SrasV1, PascalFrancis, Curation, bibRecord, 000913

Bat severe acute respiratory syndrome-like coronavirus ORF3b homologues display different interferon antagonist activities

Identifieur interne : 000913 ( PascalFrancis/Curation ); précédent : 000912; suivant : 000914

Bat severe acute respiratory syndrome-like coronavirus ORF3b homologues display different interferon antagonist activities

Auteurs : PENG ZHOU [République populaire de Chine] ; HONGXIA LI [République populaire de Chine] ; HANZHONG WANG [République populaire de Chine] ; Wang Lin-Fa [Australie] ; ZHENGLI SHI [République populaire de Chine]

Source :

Journal of general virology [ 0022-1317 ] ; 2012.

RBID : Pascal:12-0103990

Descripteurs français

Pascal (Inist)
- Coronavirus, Interféron, Syndrome respiratoire aigu sévère.

English descriptors

KwdEn :
- Coronavirus, Interferon, Severe acute respiratory syndrome.

Abstract

The ORF3b protein of severe acute respiratory syndrome coronavirus (SARS-CoV) has a nuclear localization signal (NLS) at its C terminus and antagonizes interferon (IFN) function by modulating the activity of IFN regulatory factor 3 (IRF3). SARS-like coronaviruses (SL-CoVs) found in bats share an identical genome organization and high sequence identity for most of their gene products. In this study, ORF3b homologues were identified from three bat SL-CoV strains. These ORF3b homologues were C-terminally truncated and lacked the C-terminal NLS of SARS-CoV. IFN antagonist activities analysis demonstrated that one SL-CoV ORF3b still possessed IFN antagonist and IRF3-modulating activities. These results indicate that different ORF3b proteins display different IFN antagonist activities and this function is independent of the protein's nuclear localization, suggesting a potential link between bat SL-CoV ORF3b function and viral pathogenesis.

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A08	`01`	`1`	`ENG`	`@1 Bat severe acute respiratory syndrome-like coronavirus ORF3b homologues display different interferon antagonist activities`
A11	`01`	`1`		`@1 PENG ZHOU`
A11	`02`	`1`		`@1 HONGXIA LI`
A11	`03`	`1`		`@1 HANZHONG WANG`
A11	`04`	`1`		`@1 LIN-FA (Wang)`
A11	`05`	`1`		`@1 ZHENGLI SHI`
A14	`01`			`@1 State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences @2 Wuhan @3 CHN @Z 1 aut. @Z 2 aut. @Z 3 aut. @Z 5 aut.`
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A20				`@1 275-281`
A21				`@1 2012`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 13533 @5 354000502813940060`
A44				`@0 0000 @1 © 2012 INIST-CNRS. All rights reserved.`
A45				`@0 3/4 p.`
A47	`01`	`1`		`@0 12-0103990`
A60				`@1 P`
A61				`@0 A`
A64	`01`	`1`		`@0 Journal of general virology`
A66	`01`			`@0 GBR`
C01	`01`		`ENG`	@0 The ORF3b protein of severe acute respiratory syndrome coronavirus (SARS-CoV) has a nuclear localization signal (NLS) at its C terminus and antagonizes interferon (IFN) function by modulating the activity of IFN regulatory factor 3 (IRF3). SARS-like coronaviruses (SL-CoVs) found in bats share an identical genome organization and high sequence identity for most of their gene products. In this study, ORF3b homologues were identified from three bat SL-CoV strains. These ORF3b homologues were C-terminally truncated and lacked the C-terminal NLS of SARS-CoV. IFN antagonist activities analysis demonstrated that one SL-CoV ORF3b still possessed IFN antagonist and IRF3-modulating activities. These results indicate that different ORF3b proteins display different IFN antagonist activities and this function is independent of the protein's nuclear localization, suggesting a potential link between bat SL-CoV ORF3b function and viral pathogenesis.
C02	`01`	`X`		`@0 002A05C10`
C03	`01`	`X`	`FRE`	`@0 Coronavirus @2 NW @5 01`
C03	`01`	`X`	`ENG`	`@0 Coronavirus @2 NW @5 01`
C03	`01`	`X`	`SPA`	`@0 Coronavirus @2 NW @5 01`
C03	`02`	`X`	`FRE`	`@0 Interféron @2 NK @2 FR @5 05`
C03	`02`	`X`	`ENG`	`@0 Interferon @2 NK @2 FR @5 05`
C03	`02`	`X`	`SPA`	`@0 Interferón @2 NK @2 FR @5 05`
C03	`03`	`X`	`FRE`	`@0 Syndrome respiratoire aigu sévère @2 NM @5 14`
C03	`03`	`X`	`ENG`	`@0 Severe acute respiratory syndrome @2 NM @5 14`
C03	`03`	`X`	`SPA`	`@0 Síndrome respiratorio agudo severo @2 NM @5 14`
C07	`01`	`X`	`FRE`	`@0 Coronaviridae @2 NW`
C07	`01`	`X`	`ENG`	`@0 Coronaviridae @2 NW`
C07	`01`	`X`	`SPA`	`@0 Coronaviridae @2 NW`
C07	`02`	`X`	`FRE`	`@0 Nidovirales @2 NW`
C07	`02`	`X`	`ENG`	`@0 Nidovirales @2 NW`
C07	`02`	`X`	`SPA`	`@0 Nidovirales @2 NW`
C07	`03`	`X`	`FRE`	`@0 Virus @2 NW`
C07	`03`	`X`	`ENG`	`@0 Virus @2 NW`
C07	`03`	`X`	`SPA`	`@0 Virus @2 NW`
C07	`04`	`X`	`FRE`	`@0 Pathologie de l'appareil respiratoire @5 13`
C07	`04`	`X`	`ENG`	`@0 Respiratory disease @5 13`
C07	`04`	`X`	`SPA`	`@0 Aparato respiratorio patología @5 13`
C07	`05`	`X`	`FRE`	`@0 Virose`
C07	`05`	`X`	`ENG`	`@0 Viral disease`
C07	`05`	`X`	`SPA`	`@0 Virosis`
C07	`06`	`X`	`FRE`	`@0 Infection`
C07	`06`	`X`	`ENG`	`@0 Infection`
C07	`06`	`X`	`SPA`	`@0 Infección`
C07	`07`	`X`	`FRE`	`@0 Pathologie des poumons @5 16`
C07	`07`	`X`	`ENG`	`@0 Lung disease @5 16`
C07	`07`	`X`	`SPA`	`@0 Pulmón patología @5 16`
N21				`@1 079`
N44	`01`			`@1 OTO`
N82				`@1 OTO`

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Pascal:12-0103990

Le document en format XML

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<author><name sortKey="Peng Zhou" sort="Peng Zhou" uniqKey="Peng Zhou" last="Peng Zhou">PENG ZHOU</name>
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<author><name sortKey="Zhengli Shi" sort="Zhengli Shi" uniqKey="Zhengli Shi" last="Zhengli Shi">ZHENGLI SHI</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Bat severe acute respiratory syndrome-like coronavirus ORF3b homologues display different interferon antagonist activities</title>
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<series><title level="j" type="main">Journal of general virology</title>
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<front><div type="abstract" xml:lang="en">The ORF3b protein of severe acute respiratory syndrome coronavirus (SARS-CoV) has a nuclear localization signal (NLS) at its C terminus and antagonizes interferon (IFN) function by modulating the activity of IFN regulatory factor 3 (IRF3). SARS-like coronaviruses (SL-CoVs) found in bats share an identical genome organization and high sequence identity for most of their gene products. In this study, ORF3b homologues were identified from three bat SL-CoV strains. These ORF3b homologues were C-terminally truncated and lacked the C-terminal NLS of SARS-CoV. IFN antagonist activities analysis demonstrated that one SL-CoV ORF3b still possessed IFN antagonist and IRF3-modulating activities. These results indicate that different ORF3b proteins display different IFN antagonist activities and this function is independent of the protein's nuclear localization, suggesting a potential link between bat SL-CoV ORF3b function and viral pathogenesis.</div>
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Serveur d'exploration SRAS

Bat severe acute respiratory syndrome-like coronavirus ORF3b homologues display different interferon antagonist activities

Bat severe acute respiratory syndrome-like coronavirus ORF3b homologues display different interferon antagonist activities

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