SrasV1, PascalFrancis, Curation, bibRecord, 000748

Identification of Viral and Atypical Bacterial Pathogens in Children Hospitalized With Acute Respiratory Infections in Hong Kong by Multiplex PCR Assays

Identifieur interne : 000748 ( PascalFrancis/Curation ); précédent : 000747; suivant : 000749

Identification of Viral and Atypical Bacterial Pathogens in Children Hospitalized With Acute Respiratory Infections in Hong Kong by Multiplex PCR Assays

Auteurs : R. Y. T. Sung [Hong Kong] ; Paul K. S. Chan [Hong Kong] ; Tracy Tsen [Hong Kong] ; A. M. Li [Hong Kong] ; W. Y. Lam [Hong Kong] ; Apple C. M. Yeung [Hong Kong] ; E. A. S. Nelson [Hong Kong]

Source :

Journal of medical virology [ 0146-6615 ] ; 2009.

RBID : Pascal:09-0037455

Descripteurs français

Pascal (Inist)
- Bactérie, Identification, Enfant, Hospitalisation, Aigu, Pathologie de l'appareil respiratoire, Hong Kong, Réaction chaîne polymérase multiplex, Voie respiratoire, Nasopharynx, Prélèvement.
Wicri :
- geographic : Hong Kong.
- topic : Enfant, Hospitalisation.

English descriptors

KwdEn :
- Acute, Bacteria, Child, Hong Kong, Hospitalization, Identification, Multiplex polymerase chain reaction, Nasopharynx, Respiratory disease, Respiratory tract, Samplings.

Abstract

Acute respiratory tract infection is a leading cause of hospital admission of children. This study used a broad capture, rapid and sensitive method (multiplex PCR assay) to detect 20 different respiratory pathogens including influenza A subtypes H1, H3, and H5; influenza B; parainfluenza types 1, 2, 3, and 4; respiratory syncytial virus (RSV) groups A and B; adenoviruses; human rhinoviruses; enteroviruses; human metapneumoviruses; human coronaviruses OC43, 229E, and SARS-CoV; Chlamydophila pneumoniae; Legionella pneumophila; and Mycoplasma pneumoniae; from respiratory specimens of 475 children hospitalized over a 12-month period for acute respiratory tract infections. The overall positive rate (47%) was about twice higher than previous reports based on conventional methods. Influenza A, parainfluenza and RSV accounted for 51%, and non-cultivable viruses accounted for 30% of positive cases. Influenza A peaked at March and June. Influenza B was detected in January, February, and April. Parainfluenza was prevalent throughout the year except from April to June. Most RSV infections were found between February and September. Adenovirus had multiple peaks, whereas rhino-virus and coronavirus OC43 were detected mainly in winter and early spring. RSV infection was associated with bronchiolitis, and parainfluenza was associated with croup; otherwise the clinical manifestations were largely nonspecific. In general, children infected with influenza A, adenovirus and mixed viruses had higher temperatures. In view of the increasing concern about unexpected outbreaks of severe viral infections, a rapid multiplex PCR assay is a valuable tool to enhance the management of hospitalized patients, and for the surveillance for viral infections circulating in the community.

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A03		`1`		`@0 J. med. virol.`
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A08	`01`	`1`	`ENG`	`@1 Identification of Viral and Atypical Bacterial Pathogens in Children Hospitalized With Acute Respiratory Infections in Hong Kong by Multiplex PCR Assays`
A11	`01`	`1`		`@1 SUNG (R. Y. T.)`
A11	`02`	`1`		`@1 CHAN (Paul K. S.)`
A11	`03`	`1`		`@1 TSEN (Tracy)`
A11	`04`	`1`		`@1 LI (A. M.)`
A11	`05`	`1`		`@1 LAM (W. Y.)`
A11	`06`	`1`		`@1 YEUNG (Apple C. M.)`
A11	`07`	`1`		`@1 NELSON (E. A. S.)`
A14	`01`			`@1 Department of Paediatrics, The Chinese University of Hong Kong @2 Shatin, New Territories @3 HKG @Z 1 aut. @Z 3 aut. @Z 4 aut. @Z 7 aut.`
A14	`02`			`@1 Department of Microbiology, Prince of Wales Hospital, The Chinese University of Hong Kong @2 Shatin, New Territories @3 HKG @Z 2 aut. @Z 5 aut. @Z 6 aut.`
A14	`03`			`@1 Stanley Ho Centre for Emerging Infectious Diseases, Faculty of Medicine, The Chinese University of Hong Kong @2 Shatin, New Territories @3 HKG @Z 2 aut.`
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A64	`01`	`1`		`@0 Journal of medical virology`
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C01	`01`		`ENG`	@0 Acute respiratory tract infection is a leading cause of hospital admission of children. This study used a broad capture, rapid and sensitive method (multiplex PCR assay) to detect 20 different respiratory pathogens including influenza A subtypes H1, H3, and H5; influenza B; parainfluenza types 1, 2, 3, and 4; respiratory syncytial virus (RSV) groups A and B; adenoviruses; human rhinoviruses; enteroviruses; human metapneumoviruses; human coronaviruses OC43, 229E, and SARS-CoV; Chlamydophila pneumoniae; Legionella pneumophila; and Mycoplasma pneumoniae; from respiratory specimens of 475 children hospitalized over a 12-month period for acute respiratory tract infections. The overall positive rate (47%) was about twice higher than previous reports based on conventional methods. Influenza A, parainfluenza and RSV accounted for 51%, and non-cultivable viruses accounted for 30% of positive cases. Influenza A peaked at March and June. Influenza B was detected in January, February, and April. Parainfluenza was prevalent throughout the year except from April to June. Most RSV infections were found between February and September. Adenovirus had multiple peaks, whereas rhino-virus and coronavirus OC43 were detected mainly in winter and early spring. RSV infection was associated with bronchiolitis, and parainfluenza was associated with croup; otherwise the clinical manifestations were largely nonspecific. In general, children infected with influenza A, adenovirus and mixed viruses had higher temperatures. In view of the increasing concern about unexpected outbreaks of severe viral infections, a rapid multiplex PCR assay is a valuable tool to enhance the management of hospitalized patients, and for the surveillance for viral infections circulating in the community.
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C03	`02`	`X`	`ENG`	`@0 Identification @5 05`
C03	`02`	`X`	`SPA`	`@0 Identificación @5 05`
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C03	`03`	`X`	`ENG`	`@0 Child @5 06`
C03	`03`	`X`	`SPA`	`@0 Niño @5 06`
C03	`04`	`X`	`FRE`	`@0 Hospitalisation @5 07`
C03	`04`	`X`	`ENG`	`@0 Hospitalization @5 07`
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C03	`07`	`X`	`FRE`	`@0 Hong Kong @2 NG @5 10`
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C03	`08`	`X`	`ENG`	`@0 Multiplex polymerase chain reaction @5 11`
C03	`08`	`X`	`SPA`	`@0 Reacción cadena polimerasa multiplex @5 11`
C03	`09`	`X`	`FRE`	`@0 Voie respiratoire @5 12`
C03	`09`	`X`	`ENG`	`@0 Respiratory tract @5 12`
C03	`09`	`X`	`SPA`	`@0 Vía respiratoria @5 12`
C03	`10`	`X`	`FRE`	`@0 Nasopharynx @5 67`
C03	`10`	`X`	`ENG`	`@0 Nasopharynx @5 67`
C03	`10`	`X`	`SPA`	`@0 Nasofaringe @5 67`
C03	`11`	`X`	`FRE`	`@0 Prélèvement @5 68`
C03	`11`	`X`	`ENG`	`@0 Samplings @5 68`
C03	`11`	`X`	`SPA`	`@0 Toma de muestra @5 68`
C07	`01`	`X`	`FRE`	`@0 Homme`
C07	`01`	`X`	`ENG`	`@0 Human`
C07	`01`	`X`	`SPA`	`@0 Hombre`
C07	`02`	`X`	`FRE`	`@0 Chine @2 NG`
C07	`02`	`X`	`ENG`	`@0 China @2 NG`
C07	`02`	`X`	`SPA`	`@0 China @2 NG`
C07	`03`	`X`	`FRE`	`@0 Asie @2 NG`
C07	`03`	`X`	`ENG`	`@0 Asia @2 NG`
C07	`03`	`X`	`SPA`	`@0 Asia @2 NG`
N21				`@1 026`
N44	`01`			`@1 OTO`
N82				`@1 OTO`

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Pascal:09-0037455

Le document en format XML

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<term>Identification</term>
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<front><div type="abstract" xml:lang="en">Acute respiratory tract infection is a leading cause of hospital admission of children. This study used a broad capture, rapid and sensitive method (multiplex PCR assay) to detect 20 different respiratory pathogens including influenza A subtypes H1, H3, and H5; influenza B; parainfluenza types 1, 2, 3, and 4; respiratory syncytial virus (RSV) groups A and B; adenoviruses; human rhinoviruses; enteroviruses; human metapneumoviruses; human coronaviruses OC43, 229E, and SARS-CoV; Chlamydophila pneumoniae; Legionella pneumophila; and Mycoplasma pneumoniae; from respiratory specimens of 475 children hospitalized over a 12-month period for acute respiratory tract infections. The overall positive rate (47%) was about twice higher than previous reports based on conventional methods. Influenza A, parainfluenza and RSV accounted for 51%, and non-cultivable viruses accounted for 30% of positive cases. Influenza A peaked at March and June. Influenza B was detected in January, February, and April. Parainfluenza was prevalent throughout the year except from April to June. Most RSV infections were found between February and September. Adenovirus had multiple peaks, whereas rhino-virus and coronavirus OC43 were detected mainly in winter and early spring. RSV infection was associated with bronchiolitis, and parainfluenza was associated with croup; otherwise the clinical manifestations were largely nonspecific. In general, children infected with influenza A, adenovirus and mixed viruses had higher temperatures. In view of the increasing concern about unexpected outbreaks of severe viral infections, a rapid multiplex PCR assay is a valuable tool to enhance the management of hospitalized patients, and for the surveillance for viral infections circulating in the community.</div>
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<fA11 i1="01" i2="1"><s1>SUNG (R. Y. T.)</s1>
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<fA14 i1="01"><s1>Department of Paediatrics, The Chinese University of Hong Kong</s1>
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<fA14 i1="02"><s1>Department of Microbiology, Prince of Wales Hospital, The Chinese University of Hong Kong</s1>
<s2>Shatin, New Territories</s2>
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</fA14>
<fA14 i1="03"><s1>Stanley Ho Centre for Emerging Infectious Diseases, Faculty of Medicine, The Chinese University of Hong Kong</s1>
<s2>Shatin, New Territories</s2>
<s3>HKG</s3>
<sZ>2 aut.</sZ>
</fA14>
<fA20><s1>153-159</s1>
</fA20>
<fA21><s1>2009</s1>
</fA21>
<fA23 i1="01"><s0>ENG</s0>
</fA23>
<fA43 i1="01"><s1>INIST</s1>
<s2>17422</s2>
<s5>354000184563690200</s5>
</fA43>
<fA44><s0>0000</s0>
<s1>© 2009 INIST-CNRS. All rights reserved.</s1>
</fA44>
<fA45><s0>3/4 p.</s0>
</fA45>
<fA47 i1="01" i2="1"><s0>09-0037455</s0>
</fA47>
<fA60><s1>P</s1>
</fA60>
<fA61><s0>A</s0>
</fA61>
<fA64 i1="01" i2="1"><s0>Journal of medical virology</s0>
</fA64>
<fA66 i1="01"><s0>USA</s0>
</fA66>
<fC01 i1="01" l="ENG"><s0>Acute respiratory tract infection is a leading cause of hospital admission of children. This study used a broad capture, rapid and sensitive method (multiplex PCR assay) to detect 20 different respiratory pathogens including influenza A subtypes H1, H3, and H5; influenza B; parainfluenza types 1, 2, 3, and 4; respiratory syncytial virus (RSV) groups A and B; adenoviruses; human rhinoviruses; enteroviruses; human metapneumoviruses; human coronaviruses OC43, 229E, and SARS-CoV; Chlamydophila pneumoniae; Legionella pneumophila; and Mycoplasma pneumoniae; from respiratory specimens of 475 children hospitalized over a 12-month period for acute respiratory tract infections. The overall positive rate (47%) was about twice higher than previous reports based on conventional methods. Influenza A, parainfluenza and RSV accounted for 51%, and non-cultivable viruses accounted for 30% of positive cases. Influenza A peaked at March and June. Influenza B was detected in January, February, and April. Parainfluenza was prevalent throughout the year except from April to June. Most RSV infections were found between February and September. Adenovirus had multiple peaks, whereas rhino-virus and coronavirus OC43 were detected mainly in winter and early spring. RSV infection was associated with bronchiolitis, and parainfluenza was associated with croup; otherwise the clinical manifestations were largely nonspecific. In general, children infected with influenza A, adenovirus and mixed viruses had higher temperatures. In view of the increasing concern about unexpected outbreaks of severe viral infections, a rapid multiplex PCR assay is a valuable tool to enhance the management of hospitalized patients, and for the surveillance for viral infections circulating in the community.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002A05C10</s0>
</fC02>
<fC02 i1="02" i2="X"><s0>002B05C02J</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Bactérie</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Bacteria</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Bacteria</s0>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Identification</s0>
<s5>05</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Identification</s0>
<s5>05</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Identificación</s0>
<s5>05</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Enfant</s0>
<s5>06</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Child</s0>
<s5>06</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Niño</s0>
<s5>06</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Hospitalisation</s0>
<s5>07</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Hospitalization</s0>
<s5>07</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Hospitalización</s0>
<s5>07</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Aigu</s0>
<s5>08</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Acute</s0>
<s5>08</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Agudo</s0>
<s5>08</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Pathologie de l'appareil respiratoire</s0>
<s5>09</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Respiratory disease</s0>
<s5>09</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Aparato respiratorio patología</s0>
<s5>09</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Hong Kong</s0>
<s2>NG</s2>
<s5>10</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Hong Kong</s0>
<s2>NG</s2>
<s5>10</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Hong Kong</s0>
<s2>NG</s2>
<s5>10</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE"><s0>Réaction chaîne polymérase multiplex</s0>
<s5>11</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>Multiplex polymerase chain reaction</s0>
<s5>11</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA"><s0>Reacción cadena polimerasa multiplex</s0>
<s5>11</s5>
</fC03>
<fC03 i1="09" i2="X" l="FRE"><s0>Voie respiratoire</s0>
<s5>12</s5>
</fC03>
<fC03 i1="09" i2="X" l="ENG"><s0>Respiratory tract</s0>
<s5>12</s5>
</fC03>
<fC03 i1="09" i2="X" l="SPA"><s0>Vía respiratoria</s0>
<s5>12</s5>
</fC03>
<fC03 i1="10" i2="X" l="FRE"><s0>Nasopharynx</s0>
<s5>67</s5>
</fC03>
<fC03 i1="10" i2="X" l="ENG"><s0>Nasopharynx</s0>
<s5>67</s5>
</fC03>
<fC03 i1="10" i2="X" l="SPA"><s0>Nasofaringe</s0>
<s5>67</s5>
</fC03>
<fC03 i1="11" i2="X" l="FRE"><s0>Prélèvement</s0>
<s5>68</s5>
</fC03>
<fC03 i1="11" i2="X" l="ENG"><s0>Samplings</s0>
<s5>68</s5>
</fC03>
<fC03 i1="11" i2="X" l="SPA"><s0>Toma de muestra</s0>
<s5>68</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Homme</s0>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Human</s0>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Hombre</s0>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Chine</s0>
<s2>NG</s2>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>China</s0>
<s2>NG</s2>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>China</s0>
<s2>NG</s2>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Asie</s0>
<s2>NG</s2>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Asia</s0>
<s2>NG</s2>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Asia</s0>
<s2>NG</s2>
</fC07>
<fN21><s1>026</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
</inist>
</record>

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Identification of Viral and Atypical Bacterial Pathogens in Children Hospitalized With Acute Respiratory Infections in Hong Kong by Multiplex PCR Assays

Identification of Viral and Atypical Bacterial Pathogens in Children Hospitalized With Acute Respiratory Infections in Hong Kong by Multiplex PCR Assays

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