jg" uniqKey="Meiman J">JG Meiman</name></author><author><name sortKey="Paczkowski, M" uniqKey="Paczkowski M">M Paczkowski</name></author><author><name sortKey="Curns, A" uniqKey="Curns A">A Curns</name></author><author><name sortKey="Mounts, A" uniqKey="Mounts A">A Mounts</name></author><author><name sortKey="Feikin, Dr" uniqKey="Feikin D">DR Feikin</name></author><author><name sortKey="Marano, N" uniqKey="Marano N">N Marano</name></author><author><name sortKey="Swerdlow, Dl" uniqKey="Swerdlow D">DL Swerdlow</name></author><author><name sortKey="Gerber, Si" uniqKey="Gerber S">SI Gerber</name></author><author><name sortKey="Hajjeh, R" uniqKey="Hajjeh R">R Hajjeh</name></author><author><name sortKey="Madani, Ta" uniqKey="Madani T">TA Madani</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kulcsar, Ka" uniqKey="Kulcsar K">KA Kulcsar</name></author><author><name sortKey="Coleman, Cm" uniqKey="Coleman C">CM Coleman</name></author><author><name sortKey="Beck, Se" uniqKey="Beck S">SE Beck</name></author><author><name sortKey="Frieman, Mb" uniqKey="Frieman M">MB Frieman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Roberts, A" uniqKey="Roberts A">A Roberts</name></author><author><name sortKey="Deming, D" uniqKey="Deming D">D Deming</name></author><author><name sortKey="Paddock, Cd" uniqKey="Paddock C">CD Paddock</name></author><author><name sortKey="Cheng, A" uniqKey="Cheng A">A Cheng</name></author><author><name sortKey="Yount, B" uniqKey="Yount B">B Yount</name></author><author><name sortKey="Vogel, L" uniqKey="Vogel L">L Vogel</name></author><author><name sortKey="Herman, Bd" uniqKey="Herman B">BD Herman</name></author><author><name sortKey="Sheahan, T" uniqKey="Sheahan T">T Sheahan</name></author><author><name sortKey="Heise, M" uniqKey="Heise M">M Heise</name></author><author><name sortKey="Genrich, Gl" uniqKey="Genrich G">GL Genrich</name></author><author><name sortKey="Zaki, Sr" uniqKey="Zaki S">SR Zaki</name></author><author><name sortKey="Baric, R" uniqKey="Baric R">R Baric</name></author><author><name sortKey="Subbarao, K" uniqKey="Subbarao K">K Subbarao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sheahan, Tp" uniqKey="Sheahan T">TP Sheahan</name></author><author><name sortKey="Sims, Ac" uniqKey="Sims A">AC Sims</name></author><author><name sortKey="Graham, Rl" uniqKey="Graham R">RL Graham</name></author><author><name sortKey="Menachery, Vd" uniqKey="Menachery V">VD Menachery</name></author><author><name sortKey="Gralinski, Le" uniqKey="Gralinski L">LE Gralinski</name></author><author><name sortKey="Case, Jb" uniqKey="Case J">JB Case</name></author><author><name sortKey="Leist, Sr" uniqKey="Leist S">SR Leist</name></author><author><name sortKey="Pyrc, K" uniqKey="Pyrc K">K Pyrc</name></author><author><name sortKey="Feng, Jy" uniqKey="Feng J">JY Feng</name></author><author><name sortKey="Trantcheva, I" uniqKey="Trantcheva I">I Trantcheva</name></author><author><name sortKey="Bannister, R" uniqKey="Bannister R">R Bannister</name></author><author><name sortKey="Park, Y" uniqKey="Park Y">Y Park</name></author><author><name sortKey="Babusis, D" uniqKey="Babusis D">D Babusis</name></author><author><name sortKey="Clarke, Mo" uniqKey="Clarke M">MO Clarke</name></author><author><name sortKey="Mackman, Rl" uniqKey="Mackman R">RL Mackman</name></author><author><name sortKey="Spahn, Je" uniqKey="Spahn J">JE Spahn</name></author><author><name sortKey="Palmiotti, Ca" uniqKey="Palmiotti C">CA Palmiotti</name></author><author><name sortKey="Siegel, D" uniqKey="Siegel D">D Siegel</name></author><author><name sortKey="Ray, As" uniqKey="Ray A">AS Ray</name></author><author><name sortKey="Cihlar, T" uniqKey="Cihlar T">T Cihlar</name></author><author><name sortKey="Jordan, R" uniqKey="Jordan R">R Jordan</name></author><author><name sortKey="Denison, Mr" uniqKey="Denison M">MR Denison</name></author><author><name sortKey="Baric, Rs" uniqKey="Baric R">RS Baric</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brown, Aj" uniqKey="Brown A">AJ Brown</name></author><author><name sortKey="Won, Jj" uniqKey="Won J">JJ Won</name></author><author><name sortKey="Graham, Rl" uniqKey="Graham R">RL Graham</name></author><author><name sortKey="Dinnon, Kh" uniqKey="Dinnon K">KH Dinnon</name></author><author><name sortKey="Sims, Ac" uniqKey="Sims A">AC Sims</name></author><author><name sortKey="Feng, Jy" uniqKey="Feng J">JY Feng</name></author><author><name sortKey="Cihlar, T" uniqKey="Cihlar T">T Cihlar</name></author><author><name sortKey="Denison, Mr" uniqKey="Denison M">MR Denison</name></author><author><name sortKey="Baric, Rs" uniqKey="Baric R">RS Baric</name></author><author><name sortKey="Sheahan, Tp" uniqKey="Sheahan T">TP Sheahan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, M" uniqKey="Wang M">M Wang</name></author><author><name sortKey="Cao, R" uniqKey="Cao R">R Cao</name></author><author><name sortKey="Zhang, L" uniqKey="Zhang L">L Zhang</name></author><author><name sortKey="Yang, X" uniqKey="Yang X">X Yang</name></author><author><name sortKey="Liu, J" uniqKey="Liu J">J Liu</name></author><author><name sortKey="Xu, M" uniqKey="Xu M">M Xu</name></author><author><name sortKey="Shi, Z" uniqKey="Shi Z">Z Shi</name></author><author><name sortKey="Hu, Z" uniqKey="Hu Z">Z Hu</name></author><author><name sortKey="Zhong, W" uniqKey="Zhong W">W Zhong</name></author><author><name sortKey="Xiao, G" uniqKey="Xiao G">G Xiao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gao, J" uniqKey="Gao J">J Gao</name></author><author><name sortKey="Tian, Z" uniqKey="Tian Z">Z Tian</name></author><author><name sortKey="Yang, X" uniqKey="Yang X">X Yang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schindewolf, C" uniqKey="Schindewolf C">C Schindewolf</name></author><author><name sortKey="Menachery, Vd" uniqKey="Menachery V">VD Menachery</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Menachery, Vd" uniqKey="Menachery V">VD Menachery</name></author><author><name sortKey="Yount, Bl" uniqKey="Yount B">BL Yount</name></author><author><name sortKey="Sims, Ac" uniqKey="Sims A">AC Sims</name></author><author><name sortKey="Debbink, K" uniqKey="Debbink K">K Debbink</name></author><author><name sortKey="Agnihothram, Ss" uniqKey="Agnihothram S">SS Agnihothram</name></author><author><name sortKey="Gralinski, Le" uniqKey="Gralinski L">LE Gralinski</name></author><author><name sortKey="Graham, Rl" uniqKey="Graham R">RL Graham</name></author><author><name sortKey="Scobey, T" uniqKey="Scobey T">T Scobey</name></author><author><name sortKey="Plante, Ja" uniqKey="Plante J">JA Plante</name></author><author><name sortKey="Royal, Sr" uniqKey="Royal S">SR Royal</name></author><author><name sortKey="Swanstrom, J" uniqKey="Swanstrom J">J Swanstrom</name></author><author><name sortKey="Sheahan, Tp" uniqKey="Sheahan T">TP Sheahan</name></author><author><name sortKey="Pickles, Rj" uniqKey="Pickles R">RJ Pickles</name></author><author><name sortKey="Corti, D" uniqKey="Corti D">D Corti</name></author><author><name sortKey="Randell, Sh" uniqKey="Randell S">SH Randell</name></author><author><name sortKey="Lanzavecchia, A" uniqKey="Lanzavecchia A">A Lanzavecchia</name></author><author><name sortKey="Marasco, Wa" uniqKey="Marasco W">WA Marasco</name></author><author><name sortKey="Baric, Rs" uniqKey="Baric R">RS Baric</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Menachery, Vd" uniqKey="Menachery V">VD Menachery</name></author><author><name sortKey="Yount, Bl" uniqKey="Yount B">BL Yount</name></author><author><name sortKey="Debbink, K" uniqKey="Debbink K">K Debbink</name></author><author><name sortKey="Agnihothram, S" uniqKey="Agnihothram S">S Agnihothram</name></author><author><name sortKey="Gralinski, Le" uniqKey="Gralinski L">LE Gralinski</name></author><author><name sortKey="Plante, Ja" uniqKey="Plante J">JA Plante</name></author><author><name sortKey="Graham, Rl" uniqKey="Graham R">RL Graham</name></author><author><name sortKey="Scobey, T" uniqKey="Scobey T">T Scobey</name></author><author><name sortKey="Ge, Xy" uniqKey="Ge X">XY Ge</name></author><author><name sortKey="Donaldson, Ef" uniqKey="Donaldson E">EF Donaldson</name></author><author><name sortKey="Randell, Sh" uniqKey="Randell S">SH Randell</name></author><author><name sortKey="Lanzavecchia, A" uniqKey="Lanzavecchia A">A Lanzavecchia</name></author><author><name sortKey="Marasco, Wa" uniqKey="Marasco W">WA Marasco</name></author><author><name sortKey="Shi, Zl" uniqKey="Shi Z">ZL Shi</name></author><author><name sortKey="Baric, Rs" uniqKey="Baric R">RS Baric</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ge, Xy" uniqKey="Ge X">XY Ge</name></author><author><name sortKey="Li, Jl" uniqKey="Li J">JL Li</name></author><author><name sortKey="Yang, Xl" uniqKey="Yang X">XL Yang</name></author><author><name sortKey="Chmura, Aa" uniqKey="Chmura A">AA Chmura</name></author><author><name sortKey="Zhu, G" uniqKey="Zhu G">G Zhu</name></author><author><name sortKey="Epstein, Jh" uniqKey="Epstein J">JH Epstein</name></author><author><name sortKey="Mazet, Jk" uniqKey="Mazet J">JK Mazet</name></author><author><name sortKey="Hu, B" uniqKey="Hu B">B Hu</name></author><author><name sortKey="Zhang, W" uniqKey="Zhang W">W Zhang</name></author><author><name sortKey="Peng, C" uniqKey="Peng C">C Peng</name></author><author><name sortKey="Zhang, Yj" uniqKey="Zhang Y">YJ Zhang</name></author><author><name sortKey="Luo, Cm" uniqKey="Luo C">CM Luo</name></author><author><name sortKey="Tan, B" uniqKey="Tan B">B Tan</name></author><author><name sortKey="Wang, N" uniqKey="Wang N">N Wang</name></author><author><name sortKey="Zhu, Y" uniqKey="Zhu Y">Y Zhu</name></author><author><name sortKey="Crameri, G" uniqKey="Crameri G">G Crameri</name></author><author><name sortKey="Zhang, Sy" uniqKey="Zhang S">SY Zhang</name></author><author><name sortKey="Wang, Lf" uniqKey="Wang L">LF Wang</name></author><author><name sortKey="Daszak, P" uniqKey="Daszak P">P Daszak</name></author><author><name sortKey="Shi, Zl" uniqKey="Shi Z">ZL Shi</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="article-commentary"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">mSphere</journal-id><journal-id journal-id-type="iso-abbrev">mSphere</journal-id><journal-id journal-id-type="hwp">msph</journal-id><journal-id journal-id-type="pmc">msph</journal-id><journal-id journal-id-type="publisher-id">mSphere</journal-id><journal-title-group><journal-title>mSphere</journal-title></journal-title-group><issn pub-type="epub">2379-5042</issn><publisher><publisher-name>American Society for Microbiology</publisher-name><publisher-loc>1752 N St., N.W., Washington, DC</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">32188753</article-id><article-id pub-id-type="pmc">7082143</article-id><article-id pub-id-type="publisher-id">mSphere00203-20</article-id><article-id pub-id-type="doi">10.1128/mSphere.00203-20</article-id><article-categories><subj-group subj-group-type="heading"><subject>Commentary</subject></subj-group><subj-group subj-group-type="overline"><subject>Host-Microbe Biology</subject></subj-group><subj-group subj-group-type="editorial-class"><subject>Editor's Pick</subject></subj-group></article-categories><title-group><article-title>COVID-19: Knowns, Unknowns, and Questions</article-title><alt-title alt-title-type="running-head">Commentary</alt-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Weston</surname><given-names>Stuart</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Frieman</surname><given-names>Matthew B.</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref></contrib><aff id="aff1"><label>a</label><addr-line>Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, USA</addr-line></aff></contrib-group><author-notes><corresp id="cor1">Address correspondence to Matthew B. Frieman, <email>mfrieman@som.umaryland.edu</email>.</corresp><fn fn-type="other"><p><bold>Citation</bold> Weston S, Frieman MB. 2020. COVID-19: knowns, unknowns, and questions. mSphere 5:e00203-20. <ext-link ext-link-type="uri" xlink:href="https://doi.org/10.1128/mSphere.00203-20">https://doi.org/10.1128/mSphere.00203-20</ext-link>.</p></fn></author-notes><pub-date pub-type="epub"><day>18</day><month>3</month><year>2020</year></pub-date><pub-date pub-type="collection"><season>Mar-Apr</season><year>2020</year></pub-date><volume>5</volume><issue>2</issue><elocation-id>e00203-20</elocation-id><permissions><copyright-statement>Copyright © 2020 Weston and Frieman.</copyright-statement><copyright-year>2020</copyright-year><copyright-holder>Weston and Frieman</copyright-holder><license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by/4.0/"><license-p>This is an open-access article distributed under the terms of the <ext-link ext-link-type="uri" xlink:href="https://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution 4.0 International license</ext-link>.</license-p></license></permissions><self-uri content-type="pdf" xlink:href="mSphere.00203-20.pdf"></self-uri><abstract abstract-type="precis"><p>The recent emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from the Hubei province in China in late 2019 demonstrates the epidemic potential of coronaviruses. The rapid spread of this virus across the world in only 2 months highlights the transmissibility of this family of viruses and the significant morbidity and mortality that they can cause. We highlight the current state of knowledge of coronavirus biology while answering questions concerning the current outbreak of SARS-CoV-2.</p></abstract><abstract><title>ABSTRACT</title><p>The recent emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from the Hubei province in China in late 2019 demonstrates the epidemic potential of coronaviruses. The rapid spread of this virus across the world in only 2 months highlights the transmissibility of this family of viruses and the significant morbidity and mortality that they can cause. We highlight the current state of knowledge of coronavirus biology while answering questions concerning the current outbreak of SARS-CoV-2.</p></abstract><kwd-group><title>KEYWORDS</title><kwd>COVID-19</kwd><kwd>SARS</kwd><kwd>coronavirus</kwd><kwd>SARS-CoV-2</kwd></kwd-group><counts><fig-count count="0"></fig-count><table-count count="0"></table-count><equation-count count="0"></equation-count><ref-count count="26"></ref-count><page-count count="5"></page-count><word-count count="3865"></word-count></counts><custom-meta-group><custom-meta><meta-name>cover-date</meta-name><meta-value>March/April 2020</meta-value></custom-meta></custom-meta-group></article-meta><notes notes-type="disclaimer"><p>The views expressed in this article do not necessarily reflect the views of the journal or of ASM.</p></notes></front></pmc><affiliations><list><country><li>États-Unis</li></country><region><li>Maryland</li></region></list><tree><country name="États-Unis"><region name="Maryland"><name sortKey="Weston, Stuart" sort="Weston, Stuart" uniqKey="Weston S" first="Stuart" last="Weston">Stuart Weston</name></region><name sortKey="Frieman, Matthew B" sort="Frieman, Matthew B" uniqKey="Frieman M" first="Matthew B." last="Frieman">Matthew B. 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